СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ПЕПТИДА И ПОЛУЧЕННЫЙ ПЕПТИД Российский патент 2014 года по МПК C07K5/00 C07K7/00 

Изобретение относится к области биохимии и касается рекомбинантного способа получения пептидов и полученных пептидов. В частности, изобретение относится к пептидам общей формулы

A-Thr-Lys-Pro-Б-В-Г-Х,

где А - 0, Met, Met(0), Thr, Ala, His, Phe, Lys, Gly

Б - 0, Gly, Asp, Trp, Gin, Asn, Tyr, Pro, Arg

В - 0, Arg, Phe, Tyr, Gly, His, Pro, Lys

Г - 0, Val, Gly, Tyr, Trp, Phe, His

X - OH, OCH₃, NH₂,

где 0 - отсутствие аминокислотного остатка, при условии, если А≠0, то Б и/или, В и/или Г≠0, если Б≠0, то В и/или Г≠0, исключая пептиды Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg, Thr-Lys-Pro-Arg-Gly.

Известно, что короткие пептиды обладают чрезвычайно высокой активностью, стимулируя органы, в которых произошел сбой, к самовосстановлению. Как известно, сначала короткие пептиды были получены из тканей животных, однако затем их научились создавать в лаборатории.

Препараты, содержащие пептиды, способны восстановить разрушенные клетки организма, вернуть органу все его утраченные функции, а также омолодить. Препараты, содержащие пептиды, были созданы более трех десятков лет назад, и за это время были проведены сотни экспериментов, которые доказали эффективность пептидов в лечении и профилактике заболеваний различных систем человека, а также омоложении отдельных органов и организма в целом.

В организме пептиды являются "информационными" гонцами, они переносят информацию от одной клетки к другой для того, чтобы все в организме делалось вовремя и хорошо. Клетка работает хорошо, соответственно, весь орган работает хорошо. Если же происходит сбой, то сбивается весь орган, это ведет к болезни. Конечно, можно лечить болезни, вводить в организм недостающие вещества, но тогда клетка совсем «разленится» и вовсе перестанет работать. Поэтому и надо посылать гонцов-пептидов, они заставят ее работать, организм будет лечить себя сам. В каждом органе есть запас резервных стволовых клеток. Если этот запас равномерно реализуется, тогда человек доживает до 100-110 лет. Пептиды одинаковы для всех млекопитающих. Поэтому, если взять пептид теленка и ввести его человеку, наш организм примет его как родного. Главной проблемой было научиться выделять пептиды из органов животных. И эту технологию еще в 1971 г. в Военно-медицинской академии изобрели профессоры Владимир Хавинсон и Вячеслав Морозов. Были созданы лекарственные препараты, затем на их основе сделали БАДы, так как БАД просты в применении. Изучая процессы старения и способы воздействия на него, сотрудники Института геронтологии г.Санкт-Петербурга пришли к выводу, что включая в рацион питания подопытной группы мышей пептиды, продолжительность их жизни увеличивается на 30-38%. Потом исследования пептидов были проведены на пожилых людях в Киевском институте геронтологии и в Санкт-Петербурге. Это способствовало снижению смертности почти в 2 раза, что свидетельствовало о высокой геропротективной активности пептидов. Многолетнее изучение и применение пептидных препаратов показало их высокую эффективность у пациентов различных возрастных групп, но особая эффективность была отмечена у лиц старшего возраста (старше 50 лет). Безусловным достоинством пептидных биорегуляторов является отсутствие каких-либо побочных реакций. В течение 26 лет препараты получили более 15 млн. человек с различной патологией. Эффективность применения составляла в среднем 75-95%. Дефицит пептидов, развивающийся с возрастом и при патологии, существенно ускоряет износ тканей и старение организма. Дело в том, что для адекватной работы клеток и тканей нужно адекватное количество пептидов, которые, в свою очередь, поддерживают работу генов в оптимальном режиме. Пептиды, работающие в специфичных для них клетках, в них же и синтезируются. Поэтому при патологии, а также с возрастом нарушается работа клеток, следовательно, нарушается воспроизводство пептидов, а вслед за этим, вторично, снова страдает функция клеток. Дегенерация тканей прогрессирует, что, в конечном счете, проявляется клинически. Поэтому применение коротких пептидов является одной из главных инноваций в медицине и позволяет существенно замедлить темпы старения за счет стимулирования пролиферации и регенерации тканей, а также повышения их клеточного ресурса. Еще одним немаловажным преимуществом пептидов является их выраженное противоопухолевое действие. На сегодняшний день применение пептидов является лучшим и бескомпромиссным решением в области ревитализации (омоложения организма) и профилактики онкологических заболеваний, поскольку позволяет проводить обновление клеток и тканей не только за счет регуляции и синхронизации всех циклических процессов, но также и за счет расширения возможностей деления клетки без атипии ("Атипия" - неправильное строение клеток, несоответствие норме).

Конечно, на современном этапе развития уровня техники получение коротких пептидов из тканей животных является нецелесообразным, т.к. такой способ производства является очень затратным, не говоря уже о гуманности такого способа получения.

Современным и перспективным способом получения является рекомбинантный способ с использованием микроорганизмов. Наиболее удобным микроорганизмом является Е.coli. Из уровня техники известны коммерческие штаммы Е.сoli, пригодные для использования в лабораториях, такие как Е.coli K12, Е.coli 0104. Данные и аналогичные известные штаммы Е.coli могут быть использованы для получения штаммов, продуцирующих заявляемые короткие пептиды. В любой известный, пригодный для использования в лаборатории штамм может быть встроена нуклеиновая кислота, кодирующая соответствующий интересующий короткий пептид. Для встраивания ДНК в клетки-хозяева используют векторы, такие как бактериальные плазмиды, вирусы, вирионы, гибридные вектора, содержащие ДНК фага, и плазмиды. К ним относятся, например, космиды и фазмиды.

Кроме того, пептиды, конечно, можно получать и при помощи традиционного химического синтеза.

Предложенные пептиды решают задачу расширения ассортимента средств стимуляции половой и сексуальной функции для лечения половых и сексуальных дисфункций, которая остается актуальной. В настоящее время патогенетическое лечение подобных патологий осуществляется психотерапией, антидепрессантами, анксиолитиками, адаптогенами, а также витаминами, общими стимуляторами на растительной основе, БАДами. Подобное лечение длительное, малоэффективное и сопряжено с большим количеством побочных эффектов.

Одним из наиболее эффективных классов физиологически активных веществ для создания стимуляторов половой и сексуальной функции являются пептиды, которые, являясь эндогенными веществами, практически лишены побочных негативных эффектов.

Собственными исследованиями установлено, что гептопептид «Селанк» общей формулы Thr-Lys-Pro-Arg-Pro-Gly-Pro - синтетический аналог эндогенного пептида тафтцина может быть использован в качестве средства профилактики и лечения половых и сексуальных дисфункций (Патент РФ№2404793). Однако синтез гептопептида Селанк многостадийный, что сильно удорожает стоимость лекарств на его основе, и в организме он подвержен интенсивному протеолизу, что снижает его стимулирующий эффект при профилактике и лечении половых и сексуальных дисфункций.

Целью изобретения является расширение ассортимента средств со стимулирующей половую и сексуальную функции активностью.

Техническим результатом, достигаемым при реализации данного изобретения, является повышение эффективности профилактики и лечения половых и сексуальных дисфункций, уменьшение продолжительности курсового лечения, уменьшение стоимости лекарственных средств, где в качестве лекарственного препарата предложены пептиды общей формулы

A-Thr-Lys-Pro-Б-В-Г-Х,

где А - 0, Met, Met(0), Thr, Ala, His, Phe, Lys, Gly

Б - 0, Gly, Asp, Trp, Gin, Asn, Tyr, Pro, Arg

В - 0, Arg, Phe, Tyr, Gly, His, Pro, Lys

Г - 0, Val, Gly, Tyr, Trp, Phe, His

X - ОН, ОСН₃, NH₂, где 0 - отсутствие аминокислотного остатка.

При условии, если А≠0, то Б и/или В, и/или Г≠0, если Б≠0, то В и/или Г≠0, исключая пептиды Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg, Thr-Lys-Pro-Arg-Gly.

Выбор аминокислотных остатков в положении А, Б, В, Г, Х основывается на биоинформационном анализе частоты встречаемости аминокислотных остатков в соответствующих положениях N- концевых и С-концевых остатков аминокислот по базе данных [EROP-Moscow(http://erop.mbi.ras.ru/) Замятин А.А.]. Отбор этих аминокислотных остатков осуществлен исходя из критерия выше 50% встречаемости аминокислотного остатка в данном положении. Эта выборка аминокислотных остатков экспериментально подтверждена синтезом отдельных пептидов и проверкой их стимулирующей половую и сексуальную функции активностью на моделях in vivo. Положение фармакофора в пептиде определено экспериментально. Известно, что любой пептид подвергается действию пептидаз и распадается на определенные фрагменты. С этой целью были синтезированы фрагменты гептопептида «Селанк» - Thr-Lys; Thr-Lys-Pro; Pro-Gly-Pro; Arg-Pro-Gly-Pro; Pro-Arg-Pro-Gly-Pro и проведены исследования их активности. Результаты представлены в Таблице 4. В ходе данного анализа определен фармакофор - им является Thr-Lys-Pro и показано, что присоединение к нему с С-конца отдельных экспериментально выявленных аминокислотных остатков сохраняет активность (стимулирующую половую и сексуальную функцию) при условии, что количество аминокислотных остатков в пептиде три или более четырех, как показывают исследования (Таблица 5, Пример 10). Тетрапептиды не обладают стимулирующей половую и сексуальную функции активностью.

Указанный технический результат достигается направленным синтезом различных пептидов общей формулы A-Thr-Lys-Pro-Б-В-Г-Х (кроме тетрапептидов) и использованием этих пептидов как стимулятора половой и сексуальной функции с целью профилактики и лечения половых и сексуальных дисфункций.

Собственными исследованиями было установлено, что синтезированные пептиды, а именно трипептид Thr-Lys-Pro, пентапептид Thr-Lys-Pro-Arg-Pro, гексапептид Thr-Lys-Pro-Arg-Pro-Phe, отвечающие общей формуле A-Thr-Lys-Pro-Б-В-Г-Х, могут быть рекомендованы как стимуляторы половой и сексуальной функции.

Все пептиды, общей формулы A-Thr-Lys-Pro-Б-В-Г-Х (кроме тетрапептидов), рекомендуемые как стимуляторы половой и сексуальной функции имеют общую закономерность, а именно наличие в структуре молекулы пептида - трипептида Thr-Lys-Pro.

Гептапептид Thr-Lys-Pro-Arg-Pro-Gly-Pro (Селанк) использовался в качестве контроля.

Результаты проведенных исследований показали, что пептиды общей формулы A-Thr-Lys-Pro-Б-В-Г-Х (кроме тетрапептидов) обладают стимулирующей половую и сексуальную функции активностью и могут быть использованы в качестве лекарственных средств для профилактики и лечения половых и сексуальных дисфункций.

Некоторые пептиды общей формулы A-Thr-Lys-Pro-Б-В-Г-Х представлены в Таблице 1 и включают:

Таблица 1

X-OH Х-ОСН₃ X-NH₂ Thr-Lys-Pro Thr-Lys-Pro Thr-Lys-Pro Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Phe-His Thr-Lys-Pro-Phe-His Thr-Lys-Pro-Phe-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-His-His Thr-Lys-Pro-His-His Thr-Lys-Pro-His-His Thr-Lys-Pro-Lys-His Thr-Lys-Pro-Lys-His Thr-Lys-Pro-Lys-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-His

Thr-Lys-Pro-Gly-Arg-His Thr-Lys-Pro-Gly-Arg-His Thr-Lys-Pro-Gly-Arg-His Thr-Lys-Pro-Gly-Phe-His Thr-Lys-Pro-Gly-Phe-His Thr-Lys-Pro-Gly-Phe-His Thr-Lys-Pro-Gly-Tyr-His Thr-Lys-Pro-Gly-Tyr-His Thr-Lys-Pro-Gly-Tyr-His Thr-Lys-Pro-Gly-His-His Thr-Lys-Pro-Gly-His-His Thr-Lys-Pro-Gly-His-His Thr-Lys-Pro-Gly-Pro-His Thr-Lys-Pro-Gly-Pro-His Thr-Lys-Pro-Gly-Pro-His Thr-Lys-Pro-Gly-Lys-His Thr-Lys-Pro-Gly-Lys-His Thr-Lys-Pro-Gly-Lys-His Thr-Lys-Pro-Asp-His Thr-Lys-Pro-Asp-His Thr-Lys-Pro-Asp-His Thr-Lys-Pro-Asp-Arg-His Thr-Lys-Pro-Asp-Arg-His Thr-Lys-Pro-Asp-Arg-His Thr-Lys-Pro-Asp-Phe-His Thr-Lys-Pro-Asp-Phe-His Thr-Lys-Pro-Asp-Phe-His Thr-Lys-Pro-Asp-Tyr-His Thr-Lys-Pro-Asp-Tyr-His Thr-Lys-Pro-Asp-Tyr-His Thr-Lys-Pro-Asp-His-His Thr-Lys-Pro-Asp-His-His Thr-Lys-Pro-Asp-His-His Thr-Lys-Pro-Asp-Pro-His Thr-Lys-Pro-Asp-Pro-His Thr-Lys-Pro-Asp-Pro-His Thr-Lys-Pro-Asp-Lys-His Thr-Lys-Pro-Asp-Lys-His Thr-Lys-Pro-Asp-Lys-His Thr-Lys-Pro-Trp-His Thr-Lys-Pro-Trp-His Thr-Lys-Pro-Trp-His Thr-Lys-Pro- Thr-Lys-Pro-Trp- Thr-Lys-Pro-

Trp-Arg-His Arg-His Trp-Arg-His Thr-Lys-Pro-Trp-Phe-His Thr-Lys-Pro-Trp-Phe-His Thr-Lys-Pro-Trp-Phe-His Thr-Lys-Pro-Trp-Tyr-His Thr-Lys-Pro-Trp-Tyr-His Thr-Lys-Pro-Trp-Tyr-His Thr-Lys-Pro-Trp-His-His Thr-Lys-Pro-Trp-His-His Thr-Lys-Pro-Trp-His-His Thr-Lys-Pro-Trp-Pro-His Thr-Lys-Pro-Trp-Pro-His Thr-Lys-Pro-Trp-Pro-His Thr-Lys-Pro-Trp-Lys-His Thr-Lys-Pro-Trp-Lys-His Thr-Lys-Pro-Trp-Lys-His Thr-Lys-Pro-Gln-His Thr-Lys-Pro-Gln-His Thr-Lys-Pro-Gln-His Thr-Lys-Pro-Gln-Arg-His Thr-Lys-Pro-Gln-Arg-His Thr-Lys-Pro-Gln-Arg-His Thr-Lys-Pro-Gln-Phe-His Thr-Lys-Pro-Gln-Phe-His Thr-Lys-Pro-Gln-Phe-His Thr-Lys-Pro-Gln-Tyr-His Thr-Lys-Pro-Gln-Tyr-His Thr-Lys-Pro-Gln-Tyr-His Thr-Lys-Pro-Gln-His-His Thr-Lys-Pro-Gln-His-His Thr-Lys-Pro-Gln-His-His Thr-Lys-Pro-Gln-Pro-His Thr-Lys-Pro-Gln-Pro-His Thr-Lys-Pro-Gln-Pro-His Thr-Lys-Pro-Gln-Lys-His Thr-Lys-Pro-Gln-Lys-His Thr-Lys-Pro-Gln-Lys-His Thr-Lys-Pro-Asn-His Thr-Lys-Pro-Asn-His Thr-Lys-Pro-Asn-His Thr-Lys-Pro-Asn-Arg-His Thr-Lys-Pro-Asn-Arg-His Thr-Lys-Pro-Asn-Arg-His

Thr-Lys-Pro-Asn-Phe-His Thr-Lys-Pro-Asn-Phe-His Thr-Lys-Pro-Asn-Phe-His Thr-Lys-Pro-Asn-Tyr-His Thr-Lys-Pro-Asn-Tyr-His Thr-Lys-Pro-Asn-Tyr-His Thr-Lys-Pro-Asn-His-His Thr-Lys-Pro-Asn-His-His Thr-Lys-Pro-Asn-His-His Thr-Lys-Pro-Asn-Pro-His Thr-Lys-Pro-Asn-Pro-His Thr-Lys-Pro-Asn-Pro-His Thr-Lys-Pro-Asn-Lys-His Thr-Lys-Pro-Asn-Lys-His Thr-Lys-Pro-Asn-Lys-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-Arg-His Thr-Lys-Pro-Tyr-Arg-His Thr-Lys-Pro-Tyr-Arg-His Thr-Lys-Pro-Tyr-Phe-His Thr-Lys-Pro-Tyr-Phe-His Thr-Lys-Pro-Tyr-Phe-His Thr-Lys-Pro-Tyr-Tyr-His Thr-Lys-Pro-Tyr-Tyr-His Thr-Lys-Pro-Tyr-Tyr-His Thr-Lys-Pro-Tyr-His-His Thr-Lys-Pro-Tyr-His-His Thr-Lys-Pro-Tyr-His-His Thr-Lys-Pro-Tyr-Pro-His Thr-Lys-Pro-Tyr-Pro-His Thr-Lys-Pro-Tyr-Pro-His Thr-Lys-Pro-Tyr-Lys-His Thr-Lys-Pro-Tyr-Lys-His Thr-Lys-Pro-Tyr-Lys-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-Arg-His Thr-Lys-Pro-Arg-Arg-His Thr-Lys-Pro-Arg-Arg-His Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Arg-Phe-His Arg-Phe-His Arg-Phe-His Thr-Lys-Pro-Arg-Tyr-His Thr-Lys-Pro-Arg-Tyr-His Thr-Lys-Pro-Arg-Tyr-His Thr-Lys-Pro-Arg-His-His Thr-Lys-Pro-Arg-His-His Thr-Lys-Pro-Arg-His-His Thr-Lys-Pro-Arg-Pro-His Thr-Lys-Pro-Arg-Pro-His Thr-Lys-Pro-Arg-Pro-His Thr-Lys-Pro-Arg-Lys-His Thr-Lys-Pro-Arg-Lys-His Thr-Lys-Pro-Arg-Lys-His Met-Thr-Lys-Pro-His Met-Thr-Lys-Pro-His Met-Thr-Lys-Pro-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Phe-His Met-Thr-Lys-Pro-Phe-His Met-Thr-Lys-Pro-Phe-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Gly-His Met-Thr-Lys-Pro-Gly-His Met-Thr-Lys-Pro-Gly-His Met-Thr-Lys-Pro-His-His Met-Thr-Lys-Pro-His-His Met-Thr-Lys-Pro-His-His Met-Thr-Lys-Pro-Lys-His Met-Thr-Lys-Pro-Lys-His Met-Thr-Lys-Pro-Lys-His Met-Thr-Lys-Pro-Gly-His Met-Thr-Lys-Pro-Gly-His Met-Thr-Lys-Pro-Gly-His Met-Thr-Lys-Pro-Gly-Arg-His Met-Thr-Lys-Pro-Gly-Arg-His Met-Thr-Lys-Pro-Gly-Arg-His Met-Thr-Lys-Pro-Gly-Phe-His Met-Thr-Lys-Pro-Gly-Phe-His Met-Thr-Lys-Pro-Gly-Phe-His

Met-Thr-Lys-Pro-Gly-Tyr-His Met-Thr-Lys-Pro-Gly-Tyr-His Met-Thr-Lys-Pro-Gly-Tyr-His Met-Thr-Lys-Pro-Gly-His-His Met-Thr-Lys-Pro-Gly-His-His Met-Thr-Lys-Pro-Gly-His-His Met-Thr-Lys-Pro-Gly-Pro-His Met-Thr-Lys-Pro-Gly-Pro-His Met-Thr-Lys-Pro-Gly-Pro-His Met-Thr-Lys-Pro-Gly-Lys-His Met-Thr-Lys-Pro-Gly-Lys-His Met-Thr-Lys-Pro-Gly-Lys-His Met-Thr-Lys-Pro-Asp-His Met-Thr-Lys-Pro-Asp-His Met-Thr-Lys-Pro-Asp-His Met-Thr-Lys-Pro-Asp-Arg-His Met-Thr-Lys-Pro-Asp-Arg-His Met-Thr-Lys-Pro-Asp-Arg-His Met-Thr-Lys-Pro-Asp-Phe-His Met-Thr-Lys-Pro-Asp-Phe-His Met-Thr-Lys-Pro-Asp-Phe-His Met-Thr-Lys-Pro-Asp-Tyr-His Met-Thr-Lys-Pro-Asp-Tyr-His Met-Thr-Lys-Pro-Asp-Tyr-His Met-Thr-Lys-Pro-Asp-His-His Met-Thr-Lys-Pro-Asp-His-His Met-Thr-Lys-Pro-Asp-His-His Met-Thr-Lys-Pro-Asp-Pro-His Met-Thr-Lys-Pro-Asp-Pro-His Met-Thr-Lys-Pro-Asp-Pro-His Met-Thr-Lys-Pro-Asp-Lys-His Met-Thr-Lys-Pro-Asp-Lys-His Met-Thr-Lys-Pro-Asp-Lys-His Met-Thr-Lys-Pro-Trp-His Met-Thr-Lys-Pro-Trp-His Met-Thr-Lys-Pro-Trp-His Met-Thr-Lys-Pro-Trp-Arg-His Met-Thr-Lys-Pro-Trp-Arg-His Met-Thr-Lys-Pro-Trp-Arg-His Met-Thr-Lys-Pro-Trp-Phe-His Met-Thr-Lys-Pro-Trp-Phe-His Met-Thr-Lys-Pro-Trp-Phe-His Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Trp-Tyr-His Pro-Trp-Tyr-His Pro-Trp-Tyr-His Met-Thr-Lys-Pro-Trp-His-His Met-Thr-Lys-Pro-Trp-His-His Met-Thr-Lys-Pro-Trp-His-His Met-Thr-Lys-Pro-Trp-Pro-His Met-Thr-Lys-Pro-Trp-Pro-His Met-Thr-Lys-Pro-Trp-Pro-His Met-Thr-Lys-Pro-Trp-Lys-His Met-Thr-Lys-Pro-Trp-Lys-His Met-Thr-Lys-Pro-Trp-Lys-His Met-Thr-Lys-Pro-Gln-His Met-Thr-Lys-Pro-Gln-His Met-Thr-Lys-Pro-Gln-His Met-Thr-Lys-Pro-Gln-Arg-His Met-Thr-Lys-Pro-Gln-Arg-His Met-Thr-Lys-Pro-Gln-Arg-His Met-Thr-Lys-Pro-Gln-Phe-His Met-Thr-Lys-Pro-Gln-Phe-His Met-Thr-Lys-Pro-Gln-Phe-His Met-Thr-Lys-Pro-Gln-Tyr-His Met-Thr-Lys-Pro-Gln-Tyr-His Met-Thr-Lys-Pro-Gln-Tyr-His Met-Thr-Lys-Pro-Gln-His-His Met-Thr-Lys-Pro-Gln-His-His Met-Thr-Lys-Pro-Gln-His-His Met-Thr-Lys-Pro-Gln-Pro-His Met-Thr-Lys-Pro-Gln-Pro-His Met-Thr-Lys-Pro-Gln-Pro-His Met-Thr-Lys-Pro-Gln-Lys-His Met-Thr-Lys-Pro-Gln-Lys-His Met-Thr-Lys-Pro-Gln-Lys-His Met-Thr-Lys-Pro-Asn-His Met-Thr-Lys-Pro-Asn-His Met-Thr-Lys-Pro-Asn-His Met-Thr-Lys-Pro-Asn-Arg-His Met-Thr-Lys-Pro-Asn-Arg-His Met-Thr-Lys-Pro-Asn-Arg-His Met-Thr-Lys-Pro-Asn-Phe-His Met-Thr-Lys-Pro-Asn-Phe-His Met-Thr-Lys-Pro-Asn-Phe-His Met-Thr-Lys-Pro-Asn-Tyr-His Met-Thr-Lys-Pro-Asn-Tyr-His Met-Thr-Lys-Pro-Asn-Tyr-His

Met-Thr-Lys-Pro-Asn-His-His Met-Thr-Lys-Pro-Asn-His-His Met-Thr-Lys-Pro-Asn-His-His Met-Thr-Lys-Pro-Asn-Pro-His Met-Thr-Lys-Pro-Asn-Pro-His Met-Thr-Lys-Pro-Asn-Pro-His Met-Thr-Lys-Pro-Asn-Lys-His Met-Thr-Lys-Pro-Asn-Lys-His Met-Thr-Lys-Pro-Asn-Lys-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-Arg-His Met-Thr-Lys-Pro-Tyr-Arg-His Met-Thr-Lys-Pro-Tyr-Arg-His Met-Thr-Lys-Pro-Tyr-Phe-His Met-Thr-Lys-Pro-Tyr-Phe-His Met-Thr-Lys-Pro-Tyr-Phe-His Met-Thr-Lys-Pro-Tyr-Tyr-His Met-Thr-Lys-Pro-Tyr-Tyr-His Met-Thr-Lys-Pro-Tyr-Tyr-His Met-Thr-Lys-Pro-Tyr-His-His Met-Thr-Lys-Pro-Tyr-His-His Met-Thr-Lys-Pro-Tyr-His-His Met-Thr-Lys-Pro-Tyr-Pro-His Met-Thr-Lys-Pro-Tyr-Pro-His Met-Thr-Lys-Pro-Tyr-Pro-His Met-Thr-Lys-Pro-Tyr-Lys-His Met-Thr-Lys-Pro-Tyr-Lys-His Met-Thr-Lys-Pro-Tyr-Lys-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-Arg-His Met-Thr-Lys-Pro-Arg-Arg-His Met-Thr-Lys-Pro-Arg-Arg-His Met-Thr-Lys-Pro-Arg-Phe-His Met-Thr-Lys-Pro-Arg-Phe-His Met-Thr-Lys-Pro-Arg-Phe-His Met-Thr-Lys-Pro-Arg-Tyr-His Met-Thr-Lys-Pro-Arg-Tyr-His Met-Thr-Lys-Pro-Arg-Tyr-His Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Arg-His-His Pro-Arg-His-His Pro-Arg-His-His Met-Thr-Lys-Pro-Arg-Pro-His Met-Thr-Lys-Pro-Arg-Pro-His Met-Thr-Lys-Pro-Arg-Pro-His Met-Thr-Lys-Pro-Arg-Lys-His Met-Thr-Lys-Pro-Arg-Lys-His Met-Thr-Lys-Pro-Arg-Lys-His Met(0)-Thr-Lys-Pro-His Met(0)-Thr-Lys-Pro-His Met(0)-Thr-Lys-Pro-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Phe-His Met(0)-Thr-Lys-Pro-Phe-His Met(0)-Thr-Lys-Pro-Phe-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-His-His Met(0)-Thr-Lys-Pro-His-His Met(0)-Thr-Lys-Pro-His-His Met(0)-Thr-Lys-Pro-Lys-His Met(0)-Thr-Lys-Pro-Lys-His Met(0)-Thr-Lys-Pro-Lys-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-Arg-His Met(0)-Thr-Lys-Pro-Gly-Arg-His Met(0)-Thr-Lys-Pro-Gly-Arg-His Met(0)-Thr-Lys-Pro-Gly-Phe-His Met(0)-Thr-Lys-Pro-Gly-Phe-His Met(0)-Thr-Lys-Pro-Gly-Phe-His Met(0)-Thr-Lys-Pro-Gly-Tyr-His Met(0)-Thr-Lys-Pro-Gly-Tyr-His Met(0)-Thr-Lys-Pro-Gly-Tyr-His Met(0)-Thr-Lys-Pro-Gly-His-His Met(0)-Thr-Lys-Pro-Gly-His-His Met(0)-Thr-Lys-Pro-Gly-His-His

Met(0)-Thr-Lys-Pro-Gly-Pro-His Met(0)-Thr-Lys-Pro-Gly-Pro-His Met(0)-Thr-Lys-Pro-Gly-Pro-His Met(0)-Thr-Lys-Pro-Gly-Lys-His Met(0)-Thr-Lys-Pro-Gly-Lys-His Met(0)-Thr-Lys-Pro-Gly-Lys-His Met(0)-Thr-Lys-Pro-Asp-His Met(0)-Thr-Lys-Pro-Asp-His Met(0)-Thr-Lys-Pro-Asp-His Met(0)-Thr-Lys-Pro-Asp-Arg-His Met(0)-Thr-Lys-Pro-Asp-Arg-His Met(0)-Thr-Lys-Pro-Asp-Arg-His Met(0)-Thr-Lys-Pro-Asp-Phe-His Met(0)-Thr-Lys-Pro-Asp-Phe-His Met(0)-Thr-Lys-Pro-Asp-Phe-His Met(0)-Thr-Lys-Pro-Asp-Tyr-His Met(0)-Thr-Lys-Pro-Asp-Tyr-His Met(0)-Thr-Lys-Pro-Asp-Tyr-His Met(0)-Thr-Lys-Pro-Asp-His-His Met(0)-Thr-Lys-Pro-Asp-His-His Met(0)-Thr-Lys-Pro-Asp-His-His Met(0)-Thr-Lys-Pro-Asp-Pro-His Met(0)-Thr-Lys-Pro-Asp-Pro-His Met(0)-Thr-Lys-Pro-Asp-Pro-His Met(0)-Thr-Lys-Pro-Asp-Lys-His Met(0)-Thr-Lys-Pro-Asp-Lys-His Met(0)-Thr-Lys-Pro-Asp-Lys-His Met(0)-Thr-Lys-Pro-Trp-His Met(0)-Thr-Lys-Pro-Trp-His Met(0)-Thr-Lys-Pro-Trp-His Met(0)-Thr-Lys-Pro-Trp-Arg-His Met(0)-Thr-Lys-Pro-Trp-Arg-His Met(0)-Thr-Lys-Pro-Trp-Arg-His Met(0)-Thr-Lys-Pro-Trp-Phe-His Met(0)-Thr-Lys-Pro-Trp-Phe-His Met(0)-Thr-Lys-Pro-Trp-Phe-His Met(0)-Thr-Lys-Pro-Trp-Tyr-His Met(0)-Thr-Lys-Pro-Trp-Tyr-His Met(0)-Thr-Lys-Pro-Trp-Tyr-His Met(0)-Thr-Lys-Pro-Trp-His-His Met(0)-Thr-Lys-Pro-Trp-His-His Met(0)-Thr-Lys-Pro-Trp-His-His Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Trp-Pro-His Pro-Trp-Pro-His Pro-Trp-Pro-His Met(0)-Thr-Lys-Pro-Trp-Lys-His Met(0)-Thr-Lys-Pro-Trp-Lys-His Met(0)-Thr-Lys-Pro-Trp-Lys-His Met(0)-Thr-Lys-Pro-Gln-His Met(0)-Thr-Lys-Pro-Gln-His Met(0)-Thr-Lys-Pro-Gln-His Met(0)-Thr-Lys-Pro-Gln-Arg-His Met(0)-Thr-Lys-Pro-Gln-Arg-His Met(0)-Thr-Lys-Pro-Gln-Arg-His Met(0)-Thr-Lys-Pro-Gln-Phe-His Met(0)-Thr-Lys-Pro-Gln-Phe-His Met(0)-Thr-Lys-Pro-Gln-Phe-His Met(0)-Thr-Lys-Pro-Gln-Tyr-His Met(0)-Thr-Lys-Pro-Gln-Tyr-His Met(0)-Thr-Lys-Pro-Gln-Tyr-His Met(0)-Thr-Lys-Pro-Gln-His-His Met(0)-Thr-Lys-Pro-Gln-His-His Met(0)-Thr-Lys-Pro-Gln-His-His Met(0)-Thr-Lys-Pro-Gln-Pro-His Met(0)-Thr-Lys-Pro-Gln-Pro-His Met(0)-Thr-Lys-Pro-Gln-Pro-His Met(0)-Thr-Lys-Pro-Gln-Lys-His Met(0)-Thr-Lys-Pro-Gln-Lys-His Met(0)-Thr-Lys-Pro-Gln-Lys-His Met(0)-Thr-Lys-Pro-Asn-His Met(0)-Thr-Lys-Pro-Asn-His Met(0)-Thr-Lys-Pro-Asn-His Met(0)-Thr-Lys-Pro-Asn-Arg-His Met(0)-Thr-Lys-Pro-Asn-Arg-His Met(0)-Thr-Lys-Pro-Asn-Arg-His Met(0)-Thr-Lys-Pro-Asn-Phe-His Met(0)-Thr-Lys-Pro-Asn-Phe-His Met(0)-Thr-Lys-Pro-Asn-Phe-His Met(0)-Thr-Lys-Pro-Asn-Tyr-His Met(0)-Thr-Lys-Pro-Asn-Tyr-His Met(0)-Thr-Lys-Pro-Asn-Tyr-His Met(0)-Thr-Lys-Pro-Asn-His-His Met(0)-Thr-Lys-Pro-Asn-His-His Met(0)-Thr-Lys-Pro-Asn-His-His Met(0)-Thr-Lys-Pro-Asn-Pro-His Met(0)-Thr-Lys-Pro-Asn-Pro-His Met(0)-Thr-Lys-Pro-Asn-Pro-His

Met(0)-Thr-Lys-Pro-Asn-Lys-His Met(0)-Thr-Lys-Pro-Asn-Lys-His Met(0)-Thr-Lys-Pro-Asn-Lys-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-Arg-His Met(0)-Thr-Lys-Pro-Tyr-Arg-His Met(0)-Thr-Lys-Pro-Tyr-Arg-His Met(0)-Thr-Lys-Pro-Tyr-Phe-His Met(0)-Thr-Lys-Pro-Tyr-Phe-His Met(0)-Thr-Lys-Pro-Tyr-Phe-His Met(0)-Thr-Lys-Pro-Tyr-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His-His Met(0)-Thr-Lys-Pro-Tyr-His-His Met(0)-Thr-Lys-Pro-Tyr-His-His Met(0)-Thr-Lys-Pro-Tyr-Pro-His Met(0)-Thr-Lys-Pro-Tyr-Pro-His Met(0)-Thr-Lys-Pro-Tyr-Pro-His Met(0)-Thr-Lys-Pro-Tyr-Lys-His Met(0)-Thr-Lys-Pro-Tyr-Lys-His Met(0)-Thr-Lys-Pro-Tyr-Lys-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-Arg-His Met(0)-Thr-Lys-Pro-Arg-Arg-His Met(0)-Thr-Lys-Pro-Arg-Arg-His Met(0)-Thr-Lys-Pro-Arg-Phe-His Met(0)-Thr-Lys-Pro-Arg-Phe-His Met(0)-Thr-Lys-Pro-Arg-Phe-His Met(0)-Thr-Lys-Pro-Arg-Tyr-His Met(0)-Thr-Lys-Pro-Arg-Tyr-His Met(0)-Thr-Lys-Pro-Arg-Tyr-His Met(0)-Thr-Lys-Pro-Arg-His-His Met(0)-Thr-Lys-Pro-Arg-His-His Met(0)-Thr-Lys-Pro-Arg-His-His Met(0)-Thr-Lys-Pro-Arg-Pro-His Met(0)-Thr-Lys-Pro-Arg-Pro-His Met(0)-Thr-Lys-Pro-Arg-Pro-His Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Arg-Lys-His Pro-Arg-Lys-His Pro-Arg-Lys-His Thr-Thr-Lys-Pro-His Thr-Thr-Lys-Pro-His Thr-Thr-Lys-Pro-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Phe-His Thr-Thr-Lys-Pro-Phe-His Thr-Thr-Lys-Pro-Phe-His Thr-Thr-Lys-Pro-Tyr-His Thr-Thr-Lys-Pro-Tyr-His Thr-Thr-Lys-Pro-Tyr-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-His-His Thr-Thr-Lys-Pro-His-His Thr-Thr-Lys-Pro-His-His Thr-Thr-Lys-Pro-Lys-His Thr-Thr-Lys-Pro-Lys-His Thr-Thr-Lys-Pro-Lys-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-Arg-His Thr-Thr-Lys-Pro-Gly-Arg-His Thr-Thr-Lys-Pro-Gly-Arg-His Thr-Thr-Lys-Pro-Gly-Phe-His Thr-Thr-Lys-Pro-Gly-Phe-His Thr-Thr-Lys-Pro-Gly-Phe-His Thr-Thr-Lys-Pro-Gly-Tyr-His Thr-Thr-Lys-Pro-Gly-Tyr-His Thr-Thr-Lys-Pro-Gly-Tyr-His Thr-Thr-Lys-Pro-Gly-His-His Thr-Thr-Lys-Pro-Gly-His-His Thr-Thr-Lys-Pro-Gly-His-His Thr-Thr-Lys-Pro-Gly-Pro-His Thr-Thr-Lys-Pro-Gly-Pro-His Thr-Thr-Lys-Pro-Gly-Pro-His Thr-Thr-Lys-Pro-Gly-Lys-His Thr-Thr-Lys-Pro-Gly-Lys-His Thr-Thr-Lys-Pro-Gly-Lys-His

Thr-Thr-Lys-Pro-Asp-His Thr-Thr-Lys-Pro-Asp-His Thr-Thr-Lys-Pro-Asp-His Thr-Thr-Lys-Pro-Asp-Arg-His Thr-Thr-Lys-Pro-Asp-Arg-His Thr-Thr-Lys-Pro-Asp-Arg-His Thr-Thr-Lys-Pro-Asp-Phe-His Thr-Thr-Lys-Pro-Asp-Phe-His Thr-Thr-Lys-Pro-Asp-Phe-His Thr-Thr-Lys-Pro-Asp-Tyr-His Thr-Thr-Lys-Pro-Asp-Tyr-His Thr-Thr-Lys-Pro-Asp-Tyr-His Thr-Thr-Lys-Pro-Asp-His-His Thr-Thr-Lys-Pro-Asp-His-His Thr-Thr-Lys-Pro-Asp-His-His Thr-Thr-Lys-Pro-Asp-Pro-His Thr-Thr-Lys-Pro-Asp-Pro-His Thr-Thr-Lys-Pro-Asp-Pro-His Thr-Thr-Lys-Pro-Asp-Lys-His Thr-Thr-Lys-Pro-Asp-Lys-His Thr-Thr-Lys-Pro-Asp-Lys-His Thr-Thr-Lys-Pro-Trp-His Thr-Thr-Lys-Pro-Trp-His Thr-Thr-Lys-Pro-Trp-His Thr-Thr-Lys-Pro-Trp-Arg-His Thr-Thr-Lys-Pro-Trp-Arg-His Thr-Thr-Lys-Pro-Trp-Arg-His Thr-Thr-Lys-Pro-Trp-Phe-His Thr-Thr-Lys-Pro-Trp-Phe-His Thr-Thr-Lys-Pro-Trp-Phe-His Thr-Thr-Lys-Pro-Trp-Tyr-His Thr-Thr-Lys-Pro-Trp-Tyr-His Thr-Thr-Lys-Pro-Trp-Tyr-His Thr-Thr-Lys-Pro-Trp-His-His Thr-Thr-Lys-Pro-Trp-His-His Thr-Thr-Lys-Pro-Trp-His-His Thr-Thr-Lys-Pro-Trp-Pro-His Thr-Thr-Lys-Pro-Trp-Pro-His Thr-Thr-Lys-Pro-Trp-Pro-His Thr-Thr-Lys-Pro-Trp-Lys-His Thr-Thr-Lys-Pro-Trp-Lys-His Thr-Thr-Lys-Pro-Trp-Lys-His Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Gln-His Gln-His Pro-Gln-His Thr-Thr-Lys-Pro-Gln-Arg-His Thr-Thr-Lys-Pro-Gln-Arg-His Thr-Thr-Lys-Pro-Gln-Arg-His Thr-Thr-Lys-Pro-Gln-Phe-His Thr-Thr-Lys-Pro-Gln-Phe-His Thr-Thr-Lys-Pro-Gln-Phe-His Thr-Thr-Lys-Pro-Gln-Tyr-His Thr-Thr-Lys-Pro-Gln-Tyr-His Thr-Thr-Lys-Pro-Gln-Tyr-His Thr-Thr-Lys-Pro-Gln-His-His Thr-Thr-Lys-Pro-Gln-His-His Thr-Thr-Lys-Pro-Gln-His-His Thr-Thr-Lys-Pro-Gln-Pro-His Thr-Thr-Lys-Pro-Gln-Pro-His Thr-Thr-Lys-Pro-Gln-Pro-His Thr-Thr-Lys-Pro-Gln-Lys-His Thr-Thr-Lys-Pro-Gln-Lys-His Thr-Thr-Lys-Pro-Gln-Lys-His Thr-Thr-Lys-Pro-Asn-His Thr-Thr-Lys-Pro-Asn-His Thr-Thr-Lys-Pro-Asn-His Thr-Thr-Lys-Pro-Asn-Arg-His Thr-Thr-Lys-Pro-Asn-Arg-His Thr-Thr-Lys-Pro-Asn-Arg-His Thr-Thr-Lys-Pro-Asn-Phe-His Thr-Thr-Lys-Pro-Asn-Phe-His Thr-Thr-Lys-Pro-Asn-Phe-His Thr-Thr-Lys-Pro-Asn-Tyr-His Thr-Thr-Lys-Pro-Asn-Tyr-His Thr-Thr-Lys-Pro-Asn-Tyr-His Thr-Thr-Lys-Pro-Asn-His-His Thr-Thr-Lys-Pro-Asn-His-His Thr-Thr-Lys-Pro-Asn-His-His Thr-Thr-Lys-Pro-Asn-Pro-His Thr-Thr-Lys-Pro-Asn-Pro-His Thr-Thr-Lys-Pro-Asn-Pro-His Thr-Thr-Lys-Pro-Asn-Lys-His Thr-Thr-Lys-Pro-Asn-Lys-His Thr-Thr-Lys-Pro-Asn-Lys-His Thr-Thr-Lys-Pro-Tyr-His Thr-Thr-Lys-Pro-Tyr-His Thr-Thr-Lys-Pro-Tyr-His

Thr-Thr-Lys-Pro-Tyr-Arg-His Thr-Thr-Lys-Pro-Tyr-Arg-His Thr-Thr-Lys-Pro-Tyr-Arg-His Thr-Thr-Lys-Pro-Tyr-Phe-His Thr-Thr-Lys-Pro-Tyr-Phe-His Thr-Thr-Lys-Pro-Tyr-Phe-His Thr-Thr-Lys-Pro-Tyr-Tyr-His Thr-Thr-Lys-Pro-Tyr-Tyr-His Thr-Thr-Lys-Pro-Tyr-Tyr-His Thr-Thr-Lys-Pro-Tyr-His-His Thr-Thr-Lys-Pro-Tyr-His-His Thr-Thr-Lys-Pro-Tyr-His-His Thr-Thr-Lys-Pro-Tyr-Pro-His Thr-Thr-Lys-Pro-Tyr-Pro-His Thr-Thr-Lys-Pro-Tyr-Pro-His Thr-Thr-Lys-Pro-Tyr-Lys-His Thr-Thr-Lys-Pro-Tyr-Lys-His Thr-Thr-Lys-Pro-Tyr-Lys-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-Arg-His Thr-Thr-Lys-Pro-Arg-Arg-His Thr-Thr-Lys-Pro-Arg-Arg-His Thr-Thr-Lys-Pro-Arg-Phe-His Thr-Thr-Lys-Pro-Arg-Phe-His Thr-Thr-Lys-Pro-Arg-Phe-His Thr-Thr-Lys-Pro-Arg-Tyr-His Thr-Thr-Lys-Pro-Arg-Tyr-His Thr-Thr-Lys-Pro-Arg-Tyr-His Thr-Thr-Lys-Pro-Arg-His-His Thr-Thr-Lys-Pro-Arg-His-His Thr-Thr-Lys-Pro-Arg-His-His Thr-Thr-Lys-Pro-Arg-Pro-His Thr-Thr-Lys-Pro-Arg-Pro-His Thr-Thr-Lys-Pro-Arg-Pro-His Thr-Thr-Lys-Pro-Arg-Lys-His Thr-Thr-Lys-Pro-Arg-Lys-His Thr-Thr-Lys-Pro-Arg-Lys-His Ala-Thr-Lys-Pro-His Ala-Thr-Lys-Pro-His Ala-Thr-Lys-Pro-His Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Arg-His Arg-His Pro-Arg-His Ala-Thr-Lys-Pro-Phe-His Ala-Thr-Lys-Pro-Phe-His Ala-Thr-Lys-Pro-Phe-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-His-His Ala-Thr-Lys-Pro-His-His Ala-Thr-Lys-Pro-His-His Ala-Thr-Lys-Pro-Lys-His Ala-Thr-Lys-Pro-Lys-His Ala-Thr-Lys-Pro-Lys-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-Arg-His Ala-Thr-Lys-Pro-Gly-Arg-His Ala-Thr-Lys-Pro-Gly-Arg-His Ala-Thr-Lys-Pro-Gly-Phe-His Ala-Thr-Lys-Pro-Gly-Phe-His Ala-Thr-Lys-Pro-Gly-Phe-His Ala-Thr-Lys-Pro-Gly-Tyr-His Ala-Thr-Lys-Pro-Gly-Tyr-His Ala-Thr-Lys-Pro-Gly-Tyr-His Ala-Thr-Lys-Pro-Gly-His-His Ala-Thr-Lys-Pro-Gly-His-His Ala-Thr-Lys-Pro-Gly-His-His Ala-Thr-Lys-Pro-Gly-Pro-His Ala-Thr-Lys-Pro-Gly-Pro-His Ala-Thr-Lys-Pro-Gly-Pro-His Ala-Thr-Lys-Pro-Gly-Lys-His Ala-Thr-Lys-Pro-Gly-Lys-His Ala-Thr-Lys-Pro-Gly-Lys-His Ala-Thr-Lys-Pro-Asp-His Ala-Thr-Lys-Pro-Asp-His Ala-Thr-Lys-Pro-Asp-His Ala-Thr-Lys-Pro-Asp-Arg-His Ala-Thr-Lys-Pro-Asp-Arg-His Ala-Thr-Lys-Pro-Asp-Arg-His

Ala-Thr-Lys-Pro-Asp-Phe-His Ala-Thr-Lys-Pro-Asp-Phe-His Ala-Thr-Lys-Pro-Asp-Phe-His Ala-Thr-Lys-Pro-Asp-Tyr-His Ala-Thr-Lys-Pro-Asp-Tyr-His Ala-Thr-Lys-Pro-Asp-Tyr-His Ala-Thr-Lys-Pro-Asp-His-His Ala-Thr-Lys-Pro-Asp-His-His Ala-Thr-Lys-Pro-Asp-His-His Ala-Thr-Lys-Pro-Asp-Pro-His Ala-Thr-Lys-Pro-Asp-Pro-His Ala-Thr-Lys-Pro-Asp-Pro-His Ala-Thr-Lys-Pro-Asp-Lys-His Ala-Thr-Lys-Pro-Asp-Lys-His Ala-Thr-Lys-Pro-Asp-Lys-His Ala-Thr-Lys-Pro-Trp-His Ala-Thr-Lys-Pro-Trp-His Ala-Thr-Lys-Pro-Trp-His Ala-Thr-Lys-Pro-Trp-Arg-His Ala-Thr-Lys-Pro-Trp-Arg-His Ala-Thr-Lys-Pro-Trp-Arg-His Ala-Thr-Lys-Pro-Trp-Phe-His Ala-Thr-Lys-Pro-Trp-Phe-His Ala-Thr-Lys-Pro-Trp-Phe-His Ala-Thr-Lys-Pro-Trp-Tyr-His Ala-Thr-Lys-Pro-Trp-Tyr-His Ala-Thr-Lys-Pro-Trp-Tyr-His Ala-Thr-Lys-Pro-Trp-His-His Ala-Thr-Lys-Pro-Trp-His-His Ala-Thr-Lys-Pro-Trp-His-His Ala-Thr-Lys-Pro-Trp-Pro-His Ala-Thr-Lys-Pro-Trp-Pro-His Ala-Thr-Lys-Pro-Trp-Pro-His Ala-Thr-Lys-Pro-Trp-Lys-His Ala-Thr-Lys-Pro-Trp-Lys-His Ala-Thr-Lys-Pro-Trp-Lys-His Ala-Thr-Lys-Pro-Gln-His Ala-Thr-Lys-Pro-Gln-His Ala-Thr-Lys-Pro-Gln-His Ala-Thr-Lys-Pro-Gln-Arg-His Ala-Thr-Lys-Pro-Gln-Arg-His Ala-Thr-Lys-Pro-Gln-Arg-His Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Gln-Phe-His Gln-Phe-His Pro-Gln-Phe-His Ala-Thr-Lys-Pro-Gln-Tyr-His Ala-Thr-Lys-Pro-Gln-Tyr-His Ala-Thr-Lys-Pro-Gln-Tyr-His Ala-Thr-Lys-Pro-Gln-His-His Ala-Thr-Lys-Pro-Gln-His-His Ala-Thr-Lys-Pro-Gln-His-His Ala-Thr-Lys-Pro-Gln-Pro-His Ala-Thr-Lys-Pro-Gln-Pro-His Ala-Thr-Lys-Pro-Gln-Pro-His Ala-Thr-Lys-Pro-Gln-Lys-His Ala-Thr-Lys-Pro-Gln-Lys-His Ala-Thr-Lys-Pro-Gln-Lys-His Ala-Thr-Lys-Pro-Asn-His Ala-Thr-Lys-Pro-Asn-His Ala-Thr-Lys-Pro-Asn-His Ala-Thr-Lys-Pro-Asn-Arg-His Ala-Thr-Lys-Pro-Asn-Arg-His Ala-Thr-Lys-Pro-Asn-Arg-His Ala-Thr-Lys-Pro-Asn-Phe-His Ala-Thr-Lys-Pro-Asn-Phe-His Ala-Thr-Lys-Pro-Asn-Phe-His Ala-Thr-Lys-Pro-Asn-Tyr-His Ala-Thr-Lys-Pro-Asn-Tyr-His Ala-Thr-Lys-Pro-Asn-Tyr-His Ala-Thr-Lys-Pro-Asn-His-His Ala-Thr-Lys-Pro-Asn-His-His Ala-Thr-Lys-Pro-Asn-His-His Ala-Thr-Lys-Pro-Asn-Pro-His Ala-Thr-Lys-Pro-Asn-Pro-His Ala-Thr-Lys-Pro-Asn-Pro-His Ala-Thr-Lys-Pro-Asn-Lys-His Ala-Thr-Lys-Pro-Asn-Lys-His Ala-Thr-Lys-Pro-Asn-Lys-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-Arg-His Ala-Thr-Lys-Pro-Tyr-Arg-His Ala-Thr-Lys-Pro-Tyr-Arg-His Ala-Thr-Lys-Pro-Tyr-Phe-His Ala-Thr-Lys-Pro-Tyr-Phe-His Ala-Thr-Lys-Pro-Tyr-Phe-His

Ala-Thr-Lys-Pro-Tyr-Tyr-His Ala-Thr-Lys-Pro-Tyr-Tyr-His Ala-Thr-Lys-Pro-Tyr-Tyr-His Ala-Thr-Lys-Pro-Tyr-His-His Ala-Thr-Lys-Pro-Tyr-His-His Ala-Thr-Lys-Pro-Tyr-His-His Ala-Thr-Lys-Pro-Tyr-Pro-His Ala-Thr-Lys-Pro-Tyr-Pro-His Ala-Thr-Lys-Pro-Tyr-Pro-His Ala-Thr-Lys-Pro-Tyr-Lys-His Ala-Thr-Lys-Pro-Tyr-Lys-His Ala-Thr-Lys-Pro-Tyr-Lys-His Ala-Thr-Lys-Pro-Arg-His Ala-Thr-Lys-Pro-Arg-His Ala-Thr-Lys-Pro-Arg-His Ala-Thr-Lys-Pro-Arg-Arg-His Ala-Thr-Lys-Pro-Arg-Arg-His Ala-Thr-Lys-Pro-Arg-Arg-His Ala-Thr-Lys-Pro-Arg-Phe-His Ala-Thr-Lys-Pro-Arg-Phe-His Ala-Thr-Lys-Pro-Arg-Phe-His Ala-Thr-Lys-Pro-Arg-Tyr-His Ala-Thr-Lys-Pro-Arg-Tyr-His Ala-Thr-Lys-Pro-Arg-Tyr-His Ala-Thr-Lys-Pro-Arg-His-His Ala-Thr-Lys-Pro-Arg-His-His Ala-Thr-Lys-Pro-Arg-His-His Ala-Thr-Lys-Pro-Arg-Pro-His Ala-Thr-Lys-Pro-Arg-Pro-His Ala-Thr-Lys-Pro-Arg-Pro-His Ala-Thr-Lys-Pro-Arg-Lys-His Ala-Thr-Lys-Pro-Arg-Lys-His Ala-Thr-Lys-Pro-Arg-Lys-His His-Thr-Lys-Pro-His His-Thr-Lys-Pro-His His-Thr-Lys-Pro-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Phe-His His-Thr-Lys-Pro-Phe-His His-Thr-Lys-Pro-Phe-His His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Tyr-His Tyr-His Pro-Tyr-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-His-His His-Thr-Lys-Pro-His-His His-Thr-Lys-Pro-His-His His-Thr-Lys-Pro-Lys-His His-Thr-Lys-Pro-Lys-His His-Thr-Lys-Pro-Lys-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-Arg-His His-Thr-Lys-Pro-Gly-Arg-His His-Thr-Lys-Pro-Gly-Arg-His His-Thr-Lys-Pro-Gly-Phe-His His-Thr-Lys-Pro-Gly-Phe-His His-Thr-Lys-Pro-Gly-Phe-His His-Thr-Lys-Pro-Gly-Tyr-His His-Thr-Lys-Pro-Gly-Tyr-His His-Thr-Lys-Pro-Gly-Tyr-His His-Thr-Lys-Pro-Gly-His-His His-Thr-Lys-Pro-Gly-His-His His-Thr-Lys-Pro-Gly-His-His His-Thr-Lys-Pro-Gly-Pro-His His-Thr-Lys-Pro-Gly-Pro-His His-Thr-Lys-Pro-Gly-Pro-His His-Thr-Lys-Pro-Gly-Lys-His His-Thr-Lys-Pro-Gly-Lys-His His-Thr-Lys-Pro-Gly-Lys-His His-Thr-Lys-Pro-Asp-His His-Thr-Lys-Pro-Asp-His His-Thr-Lys-Pro-Asp-His His-Thr-Lys-Pro-Asp-Arg-His His-Thr-Lys-Pro-Asp-Arg-His His-Thr-Lys-Pro-Asp-Arg-His His-Thr-Lys-Pro-Asp-Phe-His His-Thr-Lys-Pro-Asp-Phe-His His-Thr-Lys-Pro-Asp-Phe-His His-Thr-Lys-Pro-Asp-Tyr-His His-Thr-Lys-Pro-Asp-Tyr-His His-Thr-Lys-Pro-Asp-Tyr-His

