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RU

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2 776 449

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C1

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IPC

A61B18/20(2006-01-01)

A61K31/409(2006-01-01)

A61K47/36(2006-01-01)

A61P35/00(2006-01-01)

A61N5/67(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2021131846, 2021-10-30

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Start date

2021-10-30

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Actual filing date

2021-10-30

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Published

2022-07-21

(72)

Inventor

Abramova Olga BorisovnaChurikova Tatiana PetrovnaKozlovtseva Ekaterina AleksandrovnaDrozhzhina Valentina VladimirovnaKaplan Mikhail AleksandrovichIvanov Sergei AnatolevichKaprin Andrei Dmitrievich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Radiologii» Ministerstva Zdravookhraneniia Rossiiskoi Federatsii Radiologii» Minzdrava Rossii)

METHOD FOR PHOTODYNAMIC THERAPY OF RAT SURFACE SOLID CONNECTIVE TISSUE SARCOMA M-1 Russian patent published in 2022 - IPC A61B18/20 A61K31/409 A61K47/36 A61P35/00 A61N5/67 G09B23/28 

Abstract RU 2776449 C1

FIELD: experimental medicine.

SUBSTANCE: invention relates to experimental medicine, namely to oncology, and can be used for carrying out photodynamic therapy (PDT) of transplanted superficial solid connective tissue tumor M-1 sarcoma in rats. To do this, the photosensitizer Heliochlorin is administered intravenously at a dose of 2.5 mg/kg. Then, after 30 minutes, the tumor is exposed to laser radiation with an energy density of E = 150 J/cm2, a wavelength of 662 nm and a power density of Ps = 0.48 W/cm2.

EFFECT: method provides maximum antitumor effect, 100% cure of animals on the 90th day after PDT session with no neoplasm recurrence, while reducing the amount of photosensitizer administered and the dose of laser exposure to animals.

1 cl, 1 dwg, 3 tbl

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RU 2 776 449 C1

Authors

Abramova Olga Borisovna

Churikova Tatiana Petrovna

Kozlovtseva Ekaterina Aleksandrovna

Drozhzhina Valentina Vladimirovna

Kaplan Mikhail Aleksandrovich

Ivanov Sergei Anatolevich

Kaprin Andrei Dmitrievich

Dates

2022-07-21—Published

2021-10-30—Filed

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