METHOD FOR PREDICTING RISK OF DEVELOPING MALE INFERTILITY BASED ON ASSOCIATION WITH POLYMORPHIC VARIANT rs25487 OF XRCC1 DNA REPAIR PROTEIN GENE Russian patent published in 2024 - IPC G01N33/48 G01N33/50 C12Q1/6876 

Abstract RU 2827620 C1

FIELD: molecular biology.

SUBSTANCE: what is described is a method for prediction of idiopathic male infertility involving DNA recovery and genotyping of a polymorphic variant rs25487 of the DNA repair system gene (XRCC1). According to the invention, the method employs a native ejaculate produced by way of mastication, and if the genotype GG or allele G of the polymorphic variant rs25487 is detected, a risk of developing idiopathic male infertility in the form of oligoasthenoteratospermia or asthenoteratozoospermia is predicted.

EFFECT: higher prediction accuracy.

1 cl, 1 tbl, 4 ex

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RU 2 827 620 C1

Authors

Galimova Elmira Fanisovna

Giliazova Irina Rishatovna

Galimov Shamil Narimanovich

Galimova Saida Shamilevna

Mochalov Konstantin Sergeevich

Galimov Kamil Shamilevich

Gromenko Iuliia Iurevna

Pavlov Valentin Nikolaevich

Dates

2024-09-30Published

2024-02-20Filed