His-Thr-Lys-Pro-Asp-His-His His-Thr-Lys-Pro-Asp-His-His His-Thr-Lys-Pro-Asp-His-His His-Thr-Lys-Pro-Asp-Pro-His His-Thr-Lys-Pro-Asp-Pro-His His-Thr-Lys-Pro-Asp-Pro-His His-Thr-Lys-Pro-Asp-Lys-His His-Thr-Lys-Pro-Asp-Lys-His His-Thr-Lys-Pro-Asp-Lys-His His-Thr-Lys-Pro-Trp-His His-Thr-Lys-Pro-Trp-His His-Thr-Lys-Pro-Trp-His His-Thr-Lys-Pro-Trp-Arg-His His-Thr-Lys-Pro-Trp-Arg-His His-Thr-Lys-Pro-Trp-Arg-His His-Thr-Lys-Pro-Trp-Phe-His His-Thr-Lys-Pro-Trp-Phe-His His-Thr-Lys-Pro-Trp-Phe-His His-Thr-Lys-Pro-Trp-Tyr-His His-Thr-Lys-Pro-Trp-Tyr-His His-Thr-Lys-Pro-Trp-Tyr-His His-Thr-Lys-Pro-Trp-His-His His-Thr-Lys-Pro-Trp-His-His His-Thr-Lys-Pro-Trp-His-His His-Thr-Lys-Pro-Trp-Pro-His His-Thr-Lys-Pro-Trp-Pro-His His-Thr-Lys-Pro-Trp-Pro-His His-Thr-Lys-Pro-Trp-Lys-His His-Thr-Lys-Pro-Trp-Lys-His His-Thr-Lys-Pro-Trp-Lys-His His-Thr-Lys-Pro-Gln-His His-Thr-Lys-Pro-Gln-His His-Thr-Lys-Pro-Gln-His His-Thr-Lys-Pro-Gln-Arg-His His-Thr-Lys-Pro-Gln-Arg-His His-Thr-Lys-Pro-Gln-Arg-His His-Thr-Lys-Pro-Gln-Phe-His His-Thr-Lys-Pro-Gln-Phe-His His-Thr-Lys-Pro-Gln-Phe-His His-Thr-Lys-Pro-Gln-Tyr-His His-Thr-Lys-Pro-Gln-Tyr-His His-Thr-Lys-Pro-Gln-Tyr-His His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Gln-His-His Gln-His-His Pro-Gln-His-His His-Thr-Lys-Pro-Gln-Pro-His His-Thr-Lys-Pro-Gln-Pro-His His-Thr-Lys-Pro-Gln-Pro-His His-Thr-Lys-Pro-Gln-Lys-His His-Thr-Lys-Pro-Gln-Lys-His His-Thr-Lys-Pro-Gln-Lys-His His-Thr-Lys-Pro-Asn-His His-Thr-Lys-Pro-Asn-His His-Thr-Lys-Pro-Asn-His His-Thr-Lys-Pro-Asn-Arg-His His-Thr-Lys-Pro-Asn-Arg-His His-Thr-Lys-Pro-Asn-Arg-His His-Thr-Lys-Pro-Asn-Phe-His His-Thr-Lys-Pro-Asn-Phe-His His-Thr-Lys-Pro-Asn-Phe-His His-Thr-Lys-Pro-Asn-Tyr-His His-Thr-Lys-Pro-Asn-Tyr-His His-Thr-Lys-Pro-Asn-Tyr-His His-Thr-Lys-Pro-Asn-His-His His-Thr-Lys-Pro-Asn-His-His His-Thr-Lys-Pro-Asn-His-His His-Thr-Lys-Pro-Asn-Pro-His His-Thr-Lys-Pro-Asn-Pro-His His-Thr-Lys-Pro-Asn-Pro-His His-Thr-Lys-Pro-Asn-Lys-His His-Thr-Lys-Pro-Asn-Lys-His His-Thr-Lys-Pro-Asn-Lys-His His-Thr-Lys-Pro-Tyr-His His-Thr-Lys-Pro-Tyr-His His-Thr-Lys-Pro-Tyr-His His-Thr-Lys-Pro-Tyr-Arg-His His-Thr-Lys-Pro-Tyr-Arg-His His-Thr-Lys-Pro-Tyr-Arg-His His-Thr-Lys-Pro-Tyr-Phe-His His-Thr-Lys-Pro-Tyr-Phe-His His-Thr-Lys-Pro-Tyr-Phe-His His-Thr-Lys-Pro-Tyr-Tyr-His His-Thr-Lys-Pro-Tyr-Tyr-His His-Thr-Lys-Pro-Tyr-Tyr-His His-Thr-Lys-Pro-Tyr-His-His His-Thr-Lys-Pro-Tyr-His-His His-Thr-Lys-Pro-Tyr-His-His

His-Thr-Lys-Pro-Tyr-Pro-His His-Thr-Lys-Pro-Tyr-Pro-His His-Thr-Lys-Pro-Tyr-Pro-His His-Thr-Lys-Pro-Tyr-Lys-His His-Thr-Lys-Pro-Tyr-Lys-His His-Thr-Lys-Pro-Tyr-Lys-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-Arg-His His-Thr-Lys-Pro-Arg-Arg-His His-Thr-Lys-Pro-Arg-Arg-His His-Thr-Lys-Pro-Arg-Phe-His His-Thr-Lys-Pro-Arg-Phe-His His-Thr-Lys-Pro-Arg-Phe-His His-Thr-Lys-Pro-Arg-Tyr-His His-Thr-Lys-Pro-Arg-Tyr-His His-Thr-Lys-Pro-Arg-Tyr-His His-Thr-Lys-Pro-Arg-His-His His-Thr-Lys-Pro-Arg-His-His His-Thr-Lys-Pro-Arg-His-His His-Thr-Lys-Pro-Arg-Pro-His His-Thr-Lys-Pro-Arg-Pro-His His-Thr-Lys-Pro-Arg-Pro-His His-Thr-Lys-Pro-Arg-Lys-His His-Thr-Lys-Pro-Arg-Lys-His His-Thr-Lys-Pro-Arg-Lys-His Lys-Thr-Lys-Pro-His Lys-Thr-Lys-Pro-His Lys-Thr-Lys-Pro-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Phe-His Lys-Thr-Lys-Pro-Phe-His Lys-Thr-Lys-Pro-Phe-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-His-His Pro-His-His Pro-His-His Lys-Thr-Lys-Pro-Lys-His Lys-Thr-Lys-Pro-Lys-His Lys-Thr-Lys-Pro-Lys-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-Arg-His Lys-Thr-Lys-Pro-Gly-Arg-His Lys-Thr-Lys-Pro-Gly-Arg-His Lys-Thr-Lys-Pro-Gly-Phe-His Lys-Thr-Lys-Pro-Gly-Phe-His Lys-Thr-Lys-Pro-Gly-Phe-His Lys-Thr-Lys-Pro-Gly-Tyr-His Lys-Thr-Lys-Pro-Gly-Tyr-His Lys-Thr-Lys-Pro-Gly-Tyr-His Lys-Thr-Lys-Pro-Gly-His-His Lys-Thr-Lys-Pro-Gly-His-His Lys-Thr-Lys-Pro-Gly-His-His Lys-Thr-Lys-Pro-Gly-Pro-His Lys-Thr-Lys-Pro-Gly-Pro-His Lys-Thr-Lys-Pro-Gly-Pro-His Lys-Thr-Lys-Pro-Gly-Lys-His Lys-Thr-Lys-Pro-Gly-Lys-His Lys-Thr-Lys-Pro-Gly-Lys-His Lys-Thr-Lys-Pro-Asp-His Lys-Thr-Lys-Pro-Asp-His Lys-Thr-Lys-Pro-Asp-His Lys-Thr-Lys-Pro-Asp-Arg-His Lys-Thr-Lys-Pro-Asp-Arg-His Lys-Thr-Lys-Pro-Asp-Arg-His Lys-Thr-Lys-Pro-Asp-Phe-His Lys-Thr-Lys-Pro-Asp-Phe-His Lys-Thr-Lys-Pro-Asp-Phe-His Lys-Thr-Lys-Pro-Asp-Tyr-His Lys-Thr-Lys-Pro-Asp-Tyr-His Lys-Thr-Lys-Pro-Asp-Tyr-His Lys-Thr-Lys-Pro-Asp-His-His Lys-Thr-Lys-Pro-Asp-His-His Lys-Thr-Lys-Pro-Asp-His-His Lys-Thr-Lys-Pro-Asp-Pro-His Lys-Thr-Lys-Pro-Asp-Pro-His Lys-Thr-Lys-Pro-Asp-Pro-His

Lys-Thr-Lys-Pro-Asp-Lys-His Lys-Thr-Lys-Pro-Asp-Lys-His Lys-Thr-Lys-Pro-Asp-Lys-His Lys-Thr-Lys-Pro-Trp-His Lys-Thr-Lys-Pro-Trp-His Lys-Thr-Lys-Pro-Trp-His Lys-Thr-Lys-Pro-Trp-Arg-His Lys-Thr-Lys-Pro-Trp-Arg-His Lys-Thr-Lys-Pro-Trp-Arg-His Lys-Thr-Lys-Pro-Trp-Phe-His Lys-Thr-Lys-Pro-Trp-Phe-His Lys-Thr-Lys-Pro-Trp-Phe-His Lys-Thr-Lys-Pro-Trp-Tyr-His Lys-Thr-Lys-Pro-Trp-Tyr-His Lys-Thr-Lys-Pro-Trp-Tyr-His Lys-Thr-Lys-Pro-Trp-His-His Lys-Thr-Lys-Pro-Trp-His-His Lys-Thr-Lys-Pro-Trp-His-His Lys-Thr-Lys-Pro-Trp-Pro-His Lys-Thr-Lys-Pro-Trp-Pro-His Lys-Thr-Lys-Pro-Trp-Pro-His Lys-Thr-Lys-Pro-Trp-Lys-His Lys-Thr-Lys-Pro-Trp-Lys-His Lys-Thr-Lys-Pro-Trp-Lys-His Lys-Thr-Lys-Pro-Gln-His Lys-Thr-Lys-Pro-Gln-His Lys-Thr-Lys-Pro-Gln-His Lys-Thr-Lys-Pro-Gln-Arg-His Lys-Thr-Lys-Pro-Gln-Arg-His Lys-Thr-Lys-Pro-Gln-Arg-His Lys-Thr-Lys-Pro-Gln-Phe-His Lys-Thr-Lys-Pro-Gln-Phe-His Lys-Thr-Lys-Pro-Gln-Phe-His Lys-Thr-Lys-Pro-Gln-Tyr-His Lys-Thr-Lys-Pro-Gln-Tyr-His Lys-Thr-Lys-Pro-Gln-Tyr-His Lys-Thr-Lys-Pro-Gln-His-His Lys-Thr-Lys-Pro-Gln-His-His Lys-Thr-Lys-Pro-Gln-His-His Lys-Thr-Lys-Pro-Gln-Pro-His Lys-Thr-Lys-Pro-Gln-Pro-His Lys-Thr-Lys-Pro-Gln-Pro-His Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Gln-Lys-His Pro-Gln-Lys-His Pro-Gln-Lys-His Lys-Thr-Lys-Pro-Asn-His Lys-Thr-Lys-Pro-Asn-His Lys-Thr-Lys-Pro-Asn-His Lys-Thr-Lys-Pro-Asn-Arg-His Lys-Thr-Lys-Pro-Asn-Arg-His Lys-Thr-Lys-Pro-Asn-Arg-His Lys-Thr-Lys-Pro-Asn-Phe-His Lys-Thr-Lys-Pro-Asn-Phe-His Lys-Thr-Lys-Pro-Asn-Phe-His Lys-Thr-Lys-Pro-Asn-Tyr-His Lys-Thr-Lys-Pro-Asn-Tyr-His Lys-Thr-Lys-Pro-Asn-Tyr-His Lys-Thr-Lys-Pro-Asn-His-His Lys-Thr-Lys-Pro-Asn-His-His Lys-Thr-Lys-Pro-Asn-His-His Lys-Thr-Lys-Pro-Asn-Pro-His Lys-Thr-Lys-Pro-Asn-Pro-His Lys-Thr-Lys-Pro-Asn-Pro-His Lys-Thr-Lys-Pro-Asn-Lys-His Lys-Thr-Lys-Pro-Asn-Lys-His Lys-Thr-Lys-Pro-Asn-Lys-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-Arg-His Lys-Thr-Lys-Pro-Tyr-Arg-His Lys-Thr-Lys-Pro-Tyr-Arg-His Lys-Thr-Lys-Pro-Tyr-Phe-His Lys-Thr-Lys-Pro-Tyr-Phe-His Lys-Thr-Lys-Pro-Tyr-Phe-His Lys-Thr-Lys-Pro-Tyr-Tyr-His Lys-Thr-Lys-Pro-Tyr-Tyr-His Lys-Thr-Lys-Pro-Tyr-Tyr-His Lys-Thr-Lys-Pro-Tyr-His-His Lys-Thr-Lys-Pro-Tyr-His-His Lys-Thr-Lys-Pro-Tyr-His-His Lys-Thr-Lys-Pro-Tyr-Pro-His Lys-Thr-Lys-Pro-Tyr-Pro-His Lys-Thr-Lys-Pro-Tyr-Pro-His Lys-Thr-Lys-Pro-Tyr-Lys-His Lys-Thr-Lys-Pro-Tyr-Lys-His Lys-Thr-Lys-Pro-Tyr-Lys-His

Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-Arg-His Lys-Thr-Lys-Pro-Arg-Arg-His Lys-Thr-Lys-Pro-Arg-Arg-His Lys-Thr-Lys-Pro-Arg-Phe-His Lys-Thr-Lys-Pro-Arg-Phe-His Lys-Thr-Lys-Pro-Arg-Phe-His Lys-Thr-Lys-Pro-Arg-Tyr-His Lys-Thr-Lys-Pro-Arg-Tyr-His Lys-Thr-Lys-Pro-Arg-Tyr-His Lys-Thr-Lys-Pro-Arg-His-His Lys-Thr-Lys-Pro-Arg-His-His Lys-Thr-Lys-Pro-Arg-His-His Lys-Thr-Lys-Pro-Arg-Pro-His Lys-Thr-Lys-Pro-Arg-Pro-His Lys-Thr-Lys-Pro-Arg-Pro-His Lys-Thr-Lys-Pro-Arg-Lys-His Lys-Thr-Lys-Pro-Arg-Lys-His Lys-Thr-Lys-Pro-Arg-Lys-His Gly-Thr-Lys-Pro-His Gly-Thr-Lys-Pro-His Gly-Thr-Lys-Pro-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Phe-His Gly-Thr-Lys-Pro-Phe-His Gly-Thr-Lys-Pro-Phe-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Gly-His Gly-Thr-Lys-Pro-Gly-His Gly-Thr-Lys-Pro-Gly-His Gly-Thr-Lys-Pro-His-His Gly-Thr-Lys-Pro-His-His Gly-Thr-Lys-Pro-His-His Gly-Thr-Lys-Pro-Lys-His Gly-Thr-Lys-Pro-Lys-His Gly-Thr-Lys-Pro-Lys-His Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Gly-His Pro-Gly-His Pro-Gly-His Gly-Thr-Lys-Pro-Gly-Arg-His Gly-Thr-Lys-Pro-Gly-Arg-His Gly-Thr-Lys-Pro-Gly-Arg-His Gly-Thr-Lys-Pro-Gly-Phe-His Gly-Thr-Lys-Pro-Gly-Phe-His Gly-Thr-Lys-Pro-Gly-Phe-His Gly-Thr-Lys-Pro-Gly-Tyr-His Gly-Thr-Lys-Pro-Gly-Tyr-His Gly-Thr-Lys-Pro-Gly-Tyr-His Gly-Thr-Lys-Pro-Gly-His-His Gly-Thr-Lys-Pro-Gly-His-His Gly-Thr-Lys-Pro-Gly-His-His Gly-Thr-Lys-Pro-Gly-Pro-His Gly-Thr-Lys-Pro-Gly-Pro-His Gly-Thr-Lys-Pro-Gly-Pro-His Gly-Thr-Lys-Pro-Gly-Lys-His Gly-Thr-Lys-Pro-Gly-Lys-His Gly-Thr-Lys-Pro-Gly-Lys-His Gly-Thr-Lys-Pro-Asp-His Gly-Thr-Lys-Pro-Asp-His Gly-Thr-Lys-Pro-Asp-His Gly-Thr-Lys-Pro-Asp-Arg-His Gly-Thr-Lys-Pro-Asp-Arg-His Gly-Thr-Lys-Pro-Asp-Arg-His Gly-Thr-Lys-Pro-Asp-Phe-His Gly-Thr-Lys-Pro-Asp-Phe-His Gly-Thr-Lys-Pro-Asp-Phe-His Gly-Thr-Lys-Pro-Asp-Tyr-His Gly-Thr-Lys-Pro-Asp-Tyr-His Gly-Thr-Lys-Pro-Asp-Tyr-His Gly-Thr-Lys-Pro-Asp-His-His Gly-Thr-Lys-Pro-Asp-His-His Gly-Thr-Lys-Pro-Asp-His-His Gly-Thr-Lys-Pro-Asp-Pro-His Gly-Thr-Lys-Pro-Asp-Pro-His Gly-Thr-Lys-Pro-Asp-Pro-His Gly-Thr-Lys-Pro-Asp-Lys-His Gly-Thr-Lys-Pro-Asp-Lys-His Gly-Thr-Lys-Pro-Asp-Lys-His Gly-Thr-Lys-Pro-Trp-His Gly-Thr-Lys-Pro-Trp-His Gly-Thr-Lys-Pro-Trp-His

Gly-Thr-Lys-Pro-Trp-Arg-His Gly-Thr-Lys-Pro-Trp-Arg-His Gly-Thr-Lys-Pro-Trp-Arg-His Gly-Thr-Lys-Pro-Trp-Phe-His Gly-Thr-Lys-Pro-Trp-Phe-His Gly-Thr-Lys-Pro-Trp-Phe-His Gly-Thr-Lys-Pro-Trp-Tyr-His Gly-Thr-Lys-Pro-Trp-Tyr-His Gly-Thr-Lys-Pro-Trp-Tyr-His Gly-Thr-Lys-Pro-Trp-His-His Gly-Thr-Lys-Pro-Trp-His-His Gly-Thr-Lys-Pro-Trp-His-His Gly-Thr-Lys-Pro-Trp-Pro-His Gly-Thr-Lys-Pro-Trp-Pro-His Gly-Thr-Lys-Pro-Trp-Pro-His Gly-Thr-Lys-Pro-Trp-Lys-His Gly-Thr-Lys-Pro-Trp-Lys-His Gly-Thr-Lys-Pro-Trp-Lys-His Gly-Thr-Lys-Pro-Gln-His Gly-Thr-Lys-Pro-Gln-His Gly-Thr-Lys-Pro-Gln-His Gly-Thr-Lys-Pro-Gln-Arg-His Gly-Thr-Lys-Pro-Gln-Arg-His Gly-Thr-Lys-Pro-Gln-Arg-His Gly-Thr-Lys-Pro-Gln-Phe-His Gly-Thr-Lys-Pro-Gln-Phe-His Gly-Thr-Lys-Pro-Gln-Phe-His Gly-Thr-Lys-Pro-Gln-Tyr-His Gly-Thr-Lys-Pro-Gln-Tyr-His Gly-Thr-Lys-Pro-Gln-Tyr-His Gly-Thr-Lys-Pro-Gln-His-His Gly-Thr-Lys-Pro-Gln-His-His Gly-Thr-Lys-Pro-Gln-His-His Gly-Thr-Lys-Pro-Gln-Pro-His Gly-Thr-Lys-Pro-Gln-Pro-His Gly-Thr-Lys-Pro-Gln-Pro-His Gly-Thr-Lys-Pro-Gln-Lys-His Gly-Thr-Lys-Pro-Gln-Lys-His Gly-Thr-Lys-Pro-Gln-Lys-His Gly-Thr-Lys-Pro-Asn-His Gly-Thr-Lys-Pro-Asn-His Gly-Thr-Lys-Pro-Asn-His Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Asn-Arg-His Pro-Asn-Arg-His Pro-Asn-Arg-His Gly-Thr-Lys-Pro-Asn-Phe-His Gly-Thr-Lys-Pro-Asn-Phe-His Gly-Thr-Lys-Pro-Asn-Phe-His Gly-Thr-Lys-Pro-Asn-Tyr-His Gly-Thr-Lys-Pro-Asn-Tyr-His Gly-Thr-Lys-Pro-Asn-Tyr-His Gly-Thr-Lys-Pro-Asn-His-His Gly-Thr-Lys-Pro-Asn-His-His Gly-Thr-Lys-Pro-Asn-His-His Gly-Thr-Lys-Pro-Asn-Pro-His Gly-Thr-Lys-Pro-Asn-Pro-His Gly-Thr-Lys-Pro-Asn-Pro-His Gly-Thr-Lys-Pro-Asn-Lys-His Gly-Thr-Lys-Pro-Asn-Lys-His Gly-Thr-Lys-Pro-Asn-Lys-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-Arg-His Gly-Thr-Lys-Pro-Tyr-Arg-His Gly-Thr-Lys-Pro-Tyr-Arg-His Gly-Thr-Lys-Pro-Tyr-Phe-His Gly-Thr-Lys-Pro-Tyr-Phe-His Gly-Thr-Lys-Pro-Tyr-Phe-His Gly-Thr-Lys-Pro-Tyr-Tyr-His Gly-Thr-Lys-Pro-Tyr-Tyr-His Gly-Thr-Lys-Pro-Tyr-Tyr-His Gly-Thr-Lys-Pro-Tyr-His-His Gly-Thr-Lys-Pro-Tyr-His-His Gly-Thr-Lys-Pro-Tyr-His-His Gly-Thr-Lys-Pro-Tyr-Pro-His Gly-Thr-Lys-Pro-Tyr-Pro-His Gly-Thr-Lys-Pro-Tyr-Pro-His Gly-Thr-Lys-Pro-Tyr-Lys-His Gly-Thr-Lys-Pro-Tyr-Lys-His Gly-Thr-Lys-Pro-Tyr-Lys-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-Arg-His Gly-Thr-Lys-Pro-Arg-Arg-His Gly-Thr-Lys-Pro-Arg-Arg-His

Gly-Thr-Lys-Pro-Arg-Phe-His Gly-Thr-Lys-Pro-Arg-Phe-His Gly-Thr-Lys-Pro-Arg-Phe-His Gly-Thr-Lys-Pro-Arg-Tyr-His Gly-Thr-Lys-Pro-Arg-Tyr-His Gly-Thr-Lys-Pro-Arg-Tyr-His Gly-Thr-Lys-Pro-Arg-His-His Gly-Thr-Lys-Pro-Arg-His-His Gly-Thr-Lys-Pro-Arg-His-His Gly-Thr-Lys-Pro-Arg-Pro-His Gly-Thr-Lys-Pro-Arg-Pro-His Gly-Thr-Lys-Pro-Arg-Pro-His Gly-Thr-Lys-Pro-Arg-Lys-His Gly-Thr-Lys-Pro-Arg-Lys-His Gly-Thr-Lys-Pro-Arg-Lys-His Thr-Lys-Pro Thr-Lys-Pro Thr-Lys-Pro Thr-Lys-Pro-Gly-Arg Thr-Lys-Pro-Gly-Arg Thr-Lys-Pro-Gly-Arg Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-His Thr-Lys-Pro-Gly-Pro Thr-Lys-Pro-Gly-Pro Thr-Lys-Pro-Gly-Pro Thr-Lys-Pro-Gly-Lys Thr-Lys-Pro-Gly-Lys Thr-Lys-Pro-Gly-Lys Thr-Lys-Pro-Asp-Arg Thr-Lys-Pro-Asp-Arg Thr-Lys-Pro-Asp-Arg Thr-Lys-Pro-Asp-Phe Thr-Lys-Pro-Asp-Phe Thr-Lys-Pro-Asp-Phe Thr-Lys-Pro-Asp-Tyr Thr-Lys-Pro-Asp-Tyr Thr-Lys-Pro-Asp-Tyr

Thr-Lys-Pro-Asp-His Thr-Lys-Pro-Asp-His Thr-Lys-Pro-Asp-His Thr-Lys-Pro-Asp-Pro Thr-Lys-Pro-Asp-Pro Thr-Lys-Pro-Asp-Pro Thr-Lys-Pro-Asp-Lys Thr-Lys-Pro-Asp-Lys Thr-Lys-Pro-Asp-Lys Thr-Lys-Pro-Trp-Arg Thr-Lys-Pro-Trp-Arg Thr-Lys-Pro-Trp-Arg Thr-Lys-Pro-Trp-Phe Thr-Lys-Pro-Trp-Phe Thr-Lys-Pro-Trp-Phe Thr-Lys-Pro-Trp-Tyr Thr-Lys-Pro-Trp-Tyr Thr-Lys-Pro-Trp-Tyr Thr-Lys-Pro-Trp-His Thr-Lys-Pro-Trp-His Thr-Lys-Pro-Trp-His Thr-Lys-Pro-Trp-Pro Thr-Lys-Pro-Trp-Pro Thr-Lys-Pro-Trp-Pro Thr-Lys-Pro-Trp-Lys Thr-Lys-Pro-Trp-Lys Thr-Lys-Pro-Trp-Lys Thr-Lys-Pro-Gln-Arg Thr-Lys-Pro-Gln-Arg Thr-Lys-Pro-Gln-Arg Thr-Lys-Pro-Gln-Phe Thr-Lys-Pro-Gln-Phe Thr-Lys-Pro-Gln-Phe Thr-Lys-Pro-Gln-Tyr Thr-Lys-Pro-Gln-Tyr Thr-Lys-Pro-Gln-Tyr Thr-Lys-Pro-Gln-His Thr-Lys-Pro-Gln-His Thr-Lys-Pro-Gln-His Thr-Lys-Pro-Gln-Pro Thr-Lys-Pro-Gln-Pro Thr-Lys-Pro-Gln-Pro Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Gln-Lys Gln-Lys Gln-Lys Thr-Lys-Pro-Asn-Arg Thr-Lys-Pro-Asn-Arg Thr-Lys-Pro-Asn-Arg Thr-Lys-Pro-Asn-Phe Thr-Lys-Pro-Asn-Phe Thr-Lys-Pro-Asn-Phe Thr-Lys-Pro-Asn-Tyr Thr-Lys-Pro-Asn-Tyr Thr-Lys-Pro-Asn-Tyr Thr-Lys-Pro-Asn-His Thr-Lys-Pro-Asn-His Thr-Lys-Pro-Asn-His Thr-Lys-Pro-Asn-Pro Thr-Lys-Pro-Asn-Pro Thr-Lys-Pro-Asn-Pro Thr-Lys-Pro-Asn-Lys Thr-Lys-Pro-Asn-Lys Thr-Lys-Pro-Asn-Lys Thr-Lys-Pro-Tyr-Arg Thr-Lys-Pro-Tyr-Arg Thr-Lys-Pro-Tyr-Arg Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-His Thr-Lys-Pro-Tyr-Pro Thr-Lys-Pro-Tyr-Pro Thr-Lys-Pro-Tyr-Pro Thr-Lys-Pro-Tyr-Lys Thr-Lys-Pro-Tyr-Lys Thr-Lys-Pro-Tyr-Lys Thr-Lys-Pro-Arg-Arg Thr-Lys-Pro-Arg-Arg Thr-Lys-Pro-Arg-Arg Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Phe

Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-His Thr-Lys-Pro-Arg-Pro Thr-Lys-Pro-Arg-Pro Thr-Lys-Pro-Arg-Pro Thr-Lys-Pro-Arg-Lys Thr-Lys-Pro-Arg-Lys Thr-Lys-Pro-Arg-Lys Met-Thr-Lys-Pro-Arg Met-Thr-Lys-Pro-Arg Met-Thr-Lys-Pro-Arg Met-Thr-Lys-Pro-Phe Met-Thr-Lys-Pro-Phe Met-Thr-Lys-Pro-Phe Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-His Met-Thr-Lys-Pro-His Met-Thr-Lys-Pro-His Met-Thr-Lys-Pro-Lys Met-Thr-Lys-Pro-Lys Met-Thr-Lys-Pro-Lys Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly-Arg Met-Thr-Lys-Pro-Gly-Arg Met-Thr-Lys-Pro-Gly-Arg Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Gly-His Pro-Gly-His Pro-Gly-His Met-Thr-Lys-Pro-Gly-Pro Met-Thr-Lys-Pro-Gly-Pro Met-Thr-Lys-Pro-Gly-Pro Met-Thr-Lys-Pro-Gly-Lys Met-Thr-Lys-Pro-Gly-Lys Met-Thr-Lys-Pro-Gly-Lys Met-Thr-Lys-Pro-Asp Met-Thr-Lys-Pro-Asp Met-Thr-Lys-Pro-Asp Met-Thr-Lys-Pro-Asp-Arg Met-Thr-Lys-Pro-Asp-Arg Met-Thr-Lys-Pro-Asp-Arg Met-Thr-Lys-Pro-Asp-Phe Met-Thr-Lys-Pro-Asp-Phe Met-Thr-Lys-Pro-Asp-Phe Met-Thr-Lys-Pro-Asp-Tyr Met-Thr-Lys-Pro-Asp-Tyr Met-Thr-Lys-Pro-Asp-Tyr Met-Thr-Lys-Pro-Asp-His Met-Thr-Lys-Pro-Asp-His Met-Thr-Lys-Pro-Asp-His Met-Thr-Lys-Pro-Asp-Pro Met-Thr-Lys-Pro-Asp-Pro Met-Thr-Lys-Pro-Asp-Pro Met-Thr-Lys-Pro-Asp-Lys Met-Thr-Lys-Pro-Asp-Lys Met-Thr-Lys-Pro-Asp-Lys Met-Thr-Lys-Pro-Trp Met-Thr-Lys-Pro-Trp Met-Thr-Lys-Pro-Trp Met-Thr-Lys-Pro-Trp-Arg Met-Thr-Lys-Pro-Trp-Arg Met-Thr-Lys-Pro-Trp-Arg Met-Thr-Lys-Pro-Trp-Phe Met-Thr-Lys-Pro-Trp-Phe Met-Thr-Lys-Pro-Trp-Phe Met-Thr-Lys-Pro-Trp-Tyr Met-Thr-Lys-Pro-Trp-Tyr Met-Thr-Lys-Pro-Trp-Tyr Met-Thr-Lys-Pro-Trp-His Met-Thr-Lys-Pro-Trp-His Met-Thr-Lys-Pro-Trp-His

Met-Thr-Lys-Pro-Trp-Pro Met-Thr-Lys-Pro-Trp-Pro Met-Thr-Lys-Pro-Trp-Pro Met-Thr-Lys-Pro-Trp-Lys Met-Thr-Lys-Pro-Trp-Lys Met-Thr-Lys-Pro-Trp-Lys Met-Thr-Lys-Pro-Gln Met-Thr-Lys-Pro-Gln Met-Thr-Lys-Pro-Gln Met-Thr-Lys-Pro-Gln-Arg Met-Thr-Lys-Pro-Gln-Arg Met-Thr-Lys-Pro-Gln-Arg Met-Thr-Lys-Pro-Gln-Phe Met-Thr-Lys-Pro-Gln-Phe Met-Thr-Lys-Pro-Gln-Phe Met-Thr-Lys-Pro-Gln-Tyr Met-Thr-Lys-Pro-Gln-Tyr Met-Thr-Lys-Pro-Gln-Tyr Met-Thr-Lys-Pro-Gln-His Met-Thr-Lys-Pro-Gln-His Met-Thr-Lys-Pro-Gln-His Met-Thr-Lys-Pro-Gln-Pro Met-Thr-Lys-Pro-Gln-Pro Met-Thr-Lys-Pro-Gln-Pro Met-Thr-Lys-Pro-Gln-Lys Met-Thr-Lys-Pro-Gln-Lys Met-Thr-Lys-Pro-Gln-Lys Met-Thr-Lys-Pro-Asn Met-Thr-Lys-Pro-Asn Met-Thr-Lys-Pro-Asn Met-Thr-Lys-Pro-Asn-Arg Met-Thr-Lys-Pro-Asn-Arg Met-Thr-Lys-Pro-Asn-Arg Met-Thr-Lys-Pro-Asn-Phe Met-Thr-Lys-Pro-Asn-Phe Met-Thr-Lys-Pro-Asn-Phe Met-Thr-Lys-Pro-Asn-Tyr Met-Thr-Lys-Pro-Asn-Tyr Met-Thr-Lys-Pro-Asn-Tyr Met-Thr-Lys-Pro-Asn-His Met-Thr-Lys-Pro-Asn-His Met-Thr-Lys-Pro-Asn-His Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Asn-Pro Pro-Asn-Pro Pro-Asn-Pro Met-Thr-Lys-Pro-Asn-Lys Met-Thr-Lys-Pro-Asn-Lys Met-Thr-Lys-Pro-Asn-Lys Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr-Arg Met-Thr-Lys-Pro-Tyr-Arg Met-Thr-Lys-Pro-Tyr-Arg Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-His Met-Thr-Lys-Pro-Tyr-His Met^Thr-Lys-Pro-Tyr-Pro Met-Thr-Lys-Pro-Tyr-Pro Met-Thr-Lys-Pro-Tyr-Pro Met-Thr-Lys-Pro-Tyr-Lys Met-Thr-Lys-Pro-Tyr-Lys Met-Thr-Lys-Pro-Tyr-Lys Met-Thr-Lys-Pro-Arg Met-Thr-Lys-Pro-Arg Met-Thr-Lys-Pro-Arg Met-Thr-Lys-Pro-Arg-Arg Met-Thr-Lys-Pro-Arg-Arg Met-Thr-Lys-Pro-Arg-Arg Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-His Met-Thr-Lys-Pro-Arg-Pro Met-Thr-Lys-Pro-Arg-Pro Met-Thr-Lys-Pro-Arg-Pro

Met-Thr-Lys-Pro-Arg-Lys Met-Thr-Lys-Pro-Arg-Lys Met-Thr-Lys-Pro-Arg-Lys Met(0)-Thr-Lys-Pro-Arg Met(0)-Thr-Lys-Pro-Arg Met(0)-Thr-Lys-Pro-Arg Met(0)-Thr-Lys-Pro-Phe Met(0)-Thr-Lys-Pro-Phe Met(0)-Thr-Lys-Pro-Phe Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-His Met(0)-Thr-Lys-Pro-His Met(0)-Thr-Lys-Pro-His Met(0)-Thr-Lys-Pro-Lys Met(0)-Thr-Lys-Pro-Lys Met(0)-Thr-Lys-Pro-Lys Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly-Arg Met(0)-Thr-Lys-Pro-Gly-Arg Met(0)-Thr-Lys-Pro-Gly-Arg Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-His Met(0)-Thr-Lys-Pro-Gly-Pro Met(0)-Thr-Lys-Pro-Gly-Pro Met(0)-Thr-Lys-Pro-Gly-Pro Met(0)-Thr-Lys-Pro-Gly-Lys Met(0)-Thr-Lys-Pro-Gly-Lys Met(0)-Thr-Lys-Pro-Gly-Lys Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Asp Pro-Asp Pro-Asp Met(0)-Thr-Lys-Pro-Asp-Arg Met(0)-Thr-Lys-Pro-Asp-Arg Met(0)-Thr-Lys-Pro-Asp-Arg Met(0)-Thr-Lys-Pro-Asp-Phe Met(0)-Thr-Lys-Pro-Asp-Phe Met(0)-Thr-Lys-Pro-Asp-Phe Met(0)-Thr-Lys-Pro-Asp-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr Met(0)-Thr-Lys-Pro-Asp-His Met(0)-Thr-Lys-Pro-Asp-His Met(0)-Thr-Lys-Pro-Asp-His Met(0)-Thr-Lys-Pro-Asp-Pro Met(0)-Thr-Lys-Pro-Asp-Pro Met(0)-Thr-Lys-Pro-Asp-Pro Met(0)-Thr-Lys-Pro-Asp-Lys Met(0)-Thr-Lys-Pro-Asp-Lys Met(0)-Thr-Lys-Pro-Asp-Lys Met(0)-Thr-Lys-Pro-Trp Met(0)-Thr-Lys-Pro-Trp Met(0)-Thr-Lys-Pro-Trp Met(0)-Thr-Lys-Pro-Trp-Arg Met(0)-Thr-Lys-Pro-Trp-Arg Met(0)-Thr-Lys-Pro-Trp-Arg Met(0)-Thr-Lys-Pro-Trp-Phe Met(0)-Thr-Lys-Pro-Trp-Phe Met(0)-Thr-Lys-Pro-Trp-Phe Met(0)-Thr-Lys-Pro-Trp-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr Met(0)-Thr-Lys-Pro-Trp-His Met(0)-Thr-Lys-Pro-Trp-His Met(0)-Thr-Lys-Pro-Trp-His Met(0)-Thr-Lys-Pro-Trp-Pro Met(0)-Thr-Lys-Pro-Trp-Pro Met(0)-Thr-Lys-Pro-Trp-Pro Met(0)-Thr-Lys-Pro-Trp-Lys Met(0)-Thr-Lys-Pro-Trp-Lys Met(0)-Thr-Lys-Pro-Trp-Lys Met(0)-Thr-Lys-Pro-Gln Met(0)-Thr-Lys-Pro-Gln Met(0)-Thr-Lys-Pro-Gln

Met(0)-Thr-Lys-Pro-Gln-Arg Met(0)-Thr-Lys-Pro-Gln-Arg Met(0)-Thr-Lys-Pro-Gln-Arg Met(0)-Thr-Lys-Pro-Gln-Phe Met(0)-Thr-Lys-Pro-Gln-Phe Met(0)-Thr-Lys-Pro-Gln-Phe Met(0)-Thr-Lys-Pro-Gln-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr Met(0)-Thr-Lys-Pro-Gln-His Met(0)-Thr-Lys-Pro-Gln-His Met(0)-Thr-Lys-Pro-Gln-His Met(0)-Thr-Lys-Pro-Gln-Pro Met(0)-Thr-Lys-Pro-Gln-Pro Met(0)-Thr-Lys-Pro-Gln-Pro Met(0)-Thr-Lys-Pro-Gln-Lys Met(0)-Thr-Lys-Pro-Gln-Lys Met(0)-Thr-Lys-Pro-Gln-Lys Met(0)-Thr-Lys-Pro-Asn Met(0)-Thr-Lys-Pro-Asn Met(0)-Thr-Lys-Pro-Asn Met(0)-Thr-Lys-Pro-Asn-Arg Met(0)-Thr-Lys-Pro-Asn-Arg Met(0)-Thr-Lys-Pro-Asn-Arg Met(0)-Thr-Lys-Pro-Asn-Phe Met(0)-Thr-Lys-Pro-Asn-Phe Met(0)-Thr-Lys-Pro-Asn-Phe Met(0)-Thr-Lys-Pro-Asn-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr Met(0)-Thr-Lys-Pro-Asn-His Met(0)-Thr-Lys-Pro-Asn-His Met(0)-Thr-Lys-Pro-Asn-His Met(0)-Thr-Lys-Pro-Asn-Pro Met(0)-Thr-Lys-Pro-Asn-Pro Met(0)-Thr-Lys-Pro-Asn-Pro Met(0)-Thr-Lys-Pro-Asn-Lys Met(0)-Thr-Lys-Pro-Asn-Lys Met(0)-Thr-Lys-Pro-Asn-Lys Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Tyr-Arg Pro-Tyr-Arg Pro-Tyr-Arg Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-His Met(0)-Thr-Lys-Pro-Tyr-Pro Met(0)-Thr-Lys-Pro-Tyr-Pro Met(0)-Thr-Lys-Pro-Tyr-Pro Met(0)-Thr-Lys-Pro-Tyr-Lys Met(0)-Thr-Lys-Pro-Tyr-Lys Met(0)-Thr-Lys-Pro-Tyr-Lys Met(0)-Thr-Lys-Pro-Arg Met(0)-Thr-Lys-Pro-Arg Met(0)-Thr-Lys-Pro-Arg Met(0)-Thr-Lys-Pro-Arg-Arg Met(0)-Thr-Lys-Pro-Arg-Arg Met(0)-Thr-Lys-Pro-Arg-Arg Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-His Met(0)-Thr-Lys-Pro-Arg-Pro Met(0)-Thr-Lys-Pro-Arg-Pro Met(0)-Thr-Lys-Pro-Arg-Pro Met(0)-Thr-Lys-Pro-Arg-Lys Met(0)-Thr-Lys-Pro-Arg-Lys Met(0)-Thr-Lys-Pro-Arg-Lys Thr-Thr-Lys-Pro-Arg Thr-Thr-Lys-Pro-Arg Thr-Thr-Lys-Pro-Arg Thr-Thr-Lys-Pro-Phe Thr-Thr-Lys-Pro-Phe Thr-Thr-Lys-Pro-Phe

Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-His Thr-Thr-Lys-Pro-His Thr-Thr-Lys-Pro-His Thr-Thr-Lys-Pro-Lys Thr-Thr-Lys-Pro-Lys Thr-Thr-Lys-Pro-Lys Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly-Arg Thr-Thr-Lys-Pro-Gly-Arg Thr-Thr-Lys-Pro-Gly-Arg Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-His Thr-Thr-Lys-Pro-Gly-Pro Thr-Thr-Lys-Pro-Gly-Pro Thr-Thr-Lys-Pro-Gly-Pro Thr-Thr-Lys-Pro-Gly-Lys Thr-Thr-Lys-Pro-Gly-Lys Thr-Thr-Lys-Pro-Gly-Lys Thr-Thr-Lys-Pro-Asp Thr-Thr-Lys-Pro-Asp Thr-Thr-Lys-Pro-Asp Thr-Thr-Lys-Pro-Asp-Arg Thr-Thr-Lys-Pro-Asp-Arg Thr-Thr-Lys-Pro-Asp-Arg Thr-Thr-Lys-Pro-Asp-Phe Thr-Thr-Lys-Pro-Asp-Phe Thr-Thr-Lys-Pro-Asp-Phe Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Asp-Tyr Asp-Tyr Pro-Asp-Tyr Thr-Thr-Lys-Pro-Asp-His Thr-Thr-Lys-Pro-Asp-His Thr-Thr-Lys-Pro-Asp-His Thr-Thr-Lys-Pro-Asp-Pro Thr-Thr-Lys-Pro-Asp-Pro Thr-Thr-Lys-Pro-Asp-Pro Thr-Thr-Lys-Pro-Asp-Lys Thr-Thr-Lys-Pro-Asp-Lys Thr-Thr-Lys-Pro-Asp-Lys Thr-Thr-Lys-Pro-Trp Thr-Thr-Lys-Pro-Trp Thr-Thr-Lys-Pro-Trp Thr-Thr-Lys-Pro-Trp-Arg Thr-Thr-Lys-Pro-Trp-Arg Thr-Thr-Lys-Pro-Trp-Arg Thr-Thr-Lys-Pro-Trp-Phe Thr-Thr-Lys-Pro-Trp-Phe Thr-Thr-Lys-Pro-Trp-Phe Thr-Thr-Lys-Pro-Trp-Tyr Thr-Thr-Lys-Pro-Trp-Tyr Thr-Thr-Lys-Pro-Trp-Tyr Thr-Thr-Lys-Pro-Trp-His Thr-Thr-Lys-Pro-Trp-His Thr-Thr-Lys-Pro-Trp-His Thr-Thr-Lys-Pro-Trp-Pro Thr-Thr-Lys-Pro-Trp-Pro Thr-Thr-Lys-Pro-Trp-Pro Thr-Thr-Lys-Pro-Trp-Lys Thr-Thr-Lys-Pro-Trp-Lys Thr-Thr-Lys-Pro-Trp-Lys Thr-Thr-Lys-Pro-Gln Thr-Thr-Lys-Pro-Gin Thr-Thr-Lys-Pro-Gln Thr-Thr-Lys-Pro-Gln-Arg Thr-Thr-Lys-Pro-Gln-Arg Thr-Thr-Lys-Pro-Gln-Arg Thr-Thr-Lys-Pro-Gln-Phe Thr-Thr-Lys-Pro-Gln-Phe Thr-Thr-Lys-Pro-Gln-Phe Thr-Thr-Lys-Pro-Gln-Tyr Thr-Thr-Lys-Pro-Gln-Tyr Thr-Thr-Lys-Pro-Gln-Tyr

Thr-Thr-Lys-Pro-Gln-His Thr-Thr-Lys-Pro-Gln-His Thr-Thr-Lys-Pro-Gln-His Thr-Thr-Lys-Pro-Gln-Pro Thr-Thr-Lys-Pro-Gln-Pro Thr-Thr-Lys-Pro-Gln-Pro Thr-Thr-Lys-Pro-Gln-Lys Thr-Thr-Lys-Pro-Gln-Lys Thr-Thr-Lys-Pro-Gln-Lys Thr-Thr-Lys-Pro-Asn Thr-Thr-Lys-Pro-Asn Thr-Thr-Lys-Pro-Asn Thr-Thr-Lys-Pro-Asn-Arg Thr-Thr-Lys-Pro-Asn-Arg Thr-Thr-Lys-Pro-Asn-Arg Thr-Thr-Lys-Pro-Asn-Phe Thr-Thr-Lys-Pro-Asn-Phe Thr-Thr-Lys-Pro-Asn-Phe Thr-Thr-Lys-Pro-Asn-Tyr Thr-Thr-Lys-Pro-Asn-Tyr Thr-Thr-Lys-Pro-Asn-Tyr Thr-Thr-Lys-Pro-Asn-His Thr-Thr-Lys-Pro-Asn-His Thr-Thr-Lys-Pro-Asn-His Thr-Thr-Lys-Pro-Asn-Pro Thr-Thr-Lys-Pro-Asn-Pro Thr-Thr-Lys-Pro-Asn-Pro Thr-Thr-Lys-Pro-Asn-Lys Thr-Thr-Lys-Pro-Asn-Lys Thr-Thr-Lys-Pro-Asn-Lys Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr-Arg Thr-Thr-Lys-Pro-Tyr-Arg Thr-Thr-Lys-Pro-Tyr-Arg Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Tyr-His Tyr-His Pro-Tyr-His Thr-Thr-Lys-Pro-Tyr-Pro Thr-Thr-Lys-Pro-Tyr-Pro Thr-Thr-Lys-Pro-Tyr-Pro Thr-Thr-Lys-Pro-Tyr-Lys Thr-Thr-Lys-Pro-Tyr-Lys Thr-Thr-Lys-Pro-Tyr-Lys Thr-Thr-Lys-Pro-Arg Thr-Thr-Lys-Pro-Arg Thr-Thr-Lys-Pro-Arg Thr-Thr-Lys-Pro-Arg-Arg Thr-Thr-Lys-Pro-Arg-Arg Thr-Thr-Lys-Pro-Arg-Arg Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Tyr Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-His Thr-Thr-Lys-Pro-Arg-Pro Thr-Thr-Lys-Pro-Arg-Pro Thr-Thr-Lys-Pro-Arg-Pro Thr-Thr-Lys-Pro-Arg-Lys Thr-Thr-Lys-Pro-Arg-Lys Thr-Thr-Lys-Pro-Arg-Lys Ala-Thr-Lys-Pro-Arg Ala-Thr-Lys-Pro-Arg Ala-Thr-Lys-Pro-Arg Ala-Thr-Lys-Pro-Phe Ala-Thr-Lys-Pro-Phe Ala-Thr-Lys-Pro-Phe Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-His Ala-Thr-Lys-Pro-His Ala-Thr-Lys-Pro-His

Ala-Thr-Lys-Pro-Lys Ala-Thr-Lys-Pro-Lys Ala-Thr-Lys-Pro-Lys Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly-Arg Ala-Thr-Lys-Pro-Gly-Arg Ala-Thr-Lys-Pro-Gly-Arg Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-His Ala-Thr-Lys-Pro-Gly-Pro Ala-Thr-Lys-Pro-Gly-Pro Ala-Thr-Lys-Pro-Gly-Pro Ala-Thr-Lys-Pro-Gly-Lys Ala-Thr-Lys-Pro-Gly-Lys Ala-Thr-Lys-Pro-Gly-Lys Ala-Thr-Lys-Pro-Asp Ala-Thr-Lys-Pro-Asp Ala-Thr-Lys-Pro-Asp Ala-Thr-Lys-Pro-Asp-Arg Ala-Thr-Lys-Pro-Asp-Arg Ala-Thr-Lys-Pro-Asp-Arg Ala-Thr-Lys-Pro-Asp-Phe Ala-Thr-Lys-Pro-Asp-Phe Ala-Thr-Lys-Pro-Asp-Phe Ala-Thr-Lys-Pro-Asp-Tyr Ala-Thr-Lys-Pro-Asp-Tyr Ala-Thr-Lys-Pro-Asp-Tyr Ala-Thr-Lys-Pro-Asp-His Ala-Thr-Lys-Pro-Asp-His Ala-Thr-Lys-Pro-Asp-His Ala-Thr-Lys-Pro-Asp-Pro Ala-Thr-Lys-Pro-Asp-Pro Ala-Thr-Lys-Pro-Asp-Pro Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Asp-Lys Asp-Lys Pro-Asp-Lys Ala-Thr-Lys-Pro-Trp Ala-Thr-Lys-Pro-Trp Ala-Thr-Lys-Pro-Trp Ala-Thr-Lys-Pro-Trp-Arg Ala-Thr-Lys-Pro-Trp-Arg Ala-Thr-Lys-Pro-Trp-Arg Ala-Thr-Lys-Pro-Trp-Phe Ala-Thr-Lys-Pro-Trp-Phe Ala-Thr-Lys-Pro-Trp-Phe Ala-Thr-Lys-Pro-Trp-Tyr Ala-Thr-Lys-Pro-Trp-Tyr Ala-Thr-Lys-Pro-Trp-Tyr Ala-Thr-Lys-Pro-Trp-His Ala-Thr-Lys-Pro-Trp-His Ala-Thr-Lys-Pro-Trp-His Ala-Thr-Lys-Pro-Trp-Pro Ala-Thr-Lys-Pro-Trp-Pro Ala-Thr-Lys-Pro-Trp-Pro Ala-Thr-Lys-Pro-Trp-Lys Ala-Thr-Lys-Pro-Trp-Lys Ala-Thr-Lys-Pro-Trp-Lys Ala-Thr-Lys-Pro-Gln Ala-Thr-Lys-Pro-Gin Ala-Thr-Lys-Pro-Gln Ala-Thr-Lys-Pro-Gln-Arg Ala-Thr-Lys-Pro-Gln-Arg Ala-Thr-Lys-Pro-Gln-Arg Ala-Thr-Lys-Pro-Gln-Phe Ala-Thr-Lys-Pro-Gln-Phe Ala-Thr-Lys-Pro-Gln-Phe Ala-Thr-Lys-Pro-Gln-Tyr Ala-Thr-Lys-Pro-Gln-Tyr Ala-Thr-Lys-Pro-Gln-Tyr Ala-Thr-Lys-Pro-Gln-His Ala-Thr-Lys-Pro-Gln-His Ala-Thr-Lys-Pro-Gln-His Ala-Thr-Lys-Pro-Gln-Pro Ala-Thr-Lys-Pro-Gln-Pro Ala-Thr-Lys-Pro-Gln-Pro Ala-Thr-Lys-Pro-Gln-Lys Ala-Thr-Lys-Pro-Gln-Lys Ala-Thr-Lys-Pro-Gln-Lys

Ala-Thr-Lys-Pro-Asn Ala-Thr-Lys-Pro-Asn Ala-Thr-Lys-Pro-Asn Ala-Thr-Lys-Pro-Asn-Arg Ala-Thr-Lys-Pro-Asn-Arg Ala-Thr-Lys-Pro-Asn-Arg Ala-Thr-Lys-Pro-Asn-Phe Ala-Thr-Lys-Pro-Asn-Phe Ala-Thr-Lys-Pro-Asn-Phe Ala-Thr-Lys-Pro-Asn-Tyr Ala-Thr-Lys-Pro-Asn-Tyr Ala-Thr-Lys-Pro-Asn-Tyr Ala-Thr-Lys-Pro-Asn-His Ala-Thr-Lys-Pro-Asn-His Ala-Thr-Lys-Pro-Asn-His Ala-Thr-Lys-Pro-Asn-Pro Ala-Thr-Lys-Pro-Asn-Pro Ala-Thr-Lys-Pro-Asn-Pro Ala-Thr-Lys-Pro-Asn-Lys Ala-Thr-Lys-Pro-Asn-Lys Ala-Thr-Lys-Pro-Asn-Lys Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr-Arg Ala-Thr-Lys-Pro-Tyr-Arg Ala-Thr-Lys-Pro-Tyr-Arg Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-His Ala-Thr-Lys-Pro-Tyr-Pro Ala-Thr-Lys-Pro-Tyr-Pro Ala-Thr-Lys-Pro-Tyr-Pro Ala-Thr-Lys-Pro-Tyr-Lys Ala-Thr-Lys-Pro-Tyr-Lys Ala-Thr-Lys-Pro-Tyr-Lys Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Arg Arg Pro-Arg Ala-Thr-Lys-Pro-Arg-Arg Ala-Thr-Lys-Pro-Arg-Arg Ala-Thr-Lys-Pro-Arg-Arg Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-His Ala-Thr-Lys-Pro-Arg-His Ala-Thr-Lys-Pro-Arg-His Ala-Thr-Lys-Pro-Arg-Pro Ala-Thr-Lys-Pro-Arg-Pro Ala-Thr-Lys-Pro-Arg-Pro Ala-Thr-Lys-Pro-Arg-Lys Ala-Thr-Lys-Pro-Arg-Lys Ala-Thr-Lys-Pro-Arg-Lys His-Thr-Lys-Pro-Arg His-Thr-Lys-Pro-Arg His-Thr-Lys-Pro-Arg His-Thr-Lys-Pro-Phe His-Thr-Lys-Pro-Phe His-Thr-Lys-Pro-Phe His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-His His-Thr-Lys-Pro-His His-Thr-Lys-Pro-His His-Thr-Lys-Pro-Lys His-Thr-Lys-Pro-Lys His-Thr-Lys-Pro-Lys His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly-Arg His-Thr-Lys-Pro-Gly-Arg His-Thr-Lys-Pro-Gly-Arg

