FIELD: biotechnology.
SUBSTANCE: invention relates to a method of editing the genome of a mammal by homologous repair using the CRISPR system, including the formation of a genome break. This method involves attracting the PALB2 protein to the site of rupture.
EFFECT: invention makes it possible to expand the arsenal of means for increasing the efficiency of genome editing through homologous repair in mammalian cells.
1 cl, 3 dwg
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