FIELD: biotechnology.
SUBSTANCE: invention relates to a genetically modified mouse containing all human IGHV genes in an endogenous immunoglobulin heavy chain gene locus, all human IGHD genes and all human IGHJ genes in human chromosome 14 immunoglobulin heavy chain gene locus, as well as to its cell.
EFFECT: invention is effective for producing humanised antibodies.
14 cl, 82 dwg, 16 tbl, 17 ex
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