His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-His His-Thr-Lys-Pro-Gly-Pro His-Thr-Lys-Pro-Gly-Pro His-Thr-Lys-Pro-Gly-Pro His-Thr-Lys-Pro-Gly-Lys His-Thr-Lys-Pro-Gly-Lys His-Thr-Lys-Pro-Gly-Lys His-Thr-Lys-Pro-Asp His-Thr-Lys-Pro-Asp His-Thr-Lys-Pro-Asp His-Thr-Lys-Pro-Asp-Arg His-Thr-Lys-Pro-Asp-Arg His-Thr-Lys-Pro-Asp-Arg His-Thr-Lys-Pro-Asp-Phe His-Thr-Lys-Pro-Asp-Phe His-Thr-Lys-Pro-Asp-Phe His-Thr-Lys-Pro-Asp-Tyr His-Thr-Lys-Pro-Asp-Tyr His-Thr-Lys-Pro-Asp-Tyr His-Thr-Lys-Pro-Asp-His His-Thr-Lys-Pro-Asp-His His-Thr-Lys-Pro-Asp-His His-Thr-Lys-Pro-Asp-Pro His-Thr-Lys-Pro-Asp-Pro His-Thr-Lys-Pro-Asp-Pro His-Thr-Lys-Pro-Asp-Lys His-Thr-Lys-Pro-Asp-Lys His-Thr-Lys-Pro-Asp-Lys His-Thr-Lys-Pro-Trp His-Thr-Lys-Pro-Trp His-Thr-Lys-Pro-Trp His-Thr-Lys-Pro-Trp-Arg His-Thr-Lys-Pro-Trp-Arg His-Thr-Lys-Pro-Trp-Arg His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Trp-Phe Trp-Phe Pro-Trp-Phe His-Thr-Lys-Pro-Trp-Tyr His-Thr-Lys-Pro-Trp-Tyr His-Thr-Lys-Pro-Trp-Tyr His-Thr-Lys-Pro-Trp-His His-Thr-Lys-Pro-Trp-His His-Thr-Lys-Pro-Trp-His His-Thr-Lys-Pro-Trp-Pro His-Thr-Lys-Pro-Trp-Pro His-Thr-Lys-Pro-Trp-Pro His-Thr-Lys-Pro-Trp-Lys His-Thr-Lys-Pro-Trp-Lys His-Thr-Lys-Pro-Trp-Lys His-Thr-Lys-Pro-Gln His-Thr-Lys-Pro-Gin His-Thr-Lys-Pro-Gln His-Thr-Lys-Pro-Gln-Arg His-Thr-Lys-Pro-Gln-Arg His-Thr-Lys-Pro-Gln-Arg His-Thr-Lys-Pro-Gln-Phe His-Thr-Lys-Pro-Gln-Phe His-Thr-Lys-Pro-Gln-Phe His-Thr-Lys-Pro-Gln-Tyr His-Thr-Lys-Pro-Gln-Tyr His-Thr-Lys-Pro-Gln-Tyr His-Thr-Lys-Pro-Gln-His His-Thr-Lys-Pro-Gln-His His-Thr-Lys-Pro-Gln-His His-Thr-Lys-Pro-Gln-Pro His-Thr-Lys-Pro-Gln-Pro His-Thr-Lys-Pro-Gln-Pro His-Thr-Lys-Pro-Gln-Lys His-Thr-Lys-Pro-Gln-Lys His-Thr-Lys-Pro-Gln-Lys His-Thr-Lys-Pro-Asn His-Thr-Lys-Pro-Asn His-Thr-Lys-Pro-Asn His-Thr-Lys-Pro-Asn-Arg His-Thr-Lys-Pro-Asn-Arg His-Thr-Lys-Pro-Asn-Arg His-Thr-Lys-Pro-Asn-Phe His-Thr-Lys-Pro-Asn-Phe His-Thr-Lys-Pro-Asn-Phe

His-Thr-Lys-Pro-Asn-Tyr His-Thr-Lys-Pro-Asn-Tyr His-Thr-Lys-Pro-Asn-Tyr His-Thr-Lys-Pro-Asn-His His-Thr-Lys-Pro-Asn-His His-Thr-Lys-Pro-Asn-His His-Thr-Lys-Pro-Asn-Pro His-Thr-Lys-Pro-Asn-Pro His-Thr-Lys-Pro-Asn-Pro His-Thr-Lys-Pro-Asn-Lys His-Thr-Lys-Pro-Asn-Lys His-Thr-Lys-Pro-Asn-Lys His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr-Arg His-Thr-Lys-Pro-Tyr-Arg His-Thr-Lys-Pro-Tyr-Arg His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-His His-Thr-Lys-Pro-Tyr-His His-Thr-Lys-Pro-Tyr-His His-Thr-Lys-Pro-Tyr-Pro His-Thr-Lys-Pro-Tyr-Pro His-Thr-Lys-Pro-Tyr-Pro His-Thr-Lys-Pro-Tyr-Lys His-Thr-Lys-Pro-Tyr-Lys His-Thr-Lys-Pro-Tyr-Lys His-Thr-Lys-Pro-Arg His-Thr-Lys-Pro-Arg His-Thr-Lys-Pro-Arg His-Thr-Lys-Pro-Arg-Arg His-Thr-Lys-Pro-Arg-Arg His-Thr-Lys-Pro-Arg-Arg His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Arg-Tyr Arg-Tyr Pro-Arg-Tyr His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-His His-Thr-Lys-Pro-Arg-Pro His-Thr-Lys-Pro-Arg-Pro His-Thr-Lys-Pro-Arg-Pro His-Thr-Lys-Pro-Arg-Lys His-Thr-Lys-Pro-Arg-Lys His-Thr-Lys-Pro-Arg-Lys Lys-Thr-Lys-Pro-Arg Lys-Thr-Lys-Pro-Arg Lys-Thr-Lys-Pro-Arg Lys-Thr-Lys-Pro-Phe Lys-Thr-Lys-Pro-Phe Lys-Thr-Lys-Pro-Phe Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-His Lys-Thr-Lys-Pro-His Lys-Thr-Lys-Pro-His Lys-Thr-Lys-Pro-Lys Lys-Thr-Lys-Pro-Lys Lys-Thr-Lys-Pro-Lys Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly-Arg Lys-Thr-Lys-Pro-Gly-Arg Lys-Thr-Lys-Pro-Gly-Arg Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-His Lys-Thr-Lys-Pro-Gly-His

Lys-Thr-Lys-Pro-Gly-Pro Lys-Thr-Lys-Pro-Gly-Pro Lys-Thr-Lys-Pro-Gly-Pro Lys-Thr-Lys-Pro-Gly-Lys Lys-Thr-Lys-Pro-Gly-Lys Lys-Thr-Lys-Pro-Gly-Lys Lys-Thr-Lys-Pro-Asp Lys-Thr-Lys-Pro-Asp Lys-Thr-Lys-Pro-Asp Lys-Thr-Lys-Pro-Asp-Arg Lys-Thr-Lys-Pro-Asp-Arg Lys-Thr-Lys-Pro-Asp-Arg Lys-Thr-Lys-Pro-Asp-Phe Lys-Thr-Lys-Pro-Asp-Phe Lys-Thr-Lys-Pro-Asp-Phe Lys-Thr-Lys-Pro-Asp-Tyr Lys-Thr-Lys-Pro-Asp-Tyr Lys-Thr-Lys-Pro-Asp-Tyr Lys-Thr-Lys-Pro-Asp-His Lys-Thr-Lys-Pro-Asp-His Lys-Thr-Lys-Pro-Asp-His Lys-Thr-Lys-Pro-Asp-Pro Lys-Thr-Lys-Pro-Asp-Pro Lys-Thr-Lys-Pro-Asp-Pro Lys-Thr-Lys-Pro-Asp-Lys Lys-Thr-Lys-Pro-Asp-Lys Lys-Thr-Lys-Pro-Asp-Lys Lys-Thr-Lys-Pro-Trp Lys-Thr-Lys-Pro-Trp Lys-Thr-Lys-Pro-Trp Lys-Thr-Lys-Pro-Trp-Arg Lys-Thr-Lys-Pro-Trp-Arg Lys-Thr-Lys-Pro-Trp-Arg Lys-Thr-Lys-Pro-Trp-Phe Lys-Thr-Lys-Pro-Trp-Phe Lys-Thr-Lys-Pro-Trp-Phe Lys-Thr-Lys-Pro-Trp-Tyr Lys-Thr-Lys-Pro-Trp-Tyr Lys-Thr-Lys-Pro-Trp-Tyr Lys-Thr-Lys-Pro-Trp-His Lys-Thr-Lys-Pro-Trp-His Lys-Thr-Lys-Pro-Trp-His Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Trp-Pro Pro-Trp-Pro Pro-Trp-Pro Lys-Thr-Lys-Pro-Trp-Lys Lys-Thr-Lys-Pro-Trp-Lys Lys-Thr-Lys-Pro-Trp-Lys Lys-Thr-Lys-Pro-Gln Lys-Thr-Lys-Pro-Gln Lys-Thr-Lys-Pro-Gln Lys-Thr-Lys-Pro-Gln-Arg Lys-Thr-Lys-Pro-Gln-Arg Lys-Thr-Lys-Pro-Gln-Arg Lys-Thr-Lys-Pro-Gln-Phe Lys-Thr-Lys-Pro-Gln-Phe Lys-Thr-Lys-Pro-Gln-Phe Lys-Thr-Lys-Pro-Gln-Tyr Lys-Thr-Lys-Pro-Gln-Tyr Lys-Thr-Lys-Pro-Gln-Tyr Lys-Thr-Lys-Pro-Gln-His Lys-Thr-Lys-Pro-Gln-His Lys-Thr-Lys-Pro-Gln-His Lys-Thr-Lys-Pro-Gln-Pro Lys-Thr-Lys-Pro-Gln-Pro Lys-Thr-Lys-Pro-Gln-Pro Lys-Thr-Lys-Pro-Gln-Lys Lys-Thr-Lys-Pro-Gln-Lys Lys-Thr-Lys-Pro-Gln-Lys Lys-Thr-Lys-Pro-Asn Lys-Thr-Lys-Pro-Asn Lys-Thr-Lys-Pro-Asn Lys-Thr-Lys-Pro-Asn-Arg Lys-Thr-Lys-Pro-Asn-Arg Lys-Thr-Lys-Pro-Asn-Arg Lys-Thr-Lys-Pro-Asn-Phe Lys-Thr-Lys-Pro-Asn-Phe Lys-Thr-Lys-Pro-Asn-Phe Lys-Thr-Lys-Pro-Asn-Tyr Lys-Thr-Lys-Pro-Asn-Tyr Lys-Thr-Lys-Pro-Asn-Tyr Lys-Thr-Lys-Pro-Asn-His Lys-Thr-Lys-Pro-Asn-His Lys-Thr-Lys-Pro-Asn-His Lys-Thr-Lys-Pro-Asn-Pro Lys-Thr-Lys-Pro-Asn-Pro Lys-Thr-Lys-Pro-Asn-Pro

Lys-Thr-Lys-Pro-Asn-Lys Lys-Thr-Lys-Pro-Asn-Lys Lys-Thr-Lys-Pro-Asn-Lys Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr-Arg Lys-Thr-Lys-Pro-Tyr-Arg Lys-Thr-Lys-Pro-Tyr-Arg Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-His Lys-Thr-Lys-Pro-Tyr-Pro Lys-Thr-Lys-Pro-Tyr-Pro Lys-Thr-Lys-Pro-Tyr-Pro Lys-Thr-Lys-Pro-Tyr-Lys Lys-Thr-Lys-Pro-Tyr-Lys Lys-Thr-Lys-Pro-Tyr-Lys Lys-Thr-Lys-Pro-Arg Lys-Thr-Lys-Pro-Arg Lys-Thr-Lys-Pro-Arg Lys-Thr-Lys-Pro-Arg-Arg Lys-Thr-Lys-Pro-Arg-Arg Lys-Thr-Lys-Pro-Arg-Arg Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-His Lys-Thr-Lys-Pro-Arg-Pro Lys-Thr-Lys-Pro-Arg-Pro Lys-Thr-Lys-Pro-Arg-Pro Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Arg-Lys Pro-Arg-Lys Pro-Arg-Lys Gly-Thr-Lys-Pro-Arg Gly-Thr-Lys-Pro-Arg Gly-Thr-Lys-Pro-Arg Gly-Thr-Lys-Pro-Phe Gly-Thr-Lys-Pro-Phe Gly-Thr-Lys-Pro-Phe Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-His Gly-Thr-Lys-Pro-His Gly-Thr-Lys-Pro-His Gly-Thr-Lys-Pro-Lys Gly-Thr-Lys-Pro-Lys Gly-Thr-Lys-Pro-Lys Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly-Arg Gly-Thr-Lys-Pro-Gly-Arg Gly-Thr-Lys-Pro-Gly-Arg Gly-Thr-Lys-Pro-Gly-Phe Gly-Thr-Lys-Pro-Gly-Phe Gly-Thr-Lys-Pro-Gly-Phe Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-His Gly-Thr-Lys-Pro-Gly-His Gly-Thr-Lys-Pro-Gly-His Gly-Thr-Lys-Pro-Gly-Pro Gly-Thr-Lys-Pro-Gly-Pro Gly-Thr-Lys-Pro-Gly-Pro Gly-Thr-Lys-Pro-Gly-Lys Gly-Thr-Lys-Pro-Gly-Lys Gly-Thr-Lys-Pro-Gly-Lys Gly-Thr-Lys-Pro-Asp Gly-Thr-Lys-Pro-Asp Gly-Thr-Lys-Pro-Asp

Gly-Thr-Lys-Pro-Asp-Arg Gly-Thr-Lys-Pro-Asp-Arg Gly-Thr-Lys-Pro-Asp-Arg Gly-Thr-Lys-Pro-Asp-Phe Gly-Thr-Lys-Pro-Asp-Phe Gly-Thr-Lys-Pro-Asp-Phe Gly-Thr-Lys-Pro-Asp-Tyr Gly-Thr-Lys-Pro-Asp-Tyr Gly-Thr-Lys-Pro-Asp-Tyr Gly-Thr-Lys-Pro-Asp-His Gly-Thr-Lys-Pro-Asp-His Gly-Thr-Lys-Pro-Asp-His Gly-Thr-Lys-Pro-Asp-Pro Gly-Thr-Lys-Pro-Asp-Pro Gly-Thr-Lys-Pro-Asp-Pro Gly-Thr-Lys-Pro-Asp-Lys Gly-Thr-Lys-Pro-Asp-Lys Gly-Thr-Lys-Pro-Asp-Lys Gly-Thr-Lys-Pro-Trp Gly-Thr-Lys-Pro-Trp Gly-Thr-Lys-Pro-Trp Gly-Thr-Lys-Pro-Trp-Arg Gly-Thr-Lys-Pro-Trp-Arg Gly-Thr-Lys-Pro-Trp-Arg Gly-Thr-Lys-Pro-Trp-Phe Gly-Thr-Lys-Pro-Trp-Phe Gly-Thr-Lys-Pro-Trp-Phe Gly-Thr-Lys-Pro-Trp-Tyr Gly-Thr-Lys-Pro-Trp-Tyr Gly-Thr-Lys-Pro-Trp-Tyr Gly-Thr-Lys-Pro-Trp-His Gly-Thr-Lys-Pro-Trp-His Gly-Thr-Lys-Pro-Trp-His Gly-Thr-Lys-Pro-Trp-Pro Gly-Thr-Lys-Pro-Trp-Pro Gly-Thr-Lys-Pro-Trp-Pro Gly-Thr-Lys-Pro-Trp-Lys Gly-Thr-Lys-Pro-Trp-Lys Gly-Thr-Lys-Pro-Trp-Lys Gly-Thr-Lys-Pro-Gln Gly-Thr-Lys-Pro-Gln Gly-Thr-Lys-Pro-Gln Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Gln-Arg Pro-Gln-Arg Pro-Gln-Arg Gly-Thr-Lys-Pro-Gln-Phe Gly-Thr-Lys-Pro-Gln-Phe Gly-Thr-Lys-Pro-Gln-Phe Gly-Thr-Lys-Pro-Gln-Tyr Gly-Thr-Lys-Pro-Gln-Tyr Gly-Thr-Lys-Pro-Gln-Tyr Gly-Thr-Lys-Pro-Gln-His Gly-Thr-Lys-Pro-Gln-His Gly-Thr-Lys-Pro-Gln-His Gly-Thr-Lys-Pro-Gln-Pro Gly-Thr-Lys-Pro-Gln-Pro Gly-Thr-Lys-Pro-Gln-Pro Gly-Thr-Lys-Pro-Gln-Lys Gly-Thr-Lys-Pro-Gln-Lys Gly-Thr-Lys-Pro-Gln-Lys Gly-Thr-Lys-Pro-Asn Gly-Thr-Lys-Pro-Asn Gly-Thr-Lys-Pro-Asn Gly-Thr-Lys-Pro-Asn-Arg Gly-Thr-Lys-Pro-Asn-Arg Gly-Thr-Lys-Pro-Asn-Arg Gly-Thr-Lys-Pro-Asn-Phe Gly-Thr-Lys-Pro-Asn-Phe Gly-Thr-Lys-Pro-Asn-Phe Gly-Thr-Lys-Pro-Asn-Tyr Gly-Thr-Lys-Pro-Asn-Tyr Gly-Thr-Lys-Pro-Asn-Tyr Gly-Thr-Lys-Pro-Asn-His Gly-Thr-Lys-Pro-Asn-His Gly-Thr-Lys-Pro-Asn-His Gly-Thr-Lys-Pro-Asn-Pro Gly-Thr-Lys-Pro-Asn-Pro Gly-Thr-Lys-Pro-Asn-Pro Gly-Thr-Lys-Pro-Asn-Lys Gly-Thr-Lys-Pro-Asn-Lys Gly-Thr-Lys-Pro-Asn-Lys Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr-Arg Gly-Thr-Lys-Pro-Tyr-Arg Gly-Thr-Lys-Pro-Tyr-Arg

Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-His Gly-Thr-Lys-Pro-Tyr-Pro Gly-Thr-Lys-Pro-Tyr-Pro Gly-Thr-Lys-Pro-Tyr-Pro Gly-Thr-Lys-Pro-Tyr-Lys Gly-Thr-Lys-Pro-Tyr-Lys Gly-Thr-Lys-Pro-Tyr-Lys Gly-Thr-Lys-Pro-Arg Gly-Thr-Lys-Pro-Arg Gly-Thr-Lys-Pro-Arg Gly-Thr-Lys-Pro-Arg-Arg Gly-Thr-Lys-Pro-Arg-Arg Gly-Thr-Lys-Pro-Arg-Arg Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-His Gly-Thr-Lys-Pro-Arg-Pro Gly-Thr-Lys-Pro-Arg-Pro Gly-Thr-Lys-Pro-Arg-Pro Gly-Thr-Lys-Pro-Arg-Lys Gly-Thr-Lys-Pro-Arg-Lys Gly-Thr-Lys-Pro-Arg-Lys Thr-Lys-Pro-Arg-Val Thr-Lys-Pro-Arg-Val Thr-Lys-Pro-Arg-Val Thr-Lys-Pro-Phe-Val Thr-Lys-Pro-Phe-Val Thr-Lys-Pro-Phe-Val Thr-Lys-Pro- Thr-Lys-Pro-Tyr- Thr-Lys-Pro-

Tyr-Val Val Tyr-Val Thr-Lys-Pro-Gly-Val Thr-Lys-Pro-Gly-Val Thr-Lys-Pro-Gly-Val Thr-Lys-Pro-His-Val Thr-Lys-Pro-His-Val Thr-Lys-Pro-His-Val Thr-Lys-Pro-Lys-Val Thr-Lys-Pro-Lys-Val Thr-Lys-Pro-Lys-Val Thr-Lys-Pro-Gly-Val Thr-Lys-Pro-Gly-Val Thr-Lys-Pro-Gly-Val Thr-Lys-Pro-Gly-Arg-Val Thr-Lys-Pro-Gly-Arg-Val Thr-Lys-Pro-Gly-Arg-Val Thr-Lys-Pro-Gly-Phe-Val Thr-Lys-Pro-Gly-Phe-Val Thr-Lys-Pro-Gly-Phe-Val Thr-Lys-Pro-Gly-Tyr-Val Thr-Lys-Pro-Gly-Tyr-Val Thr-Lys-Pro-Gly-Tyr-Val Thr-Lys-Pro-Gly-His-Val Thr-Lys-Pro-Gly-His-Val Thr-Lys-Pro-Gly-His-Val Thr-Lys-Pro-Gly-Pro-Val Thr-Lys-Pro-Gly-Pro-Val Thr-Lys-Pro-Gly-Pro-Val Thr-Lys-Pro-Gly-Lys-Val Thr-Lys-Pro-Gly-Lys-Val Thr-Lys-Pro-Gly-Lys-Val Thr-Lys-Pro-Asp-Val Thr-Lys-Pro-Asp-Val Thr-Lys-Pro-Asp-Val Thr-Lys-Pro-Asp-Arg-Val Thr-Lys-Pro-Asp-Arg-Val Thr-Lys-Pro-Asp-Arg-Val Thr-Lys-Pro-Asp-Phe-Val Thr-Lys-Pro-Asp-Phe-Val Thr-Lys-Pro-Asp-Phe-Val Thr-Lys-Pro-Asp-Tyr-Val Thr-Lys-Pro-Asp-Tyr-Val Thr-Lys-Pro-Asp-Tyr-Val

Thr-Lys-Pro-Asp-His-Val Thr-Lys-Pro-Asp-His-Val Thr-Lys-Pro-Asp-His-Val Thr-Lys-Pro-Asp-Pro-Val Thr-Lys-Pro-Asp-Pro-Val Thr-Lys-Pro-Asp-Pro-Val Thr-Lys-Pro-Asp-Lys-Val Thr-Lys-Pro-Asp-Lys-Val Thr-Lys-Pro-Asp-Lys-Val Thr-Lys-Pro-Trp-Val Thr-Lys-Pro-Trp-Val Thr-Lys-Pro-Trp-Val Thr-Lys-Pro-Trp-Arg-Val Thr-Lys-Pro-Trp-Arg-Val Thr-Lys-Pro-Trp-Arg-Val Thr-Lys-Pro-Trp-Phe-Val Thr-Lys-Pro-Trp-Phe-Val Thr-Lys-Pro-Trp-Phe-Val Thr-Lys-Pro-Trp-Tyr-Val Thr-Lys-Pro-Trp-Tyr-Val Thr-Lys-Pro-Trp-Tyr-Val Thr-Lys-Pro-Trp-His-Val Thr-Lys-Pro-Trp-His-Val Thr-Lys-Pro-Trp-His-Val Thr-Lys-Pro-Trp-Pro-Val Thr-Lys-Pro-Trp-Pro-Val Thr-Lys-Pro-Trp-Pro-Val Thr-Lys-Pro-Trp-Lys-Val Thr-Lys-Pro-Trp-Lys-Val Thr-Lys-Pro-Trp-Lys-Val Thr-Lys-Pro-Gln-Val Thr-Lys-Pro-Gln-Val Thr-Lys-Pro-Gln-Val Thr-Lys-Pro-Gln-Arg-Val Thr-Lys-Pro-Gln-Arg-Val Thr-Lys-Pro-Gln-Arg-Val Thr-Lys-Pro-Gln-Phe-Val Thr-Lys-Pro-Gln-Phe-Val Thr-Lys-Pro-Gln-Phe-Val Thr-Lys-Pro-Gln-Tyr-Val Thr-Lys-Pro-Gln-Tyr-Val Thr-Lys-Pro-Gln-Tyr-Val Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Gln-His-Val Gln-His-Val Gln-His-Val Thr-Lys-Pro-Gln-Pro-Val Thr-Lys-Pro-Gln-Pro-Val Thr-Lys-Pro-Gln-Pro-Val Thr-Lys-Pro-Gln-Lys-Val Thr-Lys-Pro-Gln-Lys-Val Thr-Lys-Pro-Gln-Lys-Val Thr-Lys-Pro-Asn-Val Thr-Lys-Pro-Asn-Val Thr-Lys-Pro-Asn-Val Thr-Lys-Pro-Asn-Arg-Val Thr-Lys-Pro-Asn-Arg-Val Thr-Lys-Pro-Asn-Arg-Val Thr-Lys-Pro-Asn-Phe-Val Thr-Lys-Pro-Asn-Phe-Val Thr-Lys-Pro-Asn-Phe-Val Thr-Lys-Pro-Asn-Tyr-Val Thr-Lys-Pro-Asn-Tyr-Val Thr-Lys-Pro-Asn-Tyr-Val Thr-Lys-Pro-Asn-His-Val Thr-Lys-Pro-Asn-His-Val Thr-Lys-Pro-Asn-His-Val Thr-Lys-Pro-Asn-Pro-Val Thr-Lys-Pro-Asn-Pro-Val Thr-Lys-Pro-Asn-Pro-Val Thr-Lys-Pro-Asn-Lys-Val Thr-Lys-Pro-Asn-Lys-Val Thr-Lys-Pro-Asn-Lys-Val Thr-Lys-Pro-Tyr-Val Thr-Lys-Pro-Tyr-Val Thr-Lys-Pro-Tyr-Val Thr-Lys-Pro-Tyr-Arg-Val Thr-Lys-Pro-Tyr-Arg-Val Thr-Lys-Pro-Tyr-Arg-Val Thr-Lys-Pro-Tyr-Phe-Val Thr-Lys-Pro-Tyr-Phe-Val Thr-Lys-Pro-Tyr-Phe-Val Thr-Lys-Pro-Tyr-Tyr-Val Thr-Lys-Pro-Tyr-Tyr-Val Thr-Lys-Pro-Tyr-Tyr-Val Thr-Lys-Pro-Tyr-His-Val Thr-Lys-Pro-Tyr-His-Val Thr-Lys-Pro-Tyr-His-Val

Thr-Lys-Pro-Tyr-Pro-Val Thr-Lys-Pro-Tyr-Pro-Val Thr-Lys-Pro-Tyr-Pro-Val Thr-Lys-Pro-Tyr-Lys-Val Thr-Lys-Pro-Tyr-Lys-Val Thr-Lys-Pro-Tyr-Lys-Val Thr-Lys-Pro-Arg-Val Thr-Lys-Pro-Arg-Val Thr-Lys-Pro-Arg-Val Thr-Lys-Pro-Arg-Arg-Val Thr-Lys-Pro-Arg-Arg-Val Thr-Lys-Pro-Arg-Arg-Val Thr-Lys-Pro-Arg-Phe-Val Thr-Lys-Pro-Arg-Phe-Val Thr-Lys-Pro-Arg-Phe-Val Thr-Lys-Pro-Arg-Tyr-Val Thr-Lys-Pro-Arg-Tyr-Val Thr-Lys-Pro-Arg-Tyr-Val Thr-Lys-Pro-Arg-His-Val Thr-Lys-Pro-Arg-His-Val Thr-Lys-Pro-Arg-His-Val Thr-Lys-Pro-Arg-Pro-Val Thr-Lys-Pro-Arg-Pro-Val Thr-Lys-Pro-Arg-Pro-Val Thr-Lys-Pro-Arg-Lys-Val Thr-Lys-Pro-Arg-Lys-Val Thr-Lys-Pro-Arg-Lys-Val Met-Thr-Lys-Pro-Val Met-Thr-Lys-Pro-Val Met-Thr-Lys-Pro-Val Met-Thr-Lys-Pro-Arg-Val Met-Thr-Lys-Pro-Arg-Val Met-Thr-Lys-Pro-Arg-Val Met-Thr-Lys-Pro-Phe-Val Met-Thr-Lys-Pro-Phe-Val Met-Thr-Lys-Pro-Phe-Val Met-Thr-Lys-Pro-Tyr-Val Met-Thr-Lys-Pro-Tyr-Val Met-Thr-Lys-Pro-Tyr-Val Met-Thr-Lys-Pro-His-Val Met-Thr-Lys-Pro-His-Val Met-Thr-Lys-Pro-His-Val Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Lys-Val Pro-Lys-Val Pro-Lys-Val Met-Thr-Lys-Pro-Gly-Val Met-Thr-Lys-Pro-Gly-Val Met-Thr-Lys-Pro-Gly-Val Met-Thr-Lys-Pro-Gly-Arg-Val Met-Thr-Lys-Pro-Gly-Arg-Val Met-Thr-Lys-Pro-Gly-Arg-Val Met-Thr-Lys-Pro-Gly-Phe-Val Met-Thr-Lys-Pro-Gly-Phe-Val Met-Thr-Lys-Pro-Gly-Phe-Val Met-Thr-Lys-Pro-Gly-Tyr-Val Met-Thr-Lys-Pro-Gly-Tyr-Val Met-Thr-Lys-Pro-Gly-Tyr-Val Met-Thr-Lys-Pro-Gly-His-Val Met-Thr-Lys-Pro-Gly-His-Val Met-Thr-Lys-Pro-Gly-His-Val Met-Thr-Lys-Pro-Gly-Pro-Val Met-Thr-Lys-Pro-Gly-Pro-Val Met-Thr-Lys-Pro-Gly-Pro-Val Met-Thr-Lys-Pro-Gly-Lys-Val Met-Thr-Lys-Pro-Gly-Lys-Val Met-Thr-Lys-Pro-Gly-Lys-Val Met-Thr-Lys-Pro-Asp-Val Met-Thr-Lys-Pro-Asp-Val Met-Thr-Lys-Pro-Asp-Val Met-Thr-Lys-Pro-Asp-Arg-Val Met-Thr-Lys-Pro-Asp-Arg-Val Met-Thr-Lys-Pro-Asp-Arg-Val Met-Thr-Lys-Pro-Asp-Phe-Val Met-Thr-Lys-Pro-Asp-Phe-Val Met-Thr-Lys-Pro-Asp-Phe-Val Met-Thr-Lys-Pro-Asp-Tyr-Val Met-Thr-Lys-Pro-Asp-Tyr-Val Met-Thr-Lys-Pro-Asp-Tyr-Val Met-Thr-Lys-Pro-Asp-His-Val Met-Thr-Lys-Pro-Asp-His-Val Met-Thr-Lys-Pro-Asp-His-Val Met-Thr-Lys-Pro-Asp-Pro-Val Met-Thr-Lys-Pro-Asp-Pro-Val Met-Thr-Lys-Pro-Asp-Pro-Val Met-Thr-Lys-Pro-Asp-Lys-Val Met-Thr-Lys-Pro-Asp-Lys-Val Met-Thr-Lys-Pro-Asp-Lys-Val

Met-Thr-Lys-Pro-Trp-Val Met-Thr-Lys-Pro-Trp-Val Met-Thr-Lys-Pro-Trp-Val Met-Thr-Lys-Pro-Trp-Arg-Val Met-Thr-Lys-Pro-Trp-Arg-Val Met-Thr-Lys-Pro-Trp-Arg-Val Met-Thr-Lys-Pro-Trp-Phe-Val Met-Thr-Lys-Pro-Trp-Phe-Val Met-Thr-Lys-Pro-Trp-Phe-Val Met-Thr-Lys-Pro-Trp-Tyr-Val Met-Thr-Lys-Pro-Trp-Tyr-Val Met-Thr-Lys-Pro-Trp-Tyr-Val Met-Thr-Lys-Pro-Trp-His-Val Met-Thr-Lys-Pro-Trp-His-Val Met-Thr-Lys-Pro-Trp-His-Val Met-Thr-Lys-Pro-Trp-Pro-Val Met-Thr-Lys-Pro-Trp-Pro-Val Met-Thr-Lys-Pro-Trp-Pro-Val Met-Thr-Lys-Pro-Trp-Lys-Val Met-Thr-Lys-Pro-Trp-Lys-Val Met-Thr-Lys-Pro-Trp-Lys-Val Met-Thr-Lys-Pro-Gln-Val Met-Thr-Lys-Pro-Gln-Val Met-Thr-Lys-Pro-Gln-Val Met-Thr-Lys-Pro-Gln-Arg-Val Met-Thr-Lys-Pro-Gln-Arg-Val Met-Thr-Lys-Pro-Gln-Arg-Val Met-Thr-Lys-Pro-Gln-Phe-Val Met-Thr-Lys-Pro-Gln-Phe-Val Met-Thr-Lys-Pro-Gln-Phe-Val Met-Thr-Lys-Pro-Gln-Tyr-Val Met-Thr-Lys-Pro-Gln-Tyr-Val Met-Thr-Lys-Pro-Gln-Tyr-Val Met-Thr-Lys-Pro-Gln-His-Val Met-Thr-Lys-Pro-Gln-His-Val Met-Thr-Lys-Pro-Gln-His-Val Met-Thr-Lys-Pro-Gln-Pro-Val Met-Thr-Lys-Pro-Gln-Pro-Val Met-Thr-Lys-Pro-Gln-Pro-Val Met-Thr-Lys-Pro-Gln-Lys-Val Met-Thr-Lys-Pro-Gln-Lys-Val Met-Thr-Lys-Pro-Gln-Lys-Val Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Asn-Val Pro-Asn-Val Pro-Asn-Val Met-Thr-Lys-Pro-Asn-Arg-Val Met-Thr-Lys-Pro-Asn-Arg-Val Met-Thr-Lys-Pro-Asn-Arg-Val Met-Thr-Lys-Pro-Asn-Phe-Val Met-Thr-Lys-Pro-Asn-Phe-Val Met-Thr-Lys-Pro-Asn-Phe-Val Met-Thr-Lys-Pro-Asn-Tyr-Val Met-Thr-Lys-Pro-Asn-Tyr-Val Met-Thr-Lys-Pro-Asn-Tyr-Val Met-Thr-Lys-Pro-Asn-His-Val Met-Thr-Lys-Pro-Asn-His-Val Met-Thr-Lys-Pro-Asn-His-Val Met-Thr-Lys-Pro-Asn-Pro-Val Met-Thr-Lys-Pro-Asn-Pro-Val Met-Thr-Lys-Pro-Asn-Pro-Val Met-Thr-Lys-Pro-Asn-Lys-Val Met-Thr-Lys-Pro-Asn-Lys-Val Met-Thr-Lys-Pro-Asn-Lys-Val Met-Thr-Lys-Pro-Tyr-Val Met-Thr-Lys-Pro-Tyr-Val Met-Thr-Lys-Pro-Tyr-Val Met-Thr-Lys-Pro-Tyr-Arg-Val Met-Thr-Lys-Pro-Tyr-Arg-Val Met-Thr-Lys-Pro-Tyr-Arg-Val Met-Thr-Lys-Pro-Tyr-Phe-Val Met-Thr-Lys-Pro-Tyr-Phe-Val Met-Thr-Lys-Pro-Tyr-Phe-Val Met-Thr-Lys-Pro-Tyr-Tyr-Val Met-Thr-Lys-Pro-Tyr-Tyr-Val Met-Thr-Lys-Pro-Tyr-Tyr-Val Met-Thr-Lys-Pro-Tyr-His-Val Met-Thr-Lys-Pro-Tyr-His-Val Met-Thr-Lys-Pro-Tyr-His-Val Met-Thr-Lys-Pro-Tyr-Pro-Val Met-Thr-Lys-Pro-Tyr-Pro-Val Met-Thr-Lys-Pro-Tyr-Pro-Val Met-Thr-Lys-Pro-Tyr-Lys-Val Met-Thr-Lys-Pro-Tyr-Lys-Val Met-Thr-Lys-Pro-Tyr-Lys-Val Met-Thr-Lys-Pro-Arg-Val Met-Thr-Lys-Pro-Arg-Val Met-Thr-Lys-Pro-Arg-Val

Met-Thr-Lys-Pro-Arg-Arg-Val Met-Thr-Lys-Pro-Arg-Arg-Val Met-Thr-Lys-Pro-Arg-Arg-Val Met-Thr-Lys-Pro-Arg-Phe-Val Met-Thr-Lys-Pro-Arg-Phe-Val Met-Thr-Lys-Pro-Arg-Phe-Val Met-Thr-Lys-Pro-Arg-Tyr-Val Met-Thr-Lys-Pro-Arg-Tyr-Val Met-Thr-Lys-Pro-Arg-Tyr-Val Met-Thr-Lys-Pro-Arg-His-Val Met-Thr-Lys-Pro-Arg-His-Val Met-Thr-Lys-Pro-Arg-His-Val Met-Thr-Lys-Pro-Arg-Pro-Val Met-Thr-Lys-Pro-Arg-Pro-Val Met-Thr-Lys-Pro-Arg-Pro-Val Met-Thr-Lys-Pro-Arg-Lys-Val Met-Thr-Lys-Pro-Arg-Lys-Val Met-Thr-Lys-Pro-Arg-Lys-Val Met(0)-Thr-Lys-Pro-Val Met(0)-Thr-Lys-Pro-Val Met(0)-Thr-Lys-Pro-Val Met(0)-Thr-Lys-Pro-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Val Met(0)-Thr-Lys-Pro-Phe-Val Met(0)-Thr-Lys-Pro-Phe-Val Met(0)-Thr-Lys-Pro-Phe-Val Met(0)-Thr-Lys-Pro-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Val Met(0)-Thr-Lys-Pro-Gly-Val Met(0)-Thr-Lys-Pro-Gly-Val Met(0)-Thr-Lys-Pro-Gly-Val Met(0)-Thr-Lys-Pro-His-Val Met(0)-Thr-Lys-Pro-His-Val Met(0)-Thr-Lys-Pro-His-Val Met(0)-Thr-Lys-Pro-Lys-Val Met(0)-Thr-Lys-Pro-Lys-Val Met(0)-Thr-Lys-Pro-Lys-Val Met(0)-Thr-Lys-Pro-Gly-Val Met(0)-Thr-Lys-Pro-Gly-Val Met(0)-Thr-Lys-Pro-Gly-Val Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Gly-Arg-Val Pro-Gly-Arg-Val Pro-Gly-Arg-Val Met(0)-Thr-Lys-Pro-Gly-Phe-Val Met(0)-Thr-Lys-Pro-Gly-Phe-Val Met(0)-Thr-Lys-Pro-Gly-Phe-Val Met(0)-Thr-Lys-Pro-Gly-Tyr-Val Met(0)-Thr-Lys-Pro-Gly-Tyr-Val Met(0)-Thr-Lys-Pro-Gly-Tyr-Val Met(0)-Thr-Lys-Pro-Gly-His-Val Met(0)-Thr-Lys-Pro-Gly-His-Val Met(0)-Thr-Lys-Pro-Gly-His-Val Met(0)-Thr-Lys-Pro-Gly-Pro-Val Met(0)-Thr-Lys-Pro-Gly-Pro-Val Met(0)-Thr-Lys-Pro-Gly-Pro-Val Met(0)-Thr-Lys-Pro-Gly-Lys-Val Met(0)-Thr-Lys-Pro-Gly-Lys-Val Met(0)-Thr-Lys-Pro-Gly-Lys-Val Met(0)-Thr-Lys-Pro-Asp-Val Met(0)-Thr-Lys-Pro-Asp-Val Met(0)-Thr-Lys-Pro-Asp-Val Met(0)-Thr-Lys-Pro-Asp-Arg-Val Met(0)-Thr-Lys-Pro-Asp-Arg-Val Met(0)-Thr-Lys-Pro-Asp-Arg-Val Met(0)-Thr-Lys-Pro-Asp-Phe-Val Met(0)-Thr-Lys-Pro-Asp-Phe-Val Met(0)-Thr-Lys-Pro-Asp-Phe-Val Met(0)-Thr-Lys-Pro-Asp-Tyr-Val Met(0)-Thr-Lys-Pro-Asp-Tyr-Val Met(0)-Thr-Lys-Pro-Asp-Tyr-Val Met(0)-Thr-Lys-Pro-Asp-His-Val Met(0)-Thr-Lys-Pro-Asp-His-Val Met(0)-Thr-Lys-Pro-Asp-His-Val Met(0)-Thr-Lys-Pro-Asp-Pro-Val Met(0)-Thr-Lys-Pro-Asp-Pro-Val Met(0)-Thr-Lys-Pro-Asp-Pro-Val Met(0)-Thr-Lys-Pro-Asp-Lys-Val Met(0)-Thr-Lys-Pro-Asp-Lys-Val Met(0)-Thr-Lys-Pro-Asp-Lys-Val Met(0)-Thr-Lys-Pro-Trp-Val Met(0)-Thr-Lys-Pro-Trp-Val Met(0)-Thr-Lys-Pro-Trp-Val Met(0)-Thr-Lys-Pro-Trp-Arg-Val Met(0)-Thr-Lys-Pro-Trp-Arg-Val Met(0)-Thr-Lys-Pro-Trp-Arg-Val

Met(0)-Thr-Lys-Pro-Trp-Phe-Val Met(0)-Thr-Lys-Pro-Trp-Phe-Val Met(0)-Thr-Lys-Pro-Trp-Phe-Val Met(0)-Thr-Lys-Pro-Trp-Tyr-Val Met(0)-Thr-Lys-Pro-Trp-Tyr-Val Met(0)-Thr-Lys-Pro-Trp-Tyr-Val Met(0)-Thr-Lys-Pro-Trp-His-Val Met(0)-Thr-Lys-Pro-Trp-His-Val Met(0)-Thr-Lys-Pro-Trp-His-Val Met(0)-Thr-Lys-Pro-Trp-Pro-Val Met(0)-Thr-Lys-Pro-Trp-Pro-Val Met(0)-Thr-Lys-Pro-Trp-Pro-Val Met(0)-Thr-Lys-Pro-Trp-Lys-Val Met(0)-Thr-Lys-Pro-Trp-Lys-Val Met(0)-Thr-Lys-Pro-Trp-Lys-Val Met(0)-Thr-Lys-Pro-Gln-Val Met(0)-Thr-Lys-Pro-Gln-Val Met(0)-Thr-Lys-Pro-Gln-Val Met(0)-Thr-Lys-Pro-Gln-Arg-Val Met(0)-Thr-Lys-Pro-Gln-Arg-Val Met(0)-Thr-Lys-Pro-Gln-Arg-Val Met(0)-Thr-Lys-Pro-Gln-Phe-Val Met(0)-Thr-Lys-Pro-Gln-Phe-Val Met(0)-Thr-Lys-Pro-Gln-Phe-Val Met(0)-Thr-Lys-Pro-Gln-Tyr-Val Met(0)-Thr-Lys-Pro-Gln-Tyr-Val Met(0)-Thr-Lys-Pro-Gln-Tyr-Val Met(0)-Thr-Lys-Pro-Gln-His-Val Met(0)-Thr-Lys-Pro-Gln-His-Val Met(0)-Thr-Lys-Pro-Gln-His-Val Met(0)-Thr-Lys-Pro-Gln-Pro-Val Met(0)-Thr-Lys-Pro-Gln-Pro-Val Met(0)-Thr-Lys-Pro-Gln-Pro-Val Met(0)-Thr-Lys-Pro-Gln-Lys-Val Met(0)-Thr-Lys-Pro-Gln-Lys-Val Met(0)-Thr-Lys-Pro-Gln-Lys-Val Met(0)-Thr-Lys-Pro-Asn-Val Met(0)-Thr-Lys-Pro-Asn-Val Met(0)-Thr-Lys-Pro-Asn-Val Met(0)-Thr-Lys-Pro-Asn-Arg-Val Met(0)-Thr-Lys-Pro-Asn-Arg-Val Met(0)-Thr-Lys-Pro-Asn-Arg-Val Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Asn-Phe-Val Pro-Asn-Phe-Val Pro-Asn-Phe-Val Met(0)-Thr-Lys-Pro-Asn-Tyr-Val Met(0)-Thr-Lys-Pro-Asn-Tyr-Val Met(0)-Thr-Lys-Pro-Asn-Tyr-Val Met(0)-Thr-Lys-Pro-Asn-His-Val Met(0)-Thr-Lys-Pro-Asn-His-Val Met(0)-Thr-Lys-Pro-Asn-His-Val Met(0)-Thr-Lys-Pro-Asn-Pro-Val Met(0)-Thr-Lys-Pro-Asn-Pro-Val Met(0)-Thr-Lys-Pro-Asn-Pro-Val Met(0)-Thr-Lys-Pro-Asn-Lys-Val Met(0)-Thr-Lys-Pro-Asn-Lys-Val Met(0)-Thr-Lys-Pro-Asn-Lys-Val Met(0)-Thr-Lys-Pro-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Arg-Val Met(0)-Thr-Lys-Pro-Tyr-Arg-Val Met(0)-Thr-Lys-Pro-Tyr-Arg-Val Met(0)-Thr-Lys-Pro-Tyr-Phe-Val Met(0)-Thr-Lys-Pro-Tyr-Phe-Val Met(0)-Thr-Lys-Pro-Tyr-Phe-Val Met(0)-Thr-Lys-Pro-Tyr-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-Tyr-Val Met(0)-Thr-Lys-Pro-Tyr-His-Val Met(0)-Thr-Lys-Pro-Tyr-His-Val Met(0)-Thr-Lys-Pro-Tyr-His-Val Met(0)-Thr-Lys-Pro-Tyr-Pro-Val Met(0)-Thr-Lys-Pro-Tyr-Pro-Val Met(0)-Thr-Lys-Pro-Tyr-Pro-Val Met(0)-Thr-Lys-Pro-Tyr-Lys-Val Met(0)-Thr-Lys-Pro-Tyr-Lys-Val Met(0)-Thr-Lys-Pro-Tyr-Lys-Val Met(0)-Thr-Lys-Pro-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Arg-Val Met(0)-Thr-Lys-Pro-Arg-Phe-Val Met(0)-Thr-Lys-Pro-Arg-Phe-Val Met(0)-Thr-Lys-Pro-Arg-Phe-Val

Met(0)-Thr-Lys-Pro-Arg-Tyr-Val Met(0)-Thr-Lys-Pro-Arg-Tyr-Val Met(0)-Thr-Lys-Pro-Arg-Tyr-Val Met(0)-Thr-Lys-Pro-Arg-His-Val Met(0)-Thr-Lys-Pro-Arg-His-Val Met(0)-Thr-Lys-Pro-Arg-His-Val Met(0)-Thr-Lys-Pro-Arg-Pro-Val Met(0)-Thr-Lys-Pro-Arg-Pro-Val Met(0)-Thr-Lys-Pro-Arg-Pro-Val Met(0)-Thr-Lys-Pro-Arg-Lys-Val Met(0)-Thr-Lys-Pro-Arg-Lys-Val Met(0)-Thr-Lys-Pro-Arg-Lys-Val Thr-Thr-Lys-Pro-Val Thr-Thr-Lys-Pro-Val Thr-Thr-Lys-Pro-Val Thr-Thr-Lys-Pro-Arg-Val Thr-Thr-Lys-Pro-Arg-Val Thr-Thr-Lys-Pro-Arg-Val Thr-Thr-Lys-Pro-Phe-Val Thr-Thr-Lys-Pro-Phe-Val Thr-Thr-Lys-Pro-Phe-Val Thr-Thr-Lys-Pro-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Val Thr-Thr-Lys-Pro-Gly-Val Thr-Thr-Lys-Pro-Gly-Val Thr-Thr-Lys-Pro-Gly-Val Thr-Thr-Lys-Pro-His-Val Thr-Thr-Lys-Pro-His-Val Thr-Thr-Lys-Pro-His-Val Thr-Thr-Lys-Pro-Lys-Val Thr-Thr-Lys-Pro-Lys-Val Thr-Thr-Lys-Pro-Lys-Val Thr-Thr-Lys-Pro-Gly-Val Thr-Thr-Lys-Pro-Gly-Val Thr-Thr-Lys-Pro-Gly-Val Thr-Thr-Lys-Pro-Gly-Arg-Val Thr-Thr-Lys-Pro-Gly-Arg-Val Thr-Thr-Lys-Pro-Gly-Arg-Val Thr-Thr-Lys-Pro-Gly-Phe-Val Thr-Thr-Lys-Pro-Gly-Phe-Val Thr-Thr-Lys-Pro-Gly-Phe-Val Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Gly-Tyr-Val Gly-Tyr-Val Pro-Gly-Tyr-Val Thr-Thr-Lys-Pro-Gly-His-Val Thr-fhr-Lys-Pro-Gly-His-Val Thr-Thr-Lys-Pro-Gly-His-Val Thr-Thr-Lys-Pro-Gly-Pro-Val Thr-Thr-Lys-Pro-Gly-Pro-Val Thr-Thr-Lys-Pro-Gly-Pro-Val Thr-Thr-Lys-Pro-Gly-Lys-Val Thr-Thr-Lys-Pro-Gly-Lys-Val Thr-Thr-Lys-Pro-Gly-Lys-Val Thr-Thr-Lys-Pro-Asp-Val Thr-Thr-Lys-Pro-Asp-Val Thr-Thr-Lys-Pro-Asp-Val Thr-Thr-Lys-Pro-Asp-Arg-Val Thr-Thr-Lys-Pro-Asp-Arg-Val Thr-Thr-Lys-Pro-Asp-Arg-Val Thr-Thr-Lys-Pro-Asp-Phe-Val Thr-Thr-Lys-Pro-Asp-Phe-Val Thr-Thr-Lys-Pro-Asp-Phe-Val Thr-Thr-Lys-Pro-Asp-Tyr-Val Thr-Thr-Lys-Pro-Asp-Tyr-Val Thr-Thr-Lys-Pro-Asp-Tyr-Val Thr-Thr-Lys-Pro-Asp-His-Val Thr-Thr-Lys-Pro-Asp-His-Val Thr-Thr-Lys-Pro-Asp-His-Val Thr-Thr-Lys-Pro-Asp-Pro-Val Thr-Thr-Lys-Pro-Asp-Pro-Val Thr-Thr-Lys-Pro-Asp-Pro-Val Thr-Thr-Lys-Pro-Asp-Lys-Val Thr-Thr-Lys-Pro-Asp-Lys-Val Thr-Thr-Lys-Pro-Asp-Lys-Val Thr-Thr-Lys-Pro-Trp-Val Thr-Thr-Lys-Pro-Trp-Val Thr-Thr-Lys-Pro-Trp-Val Thr-Thr-Lys-Pro-Trp-Arg-Val Thr-Thr-Lys-Pro-Trp-Arg-Val Thr-Thr-Lys-Pro-Trp-Arg-Val Thr-Thr-Lys-Pro-Trp-Phe-Val Thr-Thr-Lys-Pro-Trp-Phe-Val Thr-Thr-Lys-Pro-Trp-Phe-Val Thr-Thr-Lys-Pro-Trp-Tyr-Val Thr-Thr-Lys-Pro-Trp-Tyr-Val Thr-Thr-Lys-Pro-Trp-Tyr-Val

Thr-Thr-Lys-Pro-Trp-His-Val Thr-Thr-Lys-Pro-Trp-His-Val Thr-Thr-Lys-Pro-Trp-His-Val Thr-Thr-Lys-Pro-Trp-Pro-Val Thr-Thr-Lys-Pro-Trp-Pro-Val Thr-Thr-Lys-Pro-Trp-Pro-Val Thr-Thr-Lys-Pro-Trp-Lys-Val Thr-Thr-Lys-Pro-Trp-Lys-Val Thr-Thr-Lys-Pro-Trp-Lys-Val Thr-Thr-Lys-Pro-Gln-Val Thr-Thr-Lys-Pro-Gln-Val Thr-Thr-Lys-Pro-Gln-Val Thr-Thr-Lys-Pro-Gln-Arg-Val Thr-Thr-Lys-Pro-Gln-Arg-Val Thr-Thr-Lys-Pro-Gln-Arg-Val Thr-Thr-Lys-Pro-Gln-Phe-Val Thr-Thr-Lys-Pro-Gln-Phe-Val Thr-Thr-Lys-Pro-Gln-Phe-Val Thr-Thr-Lys-Pro-Gln-Tyr-Val Thr-Thr-Lys-Pro-Gln-Tyr-Val Thr-Thr-Lys-Pro-Gln-Tyr-Val Thr-Thr-Lys-Pro-Gln-His-Val Thr-Thr-Lys-Pro-Gln-His-Val Thr-Thr-Lys-Pro-Gln-His-Val Thr-Thr-Lys-Pro-Gln-Pro-Val Thr-Thr-Lys-Pro-Gln-Pro-Val Thr-Thr-Lys-Pro-Gln-Pro-Val Thr-Thr-Lys-Pro-Gln-Lys-Val Thr-Thr-Lys-Pro-Gln-Lys-Val Thr-Thr-Lys-Pro-Gln-Lys-Val Thr-Thr-Lys-Pro-Asn-Val Thr-Thr-Lys-Pro-Asn-Val Thr-Thr-Lys-Pro-Asn-Val Thr-Thr-Lys-Pro-Asn-Arg-Val Thr-Thr-Lys-Pro-Asn-Arg-Val Thr-Thr-Lys-Pro-Asn-Arg-Val Thr-Thr-Lys-Pro-Asn-Phe-Val Thr-Thr-Lys-Pro-Asn-Phe-Val Thr-Thr-Lys-Pro-Asn-Phe-Val Thr-Thr-Lys-Pro-Asn-Tyr-Val Thr-Thr-Lys-Pro-Asn-Tyr-Val Thr-Thr-Lys-Pro-Asn-Tyr-Val Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Asn-His-Val Asn-His-Val Pro-Asn-His-Val Thr-Thr-Lys-Pro-Asn-Pro-Val Thr-Thr-Lys-Pro-Asn-Pro-Val Thr-Thr-Lys-Pro-Asn-Pro-Val Thr-Thr-Lys-Pro-Asn-Lys-Val Thr-Thr-Lys-Pro-Asn-Lys-Val Thr-Thr-Lys-Pro-Asn-Lys-Val Thr-Thr-Lys-Pro-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Arg-Val Thr-Thr-Lys-Pro-Tyr-Arg-Val Thr-Thr-Lys-Pro-Tyr-Arg-Val Thr-Thr-Lys-Pro-Tyr-Phe-Val Thr-Thr-Lys-Pro-Tyr-Phe-Val Thr-Thr-Lys-Pro-Tyr-Phe-Val Thr-Thr-Lys-Pro-Tyr-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Tyr-Val Thr-Thr-Lys-Pro-Tyr-Tyr-Val Thr-Thr-Lys-Pro-Tyr-His-Val Thr-Thr-Lys-Pro-Tyr-His-Val Thr-Thr-Lys-Pro-Tyr-His-Val Thr-Thr-Lys-Pro-Tyr-Pro-Val Thr-Thr-Lys-Pro-Tyr-Pro-Val Thr-Thr-Lys-Pro-Tyr-Pro-Val Thr-Thr-Lys-Pro-Tyr-Lys-Val Thr-Thr-Lys-Pro-Tyr-Lys-Val Thr-Thr-Lys-Pro-Tyr-Lys-Val Thr-Thr-Lys-Pro-Arg-Val Thr-Thr-Lys-Pro-Arg-Val Thr-Thr-Lys-Pro-Arg-Val Thr-Thr-Lys-Pro-Arg-Arg-Val Thr-Thr-Lys-Pro-Arg-Arg-Val Thr-Thr-Lys-Pro-Arg-Arg-Val Thr-Thr-Lys-Pro-Arg-Phe-Val Thr-Thr-Lys-Pro-Arg-Phe-Val Thr-Thr-Lys-Pro-Arg-Phe-Val Thr-Thr-Lys-Pro-Arg-Tyr-Val Thr-Thr-Lys-Pro-Arg-Tyr-Val Thr-Thr-Lys-Pro-Arg-Tyr-Val Thr-Thr-Lys-Pro-Arg-His-Val Thr-Thr-Lys-Pro-Arg-His-Val Thr-Thr-Lys-Pro-Arg-His-Val

