FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to experimental oncology. Anesthesia is introduced in immunodeficient mice. Skin and abdominal wall tissues are incised perpendicularly to the middle line of the body in the left hypochondrium for 22 mm. Beginning of the incision is located 5 mm from the left costal arch, and its end extends 3 mm beyond the middle line into the right half of the animal's body. Gastrolienal lobe of pancreas is dissected in cranial-caudal direction at distance of 3 mm from caudal edge and 5 mm from left edge of pancreas with depth of 2 mm, length 2 mm. Fragment of human pancreatic neuroendocrine tumor 15 mm3 by means of ligature is fixed to wall of pancreas above dissection. Abdominal cavity is closed.
EFFECT: method enables to obtain an orthotopic patient-like model of neuroendocrine pancreatic cancer, most adequately reflecting features of oncogenesis occurring in the human body, and is a valuable test system for preclinical studies of various methods of treating neuroendocrine pancreatic cancer.
1 cl, 3 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF HUMAN COLON TUMOR FRAGMENT TRANSPLANTATION INTO CECUM OF IMMUNODEFICIENT MICE | 2020 |
|
RU2727868C1 |
| METHOD OF TRANSPLANTATION OF A FRAGMENT OF A HUMAN COLON TUMOR INTO THE DESCENDING COLON OF IMMUNODEFICIENT MICE | 2020 |
|
RU2753144C1 |
| METHOD FOR ACCESSING THE BODY OF THE STOMACH OF IMMUNODEFICIENCY MICE WITH ORTHOTOPIC TRANSPLANTATION OF A FRAGMENT OF A HUMAN STOMACH TUMOR | 2022 |
|
RU2790950C1 |
| METHOD OF SELECTING OPTIMAL ACCESS FOR ORTHOTOPIC TRANSPLANTATION OF HUMAN OVARIAN CANCER TUMOR INTO OVARY OF IMMUNE-DEFICIENT MOUSE | 2020 |
|
RU2740423C1 |
| METHOD OF CREATING LIVER CANCER MODEL ON IMMUNODEFICIENT MICE | 2023 |
|
RU2799132C1 |
| METHOD OF HUMAN OVARIAN CANCER TUMOR FRAGMENT TRANSPLANTATION INTO OVARY OF IMMUNE-DEFICIENT FEMALE MOUSE | 2020 |
|
RU2740443C1 |
| METHOD OF ORTHOTOPIC HUMAN CEREBRAL GLIOBLASTOMA TRANSPLANTATION INTO CEREBRAL CORTEX PARIETALIS REGION OF IMMUNODEFICIENT MICE | 2020 |
|
RU2742449C1 |
| METHOD FOR OBTAINING AN ORTHOTOPIC PDX MODEL OF SQUAMOUS CELL CARCINOMA OF THE HUMAN ESOPHAGUS FOR THE STUDY OF RADIATION THERAPY IN AN EXPERIMENT | 2021 |
|
RU2760084C1 |
| METHOD OF ORTHOTOPIC TRANSPLANTATION OF HUMAN ESOPHAGEAL CELL CULTURE INTO CERVICAL ESOPHAGEAL SEGMENT OF IMMUNODEFICIENT MICE | 2019 |
|
RU2713798C1 |
| METHOD FOR CREATING XENOGRAFT OF CANCER OF ESOPHAGUS OF INTRATHORACIC LOCALIZATION ON IMMUNE DEFICIENT MICE | 2020 |
|
RU2738308C1 |
