METHOD FOR TREATMENT OF RAT M-1 TRANSFERABLE CONNECTIVE TISSUE SARCOMA UNDER COMBINED IMPACT OF PHOTODYNAMIC THERAPY AND RADIATION THERAPY Russian patent published in 2022 - IPC G09B23/28 A61N5/67 A61N5/10 A61K31/409 A61P35/00 

FIELD: experimental medicine.

SUBSTANCE: invention relates to experimental medicine, namely to oncology, and can be used for combined therapy of grafted superficial solid connective tissue tumor M-1 sarcoma in rats. The combined effect of radiation therapy and photodynamic therapy is carried out according to the scheme: RT + PDT, with a time interval of 48 hours; a PDT session is performed with the photosensitizer amidoamine chlorine e6 (AAC), which is administered intraperitoneally at a dose of 1.25 mg/kg of animal weight, which is extrapolated to the human dose of 0.21 mg/kg, the drug-light interval between drug administration and laser irradiation is 3.0 hours, the parameters of laser exposure are: energy density E = 300 J/cm², power density Ps = 0.48 W/cm², during radiation therapy, the dose of γ-radiation was 20 Gy.

EFFECT: method allows to determine the optimal conditions for conducting combination therapy in its various sequences, at different time intervals, with a low dose of a photosensitizer and low γ-radiation parameters to achieve a pronounced positive effect, consisting in the elimination of a neoplasm, due to a set of techniques of the claimed invention.

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