Thr-Thr-Lys-Pro-Arg-Pro-Val Thr-Thr-Lys-Pro-Arg-Pro-Val Thr-Thr-Lys-Pro-Arg-Pro-Val Thr-Thr-Lys-Pro-Arg-Lys-Val Thr-Thr-Lys-Pro-Arg-Lys-Val Thr-Thr-Lys-Pro-Arg-Lys-Val Ala-Thr-Lys-Pro-Val Ala-Thr-Lys-Pro-Val Ala-Thr-Lys-Pro-Val Ala-Thr-Lys-Pro-Arg-Val Ala-Thr-Lys-Pro-Arg-Val Ala-Thr-Lys-Pro-Arg-Val Ala-Thr-Lys-Pro-Phe-Val Ala-Thr-Lys-Pro-Phe-Val Ala-Thr-Lys-Pro-Phe-Val Ala-Thr-Lys-Pro-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Val Ala-Thr-Lys-Pro-Gly-Val Ala-Thr-Lys-Pro-Gly-Val Ala-Thr-Lys-Pro-Gly-Val Ala-Thr-Lys-Pro-His-Val Ala-Thr-Lys-Pro-His-Val Ala-Thr-Lys-Pro-His-Val Ala-Thr-Lys-Pro-Lys-Val Ala-Thr-Lys-Pro-Lys-Val Ala-Thr-Lys-Pro-Lys-Val Ala-Thr-Lys-Pro-Gly-Val Ala-Thr-Lys-Pro-Gly-Val Ala-Thr-Lys-Pro-Gly-Val Ala-Thr-Lys-Pro-Gly-Arg-Val Ala-Thr-Lys-Pro-Gly-Arg-Val Ala-Thr-Lys-Pro-Gly-Arg-Val Ala-Thr-Lys-Pro-Gly-Phe-Val Ala-Thr-Lys-Pro-Gly-Phe-Val Ala-Thr-Lys-Pro-Gly-Phe-Val Ala-Thr-Lys-Pro-Gly-Tyr-Val Ala-Thr-Lys-Pro-Gly-Tyr-Val Ala-Thr-Lys-Pro-Gly-Tyr-Val Ala-Thr-Lys-Pro-Gly-His-Val Ala-Thr-Lys-Pro-Gly-His-Val Ala-Thr-Lys-Pro-Gly-His-Val Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Gly-Pro-Val Gly-Pro-Val Pro-Gly-Pro-Val Ala-Thr-Lys-Pro-Gly-Lys-Val Ala-Thr-Lys-Pro-Gly-Lys-Val Ala-Thr-Lys-Pro-Gly-Lys-Val Ala-Thr-Lys-Pro-Asp-Val Ala-Thr-Lys-Pro-Asp-Val Ala-Thr-Lys-Pro-Asp-Val Ala-Thr-Lys-Pro-Asp-Arg-Val Ala-Thr-Lys-Pro-Asp-Arg-Val Ala-Thr-Lys-Pro-Asp-Arg-Val Ala-Thr-Lys-Pro-Asp-Phe-Val Ala-Thr-Lys-Pro-Asp-Phe-Val Ala-Thr-Lys-Pro-Asp-Phe-Val Ala-Thr-Lys-Pro-Asp-Tyr-Val Ala-Thr-Lys-Pro-Asp-Tyr-Val Ala-Thr-Lys-Pro-Asp-Tyr-Val Ala-Thr-Lys-Pro-Asp-His-Val Ala-Thr-Lys-Pro-Asp-His-Val Ala-Thr-Lys-Pro-Asp-His-Val Ala-Thr-Lys-Pro-Asp-Pro-Val Ala-Thr-Lys-Pro-Asp-Pro-Val Ala-Thr-Lys-Pro-Asp-Pro-Val Ala-Thr-Lys-Pro-Asp-Lys-Val Ala-Thr-Lys-Pro-Asp-Lys-Val Ala-Thr-Lys-Pro-Asp-Lys-Val Ala-Thr-Lys-Pro-Trp-Val Ala-Thr-Lys-Pro-Trp-Val Ala-Thr-Lys-Pro-Trp-Val Ala-Thr-Lys-Pro-Trp-Arg-Val Ala-Thr-Lys-Pro-Trp-Arg-Val Ala-Thr-Lys-Pro-Trp-Arg-Val Ala-Thr-Lys-Pro-Trp-Phe-Val Ala-Thr-Lys-Pro-Trp-Phe-Val Ala-Thr-Lys-Pro-Trp-Phe-Val Ala-Thr-Lys-Pro-Trp-Tyr-Val Ala-Thr-Lys-Pro-Trp-Tyr-Val Ala-Thr-Lys-Pro-Trp-Tyr-Val Ala-Thr-Lys-Pro-Trp-His-Val Ala-Thr-Lys-Pro-Trp-His-Val Ala-Thr-Lys-Pro-Trp-His-Val Ala-Thr-Lys-Pro-Trp-Pro-Val Ala-Thr-Lys-Pro-Trp-Pro-Val Ala-Thr-Lys-Pro-Trp-Pro-Val

Ala-Thr-Lys-Pro-Trp-Lys-Val Ala-Thr-Lys-Pro-Trp-Lys-Val Ala-Thr-Lys-Pro-Trp-Lys-Val Ala-Thr-Lys-Pro-Gln-Val Ala-Thr-Lys-Pro-Gln-Val Ala-Thr-Lys-Pro-Gln-Val Ala-Thr-Lys-Pro-Gln-Arg-Val Ala-Thr-Lys-Pro-Gln-Arg-Val Ala-Thr-Lys-Pro-Gln-Arg-Val Ala-Thr-Lys-Pro-Gln-Phe-Val Ala-Thr-Lys-Pro-Gln-Phe-Val Ala-Thr-Lys-Pro-Gln-Phe-Val Ala-Thr-Lys-Pro-Gln-Tyr-Val Ala-Thr-Lys-Pro-Gln-Tyr-Val Ala-Thr-Lys-Pro-Gln-Tyr-Val Ala-Thr-Lys-Pro-Gln-His-Val Ala-Thr-Lys-Pro-Gln-His-Val Ala-Thr-Lys-Pro-Gln-His-Val Ala-Thr-Lys-Pro-Gln-Pro-Val Ala-Thr-Lys-Pro-Gln-Pro-Val Ala-Thr-Lys-Pro-Gln-Pro-Val Ala-Thr-Lys-Pro-Gln-Lys-Val Ala-Thr-Lys-Pro-Gln-Lys-Val Ala-Thr-Lys-Pro-Gln-Lys-Val Ala-Thr-Lys-Pro-Asn-Val Ala-Thr-Lys-Pro-Asn-Val Ala-Thr-Lys-Pro-Asn-Val Ala-Thr-Lys-Pro-Asn-Arg-Val Ala-Thr-Lys-Pro-Asn-Arg-Val Ala-Thr-Lys-Pro-Asn-Arg-Val Ala-Thr-Lys-Pro-Asn-Phe-Val Ala-Thr-Lys-Pro-Asn-Phe-Val Ala-Thr-Lys-Pro-Asn-Phe-Val Ala-Thr-Lys-Pro-Asn-Tyr-Val Ala-Thr-Lys-Pro-Asn-Tyr-Val Ala-Thr-Lys-Pro-Asn-Tyr-Val Ala-Thr-Lys-Pro-Asn-His-Val Ala-Thr-Lys-Pro-Asn-His-Val Ala-Thr-Lys-Pro-Asn-His-Val Ala-Thr-Lys-Pro-Asn-Pro-Val Ala-Thr-Lys-Pro-Asn-Pro-Val Ala-Thr-Lys-Pro-Asn-Pro-Val Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Asn-Lys-Val Asn-Lys-Val Pro-Asn-Lys-Val Ala-Thr-Lys-Pro-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Arg-Val Ala-Thr-Lys-Pro-Tyr-Arg-Val Ala-Thr-Lys-Pro-Tyr-Arg-Val Ala-Thr-Lys-Pro-Tyr-Phe-Val Ala-Thr-Lys-Pro-Tyr-Phe-Val Ala-Thr-Lys-Pro-Tyr-Phe-Val Ala-Thr-Lys-Pro-Tyr-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Tyr-Val Ala-Thr-Lys-Pro-Tyr-Tyr-Val Ala-Thr-Lys-Pro-Tyr-His-Val Ala-Thr-Lys-Pro-Tyr-His-Val Ala-Thr-Lys-Pro-Tyr-His-Val Ala-Thr-Lys-Pro-Tyr-Pro-Val Ala-Thr-Lys-Pro-Tyr-Pro-Val Ala-Thr-Lys-Pro-Tyr-Pro-Val Ala-Thr-Lys-Pro-Tyr-Lys-Val Ala-Thr-Lys-Pro-Tyr-Lys-Val Ala-Thr-Lys-Pro-Tyr-Lys-Val Ala-Thr-Lys-Pro-Arg-Val Ala-Thr-Lys-Pro-Arg-Val Ala-Thr-Lys-Pro-Arg-Val Ala-Thr-Lys-Pro-Arg-Arg-Val Ala-Thr-Lys-Pro-Arg-Arg-Val Ala-Thr-Lys-Pro-Arg-Arg-Val Ala-Thr-Lys-Pro-Arg-Phe-Val Ala-Thr-Lys-Pro-Arg-Phe-Val Ala-Thr-Lys-Pro-Arg-Phe-Val Ala-Thr-Lys-Pro-Arg-Tyr-Val Ala-Thr-Lys-Pro-Arg-Tyr-Val Ala-Thr-Lys-Pro-Arg-Tyr-Val Ala-Thr-Lys-Pro-Arg-His-Val Ala-Thr-Lys-Pro-Arg-His-Val Ala-Thr-Lys-Pro-Arg-His-Val Ala-Thr-Lys-Pro-Arg-Pro-Val Ala-Thr-Lys-Pro-Arg-Pro-Val Ala-Thr-Lys-Pro-Arg-Pro-Val Ala-Thr-Lys-Pro-Arg-Lys-Val Ala-Thr-Lys-Pro-Arg-Lys-Val Ala-Thr-Lys-Pro-Arg-Lys-Val

His-Thr-Lys-Pro-Val His-Thr-Lys-Pro-Val His-Thr-Lys-Pro-Val His-Thr-Lys-Pro-Arg-Val His-Thr-Lys-Pro-Arg-Val His-Thr-Lys-Pro-Arg-Val His-Thr-Lys-Pro-Phe-Val His-Thr-Lys-Pro-Phe-Val His-Thr-Lys-Pro-Phe-Val His-Thr-Lys-Pro-Tyr-Val His-Thr-Lys-Pro-Tyr-Val His-Thr-Lys-Pro-Tyr-Val His-Thr-Lys-Pro-Gly-Val His-Thr-Lys-Pro-Gly-Val His-Thr-Lys-Pro-Gly-Val His-Thr-Lys-Pro-His-Val His-Thr-Lys-Pro-His-Val His-Thr-Lys-Pro-His-Val His-Thr-Lys-Pro-Lys-Val His-Thr-Lys-Pro-Lys-Val His-Thr-Lys-Pro-Lys-Val His-Thr-Lys-Pro-Gly-Val His-Thr-Lys-Pro-Gly-Val His-Thr-Lys-Pro-Gly-Val His-Thr-Lys-Pro-Gly-Arg-Val His-Thr-Lys-Pro-Gly-Arg-Val His-Thr-Lys-Pro-Gly-Arg-Val His-Thr-Lys-Pro-Gly-Phe-Val His-Thr-Lys-Pro-Gly-Phe-Val His-Thr-Lys-Pro-Gly-Phe-Val His-Thr-Lys-Pro-Gly-Tyr-Val His-Thr-Lys-Pro-Gly-Tyr-Val His-Thr-Lys-Pro-Gly-Tyr-Val His-Thr-Lys-Pro-Gly-His-Val His-Thr-Lys-Pro-Gly-His-Val His-Thr-Lys-Pro-Gly-His-Val His-Thr-Lys-Pro-Gly-Pro-Val His-Thr-Lys-Pro-Gly-Pro-Val His-Thr-Lys-Pro-Gly-Pro-Val His-Thr-Lys-Pro-Gly-Lys-Val His-Thr-Lys-Pro-Gly-Lys-Val His-Thr-Lys-Pro-Gly-Lys-Val His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Asp-Val Asp-Val Pro-Asp-Val His-Thr-Lys-Pro-Asp-Arg-Val His-Thr-Lys-Pro-Asp-Arg-Val His-Thr-Lys-Pro-Asp-Arg-Val His-Thr-Lys-Pro-Asp-Phe-Val His-Thr-Lys-Pro-Asp-Phe-Val His-Thr-Lys-Pro-Asp-Phe-Val His-Thr-Lys-Pro-Asp-Tyr-Val His-Thr-Lys-Pro-Asp-Tyr-Val His-Thr-Lys-Pro-Asp-Tyr-Val His-Thr-Lys-Pro-Asp-His-Val His-Thr-Lys-Pro-Asp-His-Val His-Thr-Lys-Pro-Asp-His-Val His-Thr-Lys-Pro-Asp-Pro-Val His-Thr-Lys-Pro-Asp-Pro-Val His-Thr-Lys-Pro-Asp-Pro-Val His-Thr-Lys-Pro-Asp-Lys-Val His-Thr-Lys-Pro-Asp-Lys-Val His-Thr-Lys-Pro-Asp-Lys-Val His-Thr-Lys-Pro-Trp-Val His-Thr-Lys-Pro-Trp-Val His-Thr-Lys-Pro-Trp-Val His-Thr-Lys-Pro-Trp-Arg-Val His-Thr-Lys-Pro-Trp-Arg-Val His-Thr-Lys-Pro-Trp-Arg-Val His-Thr-Lys-Pro-Trp-Phe-Val His-Thr-Lys-Pro-Trp-Phe-Val His-Thr-Lys-Pro-Trp-Phe-Val His-Thr-Lys-Pro-Trp-Tyr-Val His-Thr-Lys-Pro-Trp-Tyr-Val His-Thr-Lys-Pro-Trp-Tyr-Val His-Thr-Lys-Pro-Trp-His-Val His-Thr-Lys-Pro-Trp-His-Val His-Thr-Lys-Pro-Trp-His-Val His-Thr-Lys-Pro-Trp-Pro-Val His-Thr-Lys-Pro-Trp-Pro-Val His-Thr-Lys-Pro-Trp-Pro-Val His-Thr-Lys-Pro-Trp-Lys-Val His-Thr-Lys-Pro-Trp-Lys-Val His-Thr-Lys-Pro-Trp-Lys-Val His-Thr-Lys-Pro-Gln-Val His-Thr-Lys-Pro-Gln-Val His-Thr-Lys-Pro-Gln-Val

His-Thr-Lys-Pro-Gln-Arg-Val His-Thr-Lys-Pro-Gln-Arg-Val His-Thr-Lys-Pro-Gln-Arg-Val His-Thr-Lys-Pro-Gln-Phe-Val His-Thr-Lys-Pro-Gln-Phe-Val His-Thr-Lys-Pro-Gln-Phe-Val His-Thr-Lys-Pro-Gln-Tyr-Val His-Thr-Lys-Pro-Gln-Tyr-Val His-Thr-Lys-Pro-Gln-Tyr-Val His-Thr-Lys-Pro-Gln-His-Val His-Thr-Lys-Pro-Gln-His-Val His-Thr-Lys-Pro-Gln-His-Val His-Thr-Lys-Pro-Gln-Pro-Val His-Thr-Lys-Pro-Gln-Pro-Val His-Thr-Lys-Pro-Gln-Pro-Val His-Thr-Lys-Pro-Gln-Lys-Val His-Thr-Lys-Pro-Gln-Lys-Val His-Thr-Lys-Pro-Gln-Lys-Val His-Thr-Lys-Pro-Asn-Val His-Thr-Lys-Pro-Asn-Val His-Thr-Lys-Pro-Asn-Val His-Thr-Lys-Pro-Asn-Arg-Val His-Thr-Lys-Pro-Asn-Arg-Val His-Thr-Lys-Pro-Asn-Arg-Val His-Thr-Lys-Pro-Asn-Phe-Val His-Thr-Lys-Pro-Asn-Phe-Val His-Thr-Lys-Pro-Asn-Phe-Val His-Thr-Lys-Pro-Asn-Tyr-Val His-Thr-Lys-Pro-Asn-Tyr-Val His-Thr-Lys-Pro-Asn-Tyr-Val His-Thr-Lys-Pro-Asn-His-Val His-Thr-Lys-Pro-Asn-His-Val His-Thr-Lys-Pro-Asn-His-Val His-Thr-Lys-Pro-Asn-Pro-Val His-Thr-Lys-Pro-Asn-Pro-Val His-Thr-Lys-Pro-Asn-Pro-Val His-Thr-Lys-Pro-Asn-Lys-Val His-Thr-Lys-Pro-Asn-Lys-Val His-Thr-Lys-Pro-Asn-Lys-Val His-Thr-Lys-Pro-Tyr-Val His-Thr-Lys-Pro-Tyr-Val His-Thr-Lys-Pro-Tyr-Val His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Tyr-Arg-Val Tyr-Arg-Val Pro-Tyr-Arg-Val His-Thr-Lys-Pro-Tyr-Phe-Val His-Thr-Lys-Pro-Tyr-Phe-Val His-Thr-Lys-Pro-Tyr-Phe-Val His-Thr-Lys-Pro-Tyr-Tyr-Val His-Thr-Lys-Pro-Tyr-Tyr-Val His-Thr-Lys-Pro-Tyr-Tyr-Val His-Thr-Lys-Pro-Tyr-His-Val His-Thr-Lys-Pro-Tyr-His-Val His-Thr-Lys-Pro-Tyr-His-Val His-Thr-Lys-Pro-Tyr-Pro-Val His-Thr-Lys-Pro-Tyr-Pro-Val His-Thr-Lys-Pro-Tyr-Pro-Val His-Thr-Lys-Pro-Tyr-Lys-Val His-Thr-Lys-Pro-Tyr-Lys-Val His-Thr-Lys-Pro-Tyr-Lys-Val His-Thr-Lys-Pro-Arg-Val His-Thr-Lys-Pro-Arg-Val His-Thr-Lys-Pro-Arg-Val His-Thr-Lys-Pro-Arg-Arg-Val His-Thr-Lys-Pro-Arg-Arg-Val His-Thr-Lys-Pro-Arg-Arg-Val His-Thr-Lys-Pro-Arg-Phe-Val His-Thr-Lys-Pro-Arg-Phe-Val His-Thr-Lys-Pro-Arg-Phe-Val His-Thr-Lys-Pro-Arg-Tyr-Val His-Thr-Lys-Pro-Arg-Tyr-Val His-Thr-Lys-Pro-Arg-Tyr-Val His-Thr-Lys-Pro-Arg-His-Val His-Thr-Lys-Pro-Arg-His-Val His-Thr-Lys-Pro-Arg-His-Val His-Thr-Lys-Pro-Arg-Pro-Val His-Thr-Lys-Pro-Arg-Pro-Val His-Thr-Lys-Pro-Arg-Pro-Val His-Thr-Lys-Pro-Arg-Lys-Val His-Thr-Lys-Pro-Arg-Lys-Val His-Thr-Lys-Pro-Arg-Lys-Val Lys-Thr-Lys-Pro-Val Lys-Thr-Lys-Pro-Val Lys-Thr-Lys-Pro-Val Lys-Thr-Lys-Pro-Arg-Val Lys-Thr-Lys-Pro-Arg-Val Lys-Thr-Lys-Pro-Arg-Val

Lys-Thr-Lys-Pro-Phe-Val Lys-Thr-Lys-Pro-Phe-Val Lys-Thr-Lys-Pro-Phe-Val Lys-Thr-Lys-Pro-Tyr-Val Lys-Thr-Lys-Pro-Tyr-Val Lys-Thr-Lys-Pro-Tyr-Val Lys-Thr-Lys-Pro-Gly-Val Lys-Thr-Lys-Pro-Gly-Val Lys-Thr-Lys-Pro-Gly-Val Lys-Thr-Lys-Pro-His-Val Lys-Thr-Lys-Pro-His-Val Lys-Thr-Lys-Pro-His-Val Lys-Thr-Lys-Pro-Lys-Val Lys-Thr-Lys-Pro-Lys-Val Lys-Thr-Lys-Pro-Lys-Val Lys-Thr-Lys-Pro-Gly-Val Lys-Thr-Lys-Pro-Gly-Val Lys-Thr-Lys-Pro-Gly-Val Lys-Thr-Lys-Pro-Gly-Arg-Val Lys-Thr-Lys-Pro-Gly-Arg-Val Lys-Thr-Lys-Pro-Gly-Arg-Val Lys-Thr-Lys-Pro-Gly-Phe-Val Lys-Thr-Lys-Pro-Gly-Phe-Val Lys-Thr-Lys-Pro-Gly-Phe-Val Lys-Thr-Lys-Pro-Gly-Tyr-Val Lys-Thr-Lys-Pro-Gly-Tyr-Val Lys-Thr-Lys-Pro-Gly-Tyr-Val Lys-Thr-Lys-Pro-Gly-His-Val Lys-Thr-Lys-Pro-Gly-His-Val Lys-Thr-Lys-Pro-Gly-His-Val Lys-Thr-Lys-Pro-Gly-Pro-Val Lys-Thr-Lys-Pro-Gly-Pro-Val Lys-Thr-Lys-Pro-Gly-Pro-Val Lys-Thr-Lys-Pro-Gly-Lys-Val Lys-Thr-Lys-Pro-Gly-Lys-Val Lys-Thr-Lys-Pro-Gly-Lys-Val Lys-Thr-Lys-Pro-Asp-Val Lys-Thr-Lys-Pro-Asp-Val Lys-Thr-Lys-Pro-Asp-Val Lys-Thr-Lys-Pro-Asp-Arg-Val Lys-Thr-Lys-Pro-Asp-Arg-Val Lys-Thr-Lys-Pro-Asp-Arg-Val Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Asp-Phe-Val Pro-Asp-Phe-Val Pro-Asp-Phe-Val Lys-Thr-Lys-Pro-Asp-Tyr-Val Lys-Thr-Lys-Pro-Asp-Tyr-Val Lys-Thr-Lys-Pro-Asp-Tyr-Val Lys-Thr-Lys-Pro-Asp-His-Val Lys-Thr-Lys-Pro-Asp-His-Val Lys-Thr-Lys-Pro-Asp-His-Val Lys-Thr-Lys-Pro-Asp-Pro-Val Lys-Thr-Lys-Pro-Asp-Pro-Val Lys-Thr-Lys-Pro-Asp-Pro-Val Lys-Thr-Lys-Pro-Asp-Lys-Val Lys-Thr-Lys-Pro-Asp-Lys-Val Lys-Thr-Lys-Pro-Asp-Lys-Val Lys-Thr-Lys-Pro-Trp-Val Lys-Thr-Lys-Pro-Trp-Val Lys-Thr-Lys-Pro-Trp-Val Lys-Thr-Lys-Pro-Trp-Arg-Val Lys-Thr-Lys-Pro-Trp-Arg-Val Lys-Thr-Lys-Pro-Trp-Arg-Val Lys-Thr-Lys-Pro-Trp-Phe-Val Lys-Thr-Lys-Pro-Trp-Phe-Val Lys-Thr-Lys-Pro-Trp-Phe-Val Lys-Thr-Lys-Pro-Trp-Tyr-Val Lys-Thr-Lys-Pro-Trp-Tyr-Val Lys-Thr-Lys-Pro-Trp-Tyr-Val Lys-Thr-Lys-Pro-Trp-His-Val Lys-Thr-Lys-Pro-Trp-His-Val Lys-Thr-Lys-Pro-Trp-His-Val Lys-Thr-Lys-Pro-Trp-Pro-Val Lys-Thr-Lys-Pro-Trp-Pro-Val Lys-Thr-Lys-Pro-Trp-Pro-Val Lys-Thr-Lys-Pro-Trp-Lys-Val Lys-Thr-Lys-Pro-Trp-Lys-Val Lys-Thr-Lys-Pro-Trp-Lys-Val Lys-Thr-Lys-Pro-Gln-Val Lys-Thr-Lys-Pro-Gln-Val Lys-Thr-Lys-Pro-Gln-Val Lys-Thr-Lys-Pro-Gln-Arg-Val Lys-Thr-Lys-Pro-Gln-Arg-Val Lys-Thr-Lys-Pro-Gln-Arg-Val Lys-Thr-Lys-Pro-Gln-Phe-Val Lys-Thr-Lys-Pro-Gln-Phe-Val Lys-Thr-Lys-Pro-Gln-Phe-Val

Lys-Thr-Lys-Pro-Gln-Tyr-Val Lys-Thr-Lys-Pro-Gln-Tyr-Val Lys-Thr-Lys-Pro-Gln-Tyr-Val Lys-Thr-Lys-Pro-Gln-His-Val Lys-Thr-Lys-Pro-Gln-His-Val Lys-Thr-Lys-Pro-Gln-His-Val Lys-Thr-Lys-Pro-Gln-Pro-Val Lys-Thr-Lys-Pro-Gln-Pro-Val Lys-Thr-Lys-Pro-Gln-Pro-Val Lys-Thr-Lys-Pro-Gln-Lys-Val Lys-Thr-Lys-Pro-Gln-Lys-Val Lys-Thr-Lys-Pro-Gln-Lys-Val Lys-Thr-Lys-Pro-Asn-Val Lys-Thr-Lys-Pro-Asn-Val Lys-Thr-Lys-Pro-Asn-Val Lys-Thr-Lys-Pro-Asn-Arg-Val Lys-Thr-Lys-Pro-Asn-Arg-Val Lys-Thr-Lys-Pro-Asn-Arg-Val Lys-Thr-Lys-Pro-Asn-Phe-Val Lys-Thr-Lys-Pro-Asn-Phe-Val Lys-Thr-Lys-Pro-Asn-Phe-Val Lys-Thr-Lys-Pro-Asn-Tyr-Val Lys-Thr-Lys-Pro-Asn-Tyr-Val Lys-Thr-Lys-Pro-Asn-Tyr-Val Lys-Thr-Lys-Pro-Asn-His-Val Lys-Thr-Lys-Pro-Asn-His-Val Lys-Thr-Lys-Pro-Asn-His-Val Lys-Thr-Lys-Pro-Asn-Pro-Val Lys-Thr-Lys-Pro-Asn-Pro-Val Lys-Thr-Lys-Pro-Asn-Pro-Val Lys-Thr-Lys-Pro-Asn-Lys-Val Lys-Thr-Lys-Pro-Asn-Lys-Val Lys-Thr-Lys-Pro-Asn-Lys-Val Lys-Thr-Lys-Pro-Tyr-Val Lys-Thr-Lys-Pro-Tyr-Val Lys-Thr-Lys-Pro-Tyr-Val Lys-Thr-Lys-Pro-Tyr-Arg-Val Lys-Thr-Lys-Pro-Tyr-Arg-Val Lys-Thr-Lys-Pro-Tyr-Arg-Val Lys-Thr-Lys-Pro-Tyr-Phe-Val Lys-Thr-Lys-Pro-Tyr-Phe-Val Lys-Thr-Lys-Pro-Tyr-Phe-Val Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Tyr-Tyr-Val Pro-Tyr-Tyr-Val Pro-Tyr-Tyr-Val Lys-Thr-Lys-Pro-Tyr-His-Val Lys-Thr-Lys-Pro-Tyr-His-Val Lys-Thr-Lys-Pro-Tyr-His-Val Lys-Thr-Lys-Pro-Tyr-Pro-Val Lys-Thr-Lys-Pro-Tyr-Pro-Val Lys-Thr-Lys-Pro-Tyr-Pro-Val Lys-Thr-Lys-Pro-Tyr-Lys-Val Lys-Thr-Lys-Pro-Tyr-Lys-Val Lys-Thr-Lys-Pro-Tyr-Lys-Val Lys-Thr-Lys-Pro-Arg-Val Lys-Thr-Lys-Pro-Arg-Val Lys-Thr-Lys-Pro-Arg-Val Lys-Thr-Lys-Pro-Arg-Arg-Val Lys-Thr-Lys-Pro-Arg-Arg-Val Lys-Thr-Lys-Pro-Arg-Arg-Val Lys-Thr-Lys-Pro-Arg-Phe-Val Lys-Thr-Lys-Pro-Arg-Phe-Val Lys-Thr-Lys-Pro-Arg-Phe-Val Lys-Thr-Lys-Pro-Arg-Tyr-Val Lys-Thr-Lys-Pro-Arg-Tyr-Val Lys-Thr-Lys-Pro-Arg-Tyr-Val Lys-Thr-Lys-Pro-Arg-His-Val Lys-Thr-Lys-Pro-Arg-His-Val Lys-Thr-Lys-Pro-Arg-His-Val Lys-Thr-Lys-Pro-Arg-Pro-Val Lys-Thr-Lys-Pro-Arg-Pro-Val Lys-Thr-Lys-Pro-Arg-Pro-Val Lys-Thr-Lys-Pro-Arg-Lys-Val Lys-Thr-Lys-Pro-Arg-Lys-Val Lys-Thr-Lys-Pro-Arg-Lys-Val Gly-Thr-Lys-Pro-Val Gly-Thr-Lys-Pro-Val Gly-Thr-Lys-Pro-Val Gly-Thr-Lys-Pro-Arg-Val Gly-Thr-Lys-Pro-Arg-Val Gly-Thr-Lys-Pro-Arg-Val Gly-Thr-Lys-Pro-Phe-Val Gly-Thr-Lys-Pro-Phe-Val Gly-Thr-Lys-Pro-Phe-Val Gly-Thr-Lys-Pro-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Val

Gly-Thr-Lys-Pro-Gly-Val Gly-Thr-Lys-Pro-Gly-Val Gly-Thr-Lys-Pro-Gly-Val Gly-Thr-Lys-Pro-His-Val Gly-Thr-Lys-Pro-His-Val Gly-Thr-Lys-Pro-His-Val Gly-Thr-Lys-Pro-Lys-Val Gly-Thr-Lys-Pro-Lys-Val Gly-Thr-Lys-Pro-Lys-Val Gly-Thr-Lys-Pro-Gly-Val Gly-Thr-Lys-Pro-Gly-Val Gly-Thr-Lys-Pro-Gly-Val Gly-Thr-Lys-Pro-Gly-Arg-Val Gly-Thr-Lys-Pro-Gly-Arg-Val Gly-Thr-Lys-Pro-Gly-Arg-Val Gly-Thr-Lys-Pro-Gly-Phe-Val Gly-Thr-Lys-Pro-Gly-Phe-Val Gly-Thr-Lys-Pro-Gly-Phe-Val Gly-Thr-Lys-Pro-Gly-Tyr-Val Gly-Thr-Lys-Pro-Gly-Tyr-Val Gly-Thr-Lys-Pro-Gly-Tyr-Val Gly-Thr-Lys-Pro-Gly-His-Val Gly-Thr-Lys-Pro-Gly-His-Val Gly-Thr-Lys-Pro-Gly-His-Val Gly-Thr-Lys-Pro-Gly-Pro-Val Gly-Thr-Lys-Pro-Gly-Pro-Val Gly-Thr-Lys-Pro-Gly-Pro-Val Gly-Thr-Lys-Pro-Gly-Lys-Val Gly-Thr-Lys-Pro-Gly-Lys-Val Gly-Thr-Lys-Pro-Gly-Lys-Val Gly-Thr-Lys-Pro-Asp-Val Gly-Thr-Lys-Pro-Asp-Val Gly-Thr-Lys-Pro-Asp-Val Gly-Thr-Lys-Pro-Asp-Arg-Val Gly-Thr-Lys-Pro-Asp-Arg-Val Gly-Thr-Lys-Pro-Asp-Arg-Val Gly-Thr-Lys-Pro-Asp-Phe-Val Gly-Thr-Lys-Pro-Asp-Phe-Val Gly-Thr-Lys-Pro-Asp-Phe-Val Gly-Thr-Lys-Pro-Asp-Tyr-Val Gly-Thr-Lys-Pro-Asp-Tyr-Val Gly-Thr-Lys-Pro-Asp-Tyr-Val Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Asp-His-Val Pro-Asp-His-Val Pro-Asp-His-Val Gly-Thr-Lys-Pro-Asp-Pro-Val Gly-Thr-Lys-Pro-Asp-Pro-Val Gly-Thr-Lys-Pro-Asp-Pro-Val Gly-Thr-Lys-Pro-Asp-Lys-Val Gly-Thr-Lys-Pro-Asp-Lys-Val Gly-Thr-Lys-Pro-Asp-Lys-Val Gly-Thr-Lys-Pro-Trp-Val Gly-Thr-Lys-Pro-Trp-Val Gly-Thr-Lys-Pro-Trp-Val Gly-Thr-Lys-Pro-Trp-Arg-Val Gly-Thr-Lys-Pro-Trp-Arg-Val Gly-Thr-Lys-Pro-Trp-Arg-Val Gly-Thr-Lys-Pro-Trp-Phe-Val Gly-Thr-Lys-Pro-Trp-Phe-Val Gly-Thr-Lys-Pro-Trp-Phe-Val Gly-Thr-Lys-Pro-Trp-Tyr-Val Gly-Thr-Lys-Pro-Trp-Tyr-Val Gly-Thr-Lys-Pro-Trp-Tyr-Val Gly-Thr-Lys-Pro-Trp-His-Val Gly-Thr-Lys-Pro-Trp-His-Val Gly-Thr-Lys-Pro-Trp-His-Val Gly-Thr-Lys-Pro-Trp-Pro-Val Gly-Thr-Lys-Pro-Trp-Pro-Val Gly-Thr-Lys-Pro-Trp-Pro-Val Gly-Thr-Lys-Pro-Trp-Lys-Val Gly-Thr-Lys-Pro-Trp-Lys-Val Gly-Thr-Lys-Pro-Trp-Lys-Val Gly-Thr-Lys-Pro-Gln-Val Gly-Thr-Lys-Pro-Gln-Val Gly-Thr-Lys-Pro-Gln-Val Gly-Thr-Lys-Pro-Gln-Arg-Val Gly-Thr-Lys-Pro-Gln-Arg-Val Gly-Thr-Lys-Pro-Gln-Arg-Val Gly-Thr-Lys-Pro-Gln-Phe-Val Gly-Thr-Lys-Pro-Gln-Phe-Val Gly-Thr-Lys-Pro-Gln-Phe-Val Gly-Thr-Lys-Pro-Gln-Tyr-Val Gly-Thr-Lys-Pro-Gln-Tyr-Val Gly-Thr-Lys-Pro-Gln-Tyr-Val Gly-Thr-Lys-Pro-Gln-His-Val Gly-Thr-Lys-Pro-Gln-His-Val Gly-Thr-Lys-Pro-Gln-His-Val

Gly-Thr-Lys-Pro-Gln-Pro-Val Gly-Thr-Lys-Pro-Gln-Pro-Val Gly-Thr-Lys-Pro-Gln-Pro-Val Gly-Thr-Lys-Pro-Gln-Lys-Val Gly-Thr-Lys-Pro-Gln-Lys-Val Gly-Thr-Lys-Pro-Gln-Lys-Val Gly-Thr-Lys-Pro-Asn-Val Gly-Thr-Lys-Pro-Asn-Val Gly-Thr-Lys-Pro-Asn-Val Gly-Thr-Lys-Pro-Asn-Arg-Val Gly-Thr-Lys-Pro-Asn-Arg-Val Gly-Thr-Lys-Pro-Asn-Arg-Val Gly-Thr-Lys-Pro-Asn-Phe-Val Gly-Thr-Lys-Pro-Asn-Phe-Val Gly-Thr-Lys-Pro-Asn-Phe-Val Gly-Thr-Lys-Pro-Asn-Tyr-Val Gly-Thr-Lys-Pro-Asn-Tyr-Val Gly-Thr-Lys-Pro-Asn-Tyr-Val Gly-Thr-Lys-Pro-Asn-His-Val Gly-Thr-Lys-Pro-Asn-His-Val Gly-Thr-Lys-Pro-Asn-His-Val Gly-Thr-Lys-Pro-Asn-Pro-Val Gly-Thr-Lys-Pro-Asn-Pro-Val Gly-Thr-Lys-Pro-Asn-Pro-Val Gly-Thr-Lys-Pro-Asn-Lys-Val Gly-Thr-Lys-Pro-Asn-Lys-Val Gly-Thr-Lys-Pro-Asn-Lys-Val Gly-Thr-Lys-Pro-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Arg-Val Gly-Thr-Lys-Pro-Tyr-Arg-Val Gly-Thr-Lys-Pro-Tyr-Arg-Val Gly-Thr-Lys-Pro-Tyr-Phe-Val Gly-Thr-Lys-Pro-Tyr-Phe-Val Gly-Thr-Lys-Pro-Tyr-Phe-Val Gly-Thr-Lys-Pro-Tyr-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Tyr-Val Gly-Thr-Lys-Pro-Tyr-Tyr-Val Gly-Thr-Lys-Pro-Tyr-His-Val Gly-Thr-Lys-Pro-Tyr-His-Val Gly-Thr-Lys-Pro-Tyr-His-Val Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Tyr-Pro-Val Pro-Tyr-Pro-Val Pro-Tyr-Pro-Val Gly-Thr-Lys-Pro-Tyr-Lys-Val Gly-Thr-Lys-Pro-Tyr-Lys-Val Gly-Thr-Lys-Pro-Tyr-Lys-Val Gly-Thr-Lys-Pro-Arg-Val Gly-Thr-Lys-Pro-Arg-Val Gly-Thr-Lys-Pro-Arg-Val Gly-Thr-Lys-Pro-Arg-Arg-Val Gly-Thr-Lys-Pro-Arg-Arg-Val Gly-Thr-Lys-Pro-Arg-Arg-Val Gly-Thr-Lys-Pro-Arg-Phe-Val Gly-Thr-Lys-Pro-Arg-Phe-Val Gly-Thr-Lys-Pro-Arg-Phe-Val Gly-Thr-Lys-Pro-Arg-Tyr-Val Gly-Thr-Lys-Pro-Arg-Tyr-Val Gly-Thr-Lys-Pro-Arg-Tyr-Val Gly-Thr-Lys-Pro-Arg-His-Val Gly-Thr-Lys-Pro-Arg-His-Val Gly-Thr-Lys-Pro-Arg-His-Val Gly-Thr-Lys-Pro-Arg-Pro-Val Gly-Thr-Lys-Pro-Arg-Pro-Val Gly-Thr-Lys-Pro-Arg-Pro-Val Gly-Thr-Lys-Pro-Arg-Lys-Val Gly-Thr-Lys-Pro-Arg-Lys-Val Gly-Thr-Lys-Pro-Arg-Lys-Val Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly Met-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Met(0)-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Thr-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly Ala-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly His-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly Lys-Thr-Lys-Pro-Gly

Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly Gly-Thr-Lys-Pro-Gly Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Phe-Tyr Thr-Lys-Pro-Phe-Tyr Thr-Lys-Pro-Phe-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-His-Tyr Thr-Lys-Pro-His-Tyr Thr-Lys-Pro-His-Tyr Thr-Lys-Pro-Lys-Tyr Thr-Lys-Pro-Lys-Tyr Thr-Lys-Pro-Lys-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Tyr Thr-Lys-Pro-Gly-Arg-Tyr Thr-Lys-Pro-Gly-Arg-Tyr Thr-Lys-Pro-Gly-Arg-Tyr Thr-Lys-Pro-Gly-Phe-Tyr Thr-Lys-Pro-Gly-Phe-Tyr Thr-Lys-Pro-Gly-Phe-Tyr Thr-Lys-Pro-Gly-Tyr-Tyr Thr-Lys-Pro-Gly-Tyr-Tyr Thr-Lys-Pro-Gly-Tyr-Tyr Thr-Lys-Pro-Gly-His-Tyr Thr-Lys-Pro-Gly-His-Tyr Thr-Lys-Pro-Gly-His-Tyr Thr-Lys-Pro-Gly-Pro-Tyr Thr-Lys-Pro-Gly-Pro-Tyr Thr-Lys-Pro-Gly-Pro-Tyr Thr-Lys-Pro-Gly-Lys-Tyr Thr-Lys-Pro-Gly-Lys-Tyr Thr-Lys-Pro-Gly-Lys-Tyr Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Asp-Tyr Asp-Tyr Asp-Tyr Thr-Lys-Pro-Asp-Arg-Tyr Thr-Lys-Pro-Asp-Arg-Tyr Thr-Lys-Pro-Asp-Arg-Tyr Thr-Lys-Pro-Asp-Phe-Tyr Thr-Lys-Pro-Asp-Phe-Tyr Thr-Lys-Pro-Asp-Phe-Tyr Thr-Lys-Pro-Asp-Tyr-Tyr Thr-Lys-Pro-Asp-Tyr-Tyr Thr-Lys-Pro-Asp-Tyr-Tyr Thr-Lys-Pro-Asp-His-Tyr Thr-Lys-Pro-Asp-His-Tyr Thr-Lys-Pro-Asp-His-Tyr Thr-Lys-Pro-Asp-Pro-Tyr Thr-Lys-Pro-Asp-Pro-Tyr Thr-Lys-Pro-Asp-Pro-Tyr Thr-Lys-Pro-Asp-Lys-Tyr Thr-Lys-Pro-Asp-Lys-Tyr Thr-Lys-Pro-Asp-Lys-Tyr Thr-Lys-Pro-Trp-Tyr Thr-Lys-Pro-Trp-Tyr Thr-Lys-Pro-Trp-Tyr Thr-Lys-Pro-Trp-Arg-Tyr Thr-Lys-Pro-Trp-Arg-Tyr Thr-Lys-Pro-Trp-Arg-Tyr Thr-Lys-Pro-Trp-Phe-Tyr Thr-Lys-Pro-Trp-Phe-Tyr Thr-Lys-Pro-Trp-Phe-Tyr Thr-Lys-Pro-Trp-Tyr-Tyr Thr-Lys-Pro-Trp-Tyr-Tyr Thr-Lys-Pro-Trp-Tyr-Tyr Thr-Lys-Pro-Trp-His-Tyr Thr-Lys-Pro-Trp-His-Tyr Thr-Lys-Pro-Trp-His-Tyr Thr-Lys-Pro-Trp-Pro-Tyr Thr-Lys-Pro-Trp-Pro-Tyr Thr-Lys-Pro-Trp-Pro-Tyr Thr-Lys-Pro-Trp-Lys-Tyr Thr-Lys-Pro-Trp-Lys-Tyr Thr-Lys-Pro-Trp-Lys-Tyr Thr-Lys-Pro-Gln-Tyr Thr-Lys-Pro-Gln-Tyr Thr-Lys-Pro-'Gln-Tyr

Thr-Lys-Pro-Gln-Arg-Tyr Thr-Lys-Pro-Gln-Arg-Tyr Thr-Lys-Pro-Gln-Arg-Tyr Thr-Lys-Pro-Gln-Phe-Tyr Thr-Lys-Pro-Gln-Phe-Tyr Thr-Lys-Pro-Gln-Phe-Tyr Thr-Lys-Pro-Gln-Tyr-Tyr Thr-Lys-Pro-Gln-Tyr-Tyr Thr-Lys-Pro-Gln-Tyr-Tyr Thr-Lys-Pro-Gln-His-Tyr Thr-Lys-Pro-Gln-His-Tyr Thr-Lys-Pro-Gln-His-Tyr Thr-Lys-Pro-Gln-Pro-Tyr Thr-Lys-Pro-Gln-Pro-Tyr Thr-Lys-Pro-Gln-Pro-Tyr Thr-Lys-Pro-Gln-Lys-Tyr Thr-Lys-Pro-Gln-Lys-Tyr Thr-Lys-Pro-Gln-Lys-Tyr Thr-Lys-Pro-Asn-Tyr Thr-Lys-Pro-Asn-Tyr Thr-Lys-Pro-Asn-Tyr Thr-Lys-Pro-Asn-Arg-Tyr Thr-Lys-Pro-Asn-Arg-Tyr Thr-Lys-Pro-Asn-Arg-Tyr Thr-Lys-Pro-Asn-Phe-Tyr Thr-Lys-Pro-Asn-Phe-Tyr Thr-Lys-Pro-Asn-Phe-Tyr Thr-Lys-Pro-Asn-Tyr-Tyr Thr-Lys-Pro-Asn-Tyr-Tyr Thr-Lys-Pro-Asn-Tyr-Tyr Thr-Lys-Pro-Asn-His-Tyr Thr-Lys-Pro-Asn-His-Tyr Thr-Lys-Pro-Asn-His-Tyr Thr-Lys-Pro-Asn-Pro-Tyr Thr-Lys-Pro-Asn-Pro-Tyr Thr-Lys-Pro-Asn-Pro-Tyr Thr-Lys-Pro-Asn-Lys-Tyr Thr-Lys-Pro-Asn-Lys-Tyr Thr-Lys-Pro-Asn-Lys-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr Thr-Lys-Pro- Thr-Lys-Pro-Tyr- Thr-Lys-Pro-

Tyr-Arg-Tyr Arg-Tyr Tyr-Arg-Tyr Thr-Lys-Pro-Tyr-Phe-Tyr Thr-Lys-Pro-Tyr-Phe-Tyr Thr-Lys-Pro-Tyr-Phe-Tyr Thr-Lys-Pro-Tyr-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr-Tyr Thr-Lys-Pro-Tyr-Tyr-Tyr Thr-Lys-Pro-Tyr-His-Tyr Thr-Lys-Pro-Tyr-His-Tyr Thr-Lys-Pro-Tyr-His-Tyr Thr-Lys-Pro-Tyr-Pro-Tyr Thr-Lys-Pro-Tyr-Pro-Tyr Thr-Lys-Pro-Tyr-Pro-Tyr Thr-Lys-Pro-Tyr-Lys-Tyr Thr-Lys-Pro-Tyr-Lys-Tyr Thr-Lys-Pro-Tyr-Lys-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Tyr Thr-Lys-Pro-Arg-Arg-Tyr Thr-Lys-Pro-Arg-Arg-Tyr Thr-Lys-Pro-Arg-Arg-Tyr Thr-Lys-Pro-Arg-Phe-Tyr Thr-Lys-Pro-Arg-Phe-Tyr Thr-Lys-Pro-Arg-Phe-Tyr Thr-Lys-Pro-Arg-Tyr-Tyr Thr-Lys-Pro-Arg-Tyr-Tyr Thr-Lys-Pro-Arg-Tyr-Tyr Thr-Lys-Pro-Arg-His-Tyr Thr-Lys-Pro-Arg-His-Tyr Thr-Lys-Pro-Arg-His-Tyr Thr-Lys-Pro-Arg-Pro-Tyr Thr-Lys-Pro-Arg-Pro-Tyr Thr-Lys-Pro-Arg-Pro-Tyr Thr-Lys-Pro-Arg-Lys-Tyr Thr-Lys-Pro-Arg-Lys-Tyr Thr-Lys-Pro-Arg-Lys-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Tyr

Met-Thr-Lys-Pro-Phe-Tyr Met-Thr-Lys-Pro-Phe-Tyr Met-Thr-Lys-Pro-Phe-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-His-Tyr Met-Thr-Lys-Pro-His-Tyr Met-Thr-Lys-Pro-His-Tyr Met-Thr-Lys-Pro-Lys-Tyr Met-Thr-Lys-Pro-Lys-Tyr Met-Thr-Lys-Pro-Lys-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Tyr Met-Thr-Lys-Pro-Gly-Arg-Tyr Met-Thr-Lys-Pro-Gly-Arg-Tyr Met-Thr-Lys-Pro-Gly-Arg-Tyr Met-Thr-Lys-Pro-Gly-Phe-Tyr Met-Thr-Lys-Pro-Gly-Phe-Tyr Met-Thr-Lys-Pro-Gly-Phe-Tyr Met-Thr-Lys-Pro-Gly-Tyr-Tyr Met-Thr-Lys-Pro-Gly-Tyr-Tyr Met-Thr-Lys-Pro-Gly-Tyr-Tyr Met-Thr-Lys-Pro-Gly-His-Tyr Met-Thr-Lys-Pro-Gly-His-Tyr Met-Thr-Lys-Pro-Gly-His-Tyr Met-Thr-Lys-Pro-Gly-Pro-Tyr Met-Thr-Lys-Pro-Gly-Pro-Tyr Met-Thr-Lys-Pro-Gly-Pro-Tyr Met-Thr-Lys-Pro-Gly-Lys-Tyr Met-Thr-Lys-Pro-Gly-Lys-Tyr Met-Thr-Lys-Pro-Gly-Lys-Tyr Met-Thr-Lys-Pro-Asp-Tyr Met-Thr-Lys-Pro-Asp-Tyr Met-Thr-Lys-Pro-Asp-Tyr Met-Thr-Lys-Pro-Asp-Arg-Tyr Met-Thr-Lys-Pro-Asp-Arg-Tyr Met-Thr-Lys-Pro-Asp-Arg-Tyr Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Asp-Phe-Tyr Pro-Asp-Phe-Tyr Pro-Asp-Phe-Tyr Met-Thr-Lys-Pro-Asp-Tyr-Tyr Met-Thr-Lys-Pro-Asp-Tyr-Tyr Met-Thr-Lys-Pro-Asp-Tyr-Tyr Met-Thr-Lys-Pro-Asp-His-Tyr Met-Thr-Lys-Pro-Asp-His-Tyr Met-Thr-Lys-Pro-Asp-His-Tyr Met-Thr-Lys-Pro-Asp-Pro-Tyr Met-Thr-Lys-Pro-Asp-Pro-Tyr Met-Thr-Lys-Pro-Asp-Pro-Tyr Met-Thr-Lys-Pro-Asp-Lys-Tyr Met-Thr-Lys-Pro-Asp-Lys-Tyr Met-Thr-Lys-Pro-Asp-Lys-Tyr Met-Thr-Lys-Pro-Trp-Tyr Met-Thr-Lys-Pro-Trp-Tyr Met-Thr-Lys-Pro-Trp-Tyr Met-Thr-Lys-Pro-Trp-Arg-Tyr Met-Thr-Lys-Pro-Trp-Arg-Tyr Met-Thr-Lys-Pro-Trp-Arg-Tyr Met-Thr-Lys-Pro-Trp-Phe-Tyr Met-Thr-Lys-Pro-Trp-Phe-Tyr Met-Thr-Lys-Pro-Trp-Phe-Tyr Met-Thr-Lys-Pro-Trp-Tyr-Tyr Met-Thr-Lys-Pro-Trp-Tyr-Tyr Met-Thr-Lys-Pro-Trp-Tyr-Tyr Met-Thr-Lys-Pro-Trp-His-Tyr Met-Thr-Lys-Pro-Trp-His-Tyr Met-Thr-Lys-Pro-Trp-His-Tyr Met-Thr-Lys-Pro-Trp-Pro-Tyr Met-Thr-Lys-Pro-Trp-Pro-Tyr Met-Thr-Lys-Pro-Trp-Pro-Tyr Met-Thr-Lys-Pro-Trp-Lys-Tyr Met-Thr-Lys-Pro-Trp-Lys-Tyr Met-Thr-Lys-Pro-Trp-Lys-Tyr Met-Thr-Lys-Pro-Gln-Tyr Met-Thr-Lys-Pro-Gln-Tyr Met-Thr-Lys-Pro-Gln-Tyr Met-Thr-Lys-Pro-Gln-Arg-Tyr Met-Thr-Lys-Pro-Gln-Arg-Tyr Met-Thr-Lys-Pro-Gln-Arg-Tyr Met-Thr-Lys-Pro-Gln-Phe-Tyr Met-Thr-Lys-Pro-Gln-Phe-Tyr Met-Thr-Lys-Pro-Gln-Phe-Tyr

