MICE THAT MAKE HEAVY CHAIN ANTIBODIES Russian patent published in 2016 - IPC A01K67/27

Abstract RU 2603102 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. Genetically modified mice are described, including mice having a functional IgM gene and modified to have a deletion of a CH1 domain and a hinge region in a heavy chain constant domain that is not an IgM, e.g., in an IgG heavy chain constant domain. Genetically modified mice that make human variable/mouse constant chimeric heavy chain antibodies having only a heavy chain (antibodies that lack a light chain), fully mouse heavy chain antibodies, or fully human heavy chain antibodies are provided.

EFFECT: presented group of inventions can be applied in medicine.

63 cl, 13 dwg, 4 tbl, 7 ex

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RU 2 603 102 C2

Authors

Makdonald Linn

Stivens Shon

Merfi Endrju Dzh.

Dates

2016-11-20—Published

2010-12-10—Filed