FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a ribonucleoprotein complex for human genome editing by inserting a sequence of interest into it, which includes the spCas9 protein linked to sgRNA-BoxB with an encoded sequence that is linked to an effector chimeric protein.
EFFECT: invention is effective for creating cellular models of human diseases, which can then be used for drug screening.
1 cl, 4 dwg
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