Met-Thr-Lys-Pro-Gln-Tyr-Tyr Met-Thr-Lys-Pro-Gln-Tyr-Tyr Met-Thr-Lys-Pro-Gln-Tyr-Tyr Met-Thr-Lys-Pro-Gln-His-Tyr Met-Thr-Lys-Pro-Gln-His-Tyr Met-Thr-Lys-Pro-Gln-His-Tyr Met-Thr-Lys-Pro-Gln-Pro-Tyr Met-Thr-Lys-Pro-Gln-Pro-Tyr Met-Thr-Lys-Pro-Gln-Pro-Tyr Met-Thr-Lys-Pro-Gln-Lys-Tyr Met-Thr-Lys-Pro-Gln-Lys-Tyr Met-Thr-Lys-Pro-Gln-Lys-Tyr Met-Thr-Lys-Pro-Asn-Tyr Met-Thr-Lys-Pro-Asn-Tyr Met-Thr-Lys-Pro-Asn-Tyr Met-Thr-Lys-Pro-Asn-Arg-Tyr Met-Thr-Lys-Pro-Asn-Arg-Tyr Met-Thr-Lys-Pro-Asn-Arg-Tyr Met-Thr-Lys-Pro-Asn-Phe-Tyr Met-Thr-Lys-Pro-Asn-Phe-Tyr Met-Thr-Lys-Pro-Asn-Phe-Tyr Met-Thr-Lys-Pro-Asn-Tyr-Tyr Met-Thr-Lys-Pro-Asn-Tyr-Tyr Met-Thr-Lys-Pro-Asn-Tyr-Tyr Met-Thr-Lys-Pro-Asn-His-Tyr Met-Thr-Lys-Pro-Asn-His-Tyr Met-Thr-Lys-Pro-Asn-His-Tyr Met-Thr-Lys-Pro-Asn-Pro-Tyr Met-Thr-Lys-Pro-Asn-Pro-Tyr Met-Thr-Lys-Pro-Asn-Pro-Tyr Met-Thr-Lys-Pro-Asn-Lys-Tyr Met-Thr-Lys-Pro-Asn-Lys-Tyr Met-Thr-Lys-Pro-Asn-Lys-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-Arg-Tyr Met-Thr-Lys-Pro-Tyr-Arg-Tyr Met-Thr-Lys-Pro-Tyr-Arg-Tyr Met-Thr-Lys-Pro-Tyr-Phe-Tyr Met-Thr-Lys-Pro-Tyr-Phe-Tyr Met-Thr-Lys-Pro-Tyr-Phe-Tyr Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Tyr-Tyr-Tyr Pro-Tyr-Tyr-Tyr Pro-Tyr-Tyr-Tyr Met-Thr-Lys-Pro-Tyr-His-Tyr Met-Thr-Lys-Pro-Tyr-His-Tyr Met-Thr-Lys-Pro-Tyr-His-Tyr Met-Thr-Lys-Pro-Tyr-Pro-Tyr Met-Thr-Lys-Pro-Tyr-Pro-Tyr Met-Thr-Lys-Pro-Tyr-Pro-Tyr Met-Thr-Lys-Pro-Tyr-Lys-Tyr Met-Thr-Lys-Pro-Tyr-Lys-Tyr Met-Thr-Lys-Pro-Tyr-Lys-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Tyr Met-Thr-Lys-Pro-Arg-Arg-Tyr Met-Thr-Lys-Pro-Arg-Arg-Tyr Met-Thr-Lys-Pro-Arg-Arg-Tyr Met-Thr-Lys-Pro-Arg-Phe-Tyr Met-Thr-Lys-Pro-Arg-Phe-Tyr Met-Thr-Lys-Pro-Arg-Phe-Tyr Met-Thr-Lys-Pro-Arg-Tyr-Tyr Met-Thr-Lys-Pro-Arg-Tyr-Tyr Met-Thr-Lys-Pro-Arg-Tyr-Tyr Met-Thr-Lys-Pro-Arg-His-Tyr Met-Thr-Lys-Pro-Arg-His-Tyr Met-Thr-Lys-Pro-Arg-His-Tyr Met-Thr-Lys-Pro-Arg-Pro-Tyr Met-Thr-Lys-Pro-Arg-Pro-Tyr Met-Thr-Lys-Pro-Arg-Pro-Tyr Met-Thr-Lys-Pro-Arg-Lys-Tyr Met-Thr-Lys-Pro-Arg-Lys-Tyr Met-Thr-Lys-Pro-Arg-Lys-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Phe-Tyr Met(0)-Thr-Lys-Pro-Phe-Tyr Met(0)-Thr-Lys-Pro-Phe-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr

Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-His-Tyr Met(0)-Thr-Lys-Pro-His-Tyr Met(0)-Thr-Lys-Pro-His-Tyr Met(0)-Thr-Lys-Pro-Lys-Tyr Met(0)-Thr-Lys-Pro-Lys-Tyr Met(0)-Thr-Lys-Pro-Lys-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr Met(0)-Thr-Lys-Pro-Gly-Arg-Tyr Met(0)-Thr-Lys-Pro-Gly-Arg-Tyr Met(0)-Thr-Lys-Pro-Gly-Arg-Tyr Met(0)-Thr-Lys-Pro-Gly-Phe-Tyr Met(0)-Thr-Lys-Pro-Gly-Phe-Tyr Met(0)-Thr-Lys-Pro-Gly-Phe-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr-Tyr Met(0)-Thr-Lys-Pro-Gly-Tyr-Tyr Met(0)-Thr-Lys-Pro-Gly-His-Tyr Met(0)-Thr-Lys-Pro-Gly-His-Tyr Met(0)-Thr-Lys-Pro-Gly-His-Tyr Met(0)-Thr-Lys-Pro-Gly-Pro-Tyr Met(0)-Thr-Lys-Pro-Gly-Pro-Tyr Met(0)-Thr-Lys-Pro-Gly-Pro-Tyr Met(0)-Thr-Lys-Pro-Gly-Lys-Tyr Met(0)-Thr-Lys-Pro-Gly-Lys-Tyr Met(0)-Thr-Lys-Pro-Gly-Lys-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr Met(0)-Thr-Lys-Pro-Asp-Arg-Tyr Met(0)-Thr-Lys-Pro-Asp-Arg-Tyr Met(0)-Thr-Lys-Pro-Asp-Arg-Tyr Met(0)-Thr-Lys-Pro-Asp-Phe-Tyr Met(0)-Thr-Lys-Pro-Asp-Phe-Tyr Met(0)-Thr-Lys-Pro-Asp-Phe-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr-Tyr Met(0)-Thr-Lys-Pro-Asp-Tyr-Tyr Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Asp-His-Tyr Pro-Asp-His-Tyr Pro-Asp-His-Tyr Met(0)-Thr-Lys-Pro-Asp-Pro-Tyr Met(0)-Thr-Lys-Pro-Asp-Pro-Tyr Met(0)-Thr-Lys-Pro-Asp-Pro-Tyr Met(0)-Thr-Lys-Pro-Asp-Lys-Tyr Met(0)-Thr-Lys-Pro-Asp-Lys-Tyr Met(0)-Thr-Lys-Pro-Asp-Lys-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr Met(0)-Thr-Lys-Pro-Trp-Arg-Tyr Met(0)-Thr-Lys-Pro-Trp-Arg-Tyr Met(0)-Thr-Lys-Pro-Trp-Arg-Tyr Met(0)-Thr-Lys-Pro-Trp-Phe-Tyr Met(0)-Thr-Lys-Pro-Trp-Phe-Tyr Met(0)-Thr-Lys-Pro-Trp-Phe-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr-Tyr Met(0)-Thr-Lys-Pro-Trp-Tyr-Tyr Met(0)-Thr-Lys-Pro-Trp-His-Tyr Met(0)-Thr-Lys-Pro-Trp-His-Tyr Met(0)-Thr-Lys-Pro-Trp-His-Tyr Met(0)-Thr-Lys-Pro-Trp-Pro-Tyr Met(0)-Thr-Lys-Pro-Trp-Pro-Tyr Met(0)-Thr-Lys-Pro-Trp-Pro-Tyr Met(0)-Thr-Lys-Pro-Trp-Lys-Tyr Met(0)-Thr-Lys-Pro-Trp-Lys-Tyr Met(0)-Thr-Lys-Pro-Trp-Lys-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr Met(0)-Thr-Lys-Pro-Gln-Arg-Tyr Met(0)-Thr-Lys-Pro-Gln-Arg-Tyr Met(0)-Thr-Lys-Pro-Gln-Arg-Tyr Met(0)-Thr-Lys-Pro-Gln-Phe-Tyr Met(0)-Thr-Lys-Pro-Gln-Phe-Tyr Met(0)-Thr-Lys-Pro-Gln-Phe-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr-Tyr Met(0)-Thr-Lys-Pro-Gln-Tyr-Tyr Met(0)-Thr-Lys-Pro-Gln-His-Tyr Met(0)-Thr-Lys-Pro-Gln-His-Tyr Met(0)-Thr-Lys-Pro-Gln-His-Tyr

Met(0)-Thr-Lys-Pro-Gln-Pro-Tyr Met(0)-Thr-Lys-Pro-Gln-Pro-Tyr Met(0)-Thr-Lys-Pro-Gln-Pro-Tyr Met(0)-Thr-Lys-Pro-Gln-Lys-Tyr Met(0)-Thr-Lys-Pro-Gln-Lys-Tyr Met(0)-Thr-Lys-Pro-Gln-Lys-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr Met(0)-Thr-Lys-Pro-Asn-Arg-Tyr Met(0)-Thr-Lys-Pro-Asn-Arg-Tyr Met(0)-Thr-Lys-Pro-Asn-Arg-Tyr Met(0)-Thr-Lys-Pro-Asn-Phe-Tyr Met(0)-Thr-Lys-Pro-Asn-Phe-Tyr Met(0)-Thr-Lys-Pro-Asn-Phe-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr-Tyr Met(0)-Thr-Lys-Pro-Asn-Tyr-Tyr Met(0)-Thr-Lys-Pro-Asn-His-Tyr Met(0)-Thr-Lys-Pro-Asn-His-Tyr Met(0)-Thr-Lys-Pro-Asn-His-Tyr Met(0)-Thr-Lys-Pro-Asn-Pro-Tyr Met(0)-Thr-Lys-Pro-Asn-Pro-Tyr Met(0)-Thr-Lys-Pro-Asn-Pro-Tyr Met(0)-Thr-Lys-Pro-Asn-Lys-Tyr Met(0)-Thr-Lys-Pro-Asn-Lys-Tyr Met(0)-Thr-Lys-Pro-Asn-Lys-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Arg-Tyr Met(0)-Thr-Lys-Pro-Tyr-Arg-Tyr Met(0)-Thr-Lys-Pro-Tyr-Arg-Tyr Met(0)-Thr-Lys-Pro-Tyr-Phe-Tyr Met(0)-Thr-Lys-Pro-Tyr-Phe-Tyr Met(0)-Thr-Lys-Pro-Tyr-Phe-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-Tyr-Tyr Met(0)-Thr-Lys-Pro-Tyr-His-Tyr Met(0)-Thr-Lys-Pro-Tyr-His-Tyr Met(0)-Thr-Lys-Pro-Tyr-His-Tyr Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Tyr-Pro-Tyr Pro-Tyr-Pro-Tyr Pro-Tyr-Pro-Tyr Met(0)-Thr-Lys-Pro-Tyr-Lys-Tyr Met(0)-Thr-Lys-Pro-Tyr-Lys-Tyr Met(0)-Thr-Lys-Pro-Tyr-Lys-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Arg-Tyr Met(0)-Thr-Lys-Pro-Arg-Phe-Tyr Met(0)-Thr-Lys-Pro-Arg-Phe-Tyr Met(0)-Thr-Lys-Pro-Arg-Phe-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr-Tyr Met(0)-Thr-Lys-Pro-Arg-Tyr-Tyr Met(0)-Thr-Lys-Pro-Arg-His-Tyr Met(0)-Thr-Lys-Pro-Arg-His-Tyr Met(0)-Thr-Lys-Pro-Arg-His-Tyr Met(0)-Thr-Lys-Pro-Arg-Pro-Tyr Met(0)-Thr-Lys-Pro-Arg-Pro-Tyr Met(0)-Thr-Lys-Pro-Arg-Pro-Tyr Met(0)-Thr-Lys-Pro-Arg-Lys-Tyr Met(0)-Thr-Lys-Pro-Arg-Lys-Tyr Met(0)-Thr-Lys-Pro-Arg-Lys-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Tyr Thr-Thr-Lys-Pro-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Tyr Thr-Thr-Lys-Pro-Phe-Tyr Thr-Thr-Lys-Pro-Phe-Tyr Thr-Thr-Lys-Pro-Phe-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-His-Tyr Thr-Thr-Lys-Pro-His-Tyr Thr-Thr-Lys-Pro-His-Tyr

Thr-Thr-Lys-Pro-Lys-Tyr Thr-Thr-Lys-Pro-Lys-Tyr Thr-Thr-Lys-Pro-Lys-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Tyr Thr-Thr-Lys-Pro-Gly-Arg-Tyr Thr-Thr-Lys-Pro-Gly-Arg-Tyr Thr-Thr-Lys-Pro-Gly-Arg-Tyr Thr-Thr-Lys-Pro-Gly-Phe-Tyr Thr-Thr-Lys-Pro-Gly-Phe-Tyr Thr-Thr-Lys-Pro-Gly-Phe-Tyr Thr-Thr-Lys-Pro-Gly-Tyr-Tyr Thr-Thr-Lys-Pro-Gly-Tyr-Tyr Thr-Thr-Lys-Pro-Gly-Tyr-Tyr Thr-Thr-Lys-Pro-Gly-His-Tyr Thr-Thr-Lys-Pro-Gly-His-Tyr Thr-Thr-Lys-Pro-Gly-His-Tyr Thr-Thr-Lys-Pro-Gly-Pro-Tyr Thr-Thr-Lys-Pro-Gly-Pro-Tyr Thr-Thr-Lys-Pro-Gly-Pro-Tyr Thr-Thr-Lys-Pro-Gly-Lys-Tyr Thr-Thr-Lys-Pro-Gly-Lys-Tyr Thr-Thr-Lys-Pro-Gly-Lys-Tyr Thr-Thr-Lys-Pro-Asp-Tyr Thr-Thr-Lys-Pro-Asp-Tyr Thr-Thr-Lys-Pro-Asp-Tyr Thr-Thr-Lys-Pro-Asp-Arg-Tyr Thr-Thr-Lys-Pro-Asp-Arg-Tyr Thr-Thr-Lys-Pro-Asp-Arg-Tyr Thr-Thr-Lys-Pro-Asp-Phe-Tyr Thr-Thr-Lys-Pro-Asp-Phe-Tyr Thr-Thr-Lys-Pro-Asp-Phe-Tyr Thr-Thr-Lys-Pro-Asp-Tyr-Tyr Thr-Thr-Lys-Pro-Asp-Tyr-Tyr Thr-Thr-Lys-Pro-Asp-Tyr-Tyr Thr-Thr-Lys-Pro-Asp-His-Tyr Thr-Thr-Lys-Pro-Asp-His-Tyr Thr-Thr-Lys-Pro-Asp-His-Tyr Thr-Thr-Lys-Pro-Asp-Pro-Tyr Thr-Thr-Lys-Pro-Asp-Pro-Tyr Thr-Thr-Lys-Pro-Asp-Pro-Tyr Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Asp-Lys-Tyr Asp-Lys-Tyr Pro-Asp-Lys-Tyr Thr-Thr-Lys-Pro-Trp-Tyr Thr-Thr-Lys-Pro-Trp-Tyr Thr-Thr-Lys-Pro-Trp-Tyr Thr-Thr-Lys-Pro-Trp-Arg-Tyr Thr-Thr-Lys-Pro-Trp-Arg-Tyr Thr-Thr-Lys-Pro-Trp-Arg-Tyr Thr-Thr-Lys-Pro-Trp-Phe-Tyr Thr-Thr-Lys-Pro-Trp-Phe-Tyr Thr-Thr-Lys-Pro-Trp-Phe-Tyr Thr-Thr-Lys-Pro-Trp-Tyr-Tyr Thr-Thr-Lys-Pro-Trp-Tyr-Tyr Thr-Thr-Lys-Pro-Trp-Tyr-Tyr Thr-Thr-Lys-Pro-Trp-His-Tyr Thr-Thr-Lys-Pro-Trp-His-Tyr Thr-Thr-Lys-Pro-Trp-His-Tyr Thr-Thr-Lys-Pro-Trp-Pro-Tyr Thr-Thr-Lys-Pro-Trp-Pro-Tyr Thr-Thr-Lys-Pro-Trp-Pro-Tyr Thr-Thr-Lys-Pro-Trp-Lys-Tyr Thr-Thr-Lys-Pro-Trp-Lys-Tyr Thr-Thr-Lys-Pro-Trp-Lys-Tyr Thr-Thr-Lys-Pro-Gln-Tyr Thr-Thr-Lys-Pro-Gln-Tyr Thr-Thr-Lys-Pro-Gln-Tyr Thr-Thr-Lys-Pro-Gln-Arg-Tyr Thr-Thr-Lys-Pro-Gln-Arg-Tyr Thr-Thr-Lys-Pro-Gln-Arg-Tyr Thr-Thr-Lys-Pro-Gln-Phe-Tyr Thr-Thr-Lys-Pro-Gln-Phe-Tyr Thr-Thr-Lys-Pro-Gln-Phe-Tyr Thr-Thr-Lys-Pro-Gln-Tyr-Tyr Thr-Thr-Lys-Pro-Gln-Tyr-Tyr Thr-Thr-Lys-Pro-Gln-Tyr-Tyr Thr-Thr-Lys-Pro-Gln-His-Tyr Thr-Thr-Lys-Pro-Gln-His-Tyr Thr-Thr-Lys-Pro-Gln-His-Tyr Thr-Thr-Lys-Pro-Gln-Pro-Tyr Thr-Thr-Lys-Pro-Gln-Pro-Tyr Thr-Thr-Lys-Pro-Gln-Pro-Tyr Thr-Thr-Lys-Pro-Gln-Lys-Tyr Thr-Thr-Lys-Pro-Gln-Lys-Tyr Thr-Thr-Lys-Pro-Gln-Lys-Tyr

Thr-Thr-Lys-Pro-Asn-Tyr Thr-Thr-Lys-Pro-Asn-Tyr Thr-Thr-Lys-Pro-Asn-Tyr Thr-Thr-Lys-Pro-Asn-Arg-Tyr Thr-Thr-Lys-Pro-Asn-Arg-Tyr Thr-Thr-Lys-Pro-Asn-Arg-Tyr Thr-Thr-Lys-Pro-Asn-Phe-Tyr Thr-Thr-Lys-Pro-Asn-Phe-Tyr Thr-Thr-Lys-Pro-Asn-Phe-Tyr Thr-Thr-Lys-Pro-Asn-Tyr-Tyr Thr-Thr-Lys-Pro-Asn-Tyr-Tyr Thr-Thr-Lys-Pro-Asn-Tyr-Tyr Thr-Thr-Lys-Pro-Asn-His-Tyr Thr-Thr-Lys-Pro-Asn-His-Tyr Thr-Thr-Lys-Pro-Asn-His-Tyr Thr-Thr-Lys-Pro-Asn-Pro-Tyr Thr-Thr-Lys-Pro-Asn-Pro-Tyr Thr-Thr-Lys-Pro-Asn-Pro-Tyr Thr-Thr-Lys-Pro-Asn-Lys-Tyr Thr-Thr-Lys-Pro-Asn-Lys-Tyr Thr-Thr-Lys-Pro-Asn-Lys-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Arg-Tyr Thr-Thr-Lys-Pro-Tyr-Arg-Tyr Thr-Thr-Lys-Pro-Tyr-Arg-Tyr Thr-Thr-Lys-Pro-Tyr-Phe-Tyr Thr-Thr-Lys-Pro-Tyr-Phe-Tyr Thr-Thr-Lys-Pro-Tyr-Phe-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-Tyr-Tyr Thr-Thr-Lys-Pro-Tyr-His-Tyr Thr-Thr-Lys-Pro-Tyr-His-Tyr Thr-Thr-Lys-Pro-Tyr-His-Tyr Thr-Thr-Lys-Pro-Tyr-Pro-Tyr Thr-Thr-Lys-Pro-Tyr-Pro-Tyr Thr-Thr-Lys-Pro-Tyr-Pro-Tyr Thr-Thr-Lys-Pro-Tyr-Lys-Tyr Thr-Thr-Lys-Pro-Tyr-Lys-Tyr Thr-Thr-Lys-Pro-Tyr-Lys-Tyr Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Arg-Tyr Arg-Tyr Pro-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Arg-Tyr Thr-Thr-Lys-Pro-Arg-Phe-Tyr Thr-Thr-Lys-Pro-Arg-Phe-Tyr Thr-Thr-Lys-Pro-Arg-Phe-Tyr Thr-Thr-Lys-Pro-Arg-Tyr-Tyr Thr-Thr-Lys-Pro-Arg-Tyr-Tyr Thr-Thr-Lys-Pro-Arg-Tyr-Tyr Thr-Thr-Lys-Pro-Arg-His-Tyr Thr-Thr-Lys-Pro-Arg-His-Tyr Thr-Thr-Lys-Pro-Arg-His-Tyr Thr-Thr-Lys-Pro-Arg-Pro-Tyr Thr-Thr-Lys-Pro-Arg-Pro-Tyr Thr-Thr-Lys-Pro-Arg-Pro-Tyr Thr-Thr-Lys-Pro-Arg-Lys-Tyr Thr-Thr-Lys-Pro-Arg-Lys-Tyr Thr-Thr-Lys-Pro-Arg-Lys-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Phe-Tyr Ala-Thr-Lys-Pro-Phe-Tyr Ala-Thr-Lys-Pro-Phe-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-His-Tyr Ala-Thr-Lys-Pro-His-Tyr Ala-Thr-Lys-Pro-His-Tyr Ala-Thr-Lys-Pro-Lys-Tyr Ala-Thr-Lys-Pro-Lys-Tyr Ala-Thr-Lys-Pro-Lys-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-Tyr Ala-Thr-Lys-Pro-Gly-Tyr

Ala-Thr-Lys-Pro-Gly-Arg-Tyr Ala-Thr-Lys-Pro-Gly-Arg-Tyr Ala-Thr-Lys-Pro-Gly-Arg-Tyr Ala-Thr-Lys-Pro-Gly-Phe-Tyr Ala-Thr-Lys-Pro-Gly-Phe-Tyr Ala-Thr-Lys-Pro-Gly-Phe-Tyr Ala-Thr-Lys-Pro-Gly-Tyr-Tyr Ala-Thr-Lys-Pro-Gly-Tyr-Tyr Ala-Thr-Lys-Pro-Gly-Tyr-Tyr Ala-Thr-Lys-Pro-Gly-His-Tyr Ala-Thr-Lys-Pro-Gly-His-Tyr Ala-Thr-Lys-Pro-Gly-His-Tyr Ala-Thr-Lys-Pro-Gly-Pro-Tyr Ala-Thr-Lys-Pro-Gly-Pro-Tyr Ala-Thr-Lys-Pro-Gly-Pro-Tyr Ala-Thr-Lys-Pro-Gly-Lys-Tyr Ala-Thr-Lys-Pro-Gly-Lys-Tyr Ala-Thr-Lys-Pro-Gly-Lys-Tyr Ala-Thr-Lys-Pro-Asp-Tyr Ala-Thr-Lys-Pro-Asp-Tyr Ala-Thr-Lys-Pro-Asp-Tyr Ala-Thr-Lys-Pro-Asp-Arg-Tyr Ala-Thr-Lys-Pro-Asp-Arg-Tyr Ala-Thr-Lys-Pro-Asp-Arg-Tyr Ala-Thr-Lys-Pro-Asp-Phe-Tyr Ala-Thr-Lys-Pro-Asp-Phe-Tyr Ala-Thr-Lys-Pro-Asp-Phe-Tyr Ala-Thr-Lys-Pro-Asp-Tyr-Tyr Ala-Thr-Lys-Pro-Asp-Tyr-Tyr Ala-Thr-Lys-Pro-Asp-Tyr-Tyr Ala-Thr-Lys-Pro-Asp-His-Tyr Ala-Thr-Lys-Pro-Asp-His-Tyr Ala-Thr-Lys-Pro-Asp-His-Tyr Ala-Thr-Lys-Pro-Asp-Pro-Tyr Ala-Thr-Lys-Pro-Asp-Pro-Tyr Ala-Thr-Lys-Pro-Asp-Pro-Tyr Ala-Thr-Lys-Pro-Asp-Lys-Tyr Ala-Thr-Lys-Pro-Asp-Lys-Tyr Ala-Thr-Lys-Pro-Asp-Lys-Tyr Ala-Thr-Lys-Pro-Trp-Tyr Ala-Thr-Lys-Pro-Trp-Tyr Ala-Thr-Lys-Pro-Trp-Tyr Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Trp-Arg-Tyr Trp-Arg-Tyr Pro-Trp-Arg-Tyr Ala-Thr-Lys-Pro-Trp-Phe-Tyr Ala-Thr-Lys-Pro-Trp-Phe-Tyr Ala-Thr-Lys-Pro-Trp-Phe-Tyr Ala-Thr-Lys-Pro-Trp-Tyr-Tyr Ala-Thr-Lys-Pro-Trp-Tyr-Tyr Ala-Thr-Lys-Pro-Trp-Tyr-Tyr Ala-Thr-Lys-Pro-Trp-His-Tyr Ala-Thr-Lys-Pro-Trp-His-Tyr Ala-Thr-Lys-Pro-Trp-His-Tyr Ala-Thr-Lys-Pro-Trp-Pro-Tyr Ala-Thr-Lys-Pro-Trp-Pro-Tyr Ala-Thr-Lys-Pro-Trp-Pro-Tyr Ala-Thr-Lys-Pro-Trp-Lys-Tyr Ala-Thr-Lys-Pro-Trp-Lys-Tyr Ala-Thr-Lys-Pro-Trp-Lys-Tyr Ala-Thr-Lys-Pro-Gln-Tyr Ala-Thr-Lys-Pro-Gln-Tyr Ala-Thr-Lys-Pro-Gln-Tyr Ala-Thr-Lys-Pro-Gln-Arg-Tyr Ala-Thr-Lys-Pro-Gln-Arg-Tyr Ala-Thr-Lys-Pro-Gln-Arg-Tyr Ala-Thr-Lys-Pro-Gln-Phe-Tyr Ala-Thr-Lys-Pro-Gln-Phe-Tyr Ala-Thr-Lys-Pro-Gln-Phe-Tyr Ala-Thr-Lys-Pro-Gln-Tyr-Tyr Ala-Thr-Lys-Pro-Gln-Tyr-Tyr Ala-Thr-Lys-Pro-Gln-Tyr-Tyr Ala-Thr-Lys-Pro-Gln-His-Tyr Ala-Thr-Lys-Pro-Gln-His-Tyr Ala-Thr-Lys-Pro-Gln-His-Tyr Ala-Thr-Lys-Pro-Gln-Pro-Tyr Ala-Thr-Lys-Pro-Gln-Pro-Tyr Ala-Thr-Lys-Pro-Gln-Pro-Tyr Ala-Thr-Lys-Pro-Gln-Lys-Tyr Ala-Thr-Lys-Pro-Gln-Lys-Tyr Ala-Thr-Lys-Pro-Gln-Lys-Tyr Ala-Thr-Lys-Pro-Asn-Tyr Ala-Thr-Lys-Pro-Asn-Tyr Ala-Thr-Lys-Pro-Asn-Tyr Ala-Thr-Lys-Pro-Asn-Arg-Tyr Ala-Thr-Lys-Pro-Asn-Arg-Tyr Ala-Thr-Lys-Pro-Asn-Arg-Tyr

Ala-Thr-Lys-Pro-Asn-Phe-Tyr Ala-Thr-Lys-Pro-Asn-Phe-Tyr Ala-Thr-Lys-Pro-Asn-Phe-Tyr Ala-Thr-Lys-Pro-Asn-Tyr-Tyr Ala-Thr-Lys-Pro-Asn-Tyr-Tyr Ala-Thr-Lys-Pro-Asn-Tyr-Tyr Ala-Thr-Lys-Pro-Asn-His-Tyr Ala-Thr-Lys-Pro-Asn-His-Tyr Ala-Thr-Lys-Pro-Asn-His-Tyr Ala-Thr-Lys-Pro-Asn-Pro-Tyr Ala-Thr-Lys-Pro-Asn-Pro-Tyr Ala-Thr-Lys-Pro-Asn-Pro-Tyr Ala-Thr-Lys-Pro-Asn-Lys-Tyr Ala-Thr-Lys-Pro-Asn-Lys-Tyr Ala-Thr-Lys-Pro-Asn-Lys-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Arg-Tyr Ala-Thr-Lys-Pro-Tyr-Arg-Tyr Ala-Thr-Lys-Pro-Tyr-Arg-Tyr Ala-Thr-Lys-Pro-Tyr-Phe-Tyr Ala-Thr-Lys-Pro-Tyr-Phe-Tyr Ala-Thr-Lys-Pro-Tyr-Phe-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-Tyr-Tyr Ala-Thr-Lys-Pro-Tyr-His-Tyr Ala-Thr-Lys-Pro-Tyr-His-Tyr Ala-Thr-Lys-Pro-Tyr-His-Tyr Ala-Thr-Lys-Pro-Tyr-Pro-Tyr Ala-Thr-Lys-Pro-Tyr-Pro-Tyr Ala-Thr-Lys-Pro-Tyr-Pro-Tyr Ala-Thr-Lys-Pro-Tyr-Lys-Tyr Ala-Thr-Lys-Pro-Tyr-Lys-Tyr Ala-Thr-Lys-Pro-Tyr-Lys-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Arg-Tyr Ala-Thr-Lys-Pro-Arg-Arg-Tyr Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Arg-Phe-Tyr Arg-Phe-Tyr Pro-Arg-Phe-Tyr Ala-Thr-Lys-Pro-Arg-Tyr-Tyr Ala-Thr-Lys-Pro-Arg-Tyr-Tyr Ala-Thr-Lys-Pro-Arg-Tyr-Tyr Ala-Thr-Lys-Pro-Arg-His-Tyr Ala-Thr-Lys-Pro-Arg-His-Tyr Ala-Thr-Lys-Pro-Arg-His-Tyr Ala-Thr-Lys-Pro-Arg-Pro-Tyr Ala-Thr-Lys-Pro-Arg-Pro-Tyr Ala-Thr-Lys-Pro-Arg-Pro-Tyr Ala-Thr-Lys-Pro-Arg-Lys-Tyr Ala-Thr-Lys-Pro-Arg-Lys-Tyr Ala-Thr-Lys-Pro-Arg-Lys-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Tyr His-Thr-Lys-Pro-Arg-Tyr His-Thr-Lys-Pro-Arg-Tyr His-Thr-Lys-Pro-Arg-Tyr His-Thr-Lys-Pro-Phe-Tyr His-Thr-Lys-Pro-Phe-Tyr His-Thr-Lys-Pro-Phe-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-His-Tyr His-Thr-Lys-Pro-His-Tyr His-Thr-Lys-Pro-His-Tyr His-Thr-Lys-Pro-Lys-Tyr His-Thr-Lys-Pro-Lys-Tyr His-Thr-Lys-Pro-Lys-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Tyr His-Thr-Lys-Pro-Gly-Arg-Tyr His-Thr-Lys-Pro-Gly-Arg-Tyr His-Thr-Lys-Pro-Gly-Arg-Tyr His-Thr-Lys-Pro-Gly-Phe-Tyr His-Thr-Lys-Pro-Gly-Phe-Tyr His-Thr-Lys-Pro-Gly-Phe-Tyr

His-Thr-Lys-Pro-Gly-Tyr-Tyr His-Thr-Lys-Pro-Gly-Tyr-Tyr His-Thr-Lys-Pro-Gly-Tyr-Tyr His-Thr-Lys-Pro-Gly-His-Tyr His-Thr-Lys-Pro-Gly-His-Tyr His-Thr-Lys-Pro-Gly-His-Tyr His-Thr-Lys-Pro-Gly-Pro-Tyr His-Thr-Lys-Pro-Gly-Pro-Tyr His-Thr-Lys-Pro-Gly-Pro-Tyr His-Thr-Lys-Pro-Gly-Lys-Tyr His-Thr-Lys-Pro-Gly-Lys-Tyr His-Thr-Lys-Pro-Gly-Lys-Tyr His-Thr-Lys-Pro-Asp-Tyr His-Thr-Lys-Pro-Asp-Tyr His-Thr-Lys-Pro-Asp-Tyr His-Thr-Lys-Pro-Asp-Arg-Tyr His-Thr-Lys-Pro-Asp-Arg-Tyr His-Thr-Lys-Pro-Asp-Arg-Tyr His-Thr-Lys-Pro-Asp-Phe-Tyr His-Thr-Lys-Pro-Asp-Phe-Tyr His-Thr-Lys-Pro-Asp-Phe-Tyr His-Thr-Lys-Pro-Asp-Tyr-Tyr His-Thr-Lys-Pro-Asp-Tyr-Tyr His-Thr-Lys-Pro-Asp-Tyr-Tyr His-Thr-Lys-Pro-Asp-His-Tyr His-Thr-Lys-Pro-Asp-His-Tyr His-Thr-Lys-Pro-Asp-His-Tyr His-Thr-Lys-Pro-Asp-Pro-Tyr His-Thr-Lys-Pro-Asp-Pro-Tyr His-Thr-Lys-Pro-Asp-Pro-Tyr His-Thr-Lys-Pro-Asp-Lys-Tyr His-Thr-Lys-Pro-Asp-Lys-Tyr His-Thr-Lys-Pro-Asp-Lys-Tyr His-Thr-Lys-Pro-Trp-Tyr His-Thr-Lys-Pro-Trp-Tyr His-Thr-Lys-Pro-Trp-Tyr His-Thr-Lys-Pro-Trp-Arg-Tyr His-Thr-Lys-Pro-Trp-Arg-Tyr His-Thr-Lys-Pro-Trp-Arg-Tyr His-Thr-Lys-Pro-Trp-Phe-Tyr His-Thr-Lys-Pro-Trp-Phe-Tyr His-Thr-Lys-Pro-Trp-Phe-Tyr His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Trp-Tyr-Tyr Trp-Tyr-Tyr Pro-Trp-Tyr-Tyr His-Thr-Lys-Pro-Trp-His-Tyr His-Thr-Lys-Pro-Trp-His-Tyr His-Thr-Lys-Pro-Trp-His-Tyr His-Thr-Lys-Pro-Trp-Pro-Tyr His-Thr-Lys-Pro-Trp-Pro-Tyr His-Thr-Lys-Pro-Trp-Pro-Tyr His-Thr-Lys-Pro-Trp-Lys-Tyr His-Thr-Lys-Pro-Trp-Lys-Tyr His-Thr-Lys-Pro-Trp-Lys-Tyr His-Thr-Lys-Pro-Gln-Tyr His-Thr-Lys-Pro-Gln-Tyr His-Thr-Lys-Pro-Gln-Tyr His-Thr-Lys-Pro-Gln-Arg-Tyr His-Thr-Lys-Pro-Gln-Arg-Tyr His-Thr-Lys-Pro-Gln-Arg-Tyr His-Thr-Lys-Pro-Gln-Phe-Tyr His-Thr-Lys-Pro-Gln-Phe-Tyr His-Thr-Lys-Pro-Gln-Phe-Tyr His-Thr-Lys-Pro-Gln-Tyr-Tyr His-Thr-Lys-Pro-Gln-Tyr-Tyr His-Thr-Lys-Pro-Gln-Tyr-Tyr His-Thr-Lys-Pro-Gln-His-Tyr His-Thr-Lys-Pro-Gln-His-Tyr His-Thr-Lys-Pro-Gln-His-Tyr His-Thr-Lys-Pro-Gln-Pro-Tyr His-Thr-Lys-Pro-Gln-Pro-Tyr His-Thr-Lys-Pro-Gln-Pro-Tyr His-Thr-Lys-Pro-Gln-Lys-Tyr His-Thr-Lys-Pro-Gln-Lys-Tyr His-Thr-Lys-Pro-Gln-Lys-Tyr His-Thr-Lys-Pro-Asn-Tyr His-Thr-Lys-Pro-Asn-Tyr His-Thr-Lys-Pro-Asn-Tyr His-Thr-Lys-Pro-Asn-Arg-Tyr His-Thr-Lys-Pro-Asn-Arg-Tyr His-Thr-Lys-Pro-Asn-Arg-Tyr His-Thr-Lys-Pro-Asn-Phe-Tyr His-Thr-Lys-Pro-Asn-Phe-Tyr His-Thr-Lys-Pro-Asn-Phe-Tyr His-Thr-Lys-Pro-Asn-Tyr-Tyr His-Thr-Lys-Pro-Asn-Tyr-Tyr His-Thr-Lys-Pro-Asn-Tyr-Tyr

His-Thr-Lys-Pro-Asn-His-Tyr His-Thr-Lys-Pro-Asn-His-Tyr His-Thr-Lys-Pro-Asn-His-Tyr His-Thr-Lys-Pro-Asn-Pro-Tyr His-Thr-Lys-Pro-Asn-Pro-Tyr His-Thr-Lys-Pro-Asn-Pro-Tyr His-Thr-Lys-Pro-Asn-Lys-Tyr His-Thr-Lys-Pro-Asn-Lys-Tyr His-Thr-Lys-Pro-Asn-Lys-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Arg-Tyr His-Thr-Lys-Pro-Tyr-Arg-Tyr His-Thr-Lys-Pro-Tyr-Arg-Tyr His-Thr-Lys-Pro-Tyr-Phe-Tyr His-Thr-Lys-Pro-Tyr-Phe-Tyr His-Thr-Lys-Pro-Tyr-Phe-Tyr His-Thr-Lys-Pro-Tyr-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr-Tyr His-Thr-Lys-Pro-Tyr-Tyr-Tyr His-Thr-Lys-Pro-Tyr-His-Tyr His-Thr-Lys-Pro-Tyr-His-Tyr His-Thr-Lys-Pro-Tyr-His-Tyr His-Thr-Lys-Pro-Tyr-Pro-Tyr His-Thr-Lys-Pro-Tyr-Pro-Tyr His-Thr-Lys-Pro-Tyr-Pro-Tyr His-Thr-Lys-Pro-Tyr-Lys-Tyr His-Thr-Lys-Pro-Tyr-Lys-Tyr His-Thr-Lys-Pro-Tyr-Lys-Tyr His-Thr-Lys-Pro-Arg-Tyr His-Thr-Lys-Pro-Arg-Tyr His-Thr-Lys-Pro-Arg-Tyr His-Thr-Lys-Pro-Arg-Arg-Tyr His-Thr-Lys-Pro-Arg-Arg-Tyr His-Thr-Lys-Pro-Arg-Arg-Tyr His-Thr-Lys-Pro-Arg-Phe-Tyr His-Thr-Lys-Pro-Arg-Phe-Tyr His-Thr-Lys-Pro-Arg-Phe-Tyr His-Thr-Lys-Pro-Arg-Tyr-Tyr His-Thr-Lys-Pro-Arg-Tyr-Tyr His-Thr-Lys-Pro-Arg-Tyr-Tyr His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Arg-His-Tyr Arg-His-Tyr Pro-Arg-His-Tyr His-Thr-Lys-Pro-Arg-Pro-Tyr His-Thr-Lys-Pro-Arg-Pro-Tyr His-Thr-Lys-Pro-Arg-Pro-Tyr His-Thr-Lys-Pro-Arg-Lys-Tyr His-Thr-Lys-Pro-Arg-Lys-Tyr His-Thr-Lys-Pro-Arg-Lys-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Phe-Tyr Lys-Thr-Lys-Pro-Phe-Tyr Lys-Thr-Lys-Pro-Phe-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-His-Tyr Lys-Thr-Lys-Pro-His-Tyr Lys-Thr-Lys-Pro-His-Tyr Lys-Thr-Lys-Pro-Lys-Tyr Lys-Thr-Lys-Pro-Lys-Tyr Lys-Thr-Lys-Pro-Lys-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Tyr Lys-Thr-Lys-Pro-Gly-Arg-Tyr Lys-Thr-Lys-Pro-Gly-Arg-Tyr Lys-Thr-Lys-Pro-Gly-Arg-Tyr Lys-Thr-Lys-Pro-Gly-Phe-Tyr Lys-Thr-Lys-Pro-Gly-Phe-Tyr Lys-Thr-Lys-Pro-Gly-Phe-Tyr Lys-Thr-Lys-Pro-Gly-Tyr-Tyr Lys-Thr-Lys-Pro-Gly-Tyr-Tyr Lys-Thr-Lys-Pro-Gly-Tyr-Tyr Lys-Thr-Lys-Pro-Gly-His-Tyr Lys-Thr-Lys-Pro-Gly-His-Tyr Lys-Thr-Lys-Pro-Gly-His-Tyr

Lys-Thr-Lys-Pro-Gly-Pro-Tyr Lys-Thr-Lys-Pro-Gly-Pro-Tyr Lys-Thr-Lys-Pro-Gly-Pro-Tyr Lys-Thr-Lys-Pro-Gly-Lys-Tyr Lys-Thr-Lys-Pro-Gly-Lys-Tyr Lys-Thr-Lys-Pro-Gly-Lys-Tyr Lys-Thr-Lys-Pro-Asp-Tyr Lys-Thr-Lys-Pro-Asp-Tyr Lys-Thr-Lys-Pro-Asp-Tyr Lys-Thr-Lys-Pro-Asp-Arg-Tyr Lys-Thr-Lys-Pro-Asp-Arg-Tyr Lys-Thr-Lys-Pro-Asp-Arg-Tyr Lys-Thr-Lys-Pro-Asp-Phe-Tyr Lys-Thr-Lys-Pro-Asp-Phe-Tyr Lys-Thr-Lys-Pro-Asp-Phe-Tyr Lys-Thr-Lys-Pro-Asp-Tyr-Tyr Lys-Thr-Lys-Pro-Asp-Tyr-Tyr Lys-Thr-Lys-Pro-Asp-Tyr-Tyr Lys-Thr-Lys-Pro-Asp-His-Tyr Lys-Thr-Lys-Pro-Asp-His-Tyr Lys-Thr-Lys-Pro-Asp-His-Tyr Lys-Thr-Lys-Pro-Asp-Pro-Tyr Lys-Thr-Lys-Pro-Asp-Pro-Tyr Lys-Thr-Lys-Pro-Asp-Pro-Tyr Lys-Thr-Lys-Pro-Asp-Lys-Tyr Lys-Thr-Lys-Pro-Asp-Lys-Tyr Lys-Thr-Lys-Pro-Asp-Lys-Tyr Lys-Thr-Lys-Pro-Trp-Tyr Lys-Thr-Lys-Pro-Trp-Tyr Lys-Thr-Lys-Pro-Trp-Tyr Lys-Thr-Lys-Pro-Trp-Arg-Tyr Lys-Thr-Lys-Pro-Trp-Arg-Tyr Lys-Thr-Lys-Pro-Trp-Arg-Tyr Lys-Thr-Lys-Pro-Trp-Phe-Tyr Lys-Thr-Lys-Pro-Trp-Phe-Tyr Lys-Thr-Lys-Pro-Trp-Phe-Tyr Lys-Thr-Lys-Pro-Trp-Tyr-Tyr Lys-Thr-Lys-Pro-Trp-Tyr-Tyr Lys-Thr-Lys-Pro-Trp-Tyr-Tyr Lys-Thr-Lys-Pro-Trp-His-Tyr Lys-Thr-Lys-Pro-Trp-His-Tyr Lys-Thr-Lys-Pro-Trp-His-Tyr Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Trp-Pro-Tyr Pro-Trp-Pro-Tyr Pro-Trp-Pro-Tyr Lys-Thr-Lys-Pro-Trp-Lys-Tyr Lys-Thr-Lys-Pro-Trp-Lys-Tyr Lys-Thr-Lys-Pro-Trp-Lys-Tyr Lys-Thr-Lys-Pro-Gln-Tyr Lys-Thr-Lys-Pro-Gln-Tyr Lys-Thr-Lys-Pro-Gln-Tyr Lys-Thr-Lys-Pro-Gln-Arg-Tyr Lys-Thr-Lys-Pro-Gln-Arg-Tyr Lys-Thr-Lys-Pro-Gln-Arg-Tyr Lys-Thr-Lys-Pro-Gln-Phe-Tyr Lys-Thr-Lys-Pro-Gln-Phe-Tyr Lys-Thr-Lys-Pro-Gln-Phe-Tyr Lys-Thr-Lys-Pro-Gln-Tyr-Tyr Lys-Thr-Lys-Pro-Gln-Tyr-Tyr Lys-Thr-Lys-Pro-Gln-Tyr-Tyr Lys-Thr-Lys-Pro-Gln-His-Tyr Lys-Thr-Lys-Pro-Gln-His-Tyr Lys-Thr-Lys-Pro-Gln-His-Tyr Lys-Thr-Lys-Pro-Gln-Pro-Tyr Lys-Thr-Lys-Pro-Gln-Pro-Tyr Lys-Thr-Lys-Pro-Gln-Pro-Tyr Lys-Thr-Lys-Pro-Gln-Lys-Tyr Lys-Thr-Lys-Pro-Gln-Lys-Tyr Lys-Thr-Lys-Pro-Gln-Lys-Tyr Lys-Thr-Lys-Pro-Asn-Tyr Lys-Thr-Lys-Pro-Asn-Tyr Lys-Thr-Lys-Pro-Asn-Tyr Lys-Thr-Lys-Pro-Asn-Arg-Tyr Lys-Thr-Lys-Pro-Asn-Arg-Tyr Lys-Thr-Lys-Pro-Asn-Arg-Tyr Lys-Thr-Lys-Pro-Asn-Phe-Tyr Lys-Thr-Lys-Pro-Asn-Phe-Tyr Lys-Thr-Lys-Pro-Asn-Phe-Tyr Lys-Thr-Lys-Pro-Asn-Tyr-Tyr Lys-Thr-Lys-Pro-Asn-Tyr-Tyr Lys-Thr-Lys-Pro-Asn-Tyr-Tyr Lys-Thr-Lys-Pro-Asn-His-Tyr Lys-Thr-Lys-Pro-Asn-His-Tyr Lys-Thr-Lys-Pro-Asn-His-Tyr Lys-Thr-Lys-Pro-Asn-Pro-Tyr Lys-Thr-Lys-Pro-Asn-Pro-Tyr Lys-Thr-Lys-Pro-Asn-Pro-Tyr

Lys-Thr-Lys-Pro-Asn-Lys-Tyr Lys-Thr-Lys-Pro-Asn-Lys-Tyr Lys-Thr-Lys-Pro-Asn-Lys-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Arg-Tyr Lys-Thr-Lys-Pro-Tyr-Arg-Tyr Lys-Thr-Lys-Pro-Tyr-Arg-Tyr Lys-Thr-Lys-Pro-Tyr-Phe-Tyr Lys-Thr-Lys-Pro-Tyr-Phe-Tyr Lys-Thr-Lys-Pro-Tyr-Phe-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-Tyr-Tyr Lys-Thr-Lys-Pro-Tyr-His-Tyr Lys-Thr-Lys-Pro-Tyr-His-Tyr Lys-Thr-Lys-Pro-Tyr-His-Tyr Lys-Thr-Lys-Pro-Tyr-Pro-Tyr Lys-Thr-Lys-Pro-Tyr-Pro-Tyr Lys-Thr-Lys-Pro-Tyr-Pro-Tyr Lys-Thr-Lys-Pro-Tyr-Lys-Tyr Lys-Thr-Lys-Pro-Tyr-Lys-Tyr Lys-Thr-Lys-Pro-Tyr-Lys-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Arg-Tyr Lys-Thr-Lys-Pro-Arg-Phe-Tyr Lys-Thr-Lys-Pro-Arg-Phe-Tyr Lys-Thr-Lys-Pro-Arg-Phe-Tyr Lys-Thr-Lys-Pro-Arg-Tyr-Tyr Lys-Thr-Lys-Pro-Arg-Tyr-Tyr Lys-Thr-Lys-Pro-Arg-Tyr-Tyr Lys-Thr-Lys-Pro-Arg-His-Tyr Lys-Thr-Lys-Pro-Arg-His-Tyr Lys-Thr-Lys-Pro-Arg-His-Tyr Lys-Thr-Lys-Pro-Arg-Pro-Tyr Lys-Thr-Lys-Pro-Arg-Pro-Tyr Lys-Thr-Lys-Pro-Arg-Pro-Tyr Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Arg-Lys-Tyr Pro-Arg-Lys-Tyr Pro-Arg-Lys-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Phe-Tyr Gly-Thr-Lys-Pro-Phe-Tyr Gly-Thr-Lys-Pro-Phe-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-His-Tyr Gly-Thr-Lys-Pro-His-Tyr Gly-Thr-Lys-Pro-His-Tyr Gly-Thr-Lys-Pro-Lys-Tyr Gly-Thr-Lys-Pro-Lys-Tyr Gly-Thr-Lys-Pro-Lys-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Tyr Gly-Thr-Lys-Pro-Gly-Arg-Tyr Gly-Thr-Lys-Pro-Gly-Arg-Tyr Gly-Thr-Lys-Pro-Gly-Arg-Tyr Gly-Thr-Lys-Pro-Gly-Phe-Tyr Gly-Thr-Lys-Pro-Gly-Phe-Tyr Gly-Thr-Lys-Pro-Gly-Phe-Tyr Gly-Thr-Lys-Pro-Gly-Tyr-Tyr Gly-Thr-Lys-Pro-Gly-Tyr-Tyr Gly-Thr-Lys-Pro-Gly-Tyr-Tyr Gly-Thr-Lys-Pro-Gly-His-Tyr Gly-Thr-Lys-Pro-Gly-His-Tyr Gly-Thr-Lys-Pro-Gly-His-Tyr Gly-Thr-Lys-Pro-Gly-Pro-Tyr Gly-Thr-Lys-Pro-Gly-Pro-Tyr Gly-Thr-Lys-Pro-Gly-Pro-Tyr Gly-Thr-Lys-Pro-Gly-Lys-Tyr Gly-Thr-Lys-Pro-Gly-Lys-Tyr Gly-Thr-Lys-Pro-Gly-Lys-Tyr

Gly-Thr-Lys-Pro-Asp-Tyr Gly-Thr-Lys-Pro-Asp-Tyr Gly-Thr-Lys-Pro-Asp-Tyr Gly-Thr-Lys-Pro-Asp-Arg-Tyr Gly-Thr-Lys-Pro-Asp-Arg-Tyr Gly-Thr-Lys-Pro-Asp-Arg-Tyr Gly-Thr-Lys-Pro-Asp-Phe-Tyr Gly-Thr-Lys-Pro-Asp-Phe-Tyr Gly-Thr-Lys-Pro-Asp-Phe-Tyr Gly-Thr-Lys-Pro-Asp-Tyr-Tyr Gly-Thr-Lys-Pro-Asp-Tyr-Tyr Gly-Thr-Lys-Pro-Asp-Tyr-Tyr Gly-Thr-Lys-Pro-Asp-His-Tyr Gly-Thr-Lys-Pro-Asp-His-Tyr Gly-Thr-Lys-Pro-Asp-His-Tyr Gly-Thr-Lys-Pro-Asp-Pro-Tyr Gly-Thr-Lys-Pro-Asp-Pro-Tyr Gly-Thr-Lys-Pro-Asp-Pro-Tyr Gly-Thr-Lys-Pro-Asp-Lys-Tyr Gly-Thr-Lys-Pro-Asp-Lys-Tyr Gly-Thr-Lys-Pro-Asp-Lys-Tyr Gly-Thr-Lys-Pro-Trp-Tyr Gly-Thr-Lys-Pro-Trp-Tyr Gly-Thr-Lys-Pro-Trp-Tyr Gly-Thr-Lys-Pro-Trp-Arg-Tyr Gly-Thr-Lys-Pro-Trp-Arg-Tyr Gly-Thr-Lys-Pro-Trp-Arg-Tyr Gly-Thr-Lys-Pro-Trp-Phe-Tyr Gly-Thr-Lys-Pro-Trp-Phe-Tyr Gly-Thr-Lys-Pro-Trp-Phe-Tyr Gly-Thr-Lys-Pro-Trp-Tyr-Tyr Gly-Thr-Lys-Pro-Trp-Tyr-Tyr Gly-Thr-Lys-Pro-Trp-Tyr-Tyr Gly-Thr-Lys-Pro-Trp-His-Tyr Gly-Thr-Lys-Pro-Trp-His-Tyr Gly-Thr-Lys-Pro-Trp-His-Tyr Gly-Thr-Lys-Pro-Trp-Pro-Tyr Gly-Thr-Lys-Pro-Trp-Pro-Tyr Gly-Thr-Lys-Pro-Trp-Pro-Tyr Gly-Thr-Lys-Pro-Trp-Lys-Tyr Gly-Thr-Lys-Pro-Trp-Lys-Tyr Gly-Thr-Lys-Pro-Trp-Lys-Tyr Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Gln-Tyr Pro-Gln-Tyr Pro-Gln-Tyr Gly-Thr-Lys-Pro-Gln-Arg-Tyr Gly-Thr-Lys-Pro-Gln-Arg-Tyr Gly-Thr-Lys-Pro-Gln-Arg-Tyr Gly-Thr-Lys-Pro-Gln-Phe-Tyr Gly-Thr-Lys-Pro-Gln-Phe-Tyr Gly-Thr-Lys-Pro-Gln-Phe-Tyr Gly-Thr-Lys-Pro-Gln-Tyr-Tyr Gly-Thr-Lys-Pro-Gln-Tyr-Tyr Gly-Thr-Lys-Pro-Gln-Tyr-Tyr Gly-Thr-Lys-Pro-Gln-His-Tyr Gly-Thr-Lys-Pro-Gln-His-Tyr Gly-Thr-Lys-Pro-Gln-His-Tyr Gly-Thr-Lys-Pro-Gln-Pro-Tyr Gly-Thr-Lys-Pro-Gln-Pro-Tyr Gly-Thr-Lys-Pro-Gln-Pro-Tyr Gly-Thr-Lys-Pro-Gln-Lys-Tyr Gly-Thr-Lys-Pro-Gln-Lys-Tyr Gly-Thr-Lys-Pro-Gln-Lys-Tyr Gly-Thr-Lys-Pro-Asn-Tyr Gly-Thr-Lys-Pro-Asn-Tyr Gly-Thr-Lys-Pro-Asn-Tyr Gly-Thr-Lys-Pro-Asn-Arg-Tyr Gly-Thr-Lys-Pro-Asn-Arg-Tyr Gly-Thr-Lys-Pro-Asn-Arg-Tyr Gly-Thr-Lys-Pro-Asn-Phe-Tyr Gly-Thr-Lys-Pro-Asn-Phe-Tyr Gly-Thr-Lys-Pro-Asn-Phe-Tyr Gly-Thr-Lys-Pro-Asn-Tyr-Tyr Gly-Thr-Lys-Pro-Asn-Tyr-Tyr Gly-Thr-Lys-Pro-Asn-Tyr-Tyr Gly-Thr-Lys-Pro-Asn-His-Tyr Gly-Thr-Lys-Pro-Asn-His-Tyr Gly-Thr-Lys-Pro-Asn-His-Tyr Gly-Thr-Lys-Pro-Asn-Pro-Tyr Gly-Thr-Lys-Pro-Asn-Pro-Tyr Gly-Thr-Lys-Pro-Asn-Pro-Tyr Gly-Thr-Lys-Pro-Asn-Lys-Tyr Gly-Thr-Lys-Pro-Asn-Lys-Tyr Gly-Thr-Lys-Pro-Asn-Lys-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr

