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(19)

(11)

2 820 200

(13)

(51)

IPC

A61K31/7088(2006-01-01)

A61K45/06(2006-01-01)

C12N15/115(2010-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2022107055, 2022-03-17

(24)

Start date

2022-03-17

(22)

Actual filing date

2022-03-17

(45)

Published

2024-05-30

(72)

Inventor

Pavlova Galina ValerievnaKolesnikova Varvara AnatolevnaKopylov Aleksej Mikhajlovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Vysshej Nervnoj Deyatelnosti I Nejrofiziologii Rossijskoj Akademii Nauk

METHOD OF TREATING HUMAN GLIOMA BY REDUCING PROLIFERATION AND INDUCING DIFFERENTIATION OF HUMAN GLIOMA TUMOR CELLS Russian patent published in 2024 - IPC A61K31/7088 A61K45/06 C12N15/115 A61P35/00

Abstract RU 2820200 C2

FIELD: biotechnology; medicine.

SUBSTANCE: disclosed is a method for reducing proliferation and inducing differentiation of human tumour cells in glioma therapy. Grade III and IV glioma cells are exposed to an aptamer having the sequence GGGTGGGTGGGTGGGTTTGGGTGGGTGGGTGGG, then every second day neuroinducer factors SB431542 and LDN-193189 are added, Purmorphamine is added on 5^th day, and BDNF is added on 7^th day.

EFFECT: method enables reducing proliferation of high-grade human glioma tumour cells, in particular, by 85,7–94,1% in case of grade IV gliomas, by 96,5% in case of grade III glioma, and also enables to reduce expression of stemness markers.

1 cl, 4 dwg, 1 tbl, 3 ex

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RU 2 820 200 C2

Authors

Pavlova Galina Valerievna

Kolesnikova Varvara Anatolevna

Kopylov Aleksej Mikhajlovich

Dates

2024-05-30—Published

2022-03-17—Filed