Gly-Thr-Lys-Pro-Tyr-Arg-Tyr Gly-Thr-Lys-Pro-Tyr-Arg-Tyr Gly-Thr-Lys-Pro-Tyr-Arg-Tyr Gly-Thr-Lys-Pro-Tyr-Phe-Tyr Gly-Thr-Lys-Pro-Tyr-Phe-Tyr Gly-Thr-Lys-Pro-Tyr-Phe-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-Tyr-Tyr Gly-Thr-Lys-Pro-Tyr-His-Tyr Gly-Thr-Lys-Pro-Tyr-His-Tyr Gly-Thr-Lys-Pro-Tyr-His-Tyr Gly-Thr-Lys-Pro-Tyr-Pro-Tyr Gly-Thr-Lys-Pro-Tyr-Pro-Tyr Gly-Thr-Lys-Pro-Tyr-Pro-Tyr Gly-Thr-Lys-Pro-Tyr-Lys-Tyr Gly-Thr-Lys-Pro-Tyr-Lys-Tyr Gly-Thr-Lys-Pro-Tyr-Lys-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Arg-Tyr Gly-Thr-Lys-Pro-Arg-Phe-Tyr Gly-Thr-Lys-Pro-Arg-Phe-Tyr Gly-Thr-Lys-Pro-Arg-Phe-Tyr Gly-Thr-Lys-Pro-Arg-Tyr-Tyr Gly-Thr-Lys-Pro-Arg-Tyr-Tyr Gly-Thr-Lys-Pro-Arg-Tyr-Tyr Gly-Thr-Lys-Pro-Arg-His-Tyr Gly-Thr-Lys-Pro-Arg-His-Tyr Gly-Thr-Lys-Pro-Arg-His-Tyr Gly-Thr-Lys-Pro-Arg-Pro-Tyr Gly-Thr-Lys-Pro-Arg-Pro-Tyr Gly-Thr-Lys-Pro-Arg-Pro-Tyr Gly-Thr-Lys-Pro-Arg-Lys-Tyr Gly-Thr-Lys-Pro-Arg-Lys-Tyr Gly-Thr-Lys-Pro-Arg-Lys-Tyr Thr-Lys-Pro-Arg-Trp Thr-Lys-Pro-Arg-Trp Thr-Lys-Pro-Arg-Trp Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Phe-Trp Phe-Trp Phe-Trp Thr-Lys-Pro-Tyr-Trp Thr-Lys-Pro-Tyr-Trp Thr-Lys-Pro-Tyr-Trp Thr-Lys-Pro-Gly-Trp Thr-Lys-Pro-Gly-Trp Thr-Lys-Pro-Gly-Trp Thr-Lys-Pro-His-Trp Thr-Lys-Pro-His-Trp Thr-Lys-Pro-His-Trp Thr-Lys-Pro-Lys-Trp Thr-Lys-Pro-Lys-Trp Thr-Lys-Pro-Lys-Trp Thr-Lys-Pro-Gly-Trp Thr-Lys-Pro-Gly-Trp Thr-Lys-Pro-Gly-Trp Thr-Lys-Pro-Gly-Arg-Trp Thr-Lys-Pro-Gly-Arg-Trp Thr-Lys-Pro-Gly-Arg-Trp Thr-Lys-Pro-Gly-Phe-Trp Thr-Lys-Pro-Gly-Phe-Trp Thr-Lys-Pro-Gly-Phe-Trp Thr-Lys-Pro-Gly-Tyr-Trp Thr-Lys-Pro-Gly-Tyr-Trp Thr-Lys-Pro-Gly-Tyr-Trp Thr-Lys-Pro-Gly-His-Trp Thr-Lys-Pro-Gly-His-Trp Thr-Lys-Pro-Gly-His-Trp Thr-Lys-Pro-Gly-Pro-Trp Thr-Lys-Pro-Gly-Pro-Trp Thr-Lys-Pro-Gly-Pro-Trp Thr-Lys-Pro-Gly-Lys-Trp Thr-Lys-Pro-Gly-Lys-Trp Thr-Lys-Pro-Gly-Lys-Trp Thr-Lys-Pro-Asp-Trp Thr-Lys-Pro-Asp-Trp Thr-Lys-Pro-Asp-Trp Thr-Lys-Pro-Asp-Arg-Trp Thr-Lys-Pro-Asp-Arg-Trp Thr-Lys-Pro-Asp-Arg-Trp Thr-Lys-Pro-Asp-Phe-Trp Thr-Lys-Pro-Asp-Phe-Trp Thr-Lys-Pro-Asp-Phe-Trp

Thr-Lys-Pro-Asp-Tyr-Trp Thr-Lys-Pro-Asp-Tyr-Trp Thr-Lys-Pro-Asp-Tyr-Trp Thr-Lys-Pro-Asp-His-Trp Thr-Lys-Pro-Asp-His-Trp Thr-Lys-Pro-Asp-His-Trp Thr-Lys-Pro-Asp-Pro-Trp Thr-Lys-Pro-Asp-Pro-Trp Thr-Lys-Pro-Asp-Pro-Trp Thr-Lys-Pro-Asp-Lys-Trp Thr-Lys-Pro-Asp-Lys-Trp Thr-Lys-Pro-Asp-Lys-Trp Thr-Lys-Pro-Trp-Trp Thr-Lys-Pro-Trp-Trp Thr-Lys-Pro-Trp-Trp Thr-Lys-Pro-Trp-Arg-Trp Thr-Lys-Pro-Trp-Arg-Trp Thr-Lys-Pro-Trp-Arg-Trp Thr-Lys-Pro-Trp-Phe-Trp Thr-Lys-Pro-Trp-Phe-Trp Thr-Lys-Pro-Trp-Phe-Trp Thr-Lys-Pro-Trp-Tyr-Trp Thr-Lys-Pro-Trp-Tyr-Trp Thr-Lys-Pro-Trp-Tyr-Trp Thr-Lys-Pro-Trp-His-Trp Thr-Lys-Pro-Trp-His-Trp Thr-Lys-Pro-Trp-His-Trp Thr-Lys-Pro-Trp-Pro-Trp Thr-Lys-Pro-Trp-Pro-Trp Thr-Lys-Pro-Trp-Pro-Trp Thr-Lys-Pro-Trp-Lys-Trp Thr-Lys-Pro-Trp-Lys-Trp Thr-Lys-Pro-Trp-Lys-Trp Thr-Lys-Pro-Gln-Trp Thr-Lys-Pro-Gln-Trp Thr-Lys-Pro-Gln-Trp Thr-Lys-Pro-Gln-Arg-Trp Thr-Lys-Pro-Gln-Arg-Trp Thr-Lys-Pro-Gln-Arg-Trp Thr-Lys-Pro-Gln-Phe-Trp Thr-Lys-Pro-Gln-Phe-Trp Thr-Lys-Pro-Gln-Phe-Trp Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Gln-Tyr-Trp Gln-Tyr-Trp Gln-Tyr-Trp Thr-Lys-Pro-Gln-His-Trp Thr-Lys-Pro-Gln-His-Trp Thr-Lys-Pro-Gln-His-Trp Thr-Lys-Pro-Gln-Pro-Trp Thr-Lys-Pro-Gln-Pro-Trp Thr-Lys-Pro-Gln-Pro-Trp Thr-Lys-Pro-Gln-Lys-Trp Thr-Lys-Pro-Gln-Lys-Trp Thr-Lys-Pro-Gln-Lys-Trp Thr-Lys-Pro-Asn-Trp Thr-Lys-Pro-Asn-Trp Thr-Lys-Pro-Asn-Trp Thr-Lys-Pro-Asn-Arg-Trp Thr-Lys-Pro-Asn-Arg-Trp Thr-Lys-Pro-Asn-Arg-Trp Thr-Lys-Pro-Asn-Phe-Trp Thr-Lys-Pro-Asn-Phe-Trp Thr-Lys-Pro-Asn-Phe-Trp Thr-Lys-Pro-Asn-Tyr-Trp Thr-Lys-Pro-Asn-Tyr-Trp Thr-Lys-Pro-Asn-Tyr-Trp Thr-Lys-Pro-Asn-His-Trp Thr-Lys-Pro-Asn-His-Trp Thr-Lys-Pro-Asn-His-Trp Thr-Lys-Pro-Asn-Pro-Trp Thr-Lys-Pro-Asn-Pro-Trp Thr-Lys-Pro-Asn-Pro-Trp Thr-Lys-Pro-Asn-Lys-Trp Thr-Lys-Pro-Asn-Lys-Trp Thr-Lys-Pro-Asn-Lys-Trp Thr-Lys-Pro-Tyr-Trp Thr-Lys-Pro-Tyr-Trp Thr-Lys-Pro-Tyr-Trp Thr-Lys-Pro-Tyr-Arg-Trp Thr-Lys-Pro-Tyr-Arg-Trp Thr-Lys-Pro-Tyr-Arg-Trp Thr-Lys-Pro-Tyr-Phe-Trp Thr-Lys-Pro-Tyr-Phe-Trp Thr-Lys-Pro-Tyr-Phe-Trp Thr-Lys-Pro-Tyr-Tyr-Trp Thr-Lys-Pro-Tyr-Tyr-Trp Thr-Lys-Pro-Tyr-Tyr-Trp

Thr-Lys-Pro-Tyr-His-Trp Thr-Lys-Pro-Tyr-His-Trp Thr-Lys-Pro-Tyr-His-Trp Thr-Lys-Pro-Tyr-Pro-Trp Thr-Lys-Pro-Tyr-Pro-Trp Thr-Lys-Pro-Tyr-Pro-Trp Thr-Lys-Pro-Tyr-Lys-Trp Thr-Lys-Pro-Tyr-Lys-Trp Thr-Lys-Pro-Tyr-Lys-Trp Thr-Lys-Pro-Arg-Trp Thr-Lys-Pro-Arg-Trp Thr-Lys-Pro-Arg-Trp Thr-Lys-Pro-Arg-Arg-Trp Thr-Lys-Pro-Arg-Arg-Trp Thr-Lys-Pro-Arg-Arg-Trp Thr-Lys-Pro-Arg-Phe-Trp Thr-Lys-Pro-Arg-Phe-Trp Thr-Lys-Pro-Arg-Phe-Trp Thr-Lys-Pro-Arg-Tyr-Trp Thr-Lys-Pro-Arg-Tyr-Trp Thr-Lys-Pro-Arg-Tyr-Trp Thr-Lys-Pro-Arg-His-Trp Thr-Lys-Pro-Arg-His-Trp Thr-Lys-Pro-Arg-His-Trp Thr-Lys-Pro-Arg-Pro-Trp Thr-Lys-Pro-Arg-Pro-Trp Thr-Lys-Pro-Arg-Pro-Trp Thr-Lys-Pro-Arg-Lys-Trp Thr-Lys-Pro-Arg-Lys-Trp Thr-Lys-Pro-Arg-Lys-Trp Met-Thr-Lys-Pro-Trp Met-Thr-Lys-Pro-Trp Met-Thr-Lys-Pro-Trp Met-Thr-Lys-Pro-Arg-Trp Met-Thr-Lys-Pro-Arg-Trp Met-Thr-Lys-Pro-Arg-Trp Met-Thr-Lys-Pro-Phe-Trp Met-Thr-Lys-Pro-Phe-Trp Met-Thr-Lys-Pro-Phe-Trp Met-Thr-Lys-Pro-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Trp Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Gly-Trp Pro-Gly-Trp Pro-Gly-Trp Met-Thr-Lys-Pro-His-Trp Met-Thr-Lys-Pro-His-Trp Met-Thr-Lys-Pro-His-Trp Met-Thr-Lys-Pro-Lys-Trp Met-Thr-Lys-Pro-Lys-Trp Met-Thr-Lys-Pro-Lys-Trp Met-Thr-Lys-Pro-Gly-Trp Met-Thr-Lys-Pro-Gly-Trp Met-Thr-Lys-Pro-Gly-Trp Met-Thr-Lys-Pro-Gly-Arg-Trp Met-Thr-Lys-Pro-Gly-Arg-Trp Met-Thr-Lys-Pro-Gly-Arg-Trp Met-Thr-Lys-Pro-Gly-Phe-Trp Met-Thr-Lys-Pro-Gly-Phe-Trp Met-Thr-Lys-Pro-Gly-Phe-Trp Met-Thr-Lys-Pro-Gly-Tyr-Trp Met-Thr-Lys-Pro-Gly-Tyr-Trp Met-Thr-Lys-Pro-Gly-Tyr-Trp Met-Thr-Lys-Pro-Gly-His-Trp Met-Thr-Lys-Pro-Gly-His-Trp Met-Thr-Lys-Pro-Gly-His-Trp Met-Thr-Lys-Pro-Gly-Pro-Trp Met-Thr-Lys-Pro-Gly-Pro-Trp Met-Thr-Lys-Pro-Gly-Pro-Trp Met-Thr-Lys-Pro-Gly-Lys-Trp Met-Thr-Lys-Pro-Gly-Lys-Trp Met-Thr-Lys-Pro-Gly-Lys-Trp Met-Thr-Lys-Pro-Asp-Trp Met-Thr-Lys-Pro-Asp-Trp Met-Thr-Lys-Pro-Asp-Trp Met-Thr-Lys-Pro-Asp-Arg-Trp Met-Thr-Lys-Pro-Asp-Arg-Trp Met-Thr-Lys-Pro-Asp-Arg-Trp Met-Thr-Lys-Pro-Asp-Phe-Trp Met-Thr-Lys-Pro-Asp-Phe-Trp Met-Thr-Lys-Pro-Asp-Phe-Trp Met-Thr-Lys-Pro-Asp-Tyr-Trp Met-Thr-Lys-Pro-Asp-Tyr-Trp Met-Thr-Lys-Pro-Asp-Tyr-Trp Met-Thr-Lys-Pro-Asp-His-Trp Met-Thr-Lys-Pro-Asp-His-Trp Met-Thr-Lys-Pro-Asp-His-Trp

Met-Thr-Lys-Pro-Asp-Pro-Trp Met-Thr-Lys-Pro-Asp-Pro-Trp Met-Thr-Lys-Pro-Asp-Pro-Trp Met-Thr-Lys-Pro-Asp-Lys-Trp Met-Thr-Lys-Pro-Asp-Lys-Trp Met-Thr-Lys-Pro-Asp-Lys-Trp Met-Thr-Lys-Pro-Trp-Trp Met-Thr-Lys-Pro-Trp-Trp Met-Thr-Lys-Pro-Trp-Trp Met-Thr-Lys-Pro-Trp-Arg-Trp Met-Thr-Lys-Pro-Trp-Arg-Trp Met-Thr-Lys-Pro-Trp-Arg-Trp Met-Thr-Lys-Pro-Trp-Phe-Trp Met-Thr-Lys-Pro-Trp-Phe-Trp Met-Thr-Lys-Pro-Trp-Phe-Trp Met-Thr-Lys-Pro-Trp-Tyr-Trp Met-Thr-Lys-Pro-Trp-Tyr-Trp Met-Thr-Lys-Pro-Trp-Tyr-Trp Met-Thr-Lys-Pro-Trp-His-Trp Met-Thr-Lys-Pro-Trp-His-Trp Met-Thr-Lys-Pro-Trp-His-Trp Met-Thr-Lys-Pro-Trp-Pro-Trp Met-Thr-Lys-Pro-Trp-Pro-Trp Met-Thr-Lys-Pro-Trp-Pro-Trp Met-Thr-Lys-Pro-Trp-Lys-Trp Met-Thr-Lys-Pro-Trp-Lys-Trp Met-Thr-Lys-Pro-Trp-Lys-Trp Met-Thr-Lys-Pro-Gln-Trp Met-Thr-Lys-Pro-Gln-Trp Met-Thr-Lys-Pro-Gln-Trp Met-Thr-Lys-Pro-Gln-Arg-Trp Met-Thr-Lys-Pro-Gln-Arg-Trp Met-Thr-Lys-Pro-Gln-Arg-Trp Met-Thr-Lys-Pro-Gln-Phe-Trp Met-Thr-Lys-Pro-Gln-Phe-Trp Met-Thr-Lys-Pro-Gln-Phe-Trp Met-Thr-Lys-Pro-Gln-Tyr-Trp Met-Thr-Lys-Pro-Gln-Tyr-Trp Met-Thr-Lys-Pro-Gln-Tyr-Trp Met-Thr-Lys-Pro-Gln-His-Trp Met-Thr-Lys-Pro-Gln-His-Trp Met-Thr-Lys-Pro-Gln-His-Trp Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Gln-Pro-Trp Pro-Gln-Pro-Trp Pro-Gln-Pro-Trp Met-Thr-Lys-Pro-Gln-Lys-Trp Met-Thr-Lys-Pro-Gln-Lys-Trp Met-Thr-Lys-Pro-Gln-Lys-Trp Met-Thr-Lys-Pro-Asn-Trp Met-Thr-Lys-Pro-Asn-Trp Met-Thr-Lys-Pro-Asn-Trp Met-Thr-Lys-Pro-Asn-Arg-Trp Met-Thr-Lys-Pro-Asn-Arg-Trp Met-Thr-Lys-Pro-Asn-Arg-Trp Met-Thr-Lys-Pro-Asn-Phe-Trp Met-Thr-Lys-Pro-Asn-Phe-Trp Met-Thr-Lys-Pro-Asn-Phe-Trp Met-Thr-Lys-Pro-Asn-Tyr-Trp Met-Thr-Lys-Pro-Asn-Tyr-Trp Met-Thr-Lys-Pro-Asn-Tyr-Trp Met-Thr-Lys-Pro-Asn-His-Trp Met-Thr-Lys-Pro-Asn-His-Trp Met-Thr-Lys-Pro-Asn-His-Trp Met-Thr-Lys-Pro-Asn-Pro-Trp Met-Thr-Lys-Pro-Asn-Pro-Trp Met-Thr-Lys-Pro-Asn-Pro-Trp Met-Thr-Lys-Pro-Asn-Lys-Trp Met-Thr-Lys-Pro-Asn-Lys-Trp Met-Thr-Lys-Pro-Asn-Lys-Trp Met-Thr-Lys-Pro-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Arg-Trp Met-Thr-Lys-Pro-Tyr-Arg-Trp Met-Thr-Lys-Pro-Tyr-Arg-Trp Met-Thr-Lys-Pro-Tyr-Phe-Trp Met-Thr-Lys-Pro-Tyr-Phe-Trp Met-Thr-Lys-Pro-Tyr-Phe-Trp Met-Thr-Lys-Pro-Tyr-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Tyr-Trp Met-Thr-Lys-Pro-Tyr-Tyr-Trp Met-Thr-Lys-Pro-Tyr-His-Trp Met-Thr-Lys-Pro-Tyr-His-Trp Met-Thr-Lys-Pro-Tyr-His-Trp Met-Thr-Lys-Pro-Tyr-Pro-Trp Met-Thr-Lys-Pro-Tyr-Pro-Trp Met-Thr-Lys-Pro-Tyr-Pro-Trp

Met-Thr-Lys-Pro-Tyr-Lys-Trp Met-Thr-Lys-Pro-Tyr-Lys-Trp Met-Thr-Lys-Pro-Tyr-Lys-Trp Met-Thr-Lys-Pro-Arg-Trp Met-Thr-Lys-Pro-Arg-Trp Met-Thr-Lys-Pro-Arg-Trp Met-Thr-Lys-Pro-Arg-Arg-Trp Met-Thr-Lys-Pro-Arg-Arg-Trp Met-Thr-Lys-Pro-Arg-Arg-Trp Met-Thr-Lys-Pro-Arg-Phe-Trp Met-Thr-Lys-Pro-Arg-Phe-Trp Met-Thr-Lys-Pro-Arg-Phe-Trp Met-Thr-Lys-Pro-Arg-Tyr-Trp Met-Thr-Lys-Pro-Arg-Tyr-Trp Met-Thr-Lys-Pro-Arg-Tyr-Trp Met-Thr-Lys-Pro-Arg-His-Trp Met-Thr-Lys-Pro-Arg-His-Trp Met-Thr-Lys-Pro-Arg-His-Trp Met-Thr-Lys-Pro-Arg-Pro-Trp Met-Thr-Lys-Pro-Arg-Pro-Trp Met-Thr-Lys-Pro-Arg-Pro-Trp Met-Thr-Lys-Pro-Arg-Lys-Trp Met-Thr-Lys-Pro-Arg-Lys-Trp Met-Thr-Lys-Pro-Arg-Lys-Trp Met(0)-Thr-Lys-Pro-Trp Met(0)-Thr-Lys-Pro-Trp Met(0)-Thr-Lys-Pro-Trp Met(0)-Thr-Lys-Pro-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Trp Met(0)-Thr-Lys-Pro-Phe-Trp Met(0)-Thr-Lys-Pro-Phe-Trp Met(0)-Thr-Lys-Pro-Phe-Trp Met(0)-Thr-Lys-Pro-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Trp Met(0)-Thr-Lys-Pro-Gly-Trp Met(0)-Thr-Lys-Pro-Gly-Trp Met(0)-Thr-Lys-Pro-Gly-Trp Met(0)-Thr-Lys-Pro-His-Trp Met(0)-Thr-Lys-Pro-His-Trp Met(0)-Thr-Lys-Pro-His-Trp Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Lys-Trp Pro-Lys-Trp Pro-Lys-Trp Met(0)-Thr-Lys-Pro-Gly-Trp Met(0)-Thr-Lys-Pro-Gly-Trp Met(0)-Thr-Lys-Pro-Gly-Trp Met(0)-Thr-Lys-Pro-Gly-Arg-Trp Met(0)-Thr-Lys-Pro-Gly-Arg-Trp Met(0)-Thr-Lys-Pro-Gly-Arg-Trp Met(0)-Thr-Lys-Pro-Gly-Phe-Trp Met(0)-Thr-Lys-Pro-Gly-Phe-Trp Met(0)-Thr-Lys-Pro-Gly-Phe-Trp Met(0)-Thr-Lys-Pro-Gly-Tyr-Trp Met(0)-Thr-Lys-Pro-Gly-Tyr-Trp Met(0)-Thr-Lys-Pro-Gly-Tyr-Trp Met(0)-Thr-Lys-Pro-Gly-His-Trp Met(0)-Thr-Lys-Pro-Gly-His-Trp Met(0)-Thr-Lys-Pro-Gly-His-Trp Met(0)-Thr-Lys-Pro-Gly-Pro-Trp Met(0)-Thr-Lys-Pro-Gly-Pro-Trp Met(0)-Thr-Lys-Pro-Gly-Pro-Trp Met(0)-Thr-Lys-Pro-Gly-Lys-Trp Met(0)-Thr-Lys-Pro-Gly-Lys-Trp Met(0)-Thr-Lys-Pro-Gly-Lys-Trp Met(0)-Thr-Lys-Pro-Asp-Trp Met(0)-Thr-Lys-Pro-Asp-Trp Met(0)-Thr-Lys-Pro-Asp-Trp Met(0)-Thr-Lys-Pro-Asp-Arg-Trp Met(0)-Thr-Lys-Pro-Asp-Arg-Trp Met(0)-Thr-Lys-Pro-Asp-Arg-Trp Met(0)-Thr-Lys-Pro-Asp-Phe-Trp Met(0)-Thr-Lys-Pro-Asp-Phe-Trp Met(0)-Thr-Lys-Pro-Asp-Phe-Trp Met(0)-Thr-Lys-Pro-Asp-Tyr-Trp Met(0)-Thr-Lys-Pro-Asp-Tyr-Trp Met(0)-Thr-Lys-Pro-Asp-Tyr-Trp Met(0)-Thr-Lys-Pro-Asp-His-Trp Met(0)-Thr-Lys-Pro-Asp-His-Trp Met(0)-Thr-Lys-Pro-Asp-His-Trp Met(0)-Thr-Lys-Pro-Asp-Pro-Trp Met(0)-Thr-Lys-Pro-Asp-Pro-Trp Met(0)-Thr-Lys-Pro-Asp-Pro-Trp Met(0)-Thr-Lys-Pro-Asp-Lys-Trp Met(0)-Thr-Lys-Pro-Asp-Lys-Trp Met(0)-Thr-Lys-Pro-Asp-Lys-Trp

Met(0)-Thr-Lys-Pro-Trp-Trp Met(0)-Thr-Lys-Pro-Trp-Trp Met(0)-Thr-Lys-Pro-Trp-Trp Met(0)-Thr-Lys-Pro-Trp-Arg-Trp Met(0)-Thr-Lys-Pro-Trp-Arg-Trp Met(0)-Thr-Lys-Pro-Trp-Arg-Trp Met(0)-Thr-Lys-Pro-Trp-Phe-Trp Met(0)-Thr-Lys-Pro-Trp-Phe-Trp Met(0)-Thr-Lys-Pro-Trp-Phe-Trp Met(0)-Thr-Lys-Pro-Trp-Tyr-Trp Met(0)-Thr-Lys-Pro-Trp-Tyr-Trp Met(0)-Thr-Lys-Pro-Trp-Tyr-Trp Met(0)-Thr-Lys-Pro-Trp-His-Trp Met(0)-Thr-Lys-Pro-Trp-His-Trp Met(0)-Thr-Lys-Pro-Trp-His-Trp Met(0)-Thr-Lys-Pro-Trp-Pro-Trp Met(0)-Thr-Lys-Pro-Trp-Pro-Trp Met(0)-Thr-Lys-Pro-Trp-Pro-Trp Met(0)-Thr-Lys-Pro-Trp-Lys-Trp Met(0)-Thr-Lys-Pro-Trp-Lys-Trp Met(0)-Thr-Lys-Pro-Trp-Lys-Trp Met(0)-Thr-Lys-Pro-Gln-Trp Met(0)-Thr-Lys-Pro-Gln-Trp Met(0)-Thr-Lys-Pro-Gln-Trp Met(0)-Thr-Lys-Pro-Gln-Arg-Trp Met(0)-Thr-Lys-Pro-Gln-Arg-Trp Met(0)-Thr-Lys-Pro-Gln-Arg-Trp Met(0)-Thr-Lys-Pro-Gln-Phe-Trp Met(0)-Thr-Lys-Pro-Gln-Phe-Trp Met(0)-Thr-Lys-Pro-Gln-Phe-Trp Met(0)-Thr-Lys-Pro-Gln-Tyr-Trp Met(0)-Thr-Lys-Pro-Gln-Tyr-Trp Met(0)-Thr-Lys-Pro-Gln-Tyr-Trp Met(0)-Thr-Lys-Pro-Gln-His-Trp Met(0)-Thr-Lys-Pro-Gln-His-Trp Met(0)-Thr-Lys-Pro-Gln-His-Trp Met(0)-Thr-Lys-Pro-Gln-Pro-Trp Met(0)-Thr-Lys-Pro-Gln-Pro-Trp Met(0)-Thr-Lys-Pro-Gln-Pro-Trp Met(0)-Thr-Lys-Pro-Gln-Lys-Trp Met(0)-Thr-Lys-Pro-Gln-Lys-Trp Met(0)-Thr-Lys-Pro-Gln-Lys-Trp Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Asn-Trp Pro-Asn-Trp Pro-Asn-Trp Met(0)-Thr-Lys-Pro-Asn-Arg-Trp Met(0)-Thr-Lys-Pro-Asn-Arg-Trp Met(0)-Thr-Lys-Pro-Asn-Arg-Trp Met(0)-Thr-Lys-Pro-Asn-Phe-Trp Met(0)-Thr-Lys-Pro-Asn-Phe-Trp Met(0)-Thr-Lys-Pro-Asn-Phe-Trp Met(0)-Thr-Lys-Pro-Asn-Tyr-Trp Met(0)-Thr-Lys-Pro-Asn-Tyr-Trp Met(0)-Thr-Lys-Pro-Asn-Tyr-Trp Met(0)-Thr-Lys-Pro-Asn-His-Trp Met(0)-Thr-Lys-Pro-Asn-His-Trp Met(0)-Thr-Lys-Pro-Asn-His-Trp Met(0)-Thr-Lys-Pro-Asn-Pro-Trp Met(0)-Thr-Lys-Pro-Asn-Pro-Trp Met(0)-Thr-Lys-Pro-Asn-Pro-Trp Met(0)-Thr-Lys-Pro-Asn-Lys-Trp Met(0)-Thr-Lys-Pro-Asn-Lys-Trp Met(0)-Thr-Lys-Pro-Asn-Lys-Trp Met(0)-Thr-Lys-Pro-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Arg-Trp Met(0)-Thr-Lys-Pro-Tyr-Arg-Trp Met(0)-Thr-Lys-Pro-Tyr-Arg-Trp Met(0)-Thr-Lys-Pro-Tyr-Phe-Trp Met(0)-Thr-Lys-Pro-Tyr-Phe-Trp Met(0)-Thr-Lys-Pro-Tyr-Phe-Trp Met(0)-Thr-Lys-Pro-Tyr-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-Tyr-Trp Met(0)-Thr-Lys-Pro-Tyr-His-Trp Met(0)-Thr-Lys-Pro-Tyr-His-Trp Met(0)-Thr-Lys-Pro-Tyr-His-Trp Met(0)-Thr-Lys-Pro-Tyr-Pro-Trp Met(0)-Thr-Lys-Pro-Tyr-Pro-Trp Met(0)-Thr-Lys-Pro-Tyr-Pro-Trp Met(0)-Thr-Lys-Pro-Tyr-Lys-Trp Met(0)-Thr-Lys-Pro-Tyr-Lys-Trp Met(0)-Thr-Lys-Pro-Tyr-Lys-Trp Met(0)-Thr-Lys-Pro-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Trp

Met(0)-Thr-Lys-Pro-Arg-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Arg-Trp Met(0)-Thr-Lys-Pro-Arg-Phe-Trp Met(0)-Thr-Lys-Pro-Arg-Phe-Trp Met(0)-Thr-Lys-Pro-Arg-Phe-Trp Met(0)-Thr-Lys-Pro-Arg-Tyr-Trp Met(0)-Thr-Lys-Pro-Arg-Tyr-Trp Met(0)-Thr-Lys-Pro-Arg-Tyr-Trp Met(0)-Thr-Lys-Pro-Arg-His-Trp Met(0)-Thr-Lys-Pro-Arg-His-Trp Met(0)-Thr-Lys-Pro-Arg-His-Trp Met(0)-Thr-Lys-Pro-Arg-Pro-Trp Met(0)-Thr-Lys-Pro-Arg-Pro-Trp Met(0)-Thr-Lys-Pro-Arg-Pro-Trp Met(0)-Thr-Lys-Pro-Arg-Lys-Trp Met(0)-Thr-Lys-Pro-Arg-Lys-Trp Met(0)-Thr-Lys-Pro-Arg-Lys-Trp Thr-Thr-Lys-Pro-Trp Thr-Thr-Lys-Pro-Trp Thr-Thr-Lys-Pro-Trp Thr-Thr-Lys-Pro-Arg-Trp Thr-Thr-Lys-Pro-Arg-Trp Thr-Thr-Lys-Pro-Arg-Trp Thr-Thr-Lys-Pro-Phe-Trp Thr-Thr-Lys-Pro-Phe-Trp Thr-Thr-Lys-Pro-Phe-Trp Thr-Thr-Lys-Pro-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Trp Thr-Thr-Lys-Pro-Gly-Trp Thr-Thr-Lys-Pro-Gly-Trp Thr-Thr-Lys-Pro-Gly-Trp Thr-Thr-Lys-Pro-His-Trp Thr-Thr-Lys-Pro-His-Trp Thr-Thr-Lys-Pro-His-Trp Thr-Thr-Lys-Pro-Lys-Trp Thr-Thr-Lys-Pro-Lys-Trp Thr-Thr-Lys-Pro-Lys-Trp Thr-Thr-Lys-Pro-Gly-Trp Thr-Thr-Lys-Pro-Gly-Trp Thr-Thr-Lys-Pro-Gly-Trp Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Gly-Arg-Trp Gly-Arg-Trp Pro-Gly-Arg-Trp Thr-Thr-Lys-Pro-Gly-Phe-Trp Thr-Thr-Lys-Pro-Gly-Phe-Trp Thr-Thr-Lys-Pro-Gly-Phe-Trp Thr-Thr-Lys-Pro-Gly-Tyr-Trp Thr-Thr-Lys-Pro-Gly-Tyr-Trp Thr-Thr-Lys-Pro-Gly-Tyr-Trp Thr-Thr-Lys-Pro-Gly-His-Trp Thr-Thr-Lys-Pro-Gly-His-Trp Thr-Thr-Lys-Pro-Gly-His-Trp Thr-Thr-Lys-Pro-Gly-Pro-Trp Thr-Thr-Lys-Pro-Gly-Pro-Trp Thr-Thr-Lys-Pro-Gly-Pro-Trp Thr-Thr-Lys-Pro-Gly-Lys-Trp Thr-Thr-Lys-Pro-Gly-Lys-Trp Thr-Thr-Lys-Pro-Gly-Lys-Trp Thr-Thr-Lys-Pro-Asp-Trp Thr-Thr-Lys-Pro-Asp-Trp Thr-Thr-Lys-Pro-Asp-Trp Thr-Thr-Lys-Pro-Asp-Arg-Trp Thr-Thr-Lys-Pro-Asp-Arg-Trp Thr-Thr-Lys-Pro-Asp-Arg-Trp Thr-Thr-Lys-Pro-Asp-Phe-Trp Thr-Thr-Lys-Pro-Asp-Phe-Trp Thr-Thr-Lys-Pro-Asp-Phe-Trp Thr-Thr-Lys-Pro-Asp-Tyr-Trp Thr-Thr-Lys-Pro-Asp-Tyr-Trp Thr-Thr-Lys-Pro-Asp-Tyr-Trp Thr-Thr-Lys-Pro-Asp-His-Trp Thr-Thr-Lys-Pro-Asp-His-Trp Thr-Thr-Lys-Pro-Asp-His-Trp Thr-Thr-Lys-Pro-Asp-Pro-Trp Thr-Thr-Lys-Pro-Asp-Pro-Trp Thr-Thr-Lys-Pro-Asp-Pro-Trp Thr-Thr-Lys-Pro-Asp-Lys-Trp Thr-Thr-Lys-Pro-Asp-Lys-Trp Thr-Thr-Lys-Pro-Asp-Lys-Trp Thr-Thr-Lys-Pro-Trp-Trp Thr-Thr-Lys-Pro-Trp-Trp Thr-Thr-Lys-Pro-Trp-Trp Thr-Thr-Lys-Pro-Trp-Arg-Trp Thr-Thr-Lys-Pro-Trp-Arg-Trp Thr-Thr-Lys-Pro-Trp-Arg-Trp

Thr-Thr-Lys-Pro-Trp-Phe-Trp Thr-Thr-Lys-Pro-Trp-Phe-Trp Thr-Thr-Lys-Pro-Trp-Phe-Trp Thr-Thr-Lys-Pro-Trp-Tyr-Trp Thr-Thr-Lys-Pro-Trp-Tyr-Trp Thr-Thr-Lys-Pro-Trp-Tyr-Trp Thr-Thr-Lys-Pro-Trp-His-Trp Thr-Thr-Lys-Pro-Trp-His-Trp Thr-Thr-Lys-Pro-Trp-His-Trp Thr-Thr-Lys-Pro-Trp-Pro-Trp Thr-Thr-Lys-Pro-Trp-Pro-Trp Thr-Thr-Lys-Pro-Trp-Pro-Trp Thr-Thr-Lys-Pro-Trp-Lys-Trp Thr-Thr-Lys-Pro-Trp-Lys-Trp Thr-Thr-Lys-Pro-Trp-Lys-Trp Thr-Thr-Lys-Pro-Gln-Trp Thr-Thr-Lys-Pro-Gln-Trp Thr-Thr-Lys-Pro-Gln-Trp Thr-Thr-Lys-Pro-Gln-Arg-Trp Thr-Thr-Lys-Pro-Gln-Arg-Trp Thr-Thr-Lys-Pro-Gln-Arg-Trp Thr-Thr-Lys-Pro-Gln-Phe-Trp Thr-Thr-Lys-Pro-Gln-Phe-Trp Thr-Thr-Lys-Pro-Gln-Phe-Trp Thr-Thr-Lys-Pro-Gln-Tyr-Trp Thr-Thr-Lys-Pro-Gln-Tyr-Trp Thr-Thr-Lys-Pro-Gln-Tyr-Trp Thr-Thr-Lys-Pro-Gln-His-Trp Thr-Thr-Lys-Pro-Gln-His-Trp Thr-Thr-Lys-Pro-Gln-His-Trp Thr-Thr-Lys-Pro-Gln-Pro-Trp Thr-Thr-Lys-Pro-Gln-Pro-Trp Thr-Thr-Lys-Pro-Gln-Pro-Trp Thr-Thr-Lys-Pro-Gln-Lys-Trp Thr-Thr-Lys-Pro-Gln-Lys-Trp Thr-Thr-Lys-Pro-Gln-Lys-Trp Thr-Thr-Lys-Pro-Asn-Trp Thr-Thr-Lys-Pro-Asn-Trp Thr-Thr-Lys-Pro-Asn-Trp Thr-Thr-Lys-Pro-Asn-Arg-Trp Thr-Thr-Lys-Pro-Asn-Arg-Trp Thr-Thr-Lys-Pro-Asn-Arg-Trp Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Asn-Phe-Trp Asn-Phe-Trp Pro-Asn-Phe-Trp Thr-Thr-Lys-Pro-Asn-Tyr-Trp Thr-Thr-Lys-Pro-Asn-Tyr-Trp Thr-Thr-Lys-Pro-Asn-Tyr-Trp Thr-Thr-Lys-Pro-Asn-His-Trp Thr-Thr-Lys-Pro-Asn-His-Trp Thr-Thr-Lys-Pro-Asn-His-Trp Thr-Thr-Lys-Pro-Asn-Pro-Trp Thr-Thr-Lys-Pro-Asn-Pro-Trp Thr-Thr-Lys-Pro-Asn-Pro-Trp Thr-Thr-Lys-Pro-Asn-Lys-Trp Thr-Thr-Lys-Pro-Asn-Lys-Trp Thr-Thr-Lys-Pro-Asn-Lys-Trp Thr-Thr-Lys-Pro-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Arg-Trp Thr-Thr-Lys-Pro-Tyr-Arg-Trp Thr-Thr-Lys-Pro-Tyr-Arg-Trp Thr-Thr-Lys-Pro-Tyr-Phe-Trp Thr-Thr-Lys-Pro-Tyr-Phe-Trp Thr-Thr-Lys-Pro-Tyr-Phe-Trp Thr-Thr-Lys-Pro-Tyr-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-Tyr-Trp Thr-Thr-Lys-Pro-Tyr-His-Trp Thr-Thr-Lys-Pro-Tyr-His-Trp Thr-Thr-Lys-Pro-Tyr-His-Trp Thr-Thr-Lys-Pro-Tyr-Pro-Trp Thr-Thr-Lys-Pro-Tyr-Pro-Trp Thr-Thr-Lys-Pro-Tyr-Pro-Trp Thr-Thr-Lys-Pro-Tyr-Lys-Trp Thr-Thr-Lys-Pro-Tyr-Lys-Trp Thr-Thr-Lys-Pro-Tyr-Lys-Trp Thr-Thr-Lys-Pro-Arg-Trp Thr-Thr-Lys-Pro-Arg-Trp Thr-Thr-Lys-Pro-Arg-Trp Thr-Thr-Lys-Pro-Arg-Arg-Trp Thr-Thr-Lys-Pro-Arg-Arg-Trp Thr-Thr-Lys-Pro-Arg-Arg-Trp Thr-Thr-Lys-Pro-Arg-Phe-Trp Thr-Thr-Lys-Pro-Arg-Phe-Trp Thr-Thr-Lys-Pro-Arg-Phe-Trp

Thr-Thr-Lys-Pro-Arg-Tyr-Trp Thr-Thr-Lys-Pro-Arg-Tyr-Trp Thr-Thr-Lys-Pro-Arg-Tyr-Trp Thr-Thr-Lys-Pro-Arg-His-Trp Thr-Thr-Lys-Pro-Arg-His-Trp Thr-Thr-Lys-Pro-Arg-His-Trp Thr-Thr-Lys-Pro-Arg-Pro-Trp Thr-Thr-Lys-Pro-Arg-Pro-Trp Thr-Thr-Lys-Pro-Arg-Pro-Trp Thr-Thr-Lys-Pro-Arg-Lys-Trp Thr-Thr-Lys-Pro-Arg-Lys-Trp Thr-Thr-Lys-Pro-Arg-Lys-Trp Ala-Thr-Lys-Pro-Trp Ala-Thr-Lys-Pro-Trp Ala-Thr-Lys-Pro-Trp Ala-Thr-Lys-Pro-Arg-Trp Ala-Thr-Lys-Pro-Arg-Trp Ala-Thr-Lys-Pro-Arg-Trp Ala-Thr-Lys-Pro-Phe-Trp Ala-Thr-Lys-Pro-Phe-Trp Ala-Thr-Lys-Pro-Phe-Trp Ala-Thr-Lys-Pro-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Trp Ala-Thr-Lys-Pro-Gly-Trp Ala-Thr-Lys-Pro-Gly-Trp Ala-Thr-Lys-Pro-Gly-Trp Ala-Thr-Lys-Pro-His-Trp Ala-Thr-Lys-Pro-His-Trp Ala-Thr-Lys-Pro-His-Trp Ala-Thr-Lys-Pro-Lys-Trp Ala-Thr-Lys-Pro-Lys-Trp Ala-Thr-Lys-Pro-Lys-Trp Ala-Thr-Lys-Pro-Gly-Trp Ala-Thr-Lys-Pro-Gly-Trp Ala-Thr-Lys-Pro-Gly-Trp Ala-Thr-Lys-Pro-Gly-Arg-Trp Ala-Thr-Lys-Pro-Gly-Arg-Trp Ala-Thr-Lys-Pro-Gly-Arg-Trp Ala-Thr-Lys-Pro-Gly-Phe-Trp Ala-Thr-Lys-Pro-Gly-Phe-Trp Ala-Thr-Lys-Pro-Gly-Phe-Trp Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Gly-Tyr-Trp Gly-Tyr-Trp Pro-Gly-Tyr-Trp Ala-Thr-Lys-Pro-Gly-His-Trp Ala-Thr-Lys-Pro-Gly-His-Trp Ala-Thr-Lys-Pro-Gly-His-Trp Ala-Thr-Lys-Pro-Gly-Pro-Trp Ala-Thr-Lys-Pro-Gly-Pro-Trp Ala-Thr-Lys-Pro-Gly-Pro-Trp Ala-Thr-Lys-Pro-Gly-Lys-Trp Ala-Thr-Lys-Pro-Gly-Lys-Trp Ala-Thr-Lys-Pro-Gly-Lys-Trp Ala-Thr-Lys-Pro-Asp-Trp Ala-Thr-Lys-Pro-Asp-Trp Ala-Thr-Lys-Pro-Asp-Trp Ala-Thr-Lys-Pro-Asp-Arg-Trp Ala-Thr-Lys-Pro-Asp-Arg-Trp Ala-Thr-Lys-Pro-Asp-Arg-Trp Ala-Thr-Lys-Pro-Asp-Phe-Trp Ala-Thr-Lys-Pro-Asp-Phe-Trp Ala-Thr-Lys-Pro-Asp-Phe-Trp Ala-Thr-Lys-Pro-Asp-Tyr-Trp Ala-Thr-Lys-Pro-Asp-Tyr-Trp Ala-Thr-Lys-Pro-Asp-Tyr-Trp Ala-Thr-Lys-Pro-Asp-His-Trp Ala-Thr-Lys-Pro-Asp-His-Trp Ala-Thr-Lys-Pro-Asp-His-Trp Ala-Thr-Lys-Pro-Asp-Pro-Trp Ala-Thr-Lys-Pro-Asp-Pro-Trp Ala-Thr-Lys-Pro-Asp-Pro-Trp Ala-Thr-Lys-Pro-Asp-Lys-Trp Ala-Thr-Lys-Pro-Asp-Lys-Trp Ala-Thr-Lys-Pro-Asp-Lys-Trp Ala-Thr-Lys-Pro-Trp-Trp Ala-Thr-Lys-Pro-Trp-Trp Ala-Thr-Lys-Pro-Trp-Trp Ala-Thr-Lys-Pro-Trp-Arg-Trp Ala-Thr-Lys-Pro-Trp-Arg-Trp Ala-Thr-Lys-Pro-Trp-Arg-Trp Ala-Thr-Lys-Pro-Trp-Phe-Trp Ala-Thr-Lys-Pro-Trp-Phe-Trp Ala-Thr-Lys-Pro-Trp-Phe-Trp Ala-Thr-Lys-Pro-Trp-Tyr-Trp Ala-Thr-Lys-Pro-Trp-Tyr-Trp Ala-Thr-Lys-Pro-Trp-Tyr-Trp

Ala-Thr-Lys-Pro-Trp-His-Trp Ala-Thr-Lys-Pro-Trp-His-Trp Ala-Thr-Lys-Pro-Trp-His-Trp Ala-Thr-Lys-Pro-Trp-Pro-Trp Ala-Thr-Lys-Pro-Trp-Pro-Trp Ala-Thr-Lys-Pro-Trp-Pro-Trp Ala-Thr-Lys-Pro-Trp-Lys-Trp Ala-Thr-Lys-Pro-Trp-Lys-Trp Ala-Thr-Lys-Pro-Trp-Lys-Trp Ala-Thr-Lys-Pro-Gln-Trp Ala-Thr-Lys-Pro-Gln-Trp Ala-Thr-Lys-Pro-Gln-Trp Ala-Thr-Lys-Pro-Gln-Arg-Trp Ala-Thr-Lys-Pro-Gln-Arg-Trp Ala-Thr-Lys-Pro-Gln-Arg-Trp Ala-Thr-Lys-Pro-Gln-Phe-Trp Ala-Thr-Lys-Pro-Gln-Phe-Trp Ala-Thr-Lys-Pro-Gln-Phe-Trp Ala-Thr-Lys-Pro-Gln-Tyr-Trp Ala-Thr-Lys-Pro-Gln-Tyr-Trp Ala-Thr-Lys-Pro-Gln-Tyr-Trp Ala-Thr-Lys-Pro-Gln-His-Trp Ala-Thr-Lys-Pro-Gln-His-Trp Ala-Thr-Lys-Pro-Gln-His-Trp Ala-Thr-Lys-Pro-Gln-Pro-Trp Ala-Thr-Lys-Pro-Gln-Pro-Trp Ala-Thr-Lys-Pro-Gln-Pro-Trp Ala-Thr-Lys-Pro-Gln-Lys-Trp Ala-Thr-Lys-Pro-Gln-Lys-Trp Ala-Thr-Lys-Pro-Gln-Lys-Trp Ala-Thr-Lys-Pro-Asn-Trp Ala-Thr-Lys-Pro-Asn-Trp Ala-Thr-Lys-Pro-Asn-Trp Ala-Thr-Lys-Pro-Asn-Arg-Trp Ala-Thr-Lys-Pro-Asn-Arg-Trp Ala-Thr-Lys-Pro-Asn-Arg-Trp Ala-Thr-Lys-Pro-Asn-Phe-Trp Ala-Thr-Lys-Pro-Asn-Phe-Trp Ala-Thr-Lys-Pro-Asn-Phe-Trp Ala-Thr-Lys-Pro-Asn-Tyr-Trp Ala-Thr-Lys-Pro-Asn-Tyr-Trp Ala-Thr-Lys-Pro-Asn-Tyr-Trp Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Asn-His-Trp Asn-His-Trp Pro-Asn-His-Trp Ala-Thr-Lys-Pro-Asn-Pro-Trp Ala-Thr-Lys-Pro-Asn-Pro-Trp Ala-Thr-Lys-Pro-Asn-Pro-Trp Ala-Thr-Lys-Pro-Asn-Lys-Trp Ala-Thr-Lys-Pro-Asn-Lys-Trp Ala-Thr-Lys-Pro-Asn-Lys-Trp Ala-Thr-Lys-Pro-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Arg-Trp Ala-Thr-Lys-Pro-Tyr-Arg-Trp Ala-Thr-Lys-Pro-Tyr-Arg-Trp Ala-Thr-Lys-Pro-Tyr-Phe-Trp Ala-Thr-Lys-Pro-Tyr-Phe-Trp Ala-Thr-Lys-Pro-Tyr-Phe-Trp Ala-Thr-Lys-Pro-Tyr-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-Tyr-Trp Ala-Thr-Lys-Pro-Tyr-His-Trp Ala-Thr-Lys-Pro-Tyr-His-Trp Ala-Thr-Lys-Pro-Tyr-His-Trp Ala-Thr-Lys-Pro-Tyr-Pro-Trp Ala-Thr-Lys-Pro-Tyr-Pro-Trp Ala-Thr-Lys-Pro-Tyr-Pro-Trp Ala-Thr-Lys-Pro-Tyr-Lys-Trp Ala-Thr-Lys-Pro-Tyr-Lys-Trp Ala-Thr-Lys-Pro-Tyr-Lys-Trp Ala-Thr-Lys-Pro-Arg-Trp Ala-Thr-Lys-Pro-Arg-Trp Ala-Thr-Lys-Pro-Arg-Trp Ala-Thr-Lys-Pro-Arg-Arg-Trp Ala-Thr-Lys-Pro-Arg-Arg-Trp Ala-Thr-Lys-Pro-Arg-Arg-Trp Ala-Thr-Lys-Pro-Arg-Phe-Trp Ala-Thr-Lys-Pro-Arg-Phe-Trp Ala-Thr-Lys-Pro-Arg-Phe-Trp Ala-Thr-Lys-Pro-Arg-Tyr-Trp Ala-Thr-Lys-Pro-Arg-Tyr-Trp Ala-Thr-Lys-Pro-Arg-Tyr-Trp Ala-Thr-Lys-Pro-Arg-His-Trp Ala-Thr-Lys-Pro-Arg-His-Trp Ala-Thr-Lys-Pro-Arg-His-Trp

Ala-Thr-Lys-Pro-Arg-Pro-Trp Ala-Thr-Lys-Pro-Arg-Pro-Trp Ala-Thr-Lys-Pro-Arg-Pro-Trp Ala-Thr-Lys-Pro-Arg-Lys-Trp Ala-Thr-Lys-Pro-Arg-Lys-Trp Ala-Thr-Lys-Pro-Arg-Lys-Trp His-Thr-Lys-Pro-Trp His-Thr-Lys-Pro-Trp His-Thr-Lys-Pro-Trp His-Thr-Lys-Pro-Arg-Trp His-Thr-Lys-Pro-Arg-Trp His-Thr-Lys-Pro-Arg-Trp His-Thr-Lys-Pro-Phe-Trp His-Thr-Lys-Pro-Phe-Trp His-Thr-Lys-Pro-Phe-Trp His-Thr-Lys-Pro-Tyr-Trp His-Thr-Lys-Pro-Tyr-Trp His-Thr-Lys-Pro-Tyr-Trp His-Thr-Lys-Pro-Gly-Trp His-Thr-Lys-Pro-Gly-Trp His-Thr-Lys-Pro-Gly-Trp His-Thr-Lys-Pro-His-Trp His-Thr-Lys-Pro-His-Trp His-Thr-Lys-Pro-His-Trp His-Thr-Lys-Pro-Lys-Trp His-Thr-Lys-Pro-Lys-Trp His-Thr-Lys-Pro-Lys-Trp His-Thr-Lys-Pro-Gly-Trp His-Thr-Lys-Pro-Gly-Trp His-Thr-Lys-Pro-Gly-Trp His-Thr-Lys-Pro-Gly-Arg-Trp His-Thr-Lys-Pro-Gly-Arg-Trp His-Thr-Lys-Pro-Gly-Arg-Trp His-Thr-Lys-Pro-Gly-Phe-Trp His-Thr-Lys-Pro-Gly-Phe-Trp His-Thr-Lys-Pro-Gly-Phe-Trp His-Thr-Lys-Pro-Gly-Tyr-Trp His-Thr-Lys-Pro-Gly-Tyr-Trp His-Thr-Lys-Pro-Gly-Tyr-Trp His-Thr-Lys-Pro-Gly-His-Trp His-Thr-Lys-Pro-Gly-His-Trp His-Thr-Lys-Pro-Gly-His-Trp His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Gly-Pro-Trp Gly-Pro-Trp Pro-Gly-Pro-Trp His-Thr-Lys-Pro-Gly-Lys-Trp His-Thr-Lys-Pro-Gly-Lys-Trp His-Thr-Lys-Pro-Gly-Lys-Trp His-Thr-Lys-Pro-Asp-Trp His-Thr-Lys-Pro-Asp-Trp His-Thr-Lys-Pro-Asp-Trp His-Thr-Lys-Pro-Asp-Arg-Trp His-Thr-Lys-Pro-Asp-Arg-Trp His-Thr-Lys-Pro-Asp-Arg-Trp His-Thr-Lys-Pro-Asp-Phe-Trp His-Thr-Lys-Pro-Asp-Phe-Trp His-Thr-Lys-Pro-Asp-Phe-Trp His-Thr-Lys-Pro-Asp-Tyr-Trp His-Thr-Lys-Pro-Asp-Tyr-Trp His-Thr-Lys-Pro-Asp-Tyr-Trp His-Thr-Lys-Pro-Asp-His-Trp His-Thr-Lys-Pro-Asp-His-Trp His-Thr-Lys-Pro-Asp-His-Trp His-Thr-Lys-Pro-Asp-Pro-Trp His-Thr-Lys-Pro-Asp-Pro-Trp His-Thr-Lys-Pro-Asp-Pro-Trp His-Thr-Lys-Pro-Asp-Lys-Trp His-Thr-Lys-Pro-Asp-Lys-Trp His-Thr-Lys-Pro-Asp-Lys-Trp His-Thr-Lys-Pro-Trp-Trp His-Thr-Lys-Pro-Trp-Trp His-Thr-Lys-Pro-Trp-Trp His-Thr-Lys-Pro-Trp-Arg-Trp His-Thr-Lys-Pro-Trp-Arg-Trp His-Thr-Lys-Pro-Trp-Arg-Trp His-Thr-Lys-Pro-Trp-Phe-Trp His-Thr-Lys-Pro-Trp-Phe-Trp His-Thr-Lys-Pro-Trp-Phe-Trp His-Thr-Lys-Pro-Trp-Tyr-Trp His-Thr-Lys-Pro-Trp-Tyr-Trp His-Thr-Lys-Pro-Trp-Tyr-Trp His-Thr-Lys-Pro-Trp-His-Trp His-Thr-Lys-Pro-Trp-His-Trp His-Thr-Lys-Pro-Trp-His-Trp His-Thr-Lys-Pro-Trp-Pro-Trp His-Thr-Lys-Pro-Trp-Pro-Trp His-Thr-Lys-Pro-Trp-Pro-Trp

His-Thr-Lys-Pro-Trp-Lys-Trp His-Thr-Lys-Pro-Trp-Lys-Trp His-Thr-Lys-Pro-Trp-Lys-Trp His-Thr-Lys-Pro-Gln-Trp His-Thr-Lys-Pro-Gln-Trp His-Thr-Lys-Pro-Gln-Trp His-Thr-Lys-Pro-Gln-Arg-Trp His-Thr-Lys-Pro-Gln-Arg-Trp His-Thr-Lys-Pro-Gln-Arg-Trp His-Thr-Lys-Pro-Gln-Phe-Trp His-Thr-Lys-Pro-Gln-Phe-Trp His-Thr-Lys-Pro-Gln-Phe-Trp His-Thr-Lys-Pro-Gln-Tyr-Trp His-Thr-Lys-Pro-Gln-Tyr-Trp His-Thr-Lys-Pro-Gln-Tyr-Trp His-Thr-Lys-Pro-Gln-His-Trp His-Thr-Lys-Pro-Gln-His-Trp His-Thr-Lys-Pro-Gln-His-Trp His-Thr-Lys-Pro-Gln-Pro-Trp His-Thr-Lys-Pro-Gln-Pro-Trp His-Thr-Lys-Pro-Gln-Pro-Trp His-Thr-Lys-Pro-Gln-Lys-Trp His-Thr-Lys-Pro-Gln-Lys-Trp His-Thr-Lys-Pro-Gln-Lys-Trp His-Thr-Lys-Pro-Asn-Trp His-Thr-Lys-Pro-Asn-Trp His-Thr-Lys-Pro-Asn-Trp His-Thr-Lys-Pro-Asn-Arg-Trp His-Thr-Lys-Pro-Asn-Arg-Trp His-Thr-Lys-Pro-Asn-Arg-Trp His-Thr-Lys-Pro-Asn-Phe-Trp His-Thr-Lys-Pro-Asn-Phe-Trp His-Thr-Lys-Pro-Asn-Phe-Trp His-Thr-Lys-Pro-Asn-Tyr-Trp His-Thr-Lys-Pro-Asn-Tyr-Trp His-Thr-Lys-Pro-Asn-Tyr-Trp His-Thr-Lys-Pro-Asn-His-Trp His-Thr-Lys-Pro-Asn-His-Trp His-Thr-Lys-Pro-Asn-His-Trp His-Thr-Lys-Pro-Asn-Pro-Trp His-Thr-Lys-Pro-Asn-Pro-Trp His-Thr-Lys-Pro-Asn-Pro-Trp His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Asn-Lys-Trp Asn-Lys-Trp Pro-Asn-Lys-Trp His-Thr-Lys-Pro-Tyr-Trp His-Thr-Lys-Pro-Tyr-Trp His-Thr-Lys-Pro-Tyr-Trp His-Thr-Lys-Pro-Tyr-Arg-Trp His-Thr-Lys-Pro-Tyr-Arg-Trp His-Thr-Lys-Pro-Tyr-Arg-Trp His-Thr-Lys-Pro-Tyr-Phe-Trp His-Thr-Lys-Pro-Tyr-Phe-Trp His-Thr-Lys-Pro-Tyr-Phe-Trp His-Thr-Lys-Pro-Tyr-Tyr-Trp His-Thr-Lys-Pro-Tyr-Tyr-Trp His-Thr-Lys-Pro-Tyr-Tyr-Trp His-Thr-Lys-Pro-Tyr-His-Trp His-Thr-Lys-Pro-Tyr-His-Trp His-Thr-Lys-Pro-Tyr-His-Trp His-Thr-Lys-Pro-Tyr-Pro-Trp His-Thr-Lys-Pro-Tyr-Pro-Trp His-Thr-Lys-Pro-Tyr-Pro-Trp His-Thr-Lys-Pro-Tyr-Lys-Trp His-Thr-Lys-Pro-Tyr-Lys-Trp His-Thr-Lys-Pro-Tyr-Lys-Trp His-Thr-Lys-Pro-Arg-Trp His-Thr-Lys-Pro-Arg-Trp His-Thr-Lys-Pro-Arg-Trp His-Thr-Lys-Pro-Arg-Arg-Trp His-Thr-Lys-Pro-Arg-Arg-Trp His-Thr-Lys-Pro-Arg-Arg-Trp His-Thr-Lys-Pro-Arg-Phe-Trp His-Thr-Lys-Pro-Arg-Phe-Trp His-Thr-Lys-Pro-Arg-Phe-Trp His-Thr-Lys-Pro-Arg-Tyr-Trp His-Thr-Lys-Pro-Arg-Tyr-Trp His-Thr-Lys-Pro-Arg-Tyr-Trp His-Thr-Lys-Pro-Arg-His-Trp His-Thr-Lys-Pro-Arg-His-Trp His-Thr-Lys-Pro-Arg-His-Trp His-Thr-Lys-Pro-Arg-Pro-Trp His-Thr-Lys-Pro-Arg-Pro-Trp His-Thr-Lys-Pro-Arg-Pro-Trp His-Thr-Lys-Pro-Arg-Lys-Trp His-Thr-Lys-Pro-Arg-Lys-Trp His-Thr-Lys-Pro-Arg-Lys-Trp

Lys-Thr-Lys-Pro-Trp Lys-Thr-Lys-Pro-Trp Lys-Thr-Lys-Pro-Trp Lys-Thr-Lys-Pro-Arg-Trp Lys-Thr-Lys-Pro-Arg-Trp Lys-Thr-Lys-Pro-Arg-Trp Lys-Thr-Lys-Pro-Phe-Trp Lys-Thr-Lys-Pro-Phe-Trp Lys-Thr-Lys-Pro-Phe-Trp Lys-Thr-Lys-Pro-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-Trp Lys-Thr-Lys-Pro-Gly-Trp Lys-Thr-Lys-Pro-Gly-Trp Lys-Thr-Lys-Pro-Gly-Trp Lys-Thr-Lys-Pro-His-Trp Lys-Thr-Lys-Pro-His-Trp Lys-Thr-Lys-Pro-His-Trp Lys-Thr-Lys-Pro-Lys-Trp Lys-Thr-Lys-Pro-Lys-Trp Lys-Thr-Lys-Pro-Lys-Trp Lys-Thr-Lys-Pro-Gly-Trp Lys-Thr-Lys-Pro-Gly-Trp Lys-Thr-Lys-Pro-Gly-Trp Lys-Thr-Lys-Pro-Gly-Arg-Trp Lys-Thr-Lys-Pro-Gly-Arg-Trp Lys-Thr-Lys-Pro-Gly-Arg-Trp Lys-Thr-Lys-Pro-Gly-Phe-Trp Lys-Thr-Lys-Pro-Gly-Phe-Trp Lys-Thr-Lys-Pro-Gly-Phe-Trp Lys-Thr-Lys-Pro-Gly-Tyr-Trp Lys-Thr-Lys-Pro-Gly-Tyr-Trp Lys-Thr-Lys-Pro-Gly-Tyr-Trp Lys-Thr-Lys-Pro-Gly-His-Trp Lys-Thr-Lys-Pro-Gly-His-Trp Lys-Thr-Lys-Pro-Gly-His-Trp Lys-Thr-Lys-Pro-Gly-Pro-Trp Lys-Thr-Lys-Pro-Gly-Pro-Trp Lys-Thr-Lys-Pro-Gly-Pro-Trp Lys-Thr-Lys-Pro-Gly-Lys-Trp Lys-Thr-Lys-Pro-Gly-Lys-Trp Lys-Thr-Lys-Pro-Gly-Lys-Trp Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Asp-Trp Pro-Asp-Trp Pro-Asp-Trp Lys-Thr-Lys-Pro-Asp-Arg-Trp Lys-Thr-Lys-Pro-Asp-Arg-Trp Lys-Thr-Lys-Pro-Asp-Arg-Trp Lys-Thr-Lys-Pro-Asp-Phe-Trp Lys-Thr-Lys-Pro-Asp-Phe-Trp Lys-Thr-Lys-Pro-Asp-Phe-Trp Lys-Thr-Lys-Pro-Asp-Tyr-Trp Lys-Thr-Lys-Pro-Asp-Tyr-Trp Lys-Thr-Lys-Pro-Asp-Tyr-Trp Lys-Thr-Lys-Pro-Asp-His-Trp Lys-Thr-Lys-Pro-Asp-His-Trp Lys-Thr-Lys-Pro-Asp-His-Trp Lys-Thr-Lys-Pro-Asp-Pro-Trp Lys-Thr-Lys-Pro-Asp-Pro-Trp Lys-Thr-Lys-Pro-Asp-Pro-Trp Lys-Thr-Lys-Pro-Asp-Lys-Trp Lys-Thr-Lys-Pro-Asp-Lys-Trp Lys-Thr-Lys-Pro-Asp-Lys-Trp Lys-Thr-Lys-Pro-Trp-Trp Lys-Thr-Lys-Pro-Trp-Trp Lys-Thr-Lys-Pro-Trp-Trp Lys-Thr-Lys-Pro-Trp-Arg-Trp Lys-Thr-Lys-Pro-Trp-Arg-Trp Lys-Thr-Lys-Pro-Trp-Arg-Trp Lys-Thr-Lys-Pro-Trp-Phe-Trp Lys-Thr-Lys-Pro-Trp-Phe-Trp Lys-Thr-Lys-Pro-Trp-Phe-Trp Lys-Thr-Lys-Pro-Trp-Tyr-Trp Lys-Thr-Lys-Pro-Trp-Tyr-Trp Lys-Thr-Lys-Pro-Trp-Tyr-Trp Lys-Thr-Lys-Pro-Trp-His-Trp Lys-Thr-Lys-Pro-Trp-His-Trp Lys-Thr-Lys-Pro-Trp-His-Trp Lys-Thr-Lys-Pro-Trp-Pro-Trp Lys-Thr-Lys-Pro-Trp-Pro-Trp Lys-Thr-Lys-Pro-Trp-Pro-Trp Lys-Thr-Lys-Pro-Trp-Lys-Trp Lys-Thr-Lys-Pro-Trp-Lys-Trp Lys-Thr-Lys-Pro-Trp-Lys-Trp Lys-Thr-Lys-Pro-Gln-Trp Lys-Thr-Lys-Pro-Gln-Trp Lys-Thr-Lys-Pro-Gln-Trp

Lys-Thr-Lys-Pro-Gln-Arg-Trp Lys-Thr-Lys-Pro-Gln-Arg-Trp Lys-Thr-Lys-Pro-Gln-Arg-Trp Lys-Thr-Lys-Pro-Gln-Phe-Trp Lys-Thr-Lys-Pro-Gln-Phe-Trp Lys-Thr-Lys-Pro-Gln-Phe-Trp Lys-Thr-Lys-Pro-Gln-Tyr-Trp Lys-Thr-Lys-Pro-Gln-Tyr-Trp Lys-Thr-Lys-Pro-Gln-Tyr-Trp Lys-Thr-Lys-Pro-Gln-His-Trp Lys-Thr-Lys-Pro-Gln-His-Trp Lys-Thr-Lys-Pro-Gln-His-Trp Lys-Thr-Lys-Pro-Gln-Pro-Trp Lys-Thr-Lys-Pro-Gln-Pro-Trp Lys-Thr-Lys-Pro-Gln-Pro-Trp Lys-Thr-Lys-Pro-Gln-Lys-Trp Lys-Thr-Lys-Pro-Gln-Lys-Trp Lys-Thr-Lys-Pro-Gln-Lys-Trp Lys-Thr-Lys-Pro-Asn-Trp Lys-Thr-Lys-Pro-Asn-Trp Lys-Thr-Lys-Pro-Asn-Trp Lys-Thr-Lys-Pro-Asn-Arg-Trp Lys-Thr-Lys-Pro-Asn-Arg-Trp Lys-Thr-Lys-Pro-Asn-Arg-Trp Lys-Thr-Lys-Pro-Asn-Phe-Trp Lys-Thr-Lys-Pro-Asn-Phe-Trp Lys-Thr-Lys-Pro-Asn-Phe-Trp Lys-Thr-Lys-Pro-Asn-Tyr-Trp Lys-Thr-Lys-Pro-Asn-Tyr-Trp Lys-Thr-Lys-Pro-Asn-Tyr-Trp Lys-Thr-Lys-Pro-Asn-His-Trp Lys-Thr-Lys-Pro-Asn-His-Trp Lys-Thr-Lys-Pro-Asn-His-Trp Lys-Thr-Lys-Pro-Asn-Pro-Trp Lys-Thr-Lys-Pro-Asn-Pro-Trp Lys-Thr-Lys-Pro-Asn-Pro-Trp Lys-Thr-Lys-Pro-Asn-Lys-Trp Lys-Thr-Lys-Pro-Asn-Lys-Trp Lys-Thr-Lys-Pro-Asn-Lys-Trp Lys-Thr-Lys-Pro-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-Trp Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Tyr-Arg-Trp Pro-Tyr-Arg-Trp Pro-Tyr-Arg-Trp Lys-Thr-Lys-Pro-Tyr-Phe-Trp Lys-Thr-Lys-Pro-Tyr-Phe-Trp Lys-Thr-Lys-Pro-Tyr-Phe-Trp Lys-Thr-Lys-Pro-Tyr-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-Tyr-Trp Lys-Thr-Lys-Pro-Tyr-His-Trp Lys-Thr-Lys-Pro-Tyr-His-Trp Lys-Thr-Lys-Pro-Tyr-His-Trp Lys-Thr-Lys-Pro-Tyr-Pro-Trp Lys-Thr-Lys-Pro-Tyr-Pro-Trp Lys-Thr-Lys-Pro-Tyr-Pro-Trp Lys-Thr-Lys-Pro-Tyr-Lys-Trp Lys-Thr-Lys-Pro-Tyr-Lys-Trp Lys-Thr-Lys-Pro-Tyr-Lys-Trp Lys-Thr-Lys-Pro-Arg-Trp Lys-Thr-Lys-Pro-Arg-Trp Lys-Thr-Lys-Pro-Arg-Trp Lys-Thr-Lys-Pro-Arg-Arg-Trp Lys-Thr-Lys-Pro-Arg-Arg-Trp Lys-Thr-Lys-Pro-Arg-Arg-Trp Lys-Thr-Lys-Pro-Arg-Phe-Trp Lys-Thr-Lys-Pro-Arg-Phe-Trp Lys-Thr-Lys-Pro-Arg-Phe-Trp Lys-Thr-Lys-Pro-Arg-Tyr-Trp Lys-Thr-Lys-Pro-Arg-Tyr-Trp Lys-Thr-Lys-Pro-Arg-Tyr-Trp Lys-Thr-Lys-Pro-Arg-His-Trp Lys-Thr-Lys-Pro-Arg-His-Trp Lys-Thr-Lys-Pro-Arg-His-Trp Lys-Thr-Lys-Pro-Arg-Pro-Trp Lys-Thr-Lys-Pro-Arg-Pro-Trp Lys-Thr-Lys-Pro-Arg-Pro-Trp Lys-Thr-Lys-Pro-Arg-Lys-Trp Lys-Thr-Lys-Pro-Arg-Lys-Trp Lys-Thr-Lys-Pro-Arg-Lys-Trp Gly-Thr-Lys-Pro-Trp Gly-Thr-Lys-Pro-Trp Gly-Thr-Lys-Pro-Trp Gly-Thr-Lys-Pro-Arg-Trp Gly-Thr-Lys-Pro-Arg-Trp Gly-Thr-Lys-Pro-Arg-Trp

Gly-Thr-Lys-Pro-Phe-Trp Gly-Thr-Lys-Pro-Phe-Trp Gly-Thr-Lys-Pro-Phe-Trp Gly-Thr-Lys-Pro-Tyr-Trp Gly-Thr-Lys-Pro-Tyr-Trp Gly-Thr-Lys-Pro-Tyr-Trp Gly-Thr-Lys-Pro-Gly-Trp Gly-Thr-Lys-Pro-Gly-Trp Gly-Thr-Lys-Pro-Gly-Trp Gly-Thr-Lys-Pro-His-Trp Gly-Thr-Lys-Pro-His-Trp Gly-Thr-Lys-Pro-His-Trp Gly-Thr-Lys-Pro-Lys-Trp Gly-Thr-Lys-Pro-Lys-Trp Gly-Thr-Lys-Pro-Lys-Trp Gly-Thr-Lys-Pro-Gly-Trp Gly-Thr-Lys-Pro-Gly-Trp Gly-Thr-Lys-Pro-Gly-Trp Gly-Thr-Lys-Pro-Gly-Arg-Trp Gly-Thr-Lys-Pro-Gly-Arg-Trp Gly-Thr-Lys-Pro-Gly-Arg-Trp Gly-Thr-Lys-Pro-Gly-Phe-Trp Gly-Thr-Lys-Pro-Gly-Phe-Trp Gly-Thr-Lys-Pro-Gly-Phe-Trp Gly-Thr-Lys-Pro-Gly-Tyr-Trp Gly-Thr-Lys-Pro-Gly-Tyr-Trp Gly-Thr-Lys-Pro-Gly-Tyr-Trp Gly-Thr-Lys-Pro-Gly-His-Trp Gly-Thr-Lys-Pro-Gly-His-Trp Gly-Thr-Lys-Pro-Gly-His-Trp Gly-Thr-Lys-Pro-Gly-Pro-Trp Gly-Thr-Lys-Pro-Gly-Pro-Trp Gly-Thr-Lys-Pro-Gly-Pro-Trp Gly-Thr-Lys-Pro-Gly-Lys-Trp Gly-Thr-Lys-Pro-Gly-Lys-Trp Gly-Thr-Lys-Pro-Gly-Lys-Trp Gly-Thr-Lys-Pro-Asp-Trp Gly-Thr-Lys-Pro-Asp-Trp Gly-Thr-Lys-Pro-Asp-Trp Gly-Thr-Lys-Pro-Asp-Arg-Trp Gly-Thr-Lys-Pro-Asp-Arg-Trp Gly-Thr-Lys-Pro-Asp-Arg-Trp Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Asp-Phe-Trp Pro-Asp-Phe-Trp Pro-Asp-Phe-Trp Gly-Thr-Lys-Pro-Asp-Tyr-Trp Gly-Thr-Lys-Pro-Asp-Tyr-Trp Gly-Thr-Lys-Pro-Asp-Tyr-Trp Gly-Thr-Lys-Pro-Asp-His-Trp Gly-Thr-Lys-Pro-Asp-His-Trp Gly-Thr-Lys-Pro-Asp-His-Trp Gly-Thr-Lys-Pro-Asp-Pro-Trp Gly-Thr-Lys-Pro-Asp-Pro-Trp Gly-Thr-Lys-Pro-Asp-Pro-Trp Gly-Thr-Lys-Pro-Asp-Lys-Trp Gly-Thr-Lys-Pro-Asp-Lys-Trp Gly-Thr-Lys-Pro-Asp-Lys-Trp Gly-Thr-Lys-Pro-Trp-Trp Gly-Thr-Lys-Pro-Trp-Trp Gly-Thr-Lys-Pro-Trp-Trp Gly-Thr-Lys-Pro-Trp-Arg-Trp Gly-Thr-Lys-Pro-Trp-Arg-Trp Gly-Thr-Lys-Pro-Trp-Arg-Trp Gly-Thr-Lys-Pro-Trp-Phe-Trp Gly-Thr-Lys-Pro-Trp-Phe-Trp Gly-Thr-Lys-Pro-Trp-Phe-Trp Gly-Thr-Lys-Pro-Trp-Tyr-Trp Gly-Thr-Lys-Pro-Trp-Tyr-Trp Gly-Thr-Lys-Pro-Trp-Tyr-Trp Gly-Thr-Lys-Pro-Trp-His-Trp Gly-Thr-Lys-Pro-Trp-His-Trp Gly-Thr-Lys-Pro-Trp-His-Trp Gly-Thr-Lys-Pro-Trp-Pro-Trp Gly-Thr-Lys-Pro-Trp-Pro-Trp Gly-Thr-Lys-Pro-Trp-Pro-Trp Gly-Thr-Lys-Pro-Trp-Lys-Trp Gly-Thr-Lys-Pro-Trp-Lys-Trp Gly-Thr-Lys-Pro-Trp-Lys-Trp Gly-Thr-Lys-Pro-Gln-Trp Gly-Thr-Lys-Pro-Gln-Trp Gly-Thr-Lys-Pro-Gln-Trp Gly-Thr-Lys-Pro-Gln-Arg-Trp Gly-Thr-Lys-Pro-Gln-Arg-Trp Gly-Thr-Lys-Pro-Gln-Arg-Trp Gly-Thr-Lys-Pro-Gln-Phe-Trp Gly-Thr-Lys-Pro-Gln-Phe-Trp Gly-Thr-Lys-Pro-Gln-Phe-Trp

Gly-Thr-Lys-Pro-Gln-Tyr-Trp Gly-Thr-Lys-Pro-Gln-Tyr-Trp Gly-Thr-Lys-Pro-Gln-Tyr-Trp Gly-Thr-Lys-Pro-Gln-His-Trp Gly-Thr-Lys-Pro-Gln-His-Trp Gly-Thr-Lys-Pro-Gln-His-Trp Gly-Thr-Lys-Pro-Gln-Pro-Trp Gly-Thr-Lys-Pro-Gln-Pro-Trp Gly-Thr-Lys-Pro-Gln-Pro-Trp Gly-Thr-Lys-Pro-Gln-Lys-Trp Gly-Thr-Lys-Pro-Gln-Lys-Trp Gly-Thr-Lys-Pro-Gln-Lys-Trp Gly-Thr-Lys-Pro-Asn-Trp Gly-Thr-Lys-Pro-Asn-Trp Gly-Thr-Lys-Pro-Asn-Trp Gly-Thr-Lys-Pro-Asn-Arg-Trp Gly-Thr-Lys-Pro-Asn-Arg-Trp Gly-Thr-Lys-Pro-Asn-Arg-Trp Gly-Thr-Lys-Pro-Asn-Phe-Trp Gly-Thr-Lys-Pro-Asn-Phe-Trp Gly-Thr-Lys-Pro-Asn-Phe-Trp Gly-Thr-Lys-Pro-Asn-Tyr-Trp Gly-Thr-Lys-Pro-Asn-Tyr-Trp Gly-Thr-Lys-Pro-Asn-Tyr-Trp Gly-Thr-Lys-Pro-Asn-His-Trp Gly-Thr-Lys-Pro-Asn-His-Trp Gly-Thr-Lys-Pro-Asn-His-Trp Gly-Thr-Lys-Pro-Asn-Pro-Trp Gly-Thr-Lys-Pro-Asn-Pro-Trp Gly-Thr-Lys-Pro-Asn-Pro-Trp Gly-Thr-Lys-Pro-Asn-Lys-Trp Gly-Thr-Lys-Pro-Asn-Lys-Trp Gly-Thr-Lys-Pro-Asn-Lys-Trp Gly-Thr-Lys-Pro-Tyr-Trp Gly-Thr-Lys-Pro-Tyr-Trp Gly-Thr-Lys-Pro-Tyr-Trp Gly-Thr-Lys-Pro-Tyr-Arg-Trp Gly-Thr-Lys-Pro-Tyr-Arg-Trp Gly-Thr-Lys-Pro-Tyr-Arg-Trp Gly-Thr-Lys-Pro-Tyr-Phe-Trp Gly-Thr-Lys-Pro-Tyr-Phe-Trp Gly-Thr-Lys-Pro-Tyr-Phe-Trp Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Tyr-Tyr-Trp Pro-Tyr-Tyr-Trp Pro-Tyr-Tyr-Trp Gly-Thr-Lys-Pro-Tyr-His-Trp Gly-Thr-Lys-Pro-Tyr-His-Trp Gly-Thr-Lys-Pro-Tyr-His-Trp Gly-Thr-Lys-Pro-Tyr-Pro-Trp Gly-Thr-Lys-Pro-Tyr-Pro-Trp Gly-Thr-Lys-Pro-Tyr-Pro-Trp Gly-Thr-Lys-Pro-Tyr-Lys-Trp Gly-Thr-Lys-Pro-Tyr-Lys-Trp Gly-Thr-Lys-Pro-Tyr-Lys-Trp Gly-Thr-Lys-Pro-Arg-Trp Gly-Thr-Lys-Pro-Arg-Trp Gly-Thr-Lys-Pro-Arg-Trp Gly-Thr-Lys-Pro-Arg-Arg-Trp Gly-Thr-Lys-Pro-Arg-Arg-Trp Gly-Thr-Lys-Pro-Arg-Arg-Trp Gly-Thr-Lys-Pro-Arg-Phe-Trp Gly-Thr-Lys-Pro-Arg-Phe-Trp Gly-Thr-Lys-Pro-Arg-Phe-Trp Gly-Thr-Lys-Pro-Arg-Tyr-Trp Gly-Thr-Lys-Pro-Arg-Tyr-Trp Gly-Thr-Lys-Pro-Arg-Tyr-Trp Gly-Thr-Lys-Pro-Arg-His-Trp Gly-Thr-Lys-Pro-Arg-His-Trp Gly-Thr-Lys-Pro-Arg-His-Trp Gly-Thr-Lys-Pro-Arg-Pro-Trp Gly-Thr-Lys-Pro-Arg-Pro-Trp Gly-Thr-Lys-Pro-Arg-Pro-Trp Gly-Thr-Lys-Pro-Arg-Lys-Trp Gly-Thr-Lys-Pro-Arg-Lys-Trp Gly-Thr-Lys-Pro-Arg-Lys-Trp Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Phe-Phe Thr-Lys-Pro-Phe-Phe Thr-Lys-Pro-Phe-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Phe

Thr-Lys-Pro-His-Phe Thr-Lys-Pro-His-Phe Thr-Lys-Pro-His-Phe Thr-Lys-Pro-Lys-Phe Thr-Lys-Pro-Lys-Phe Thr-Lys-Pro-Lys-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Phe Thr-Lys-Pro-Gly-Arg-Phe Thr-Lys-Pro-Gly-Arg-Phe Thr-Lys-Pro-Gly-Arg-Phe Thr-Lys-Pro-Gly-Phe-Phe Thr-Lys-Pro-Gly-Phe-Phe Thr-Lys-Pro-Gly-Phe-Phe Thr-Lys-Pro-Gly-Tyr-Phe Thr-Lys-Pro-Gly-Tyr-Phe Thr-Lys-Pro-Gly-Tyr-Phe Thr-Lys-Pro-Gly-His-Phe Thr-Lys-Pro-Gly-His-Phe Thr-Lys-Pro-Gly-His-Phe Thr-Lys-Pro-Gly-Pro-Phe Thr-Lys-Pro-Gly-Pro-Phe Thr-Lys-Pro-Gly-Pro-Phe Thr-Lys-Pro-Gly-Lys-Phe Thr-Lys-Pro-Gly-Lys-Phe Thr-Lys-Pro-Gly-Lys-Phe Thr-Lys-Pro-Asp-Phe Thr-Lys-Pro-Asp-Phe Thr-Lys-Pro-Asp-Phe Thr-Lys-Pro-Asp-Arg-Phe Thr-Lys-Pro-Asp-Arg-Phe Thr-Lys-Pro-Asp-Arg-Phe Thr-Lys-Pro-Asp-Phe-Phe Thr-Lys-Pro-Asp-Phe-Phe Thr-Lys-Pro-Asp-Phe-Phe Thr-Lys-Pro-Asp-Tyr-Phe Thr-Lys-Pro-Asp-Tyr-Phe Thr-Lys-Pro-Asp-Tyr-Phe Thr-Lys-Pro-Asp-His-Phe Thr-Lys-Pro-Asp-His-Phe Thr-Lys-Pro-Asp-His-Phe Thr-Lys-Pro- Thr-Lys-Pro- Thr-Lys-Pro-

Asp-Pro-Phe Asp-Pro-Phe Asp-Pro-Phe Thr-Lys-Pro-Asp-Lys-Phe Thr-Lys-Pro-Asp-Lys-Phe Thr-Lys-Pro-Asp-Lys-Phe Thr-Lys-Pro-Trp-Phe Thr-Lys-Pro-Trp-Phe Thr-Lys-Pro-Trp-Phe Thr-Lys-Pro-Trp-Arg-Phe Thr-Lys-Pro-Trp-Arg-Phe Thr-Lys-Pro-Trp-Arg-Phe Thr-Lys-Pro-Trp-Phe-Phe Thr-Lys-Pro-Trp-Phe-Phe Thr-Lys-Pro-Trp-Phe-Phe Thr-Lys-Pro-Trp-Tyr-Phe Thr-Lys-Pro-Trp-Tyr-Phe Thr-Lys-Pro-Trp-Tyr-Phe Thr-Lys-Pro-Trp-His-Phe Thr-Lys-Pro-Trp-His-Phe Thr-Lys-Pro-Trp-His-Phe Thr-Lys-Pro-Trp-Pro-Phe Thr-Lys-Pro-Trp-Pro-Phe Thr-Lys-Pro-Trp-Pro-Phe Thr-Lys-Pro-Trp-Lys-Phe Thr-Lys-Pro-Trp-Lys-Phe Thr-Lys-Pro-Trp-Lys-Phe Thr-Lys-Pro-Gln-Phe Thr-Lys-Pro-Gln-Phe Thr-Lys-Pro-Gln-Phe Thr-Lys-Pro-Gln-Arg-Phe Thr-Lys-Pro-Gln-Arg-Phe Thr-Lys-Pro-Gln-Arg-Phe Thr-Lys-Pro-Gln-Phe-Phe Thr-Lys-Pro-Gln-Phe-Phe Thr-Lys-Pro-Gln-Phe-Phe Thr-Lys-Pro-Gln-Tyr-Phe Thr-Lys-Pro-Gln-Tyr-Phe Thr-Lys-Pro-Gln-Tyr-Phe Thr-Lys-Pro-Gln-His-Phe Thr-Lys-Pro-Gln-His-Phe Thr-Lys-Pro-Gln-His-Phe Thr-Lys-Pro-Gln-Pro-Phe Thr-Lys-Pro-Gln-Pro-Phe Thr-Lys-Pro-Gln-Pro-Phe

Thr-Lys-Pro-Gln-Lys-Phe Thr-Lys-Pro-Gln-Lys-Phe Thr-Lys-Pro-Gln-Lys-Phe Thr-Lys-Pro-Asn-Phe Thr-Lys-Pro-Asn-Phe Thr-Lys-Pro-Asn-Phe Thr-Lys-Pro-Asn-Arg-Phe Thr-Lys-Pro-Asn-Arg-Phe Thr-Lys-Pro-Asn-Arg-Phe Thr-Lys-Pro-Asn-Phe-Phe Thr-Lys-Pro-Asn-Phe-Phe Thr-Lys-Pro-Asn-Phe-Phe Thr-Lys-Pro-Asn-Tyr-Phe Thr-Lys-Pro-Asn-Tyr-Phe Thr-Lys-Pro-Asn-Tyr-Phe Thr-Lys-Pro-Asn-His-Phe Thr-Lys-Pro-Asn-His-Phe Thr-Lys-Pro-Asn-His-Phe Thr-Lys-Pro-Asn-Pro-Phe Thr-Lys-Pro-Asn-Pro-Phe Thr-Lys-Pro-Asn-Pro-Phe Thr-Lys-Pro-Asn-Lys-Phe Thr-Lys-Pro-Asn-Lys-Phe Thr-Lys-Pro-Asn-Lys-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Phe Thr-Lys-Pro-Tyr-Arg-Phe Thr-Lys-Pro-Tyr-Arg-Phe Thr-Lys-Pro-Tyr-Arg-Phe Thr-Lys-Pro-Tyr-Phe-Phe Thr-Lys-Pro-Tyr-Phe-Phe Thr-Lys-Pro-Tyr-Phe-Phe Thr-Lys-Pro-Tyr-Tyr-Phe Thr-Lys-Pro-Tyr-Tyr-Phe Thr-Lys-Pro-Tyr-Tyr-Phe Thr-Lys-Pro-Tyr-His-Phe Thr-Lys-Pro-Tyr-His-Phe Thr-Lys-Pro-Tyr-His-Phe Thr-Lys-Pro-Tyr-Pro-Phe Thr-Lys-Pro-Tyr-Pro-Phe Thr-Lys-Pro-Tyr-Pro-Phe Thr-Lys-Pro- Thr-Lys-Pro-Tyr- Thr-Lys-Pro-

Tyr-Lys-Phe Lys-Phe Tyr-Lys-Phe Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Phe Thr-Lys-Pro-Arg-Arg-Phe Thr-Lys-Pro-Arg-Arg-Phe Thr-Lys-Pro-Arg-Arg-Phe Thr-Lys-Pro-Arg-Phe-Phe Thr-Lys-Pro-Arg-Phe-Phe Thr-Lys-Pro-Arg-Phe-Phe Thr-Lys-Pro-Arg-Tyr-Phe Thr-Lys-Pro-Arg-Tyr-Phe Thr-Lys-Pro-Arg-Tyr-Phe Thr-Lys-Pro-Arg-His-Phe Thr-Lys-Pro-Arg-His-Phe Thr-Lys-Pro-Arg-His-Phe Thr-Lys-Pro-Arg-Pro-Phe Thr-Lys-Pro-Arg-Pro-Phe Thr-Lys-Pro-Arg-Pro-Phe Thr-Lys-Pro-Arg-Lys-Phe Thr-Lys-Pro-Arg-Lys-Phe Thr-Lys-Pro-Arg-Lys-Phe Met-Thr-Lys-Pro-Phe Met-Thr-Lys-Pro-Phe Met-Thr-Lys-Pro-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Phe-Phe Met-Thr-Lys-Pro-Phe-Phe Met-Thr-Lys-Pro-Phe-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-His-Phe Met-Thr-Lys-Pro-His-Phe Met-Thr-Lys-Pro-His-Phe Met-Thr-Lys-Pro-Lys-Phe Met-Thr-Lys-Pro-Lys-Phe Met-Thr-Lys-Pro-Lys-Phe

Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Phe Met-Thr-Lys-Pro-Gly-Arg-Phe Met-Thr-Lys-Pro-Gly-Arg-Phe Met-Thr-Lys-Pro-Gly-Arg-Phe Met-Thr-Lys-Pro-Gly-Phe-Phe Met-Thr-Lys-Pro-Gly-Phe-Phe Met-Thr-Lys-Pro-Gly-Phe-Phe Met-Thr-Lys-Pro-Gly-Tyr-Phe Met-Thr-Lys-Pro-Gly-Tyr-Phe Met-Thr-Lys-Pro-Gly-Tyr-Phe Met-Thr-Lys-Pro-Gly-His-Phe Met-Thr-Lys-Pro-Gly-His-Phe Met-Thr-Lys-Pro-Gly-His-Phe Met-Thr-Lys-Pro-Gly-Pro-Phe Met-Thr-Lys-Pro-Gly-Pro-Phe Met-Thr-Lys-Pro-Gly-Pro-Phe Met-Thr-Lys-Pro-Gly-Lys-Phe Met-Thr-Lys-Pro-Gly-Lys-Phe Met-Thr-Lys-Pro-Gly-Lys-Phe Met-Thr-Lys-Pro-Asp-Phe Met-Thr-Lys-Pro-Asp-Phe Met-Thr-Lys-Pro-Asp-Phe Met-Thr-Lys-Pro-Asp-Arg-Phe Met-Thr-Lys-Pro-Asp-Arg-Phe Met-Thr-Lys-Pro-Asp-Arg-Phe Met-Thr-Lys-Pro-Asp-Phe-Phe Met-Thr-Lys-Pro-Asp-Phe-Phe Met-Thr-Lys-Pro-Asp-Phe-Phe Met-Thr-Lys-Pro-Asp-Tyr-Phe Met-Thr-Lys-Pro-Asp-Tyr-Phe Met-Thr-Lys-Pro-Asp-Tyr-Phe Met-Thr-Lys-Pro-Asp-His-Phe Met-Thr-Lys-Pro-Asp-His-Phe Met-Thr-Lys-Pro-Asp-His-Phe Met-Thr-Lys-Pro-Asp-Pro-Phe Met-Thr-Lys-Pro-Asp-Pro-Phe Met-Thr-Lys-Pro-Asp-Pro-Phe Met-Thr-Lys-Pro-Asp-Lys-Phe Met-Thr-Lys-Pro-Asp-Lys-Phe Met-Thr-Lys-Pro-Asp-Lys-Phe Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Trp-Phe Pro-Trp-Phe Pro-Trp-Phe Met-Thr-Lys-Pro-Trp-Arg-Phe Met-Thr-Lys-Pro-Trp-Arg-Phe Met-Thr-Lys-Pro-Trp-Arg-Phe Met-Thr-Lys-Pro-Trp-Phe-Phe Met-Thr-Lys-Pro-Trp-Phe-Phe Met-Thr-Lys-Pro-Trp-Phe-Phe Met-Thr-Lys-Pro-Trp-Tyr-Phe Met-Thr-Lys-Pro-Trp-Tyr-Phe Met-Thr-Lys-Pro-Trp-Tyr-Phe Met-Thr-Lys-Pro-Trp-His-Phe Met-Thr-Lys-Pro-Trp-His-Phe Met-Thr-Lys-Pro-Trp-His-Phe Met-Thr-Lys-Pro-Trp-Pro-Phe Met-Thr-Lys-Pro-Trp-Pro-Phe Met-Thr-Lys-Pro-Trp-Pro-Phe Met-Thr-Lys-Pro-Trp-Lys-Phe Met-Thr-Lys-Pro-Trp-Lys-Phe Met-Thr-Lys-Pro-Trp-Lys-Phe Met-Thr-Lys-Pro-Gln-Phe Met-Thr-Lys-Pro-Gln-Phe Met-Thr-Lys-Pro-Gln-Phe Met-Thr-Lys-Pro-Gln-Arg-Phe Met-Thr-Lys-Pro-Gln-Arg-Phe Met-Thr-Lys-Pro-Gln-Arg-Phe Met-Thr-Lys-Pro-Gln-Phe-Phe Met-Thr-Lys-Pro-Gln-Phe-Phe Met-Thr-Lys-Pro-Gln-Phe-Phe Met-Thr-Lys-Pro-Gln-Tyr-Phe Met-Thr-Lys-Pro-Gln-Tyr-Phe Met-Thr-Lys-Pro-Gln-Tyr-Phe Met-Thr-Lys-Pro-Gln-His-Phe Met-Thr-Lys-Pro-Gln-His-Phe Met-Thr-Lys-Pro-Gln-His-Phe Met-Thr-Lys-Pro-Gln-Pro-Phe Met-Thr-Lys-Pro-Gln-Pro-Phe Met-Thr-Lys-Pro-Gln-Pro-Phe Met-Thr-Lys-Pro-Gln-Lys-Phe Met-Thr-Lys-Pro-Gln-Lys-Phe Met-Thr-Lys-Pro-Gln-Lys-Phe Met-Thr-Lys-Pro-Asn-Phe Met-Thr-Lys-Pro-Asn-Phe Met-Thr-Lys-Pro-Asn-Phe

Met-Thr-Lys-Pro-Asn-Arg-Phe Met-Thr-Lys-Pro-Asn-Arg-Phe Met-Thr-Lys-Pro-Asn-Arg-Phe Met-Thr-Lys-Pro-Asn-Phe-Phe Met-Thr-Lys-Pro-Asn-Phe-Phe Met-Thr-Lys-Pro-Asn-Phe-Phe Met-Thr-Lys-Pro-Asn-Tyr-Phe Met-Thr-Lys-Pro-Asn-Tyr-Phe Met-Thr-Lys-Pro-Asn-Tyr-Phe Met-Thr-Lys-Pro-Asn-His-Phe Met-Thr-Lys-Pro-Asn-His-Phe Met-Thr-Lys-Pro-Asn-His-Phe Met-Thr-Lys-Pro-Asn-Pro-Phe Met-Thr-Lys-Pro-Asn-Pro-Phe Met-Thr-Lys-Pro-Asn-Pro-Phe Met-Thr-Lys-Pro-Asn-Lys-Phe Met-Thr-Lys-Pro-Asn-Lys-Phe Met-Thr-Lys-Pro-Asn-Lys-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Arg-Phe Met-Thr-Lys-Pro-Tyr-Arg-Phe Met-Thr-Lys-Pro-Tyr-Arg-Phe Met-Thr-Lys-Pro-Tyr-Phe-Phe Met-Thr-Lys-Pro-Tyr-Phe-Phe Met-Thr-Lys-Pro-Tyr-Phe-Phe Met-Thr-Lys-Pro-Tyr-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Tyr-Phe Met-Thr-Lys-Pro-Tyr-Tyr-Phe Met-Thr-Lys-Pro-Tyr-His-Phe Met-Thr-Lys-Pro-Tyr-His-Phe Met-Thr-Lys-Pro-Tyr-His-Phe Met-Thr-Lys-Pro-Tyr-Pro-Phe Met-Thr-Lys-Pro-Tyr-Pro-Phe Met-Thr-Lys-Pro-Tyr-Pro-Phe Met-Thr-Lys-Pro-Tyr-Lys-Phe Met-Thr-Lys-Pro-Tyr-Lys-Phe Met-Thr-Lys-Pro-Tyr-Lys-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe Met-Thr-Lys- Met-Thr-Lys- Met-Thr-Lys-

Pro-Arg-Arg-Phe Pro-Arg-Arg-Phe Pro-Arg-Arg-Phe Met-Thr-Lys-Pro-Arg-Phe-Phe Met-Thr-Lys-Pro-Arg-Phe-Phe Met-Thr-Lys-Pro-Arg-Phe-Phe Met-Thr-Lys-Pro-Arg-Tyr-Phe Met-Thr-Lys-Pro-Arg-Tyr-Phe Met-Thr-Lys-Pro-Arg-Tyr-Phe Met-Thr-Lys-Pro-Arg-His-Phe Met-Thr-Lys-Pro-Arg-His-Phe Met-Thr-Lys-Pro-Arg-His-Phe Met-Thr-Lys-Pro-Arg-Pro-Phe Met-Thr-Lys-Pro-Arg-Pro-Phe Met-Thr-Lys-Pro-Arg-Pro-Phe Met-Thr-Lys-Pro-Arg-Lys-Phe Met-Thr-Lys-Pro-Arg-Lys-Phe Met-Thr-Lys-Pro-Arg-Lys-Phe Met(0)-Thr-Lys-Pro-Phe Met(0)-Thr-Lys-Pro-Phe Met(0)-Thr-Lys-Pro-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Phe-Phe Met(0)-Thr-Lys-Pro-Phe-Phe Met(0)-Thr-Lys-Pro-Phe-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-His-Phe Met(0)-Thr-Lys-Pro-His-Phe Met(0)-Thr-Lys-Pro-His-Phe Met(0)-Thr-Lys-Pro-Lys-Phe Met(0)-Thr-Lys-Pro-Lys-Phe Met(0)-Thr-Lys-Pro-Lys-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Phe Met(0)-Thr-Lys-Pro-Gly-Arg-Phe Met(0)-Thr-Lys-Pro-Gly-Arg-Phe Met(0)-Thr-Lys-Pro-Gly-Arg-Phe

Met(0)-Thr-Lys-Pro-Gly-Phe-Phe Met(0)-Thr-Lys-Pro-Gly-Phe-Phe Met(0)-Thr-Lys-Pro-Gly-Phe-Phe Met(0)-Thr-Lys-Pro-Gly-Tyr-Phe Met(0)-Thr-Lys-Pro-Gly-Tyr-Phe Met(0)-Thr-Lys-Pro-Gly-Tyr-Phe Met(0)-Thr-Lys-Pro-Gly-His-Phe Met(0)-Thr-Lys-Pro-Gly-His-Phe Met(0)-Thr-Lys-Pro-Gly-His-Phe Met(0)-Thr-Lys-Pro-Gly-Pro-Phe Met(0)-Thr-Lys-Pro-Gly-Pro-Phe Met(0)-Thr-Lys-Pro-Gly-Pro-Phe Met(0)-Thr-Lys-Pro-Gly-Lys-Phe Met(0)-Thr-Lys-Pro-Gly-Lys-Phe Met(0)-Thr-Lys-Pro-Gly-Lys-Phe Met(0)-Thr-Lys-Pro-Asp-Phe Met(0)-Thr-Lys-Pro-Asp-Phe Met(0)-Thr-Lys-Pro-Asp-Phe Met(0)-Thr-Lys-Pro-Asp-Arg-Phe Met(0)-Thr-Lys-Pro-Asp-Arg-Phe Met(0)-Thr-Lys-Pro-Asp-Arg-Phe Met(0)-Thr-Lys-Pro-Asp-Phe-Phe Met(0)-Thr-Lys-Pro-Asp-Phe-Phe Met(0)-Thr-Lys-Pro-Asp-Phe-Phe Met(0)-Thr-Lys-Pro-Asp-Tyr-Phe Met(0)-Thr-Lys-Pro-Asp-Tyr-Phe Met(0)-Thr-Lys-Pro-Asp-Tyr-Phe Met(0)-Thr-Lys-Pro-Asp-His-Phe Met(0)-Thr-Lys-Pro-Asp-His-Phe Met(0)-Thr-Lys-Pro-Asp-His-Phe Met(0)-Thr-Lys-Pro-Asp-Pro-Phe Met(0)-Thr-Lys-Pro-Asp-Pro-Phe Met(0)-Thr-Lys-Pro-Asp-Pro-Phe Met(0)-Thr-Lys-Pro-Asp-Lys-Phe Met(0)-Thr-Lys-Pro-Asp-Lys-Phe Met(0)-Thr-Lys-Pro-Asp-Lys-Phe Met(0)-Thr-Lys-Pro-Trp-Phe Met(0)-Thr-Lys-Pro-Trp-Phe Met(0)-Thr-Lys-Pro-Trp-Phe Met(0)-Thr-Lys-Pro-Trp-Arg-Phe Met(0)-Thr-Lys-Pro-Trp-Arg-Phe Met(0)-Thr-Lys-Pro-Trp-Arg-Phe Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Trp-Phe-Phe Pro-Trp-Phe-Phe Pro-Trp-Phe-Phe Met(0)-Thr-Lys-Pro-Trp-Tyr-Phe Met(0)-Thr-Lys-Pro-Trp-Tyr-Phe Met(0)-Thr-Lys-Pro-Trp-Tyr-Phe Met(0)-Thr-Lys-Pro-Trp-His-Phe Met(0)-Thr-Lys-Pro-Trp-His-Phe Met(0)-Thr-Lys-Pro-Trp-His-Phe Met(0)-Thr-Lys-Pro-Trp-Pro-Phe Met(0)-Thr-Lys-Pro-Trp-Pro-Phe Met(0)-Thr-Lys-Pro-Trp-Pro-Phe Met(0)-Thr-Lys-Pro-Trp-Lys-Phe Met(0)-Thr-Lys-Pro-Trp-Lys-Phe Met(0)-Thr-Lys-Pro-Trp-Lys-Phe Met(0)-Thr-Lys-Pro-Gln-Phe Met(0)-Thr-Lys-Pro-Gln-Phe Met(0)-Thr-Lys-Pro-Gln-Phe Met(0)-Thr-Lys-Pro-Gln-Arg-Phe Met(0)-Thr-Lys-Pro-Gln-Arg-Phe Met(0)-Thr-Lys-Pro-Gln-Arg-Phe Met(0)-Thr-Lys-Pro-Gln-Phe-Phe Met(0)-Thr-Lys-Pro-Gln-Phe-Phe Met(0)-Thr-Lys-Pro-Gln-Phe-Phe Met(0)-Thr-Lys-Pro-Gln-Tyr-Phe Met(0)-Thr-Lys-Pro-Gln-Tyr-Phe Met(0)-Thr-Lys-Pro-Gln-Tyr-Phe Met(0)-Thr-Lys-Pro-Gln-His-Phe Met(0)-Thr-Lys-Pro-Gln-His-Phe Met(0)-Thr-Lys-Pro-Gln-His-Phe Met(0)-Thr-Lys-Pro-Gln-Pro-Phe Met(0)-Thr-Lys-Pro-Gln-Pro-Phe Met(0)-Thr-Lys-Pro-Gln-Pro-Phe Met(0)-Thr-Lys-Pro-Gln-Lys-Phe Met(0)-Thr-Lys-Pro-Gln-Lys-Phe Met(0)-Thr-Lys-Pro-Gln-Lys-Phe Met(0)-Thr-Lys-Pro-Asn-Phe Met(0)-Thr-Lys-Pro-Asn-Phe Met(0)-Thr-Lys-Pro-Asn-Phe Met(0)-Thr-Lys-Pro-Asn-Arg-Phe Met(0)-Thr-Lys-Pro-Asn-Arg-Phe Met(0)-Thr-Lys-Pro-Asn-Arg-Phe Met(0)-Thr-Lys-Pro-Asn-Phe-Phe Met(0)-Thr-Lys-Pro-Asn-Phe-Phe Met(0)-Thr-Lys-Pro-Asn-Phe-Phe

Met(0)-Thr-Lys-Pro-Asn-Tyr-Phe Met(0)-Thr-Lys-Pro-Asn-Tyr-Phe Met(0)-Thr-Lys-Pro-Asn-Tyr-Phe Met(0)-Thr-Lys-Pro-Asn-His-Phe Met(0)-Thr-Lys-Pro-Asn-His-Phe Met(0)-Thr-Lys-Pro-Asn-His-Phe Met(0)-Thr-Lys-Pro-Asn-Pro-Phe Met(0)-Thr-Lys-Pro-Asn-Pro-Phe Met(0)-Thr-Lys-Pro-Asn-Pro-Phe Met(0)-Thr-Lys-Pro-Asn-Lys-Phe Met(0)-Thr-Lys-Pro-Asn-Lys-Phe Met(0)-Thr-Lys-Pro-Asn-Lys-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Arg-Phe Met(0)-Thr-Lys-Pro-Tyr-Arg-Phe Met(0)-Thr-Lys-Pro-Tyr-Arg-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe-Phe Met(0)-Thr-Lys-Pro-Tyr-Phe-Phe Met(0)-Thr-Lys-Pro-Tyr-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-Tyr-Phe Met(0)-Thr-Lys-Pro-Tyr-His-Phe Met(0)-Thr-Lys-Pro-Tyr-His-Phe Met(0)-Thr-Lys-Pro-Tyr-His-Phe Met(0)-Thr-Lys-Pro-Tyr-Pro-Phe Met(0)-Thr-Lys-Pro-Tyr-Pro-Phe Met(0)-Thr-Lys-Pro-Tyr-Pro-Phe Met(0)-Thr-Lys-Pro-Tyr-Lys-Phe Met(0)-Thr-Lys-Pro-Tyr-Lys-Phe Met(0)-Thr-Lys-Pro-Tyr-Lys-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Arg-Phe Met(0)-Thr-Lys-Pro-Arg-Phe-Phe Met(0)-Thr-Lys-Pro-Arg-Phe-Phe Met(0)-Thr-Lys-Pro-Arg-Phe-Phe Met(0)-Thr- Met(0)-Thr-Lys- Met(0)-Thr-Lys-

Lys-Pro-Arg-Tyr-Phe Pro-Arg-Tyr-Phe Pro-Arg-Tyr-Phe Met(0)-Thr-Lys-Pro-Arg-His-Phe Met(0)-Thr-Lys-Pro-Arg-His-Phe Met(0)-Thr-Lys-Pro-Arg-His-Phe Met(0)-Thr-Lys-Pro-Arg-Pro-Phe Met(0)-Thr-Lys-Pro-Arg-Pro-Phe Met(0)-Thr-Lys-Pro-Arg-Pro-Phe Met(0)-Thr-Lys-Pro-Arg-Lys-Phe Met(0)-Thr-Lys-Pro-Arg-Lys-Phe Met(0)-Thr-Lys-Pro-Arg-Lys-Phe Thr-Thr-Lys-Pro-Phe Thr-Thr-Lys-Pro-Phe Thr-Thr-Lys-Pro-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Phe-Phe Thr-Thr-Lys-Pro-Phe-Phe Thr-Thr-Lys-Pro-Phe-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-His-Phe Thr-Thr-Lys-Pro-His-Phe Thr-Thr-Lys-Pro-His-Phe Thr-Thr-Lys-Pro-Lys-Phe Thr-Thr-Lys-Pro-Lys-Phe Thr-Thr-Lys-Pro-Lys-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Phe Thr-Thr-Lys-Pro-Gly-Arg-Phe Thr-Thr-Lys-Pro-Gly-Arg-Phe Thr-Thr-Lys-Pro-Gly-Arg-Phe Thr-Thr-Lys-Pro-Gly-Phe-Phe Thr-Thr-Lys-Pro-Gly-Phe-Phe Thr-Thr-Lys-Pro-Gly-Phe-Phe Thr-Thr-Lys-Pro-Gly-Tyr-Phe Thr-Thr-Lys-Pro-Gly-Tyr-Phe Thr-Thr-Lys-Pro-Gly-Tyr-Phe

Thr-Thr-Lys-Pro-Gly-His-Phe Thr-Thr-Lys-Pro-Gly-His-Phe Thr-Thr-Lys-Pro-Gly-His-Phe Thr-Thr-Lys-Pro-Gly-Pro-Phe Thr-Thr-Lys-Pro-Gly-Pro-Phe Thr-Thr-Lys-Pro-Gly-Pro-Phe Thr-Thr-Lys-Pro-Gly-Lys-Phe Thr-Thr-Lys-Pro-Gly-Lys-Phe Thr-Thr-Lys-Pro-Gly-Lys-Phe Thr-Thr-Lys-Pro-Asp-Phe Thr-Thr-Lys-Pro-Asp-Phe Thr-Thr-Lys-Pro-Asp-Phe Thr-Thr-Lys-Pro-Asp-Arg-Phe Thr-Thr-Lys-Pro-Asp-Arg-Phe Thr-Thr-Lys-Pro-Asp-Arg-Phe Thr-Thr-Lys-Pro-Asp-Phe-Phe Thr-Thr-Lys-Pro-Asp-Phe-Phe Thr-Thr-Lys-Pro-Asp-Phe-Phe Thr-Thr-Lys-Pro-Asp-Tyr-Phe Thr-Thr-Lys-Pro-Asp-Tyr-Phe Thr-Thr-Lys-Pro-Asp-Tyr-Phe Thr-Thr-Lys-Pro-Asp-His-Phe Thr-Thr-Lys-Pro-Asp-His-Phe Thr-Thr-Lys-Pro-Asp-His-Phe Thr-Thr-Lys-Pro-Asp-Pro-Phe Thr-Thr-Lys-Pro-Asp-Pro-Phe Thr-Thr-Lys-Pro-Asp-Pro-Phe Thr-Thr-Lys-Pro-Asp-Lys-Phe Thr-Thr-Lys-Pro-Asp-Lys-Phe Thr-Thr-Lys-Pro-Asp-Lys-Phe Thr-Thr-Lys-Pro-Trp-Phe Thr-Thr-Lys-Pro-Trp-Phe Thr-Thr-Lys-Pro-Trp-Phe Thr-Thr-Lys-Pro-Trp-Arg-Phe Thr-Thr-Lys-Pro-Trp-Arg-Phe Thr-Thr-Lys-Pro-Trp-Arg-Phe Thr-Thr-Lys-Pro-Trp-Phe-Phe Thr-Thr-Lys-Pro-Trp-Phe-Phe Thr-Thr-Lys-Pro-Trp-Phe-Phe Thr-Thr-Lys-Pro-Trp-Tyr-Phe Thr-Thr-Lys-Pro-Trp-Tyr-Phe Thr-Thr-Lys-Pro-Trp-Tyr-Phe Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Trp-His-Phe Trp-His-Phe Pro-Trp-His-Phe Thr-Thr-Lys-Pro-Trp-Pro-Phe Thr-Thr-Lys-Pro-Trp-Pro-Phe Thr-Thr-Lys-Pro-Trp-Pro-Phe Thr-Thr-Lys-Pro-Trp-Lys-Phe Thr-Thr-Lys-Pro-Trp-Lys-Phe Thr-Thr-Lys-Pro-Trp-Lys-Phe Thr-Thr-Lys-Pro-Gln-Phe Thr-Thr-Lys-Pro-Gln-Phe Thr-Thr-Lys-Pro-Gln-Phe Thr-Thr-Lys-Pro-Gln-Arg-Phe Thr-Thr-Lys-Pro-Gln-Arg-Phe Thr-Thr-Lys-Pro-Gln-Arg-Phe Thr-Thr-Lys-Pro-Gln-Phe-Phe Thr-Thr-Lys-Pro-Gln-Phe-Phe Thr-Thr-Lys-Pro-Gln-Phe-Phe Thr-Thr-Lys-Pro-Gln-Tyr-Phe Thr-Thr-Lys-Pro-Gln-Tyr-Phe Thr-Thr-Lys-Pro-Gln-Tyr-Phe Thr-Thr-Lys-Pro-Gln-His-Phe Thr-Thr-Lys-Pro-Gln-His-Phe Thr-Thr-Lys-Pro-Gln-His-Phe Thr-Thr-Lys-Pro-Gln-Pro-Phe Thr-Thr-Lys-Pro-Gln-Pro-Phe Thr-Thr-Lys-Pro-Gln-Pro-Phe Thr-Thr-Lys-Pro-Gln-Lys-Phe Thr-Thr-Lys-Pro-Gln-Lys-Phe Thr-Thr-Lys-Pro-Gln-Lys-Phe Thr-Thr-Lys-Pro-Asn-Phe Thr-Thr-Lys-Pro-Asn-Phe Thr-Thr-Lys-Pro-Asn-Phe Thr-Thr-Lys-Pro-Asn-Arg-Phe Thr-Thr-Lys-Pro-Asn-Arg-Phe Thr-Thr-Lys-Pro-Asn-Arg-Phe Thr-Thr-Lys-Pro-Asn-Phe-Phe Thr-Thr-Lys-Pro-Asn-Phe-Phe Thr-Thr-Lys-Pro-Asn-Phe-Phe Thr-Thr-Lys-Pro-Asn-Tyr-Phe Thr-Thr-Lys-Pro-Asn-Tyr-Phe Thr-Thr-Lys-Pro-Asn-Tyr-Phe Thr-Thr-Lys-Pro-Asn-His-Phe Thr-Thr-Lys-Pro-Asn-His-Phe Thr-Thr-Lys-Pro-Asn-His-Phe

Thr-Thr-Lys-Pro-Asn-Pro-Phe Thr-Thr-Lys-Pro-Asn-Pro-Phe Thr-Thr-Lys-Pro-Asn-Pro-Phe Thr-Thr-Lys-Pro-Asn-Lys-Phe Thr-Thr-Lys-Pro-Asn-Lys-Phe Thr-Thr-Lys-Pro-Asn-Lys-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Arg-Phe Thr-Thr-Lys-Pro-Tyr-Arg-Phe Thr-Thr-Lys-Pro-Tyr-Arg-Phe Thr-Thr-Lys-Pro-Tyr-Phe-Phe Thr-Thr-Lys-Pro-Tyr-Phe-Phe Thr-Thr-Lys-Pro-Tyr-Phe-Phe Thr-Thr-Lys-Pro-Tyr-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-Tyr-Phe Thr-Thr-Lys-Pro-Tyr-His-Phe Thr-Thr-Lys-Pro-Tyr-His-Phe Thr-Thr-Lys-Pro-Tyr-His-Phe Thr-Thr-Lys-Pro-Tyr-Pro-Phe Thr-Thr-Lys-Pro-Tyr-Pro-Phe Thr-Thr-Lys-Pro-Tyr-Pro-Phe Thr-Thr-Lys-Pro-Tyr-Lys-Phe Thr-Thr-Lys-Pro-Tyr-Lys-Phe Thr-Thr-Lys-Pro-Tyr-Lys-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe Thr-Thr-Lys-Pro-Arg-Arg-Phe Thr-Thr-Lys-Pro-Arg-Arg-Phe Thr-Thr-Lys-Pro-Arg-Arg-Phe Thr-Thr-Lys-Pro-Arg-Phe-Phe Thr-Thr-Lys-Pro-Arg-Phe-Phe Thr-Thr-Lys-Pro-Arg-Phe-Phe Thr-Thr-Lys-Pro-Arg-Tyr-Phe Thr-Thr-Lys-Pro-Arg-Tyr-Phe Thr-Thr-Lys-Pro-Arg-Tyr-Phe Thr-Thr-Lys-Pro-Arg-His-Phe Thr-Thr-Lys-Pro-Arg-His-Phe Thr-Thr-Lys-Pro-Arg-His-Phe Thr-Thr-Lys- Thr-Thr-Lys-Pro- Thr-Thr-Lys-

Pro-Arg-Pro-Phe Arg-Pro-Phe Pro-Arg-Pro-Phe Thr-Thr-Lys-Pro-Arg-Lys-Phe Thr-Thr-Lys-Pro-Arg-Lys-Phe Thr-Thr-Lys-Pro-Arg-Lys-Phe Ala-Thr-Lys-Pro-Phe Ala-Thr-Lys-Pro-Phe Ala-Thr-Lys-Pro-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Phe-Phe Ala-Thr-Lys-Pro-Phe-Phe Ala-Thr-Lys-Pro-Phe-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-His-Phe Ala-Thr-Lys-Pro-His-Phe Ala-Thr-Lys-Pro-His-Phe Ala-Thr-Lys-Pro-Lys-Phe Ala-Thr-Lys-Pro-Lys-Phe Ala-Thr-Lys-Pro-Lys-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Phe Ala-Thr-Lys-Pro-Gly-Arg-Phe Ala-Thr-Lys-Pro-Gly-Arg-Phe Ala-Thr-Lys-Pro-Gly-Arg-Phe Ala-Thr-Lys-Pro-Gly-Phe-Phe Ala-Thr-Lys-Pro-Gly-Phe-Phe Ala-Thr-Lys-Pro-Gly-Phe-Phe Ala-Thr-Lys-Pro-Gly-Tyr-Phe Ala-Thr-Lys-Pro-Gly-Tyr-Phe Ala-Thr-Lys-Pro-Gly-Tyr-Phe Ala-Thr-Lys-Pro-Gly-His-Phe Ala-Thr-Lys-Pro-Gly-His-Phe Ala-Thr-Lys-Pro-Gly-His-Phe Ala-Thr-Lys-Pro-Gly-Pro-Phe Ala-Thr-Lys-Pro-Gly-Pro-Phe Ala-Thr-Lys-Pro-Gly-Pro-Phe

Ala-Thr-Lys-Pro-Gly-Lys-Phe Ala-Thr-Lys-Pro-Gly-Lys-Phe Ala-Thr-Lys-Pro-Gly-Lys-Phe Ala-Thr-Lys-Pro-Asp-Phe Ala-Thr-Lys-Pro-Asp-Phe Ala-Thr-Lys-Pro-Asp-Phe Ala-Thr-Lys-Pro-Asp-Arg-Phe Ala-Thr-Lys-Pro-Asp-Arg-Phe Ala-Thr-Lys-Pro-Asp-Arg-Phe Ala-Thr-Lys-Pro-Asp-Phe-Phe Ala-Thr-Lys-Pro-Asp-Phe-Phe Ala-Thr-Lys-Pro-Asp-Phe-Phe Ala-Thr-Lys-Pro-Asp-Tyr-Phe Ala-Thr-Lys-Pro-Asp-Tyr-Phe Ala-Thr-Lys-Pro-Asp-Tyr-Phe Ala-Thr-Lys-Pro-Asp-His-Phe Ala-Thr-Lys-Pro-Asp-His-Phe Ala-Thr-Lys-Pro-Asp-His-Phe Ala-Thr-Lys-Pro-Asp-Pro-Phe Ala-Thr-Lys-Pro-Asp-Pro-Phe Ala-Thr-Lys-Pro-Asp-Pro-Phe Ala-Thr-Lys-Pro-Asp-Lys-Phe Ala-Thr-Lys-Pro-Asp-Lys-Phe Ala-Thr-Lys-Pro-Asp-Lys-Phe Ala-Thr-Lys-Pro-Trp-Phe Ala-Thr-Lys-Pro-Trp-Phe Ala-Thr-Lys-Pro-Trp-Phe Ala-Thr-Lys-Pro-Trp-Arg-Phe Ala-Thr-Lys-Pro-Trp-Arg-Phe Ala-Thr-Lys-Pro-Trp-Arg-Phe Ala-Thr-Lys-Pro-Trp-Phe-Phe Ala-Thr-Lys-Pro-Trp-Phe-Phe Ala-Thr-Lys-Pro-Trp-Phe-Phe Ala-Thr-Lys-Pro-Trp-Tyr-Phe Ala-Thr-Lys-Pro-Trp-Tyr-Phe Ala-Thr-Lys-Pro-Trp-Tyr-Phe Ala-Thr-Lys-Pro-Trp-His-Phe Ala-Thr-Lys-Pro-Trp-His-Phe Ala-Thr-Lys-Pro-Trp-His-Phe Ala-Thr-Lys-Pro-Trp-Pro-Phe Ala-Thr-Lys-Pro-Trp-Pro-Phe Ala-Thr-Lys-Pro-Trp-Pro-Phe Ala-Thr-Lys- Ala-Thr-Lys-Pro- Ala-Thr-Lys-

Pro-Trp-Lys-Phe Trp-Lys-Phe Pro-Trp-Lys-Phe Ala-Thr-Lys-Pro-Gln-Phe Ala-Thr-Lys-Pro-Gln-Phe Ala-Thr-Lys-Pro-Gln-Phe Ala-Thr-Lys-Pro-Gln-Arg-Phe Ala-Thr-Lys-Pro-Gln-Arg-Phe Ala-Thr-Lys-Pro-Gln-Arg-Phe Ala-Thr-Lys-Pro-Gln-Phe-Phe Ala-Thr-Lys-Pro-Gln-Phe-Phe Ala-Thr-Lys-Pro-Gln-Phe-Phe Ala-Thr-Lys-Pro-Gln-Tyr-Phe Ala-Thr-Lys-Pro-Gln-Tyr-Phe Ala-Thr-Lys-Pro-Gln-Tyr-Phe Ala-Thr-Lys-Pro-Gln-His-Phe Ala-Thr-Lys-Pro-Gln-His-Phe Ala-Thr-Lys-Pro-Gln-His-Phe Ala-Thr-Lys-Pro-Gln-Pro-Phe Ala-Thr-Lys-Pro-Gln-Pro-Phe Ala-Thr-Lys-Pro-Gln-Pro-Phe Ala-Thr-Lys-Pro-Gln-Lys-Phe Ala-Thr-Lys-Pro-Gln-Lys-Phe Ala-Thr-Lys-Pro-Gln-Lys-Phe Ala-Thr-Lys-Pro-Asn-Phe Ala-Thr-Lys-Pro-Asn-Phe Ala-Thr-Lys-Pro-Asn-Phe Ala-Thr-Lys-Pro-Asn-Arg-Phe Ala-Thr-Lys-Pro-Asn-Arg-Phe Ala-Thr-Lys-Pro-Asn-Arg-Phe Ala-Thr-Lys-Pro-Asn-Phe-Phe Ala-Thr-Lys-Pro-Asn-Phe-Phe Ala-Thr-Lys-Pro-Asn-Phe-Phe Ala-Thr-Lys-Pro-Asn-Tyr-Phe Ala-Thr-Lys-Pro-Asn-Tyr-Phe Ala-Thr-Lys-Pro-Asn-Tyr-Phe Ala-Thr-Lys-Pro-Asn-His-Phe Ala-Thr-Lys-Pro-Asn-His-Phe Ala-Thr-Lys-Pro-Asn-His-Phe Ala-Thr-Lys-Pro-Asn-Pro-Phe Ala-Thr-Lys-Pro-Asn-Pro-Phe Ala-Thr-Lys-Pro-Asn-Pro-Phe Ala-Thr-Lys-Pro-Asn-Lys-Phe Ala-Thr-Lys-Pro-Asn-Lys-Phe Ala-Thr-Lys-Pro-Asn-Lys-Phe

Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Arg-Phe Ala-Thr-Lys-Pro-Tyr-Arg-Phe Ala-Thr-Lys-Pro-Tyr-Arg-Phe Ala-Thr-Lys-Pro-Tyr-Phe-Phe Ala-Thr-Lys-Pro-Tyr-Phe-Phe Ala-Thr-Lys-Pro-Tyr-Phe-Phe Ala-Thr-Lys-Pro-Tyr-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-Tyr-Phe Ala-Thr-Lys-Pro-Tyr-His-Phe Ala-Thr-Lys-Pro-Tyr-His-Phe Ala-Thr-Lys-Pro-Tyr-His-Phe Ala-Thr-Lys-Pro-Tyr-Pro-Phe Ala-Thr-Lys-Pro-Tyr-Pro-Phe Ala-Thr-Lys-Pro-Tyr-Pro-Phe Ala-Thr-Lys-Pro-Tyr-Lys-Phe Ala-Thr-Lys-Pro-Tyr-Lys-Phe Ala-Thr-Lys-Pro-Tyr-Lys-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe Ala-Thr-Lys-Pro-Arg-Arg-Phe Ala-Thr-Lys-Pro-Arg-Arg-Phe Ala-Thr-Lys-Pro-Arg-Arg-Phe Ala-Thr-Lys-Pro-Arg-Phe-Phe Ala-Thr-Lys-Pro-Arg-Phe-Phe Ala-Thr-Lys-Pro-Arg-Phe-Phe Ala-Thr-Lys-Pro-Arg-Tyr-Phe Ala-Thr-Lys-Pro-Arg-Tyr-Phe Ala-Thr-Lys-Pro-Arg-Tyr-Phe Ala-Thr-Lys-Pro-Arg-His-Phe Ala-Thr-Lys-Pro-Arg-His-Phe Ala-Thr-Lys-Pro-Arg-His-Phe Ala-Thr-Lys-Pro-Arg-Pro-Phe Ala-Thr-Lys-Pro-Arg-Pro-Phe Ala-Thr-Lys-Pro-Arg-Pro-Phe Ala-Thr-Lys-Pro-Arg-Lys-Phe Ala-Thr-Lys-Pro-Arg-Lys-Phe Ala-Thr-Lys-Pro-Arg-Lys-Phe His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Phe Phe Pro-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Phe-Phe His-Thr-Lys-Pro-Phe-Phe His-Thr-Lys-Pro-Phe-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-His-Phe His-Thr-Lys-Pro-His-Phe His-Thr-Lys-Pro-His-Phe His-Thr-Lys-Pro-Lys-Phe His-Thr-Lys-Pro-Lys-Phe His-Thr-Lys-Pro-Lys-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Phe His-Thr-Lys-Pro-Gly-Arg-Phe His-Thr-Lys-Pro-Gly-Arg-Phe His-Thr-Lys-Pro-Gly-Arg-Phe His-Thr-Lys-Pro-Gly-Phe-Phe His-Thr-Lys-Pro-Gly-Phe-Phe His-Thr-Lys-Pro-Gly-Phe-Phe His-Thr-Lys-Pro-Gly-Tyr-Phe His-Thr-Lys-Pro-Gly-Tyr-Phe His-Thr-Lys-Pro-Gly-Tyr-Phe His-Thr-Lys-Pro-Gly-His-Phe His-Thr-Lys-Pro-Gly-His-Phe His-Thr-Lys-Pro-Gly-His-Phe His-Thr-Lys-Pro-Gly-Pro-Phe His-Thr-Lys-Pro-Gly-Pro-Phe His-Thr-Lys-Pro-Gly-Pro-Phe His-Thr-Lys-Pro-Gly-Lys-Phe His-Thr-Lys-Pro-Gly-Lys-Phe His-Thr-Lys-Pro-Gly-Lys-Phe His-Thr-Lys-Pro-Asp-Phe His-Thr-Lys-Pro-Asp-Phe His-Thr-Lys-Pro-Asp-Phe

His-Thr-Lys-Pro-Asp-Arg-Phe His-Thr-Lys-Pro-Asp-Arg-Phe His-Thr-Lys-Pro-Asp-Arg-Phe His-Thr-Lys-Pro-Asp-Phe-Phe His-Thr-Lys-Pro-Asp-Phe-Phe His-Thr-Lys-Pro-Asp-Phe-Phe His-Thr-Lys-Pro-Asp-Tyr-Phe His-Thr-Lys-Pro-Asp-Tyr-Phe His-Thr-Lys-Pro-Asp-Tyr-Phe His-Thr-Lys-Pro-Asp-His-Phe His-Thr-Lys-Pro-Asp-His-Phe His-Thr-Lys-Pro-Asp-His-Phe His-Thr-Lys-Pro-Asp-Pro-Phe His-Thr-Lys-Pro-Asp-Pro-Phe His-Thr-Lys-Pro-Asp-Pro-Phe His-Thr-Lys-Pro-Asp-Lys-Phe His-Thr-Lys-Pro-Asp-Lys-Phe His-Thr-Lys-Pro-Asp-Lys-Phe His-Thr-Lys-Pro-Trp-Phe His-Thr-Lys-Pro-Trp-Phe His-Thr-Lys-Pro-Trp-Phe His-Thr-Lys-Pro-Trp-Arg-Phe His-Thr-Lys-Pro-Trp-Arg-Phe His-Thr-Lys-Pro-Trp-Arg-Phe His-Thr-Lys-Pro-Trp-Phe-Phe His-Thr-Lys-Pro-Trp-Phe-Phe His-Thr-Lys-Pro-Trp-Phe-Phe His-Thr-Lys-Pro-Trp-Tyr-Phe His-Thr-Lys-Pro-Trp-Tyr-Phe His-Thr-Lys-Pro-Trp-Tyr-Phe His-Thr-Lys-Pro-Trp-His-Phe His-Thr-Lys-Pro-Trp-His-Phe His-Thr-Lys-Pro-Trp-His-Phe His-Thr-Lys-Pro-Trp-Pro-Phe His-Thr-Lys-Pro-Trp-Pro-Phe His-Thr-Lys-Pro-Trp-Pro-Phe His-Thr-Lys-Pro-Trp-Lys-Phe His-Thr-Lys-Pro-Trp-Lys-Phe His-Thr-Lys-Pro-Trp-Lys-Phe His-Thr-Lys-Pro-Gln-Phe His-Thr-Lys-Pro-Gln-Phe His-Thr-Lys-Pro-Gln-Phe His-Thr-Lys- His-Thr-Lys-Pro- His-Thr-Lys-

Pro-Gln-Arg-Phe Gln-Arg-Phe Pro-Gln-Arg-Phe His-Thr-Lys-Pro-Gln-Phe-Phe His-Thr-Lys-Pro-Gln-Phe-Phe His-Thr-Lys-Pro-Gln-Phe-Phe His-Thr-Lys-Pro-Gln-Tyr-Phe His-Thr-Lys-Pro-Gln-Tyr-Phe His-Thr-Lys-Pro-Gln-Tyr-Phe His-Thr-Lys-Pro-Gln-His-Phe His-Thr-Lys-Pro-Gln-His-Phe His-Thr-Lys-Pro-Gln-His-Phe His-Thr-Lys-Pro-Gln-Pro-Phe His-Thr-Lys-Pro-Gln-Pro-Phe His-Thr-Lys-Pro-Gln-Pro-Phe His-Thr-Lys-Pro-Gln-Lys-Phe His-Thr-Lys-Pro-Gln-Lys-Phe His-Thr-Lys-Pro-Gln-Lys-Phe His-Thr-Lys-Pro-Asn-Phe His-Thr-Lys-Pro-Asn-Phe His-Thr-Lys-Pro-Asn-Phe His-Thr-Lys-Pro-Asn-Arg-Phe His-Thr-Lys-Pro-Asn-Arg-Phe His-Thr-Lys-Pro-Asn-Arg-Phe His-Thr-Lys-Pro-Asn-Phe-Phe His-Thr-Lys-Pro-Asn-Phe-Phe His-Thr-Lys-Pro-Asn-Phe-Phe His-Thr-Lys-Pro-Asn-Tyr-Phe His-Thr-Lys-Pro-Asn-Tyr-Phe His-Thr-Lys-Pro-Asn-Tyr-Phe His-Thr-Lys-Pro-Asn-His-Phe His-Thr-Lys-Pro-Asn-His-Phe His-Thr-Lys-Pro-Asn-His-Phe His-Thr-Lys-Pro-Asn-Pro-Phe His-Thr-Lys-Pro-Asn-Pro-Phe His-Thr-Lys-Pro-Asn-Pro-Phe His-Thr-Lys-Pro-Asn-Lys-Phe His-Thr-Lys-Pro-Asn-Lys-Phe His-Thr-Lys-Pro-Asn-Lys-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Phe His-Thr-Lys-Pro-Tyr-Arg-Phe His-Thr-Lys-Pro-Tyr-Arg-Phe His-Thr-Lys-Pro-Tyr-Arg-Phe

His-Thr-Lys-Pro-Tyr-Phe-Phe His-Thr-Lys-Pro-Tyr-Phe-Phe His-Thr-Lys-Pro-Tyr-Phe-Phe His-Thr-Lys-Pro-Tyr-Tyr-Phe His-Thr-Lys-Pro-Tyr-Tyr-Phe His-Thr-Lys-Pro-Tyr-Tyr-Phe His-Thr-Lys-Pro-Tyr-His-Phe His-Thr-Lys-Pro-Tyr-His-Phe His-Thr-Lys-Pro-Tyr-His-Phe His-Thr-Lys-Pro-tyr-Pro-Phe His-Thr-Lys-Pro-Tyr-Pro-Phe His-Thr-Lys-Pro-Tyr-Pro-Phe His-Thr-Lys-Pro-Tyr-Lys-Phe His-Thr-Lys-Pro-Tyr-Lys-Phe His-Thr-Lys-Pro-Tyr-Lys-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Phe His-Thr-Lys-Pro-Arg-Arg-Phe His-Thr-Lys-Pro-Arg-Arg-Phe His-Thr-Lys-Pro-Arg-Arg-Phe His-Thr-Lys-Pro-Arg-Phe-Phe His-Thr-Lys-Pro-Arg-Phe-Phe His-Thr-Lys-Pro-Arg-Phe-Phe His-Thr-Lys-Pro-Arg-Tyr-Phe His-Thr-Lys-Pro-Arg-Tyr-Phe His-Thr-Lys-Pro-Arg-Tyr-Phe His-Thr-Lys-Pro-Arg-His-Phe His-Thr-Lys-Pro-Arg-His-Phe His-Thr-Lys-Pro-Arg-His-Phe His-Thr-Lys-Pro-Arg-Pro-Phe His-Thr-Lys-Pro-Arg-Pro-Phe His-Thr-Lys-Pro-Arg-Pro-Phe His-Thr-Lys-Pro-Arg-Lys-Phe His-Thr-Lys-Pro-Arg-Lys-Phe His-Thr-Lys-Pro-Arg-Lys-Phe Lys-Thr-Lys-Pro-Phe Lys-Thr-Lys-Pro-Phe Lys-Thr-Lys-Pro-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Phe-Phe Pro-Phe-Phe Pro-Phe-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-His-Phe Lys-Thr-Lys-Pro-His-Phe Lys-Thr-Lys-Pro-His-Phe Lys-Thr-Lys-Pro-Lys-Phe Lys-Thr-Lys-Pro-Lys-Phe Lys-Thr-Lys-Pro-Lys-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Phe Lys-Thr-Lys-Pro-Gly-Arg-Phe Lys-Thr-Lys-Pro-Gly-Arg-Phe Lys-Thr-Lys-Pro-Gly-Arg-Phe Lys-Thr-Lys-Pro-Gly-Phe-Phe Lys-Thr-Lys-Pro-Gly-Phe-Phe Lys-Thr-Lys-Pro-Gly-Phe-Phe Lys-Thr-Lys-Pro-Gly-Tyr-Phe Lys-Thr-Lys-Pro-Gly-Tyr-Phe Lys-Thr-Lys-Pro-Gly-Tyr-Phe Lys-Thr-Lys-Pro-Gly-His-Phe Lys-Thr-Lys-Pro-Gly-His-Phe Lys-Thr-Lys-Pro-Gly-His-Phe Lys-Thr-Lys-Pro-Gly-Pro-Phe Lys-Thr-Lys-Pro-Gly-Pro-Phe Lys-Thr-Lys-Pro-Gly-Pro-Phe Lys-Thr-Lys-Pro-Gly-Lys-Phe Lys-Thr-Lys-Pro-Gly-Lys-Phe Lys-Thr-Lys-Pro-Gly-Lys-Phe Lys-Thr-Lys-Pro-Asp-Phe Lys-Thr-Lys-Pro-Asp-Phe Lys-Thr-Lys-Pro-Asp-Phe Lys-Thr-Lys-Pro-Asp-Arg-Phe Lys-Thr-Lys-Pro-Asp-Arg-Phe Lys-Thr-Lys-Pro-Asp-Arg-Phe Lys-Thr-Lys-Pro-Asp-Phe-Phe Lys-Thr-Lys-Pro-Asp-Phe-Phe Lys-Thr-Lys-Pro-Asp-Phe-Phe

Lys-Thr-Lys-Pro-Asp-Tyr-Phe Lys-Thr-Lys-Pro-Asp-Tyr-Phe Lys-Thr-Lys-Pro-Asp-Tyr-Phe Lys-Thr-Lys-Pro-Asp-His-Phe Lys-Thr-Lys-Pro-Asp-His-Phe Lys-Thr-Lys-Pro-Asp-His-Phe Lys-Thr-Lys-Pro-Asp-Pro-Phe Lys-Thr-Lys-Pro-Asp-Pro-Phe Lys-Thr-Lys-Pro-Asp-Pro-Phe Lys-Thr-Lys-Pro-Asp-Lys-Phe Lys-Thr-Lys-Pro-Asp-Lys-Phe Lys-Thr-Lys-Pro-Asp-Lys-Phe Lys-Thr-Lys-Pro-Trp-Phe Lys-Thr-Lys-Pro-Trp-Phe Lys-Thr-Lys-Pro-Trp-Phe Lys-Thr-Lys-Pro-Trp-Arg-Phe Lys-Thr-Lys-Pro-Trp-Arg-Phe Lys-Thr-Lys-Pro-Trp-Arg-Phe Lys-Thr-Lys-Pro-Trp-Phe-Phe Lys-Thr-Lys-Pro-Trp-Phe-Phe Lys-Thr-Lys-Pro-Trp-Phe-Phe Lys-Thr-Lys-Pro-Trp-Tyr-Phe Lys-Thr-Lys-Pro-Trp-Tyr-Phe Lys-Thr-Lys-Pro-Trp-Tyr-Phe Lys-Thr-Lys-Pro-Trp-His-Phe Lys-Thr-Lys-Pro-Trp-His-Phe Lys-Thr-Lys-Pro-Trp-His-Phe Lys-Thr-Lys-Pro-Trp-Pro-Phe Lys-Thr-Lys-Pro-Trp-Pro-Phe Lys-Thr-Lys-Pro-Trp-Pro-Phe Lys-Thr-Lys-Pro-Trp-Lys-Phe Lys-Thr-Lys-Pro-Trp-Lys-Phe Lys-Thr-Lys-Pro-Trp-Lys-Phe Lys-Thr-Lys-Pro-Gln-Phe Lys-Thr-Lys-Pro-Gln-Phe Lys-Thr-Lys-Pro-Gln-Phe Lys-Thr-Lys-Pro-Gln-Arg-Phe Lys-Thr-Lys-Pro-Gln-Arg-Phe Lys-Thr-Lys-Pro-Gln-Arg-Phe Lys-Thr-Lys-Pro-Gln-Phe-Phe Lys-Thr-Lys-Pro-Gln-Phe-Phe Lys-Thr-Lys-Pro-Gln-Phe-Phe Lys-Thr-Lys- Lys-Thr-Lys- Lys-Thr-Lys-

Pro-Gln-Tyr-Phe Pro-Gln-Tyr-Phe Pro-Gln-Tyr-Phe Lys-Thr-Lys-Pro-Gln-His-Phe Lys-Thr-Lys-Pro-Gln-His-Phe Lys-Thr-Lys-Pro-Gln-His-Phe Lys-Thr-Lys-Pro-Gln-Pro-Phe Lys-Thr-Lys-Pro-Gln-Pro-Phe Lys-Thr-Lys-Pro-Gln-Pro-Phe Lys-Thr-Lys-Pro-Gln-Lys-Phe Lys-Thr-Lys-Pro-Gln-Lys-Phe Lys-Thr-Lys-Pro-Gln-Lys-Phe Lys-Thr-Lys-Pro-Asn-Phe Lys-Thr-Lys-Pro-Asn-Phe Lys-Thr-Lys-Pro-Asn-Phe Lys-Thr-Lys-Pro-Asn-Arg-Phe Lys-Thr-Lys-Pro-Asn-Arg-Phe Lys-Thr-Lys-Pro-Asn-Arg-Phe Lys-Thr-Lys-Pro-Asn-Phe-Phe Lys-Thr-Lys-Pro-Asn-Phe-Phe Lys-Thr-Lys-Pro-Asn-Phe-Phe Lys-Thr-Lys-Pro-Asn-Tyr-Phe Lys-Thr-Lys-Pro-Asn-Tyr-Phe Lys-Thr-Lys-Pro-Asn-Tyr-Phe Lys-Thr-Lys-Pro-Asn-His-Phe Lys-Thr-Lys-Pro-Asn-His-Phe Lys-Thr-Lys-Pro-Asn-His-Phe Lys-Thr-Lys-Pro-Asn-Pro-Phe Lys-Thr-Lys-Pro-Asn-Pro-Phe Lys-Thr-Lys-Pro-Asn-Pro-Phe Lys-Thr-Lys-Pro-Asn-Lys-Phe Lys-Thr-Lys-Pro-Asn-Lys-Phe Lys-Thr-Lys-Pro-Asn-Lys-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Arg-Phe Lys-Thr-Lys-Pro-Tyr-Arg-Phe Lys-Thr-Lys-Pro-Tyr-Arg-Phe Lys-Thr-Lys-Pro-Tyr-Phe-Phe Lys-Thr-Lys-Pro-Tyr-Phe-Phe Lys-Thr-Lys-Pro-Tyr-Phe-Phe Lys-Thr-Lys-Pro-Tyr-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Tyr-Phe Lys-Thr-Lys-Pro-Tyr-Tyr-Phe

Lys-Thr-Lys-Pro-Tyr-His-Phe Lys-Thr-Lys-Pro-Tyr-His-Phe Lys-Thr-Lys-Pro-Tyr-His-Phe Lys-Thr-Lys-Pro-Tyr-Pro-Phe Lys-Thr-Lys-Pro-Tyr-Pro-Phe Lys-Thr-Lys-Pro-Tyr-Pro-Phe Lys-Thr-Lys-Pro-Tyr-Lys-Phe Lys-Thr-Lys-Pro-Tyr-Lys-Phe Lys-Thr-Lys-Pro-Tyr-Lys-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe Lys-Thr-Lys-Pro-Arg-Arg-Phe Lys-Thr-Lys-Pro-Arg-Arg-Phe Lys-Thr-Lys-Pro-Arg-Arg-Phe Lys-Thr-Lys-Pro-Arg-Phe-Phe Lys-Thr-Lys-Pro-Arg-Phe-Phe Lys-Thr-Lys-Pro-Arg-Phe-Phe Lys-Thr-Lys-Pro-Arg-Tyr-Phe Lys-Thr-Lys-Pro-Arg-Tyr-Phe Lys-Thr-Lys-Pro-Arg-Tyr-Phe Lys-Thr-Lys-Pro-Arg-His-Phe Lys-Thr-Lys-Pro-Arg-His-Phe Lys-Thr-Lys-Pro-Arg-His-Phe Lys-Thr-Lys-Pro-Arg-Pro-Phe Lys-Thr-Lys-Pro-Arg-Pro-Phe Lys-Thr-Lys-Pro-Arg-Pro-Phe Lys-Thr-Lys-Pro-Arg-Lys-Phe Lys-Thr-Lys-Pro-Arg-Lys-Phe Lys-Thr-Lys-Pro-Arg-Lys-Phe Gly-Thr-Lys-Pro-Phe Gly-Thr-Lys-Pro-Phe Gly-Thr-Lys-Pro-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Phe-Phe Gly-Thr-Lys-Pro-Phe-Phe Gly-Thr-Lys-Pro-Phe-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Gly-Phe Pro-Gly-Phe Pro-Gly-Phe Gly-Thr-Lys-Pro-His-Phe Gly-Thr-Lys-Pro-His-Phe Gly-Thr-Lys-Pro-His-Phe Gly-Thr-Lys-Pro-Lys-Phe Gly-Thr-Lys-Pro-Lys-Phe Gly-Thr-Lys-Pro-Lys-Phe Gly-Thr-Lys-Pro-Gly-Phe Gly-Thr-Lys-Pro-Gly-Phe Gly-Thr-Lys-Pro-Gly-Phe Gly-Thr-Lys-Pro-Gly-Arg-Phe Gly-Thr-Lys-Pro-Gly-Arg-Phe Gly-Thr-Lys-Pro-Gly-Arg-Phe Gly-Thr-Lys-Pro-Gly-Phe-Phe Gly-Thr-Lys-Pro-Gly-Phe-Phe Gly-Thr-Lys-Pro-Gly-Phe-Phe Gly-Thr-Lys-Pro-Gly-Tyr-Phe Gly-Thr-Lys-Pro-Gly-Tyr-Phe Gly-Thr-Lys-Pro-Gly-Tyr-Phe Gly-Thr-Lys-Pro-Gly-His-Phe Gly-Thr-Lys-Pro-Gly-His-Phe Gly-Thr-Lys-Pro-Gly-His-Phe Gly-Thr-Lys-Pro-Gly-Pro-Phe Gly-Thr-Lys-Pro-Gly-Pro-Phe Gly-Thr-Lys-Pro-Gly-Pro-Phe Gly-Thr-Lys-Pro-Gly-Lys-Phe Gly-Thr-Lys-Pro-Gly-Lys-Phe Gly-Thr-Lys-Pro-Gly-Lys-Phe Gly-Thr-Lys-Pro-Asp-Phe Gly-Thr-Lys-Pro-Asp-Phe Gly-Thr-Lys-Pro-Asp-Phe Gly-Thr-Lys-Pro-Asp-Arg-Phe Gly-Thr-Lys-Pro-Asp-Arg-Phe Gly-Thr-Lys-Pro-Asp-Arg-Phe Gly-Thr-Lys-Pro-Asp-Phe-Phe Gly-Thr-Lys-Pro-Asp-Phe-Phe Gly-Thr-Lys-Pro-Asp-Phe-Phe Gly-Thr-Lys-Pro-Asp-Tyr-Phe Gly-Thr-Lys-Pro-Asp-Tyr-Phe Gly-Thr-Lys-Pro-Asp-Tyr-Phe Gly-Thr-Lys-Pro-Asp-His-Phe Gly-Thr-Lys-Pro-Asp-His-Phe Gly-Thr-Lys-Pro-Asp-His-Phe

Gly-Thr-Lys-Pro-Asp-Pro-Phe Gly-Thr-Lys-Pro-Asp-Pro-Phe Gly-Thr-Lys-Pro-Asp-Pro-Phe Gly-Thr-Lys-Pro-Asp-Lys-Phe Gly-Thr-Lys-Pro-Asp-Lys-Phe Gly-Thr-Lys-Pro-Asp-Lys-Phe Gly-Thr-Lys-Pro-Trp-Phe Gly-Thr-Lys-Pro-Trp-Phe Gly-Thr-Lys-Pro-Trp-Phe Gly-Thr-Lys-Pro-Trp-Arg-Phe Gly-Thr-Lys-Pro-Trp-Arg-Phe Gly-Thr-Lys-Pro-Trp-Arg-Phe Gly-Thr-Lys-Pro-Trp-Phe-Phe Gly-Thr-Lys-Pro-Trp-Phe-Phe Gly-Thr-Lys-Pro-Trp-Phe-Phe Gly-Thr-Lys-Pro-Trp-Tyr-Phe Gly-Thr-Lys-Pro-Trp-Tyr-Phe Gly-Thr-Lys-Pro-Trp-Tyr-Phe Gly-Thr-Lys-Pro-Trp-His-Phe Gly-Thr-Lys-Pro-Trp-His-Phe Gly-Thr-Lys-Pro-Trp-His-Phe Gly-Thr-Lys-Pro-Trp-Pro-Phe Gly-Thr-Lys-Pro-Trp-Pro-Phe Gly-Thr-Lys-Pro-Trp-Pro-Phe Gly-Thr-Lys-Pro-Trp-Lys-Phe Gly-Thr-Lys-Pro-Trp-Lys-Phe Gly-Thr-Lys-Pro-Trp-Lys-Phe Gly-Thr-Lys-Pro-Gln-Phe Gly-Thr-Lys-Pro-Gln-Phe Gly-Thr-Lys-Pro-Gln-Phe Gly-Thr-Lys-Pro-Gln-Arg-Phe Gly-Thr-Lys-Pro-Gln-Arg-Phe Gly-Thr-Lys-Pro-Gln-Arg-Phe Gly-Thr-Lys-Pro-Gln-Phe-Phe Gly-Thr-Lys-Pro-Gln-Phe-Phe Gly-Thr-Lys-Pro-Gln-Phe-Phe Gly-Thr-Lys-Pro-Gln-Tyr-Phe Gly-Thr-Lys-Pro-Gln-Tyr-Phe Gly-Thr-Lys-Pro-Gln-Tyr-Phe Gly-Thr-Lys-Pro-Gln-His-Phe Gly-Thr-Lys-Pro-Gln-His-Phe Gly-Thr-Lys-Pro-Gln-His-Phe Gly-Thr-Lys- Gly-Thr-Lys- Gly-Thr-Lys-

Pro-Gln-Pro-Phe Pro-Gln-Pro-Phe Pro-Gln-Pro-Phe Gly-Thr-Lys-Pro-Gln-Lys-Phe Gly-Thr-Lys-Pro-Gln-Lys-Phe Gly-Thr-Lys-Pro-Gln-Lys-Phe Gly-Thr-Lys-Pro-Asn-Phe Gly-Thr-Lys-Pro-Asn-Phe Gly-Thr-Lys-Pro-Asn-Phe Gly-Thr-Lys-Pro-Asn-Arg-Phe Gly-Thr-Lys-Pro-Asn-Arg-Phe Gly-Thr-Lys-Pro-Asn-Arg-Phe Gly-Thr-Lys-Pro-Asn-Phe-Phe Gly-Thr-Lys-Pro-Asn-Phe-Phe Gly-Thr-Lys-Pro-Asn-Phe-Phe Gly-Thr-Lys-Pro-Asn-Tyr-Phe Gly-Thr-Lys-Pro-Asn-Tyr-Phe Gly-Thr-Lys-Pro-Asn-Tyr-Phe Gly-Thr-Lys-Pro-Asn-His-Phe Gly-Thr-Lys-Pro-Asn-His-Phe Gly-Thr-Lys-Pro-Asn-His-Phe Gly-Thr-Lys-Pro-Asn-Pro-Phe Gly-Thr-Lys-Pro-Asn-Pro-Phe Gly-Thr-Lys-Pro-Asn-Pro-Phe Gly-Thr-Lys-Pro-Asn-Lys-Phe Gly-Thr-Lys-Pro-Asn-Lys-Phe Gly-Thr-Lys-Pro-Asn-Lys-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Arg-Phe Gly-Thr-Lys-Pro-Tyr-Arg-Phe Gly-Thr-Lys-Pro-Tyr-Arg-Phe Gly-Thr-Lys-Pro-Tyr-Phe-Phe Gly-Thr-Lys-Pro-Tyr-Phe-Phe Gly-Thr-Lys-Pro-Tyr-Phe-Phe Gly-Thr-Lys-Pro-Tyr-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-Tyr-Phe Gly-Thr-Lys-Pro-Tyr-His-Phe Gly-Thr-Lys-Pro-Tyr-His-Phe Gly-Thr-Lys-Pro-Tyr-His-Phe Gly-Thr-Lys-Pro-Tyr-Pro-Phe Gly-Thr-Lys-Pro-Tyr-Pro-Phe Gly-Thr-Lys-Pro-Tyr-Pro-Phe

Gly-Thr-Lys-Pro-Tyr-Lys-Phe Gly-Thr-Lys-Pro-Tyr-Lys-Phe Gly-Thr-Lys-Pro-Tyr-Lys-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe Gly-Thr-Lys-Pro-Arg-Arg-Phe Gly-Thr-Lys-Pro-Arg-Arg-Phe Gly-Thr-Lys-Pro-Arg-Arg-Phe Gly-Thr-Lys-Pro-Arg-Phe-Phe Gly-Thr-Lys-Pro-Arg-Phe-Phe Gly-Thr-Lys-Pro-Arg-Phe-Phe Gly-Thr-Lys-Pro-Arg-Tyr-Phe Gly-Thr-Lys-Pro-Arg-Tyr-Phe Gly-Thr-Lys-Pro-Arg-Tyr-Phe Gly-Thr-Lys-Pro-Arg-His-Phe Gly-Thr-Lys-Pro-Arg-His-Phe Gly-Thr-Lys-Pro-Arg-His-Phe Gly-Thr-Lys-Pro-Arg-Pro-Phe Gly-Thr-Lys-Pro-Arg-Pro-Phe Gly-Thr-Lys-Pro-Arg-Pro-Phe Gly-Thr-Lys-Pro-Arg-Lys-Phe Gly-Thr-Lys-Pro-Arg-Lys-Phe Gly-Thr-Lys-Pro-Arg-Lys-Phe

Ниже приведены примеры, иллюстрирующие изобретение. Синтез пептидов общей формулы A-Thr-Lys-Pro-Б-В-Г-Х осуществляли методами пептидной химии в растворе с использованием L-аминокислот. Синтез пептидов проводился как ступенчатым наращиванием пептидной цепи, так и фрагментной конденсацией с применением метода смешанных ангидридов, карбодиимидного метода с добавлением 1-оксибензотриазола в качестве нуклеофильной добавки, методом активированных эфиров, методом смешанных ангидридов. Все промежуточные и конечные продукты были выделены и охарактеризованы. Упаривание растворов проводили на вакуумном испарителе при 40°C. Температуры плавления, определенные на столике для плавления Boetiys, даны без исправления. Индивидуальность полученных соединений проверяли с помощью ТСХ на пластинках с силикагелем фирмы Silufol (Чехия). Вещества обнаруживали в УФ-свете, с помощью нингидрина, реагентов Бартона, Паули и Рейнделя-Хоппе, о-толидина в среде хлора. Удельное вращение определяли на поляриметре марки «А1-ЕПО». Проверку гомогенности пептида проводили с помощью высокоэффективной жидкостной хроматографии (ВЭЖХ), а структуру подтверждали масс-спектрометрическими методами. Все растворители соответствующим образом абсолютировали. Точки плавления не корректировали.

Пептиды также получали методами генной инженерии, при помощи клеток-хозяв, сконструированных на основе известных лабораторных штаммов Е.coli, трансформированных известными коммерчески доступными плазмидами, содержащими нуклеиновую кислоту, кодирующую интересующий пептид.

В примерах приведен синтез пептидов.

Пример 1. Синтез тетрапептида Arg-Pro-Gly-Pro.

Синтез тетрапептида осуществляли по схеме, приведенной на фиг. 1.

При синтезе использовами метод смешанных ангидридов, азидный метод и карбодиимидный метод. Для синтеза использовали производные L-аминокислот. Упаривание растворов проводили на роторном испарителе при 40°C. Температуры плавления, определенные на столике для плавления Boetiys, даны без исправления. Индивидуальность полученных соединений проверяли с помощью ТСХ на пластинках с силикагелем фирмы Silufol (Чехия). Вещества обнаруживали, опрыскивая пластинки раствором нингидрина и(или) о-толидина. Приведены хроматографические подвижности (Rf) в системах растворителей: ацетон:бензол:уксусная кислота (50:100:1)-(1); хлороформ:метанол (9:1)-(2); гексан:ацетон (3:2)-(3); бутанол:уксусная кислота:вода (4:1:1)-(4); бутанол: уксусная кислота:пиридин:вода (30:6:20:24)-(5); хлороформ:метанол:аммиак (6:4:1)-(6); бензол:этанол (8:2)-(7); этилацетат:ацетон:50% уксусная кислота:вода (2:1:1)-(8); хлороформ:метанол (14:1)-(9); хлороформ:метанол:аммиак (8:1,75:0,25)-(10); хлороформ:метанол:аммиак (6,5:3,0:0,5)-(11).

Удельное вращение определяли на поляриметре «A1-ЕПО».

Элементный анализ на анализаторе "Carlo-Erba" модель 1106.

I. Boc-Pro-Glv-OEt Boc-Pro-OH 8,3 г (3,45 ммоль) растворяли в 50 мл CH₂Cl₂, охлаждали до +5°C, добавляли 38,45 ммоль (5,38 мл) ТЭА. Реакционную смесь охлаждали до -25 - -30°C. При этой температуре из пипетки прибавляли 38,45 ммоль (4,84 мл) изобутилового эфира хлормуравьиной кислоты. Температуру реакционной смеси удерживали в интервале -18 - -20°C 20 минут. Одновременно готовили раствор 5,9 г (42,3 ммоль) избыток 1,1 HCl·H-Gly-OEt в 75 мл хлороформа, содержащего 5,92 мл ТЭА. Раствор охлаждали до -25°C и, после образования смешанного ангидрида в первой колбе, ее содержимое приливали сразу же к раствору эфира. Реакционную смесь выдерживали 1 час при температуре -10°C и затем 12 часов при температуре +4°C при перемешивании на магнитной мешалке. Реакционную смесь упаривали, добавляли 250 мл этилацетата, раствор этилацетата промывали 3 раза по 25 мл 0,1 н. НС1, 3 раза по 25 мл H₂O, 1 раз насыщенным раствором NaCl. Органический слой высушивали над MgSO₄, отфильтровали и упаривали. Остаток высушивали в вакууме над P₂O₅/KOH и парафином.

Выход - 10,2 г (30,3 ммоль) 78,83%

Rf - 0,5 (7); 0,862 (8)

Т.пл. 68-70°C.

II. Boc-Pro-Glv-N₂H₃. Boc-Pro-Gly-OEt 10,2 г (30,3 ммоль) растворяли в 80 мл абсолютного метанола, добавляли 4-х кратный избыток гидразин-гидрата 5,88 мл (121,2 ммоль). Перемешивали 12 часов на магнитной мешалке при комнатной температуре. Реакционную смесь упаривали, два раза упаривали с эфиром, остаток заливали эфиром (~5 мл) и оставляли в холодильнике на ночь (для лучшей кристаллизации добавляли затравку). Выпавшие кристаллы отфильтровывали, промывали на фильтре эфиром, сушили в эксикаторе.

Выход - 6,9 г (20,79 ммоль) 68,62%

Rf - 0,284 (7); 0,474 (8); 0,189 (9)

Т.пл.98-100°C.

III. Boc-Pro-Glv-Pro-OBzl. К охлажденному до -20°C раствору Вос-Pro-Gly-N₂H₃ 4,7 г (14,6 ммоль) в 40 мл ДМФА добавляли 58,4 ммоль (4-х кратный избыток) раствора хлористого водорода в этилацетате и сразу же 1,73 мл (14,6 ммоль) свежеперегнанного трет-бутилнитрита, реакционную смесь перемешивали 30 минут при -5°C. Реакционную смесь охлаждали до -40°C и добавляли охлажденный до -10°C раствор 8,2 мл (58,4 ммоль) ТЭА в 4 мл ДМФА; когда температура реакционной смеси повышалась до -20°C, добавляли 3,7 г (15,3 ммоль) избыток 1,05 HCl-H-Pro-OBzl в 20 мл ДМФА и 2,14 мл ТЭА. Выдерживали при 4°C 24 часа, перемешивая на магнитной мешалке. Реакционную смесь упаривали, остаток растворяли в 200 мл этилацетата и промывали 2 раза по 20 мл H₂O, 3 раза по 20 мл 10% раствором KHSO₄, 3 раза по 20 мл H₂O, 3 раза по 20 мл 5% раствором NaHCO₃, 3 раза по 20 мл H₂O. Этилацетатный слой высушивали над MgSO₄. Упаривали, остаток заливали небольшим количеством эфира (~10 мл). Оставляли в холодильнике для кристаллизации. Для лучшей кристаллизации продукта добавляли затравку. Выпавшие кристаллы отфильтровывали, промывали на фильтре небольшим количеством эфира. Сушили в эксикаторе.

Выход - 5,358 г (11,65 ммоль) 79,92%

Rf - 0,326 (7); 0,947 (8); 0,390 (9)

Т.пл. 125-126°C.

[α]_D ²²=-101,18° (с=0,85; CH₃OH).

Элементный анализ: С 62,89(62,73); N 9,21(9,14); Н 7,52(7,24).

IV. ТФА H-Pro-Glv-Pro-OBzl. 5,358 г (11,65 ммоль) Boc-Pro-Gly-Pro-OBzl растворяли в 29,13 мл хлористого метилена, добавляли 29,13 мл ТФУ, выдерживали 45 минут при комнатной температуре, два раза упаривали с абс. этанолом, два раза с бензолом, два раза с эфиром, растворяли в бензоле и заливали гексаном. Гексан сливали, а полученное масло сушили в эксикаторе над P₂O₅/KOH и парафином.

Выход - 4,63 г (9,7 ммоль) 98%

Rf - 0,043 (7); 0,247 (8); 0,018 (9).

V. Boc-Arg(NOr)-Pro-Glv-Pro-OBzl. 3,09 г Boc-Arg(NO₂)-OH 9,7 ммоль растворяли в 50 мл ТГФ и 10 мл ДМФА, добавляли 2,07 г (10,67 ммоль) ДЦГК, охлаждали до 0°C, перемешивали в течение 40 минут и добавляли раствор ТФА-H-Pro-Gly-Pro-OBzl в 50 мл ТГФ и 4,46 мл (9,7 ммоль) ТЭА. Перемешивали реакционную смесь в течение трех суток. Отфильтровывали осадок ДЦМ, упаривали раствор в вакууме, к остатку приливали 200 мл гексана, при этом отделялся целевой продукт в виде масла, которое растворяли в 500 мл этилацетата и промывали 3 раза по 25 мл 0,1 н. HCl, 3 раза по 25 мл H₂O, 1 раз насыщенным раствором NaCl. Органический слой высушивали над MgSO₄, отфильтровывали и упаривали. Остаток растворяли в ЭА и высаждали сухим эфиром. Выпавший осадок отфильтровывали и высушивали в вакууме над P₂O₅/KOH и парафином, меняя несколько раз осушитель.

Выход - 4,76 г (7,9 ммоль) 85%

Rf - 0,44 (1); 0,8 (11)

Т.пл. 108-110°C

[α]_D ²² -77,8° (с=0,5; CH₃COOH).

VI. Boc-Arg-Pro-Glv-Pro. 4,76 г (6,5 ммоль) Boc-Arg(NO₂)-Pro-Gly-Pro-OBzl растворяли в 100 мл метанола, добавляли 1 мл 1 н. соляной кислоты и 4,67 г катализатора - 10% окись палладия на нейтральной окиси алюминия, гидрировали в токе сухого водорода при комнатной температуре и давлении 1 атм в течение 6 часов. Затем катализатор отфильтровывали, промывали на фильтре метанолом. Объединенный фильтрат упаривали досуха. Остаток высаждали из абс. метанола эфиром. Сушили в вакууме, несколько раз меняя осушители.

Выход - 4,23 г (5,8 ммоль) 89%

Rf - 0,125 (4); 0,57 (6); 0,37 (5)

Т.пл. 123-125°C.

VII. Arg-Pro-Glv-Pro. 4,23 г (5,8 ммоль) Вос-Arg-Pro-Gly-Pro-OH суспензировали в 10 мл 2 н. соляной кислоты в диоксане и выдерживали при комнатной температуре в течение 45 мин. Затем добавляли сухой эфир, выпавший осадок промывали декантацией сухим эфиром. Переосаждали из абсолютного метанола эфиром. Полученный осадок растворяли в 7,5 мл 30% этанола и наносили на колонку со смолой Амберлист А-21 (AcO^--форма) для обмена хлористоводородной соли на ацетат. Элюировали пептид 200 мл 30% этанола, упаривали в вакууме досуха и высаждали из метанола абс. эфиром.

Выход - 3,69 г (4,93 ммоль) 85%

Rf - 0,287 (4); 0,145 (5); 0,338 (14)

Т.пл. 120-122°C.

Результаты ВЭЖХ: Колонка Supercosil ABZ+Plus размер 4,6×250 мм; скорость потока 1 мл/мин; Элюент A: NH₄H₂PO₄+H₃PO₄ (50 mM, pH 2.8); элюент В: МеОН. Градиент: 0-20 мин (0-40% В); время выхода 21,21 мин.

Rf - 0,24 (6)

Т.пл.=151°C

[α]_D ²²=-65,0° (0=0,5 CH₃COOH).

Результаты ВЭЖХ: Колонка Zorbax ODS d=4,6 mm; t=35°C скорость потока 1 мл/мин; A=50 mM NH₄H₂PO₄ (pH 2,5); В-А+МеОН (1:1); 10-60% В (за 25 мин). Время выхода 16,5 мин.

Пример 2. Синтез пентапептида Pro-Arg-Pro-Gly-Pro.

Синтез пептида осуществляли классическими методами пептидной химии с использованием природных L-аминокислот по схеме, приведенной на фиг. 2.

Сначала получали трипептид Pro-Gly-Pro, а затем ступенчатым наращиванием пептидной цепи с N-конца получали пентапептид. При синтезе использовали метод смешанных ангидридов, азидный метод и карбодиимидный метод.

Приведены хроматографические подвижности (Rf) в системах растворителей: бутанол:уксусная кислота:вода (4:1:1)-(1); хлороформ:метанол:аммиак (6:4:1)-(2); ацетон:бензол:уксусная кислота (50:100:1)-(3); хлороформ:метанол (9:1)-(4); гексан:ацетон (3:2)-(5); бутанол:уксусная кислота:пиридин:вода (30:6:20:24)-(6); хлороформ:метанол (14:1)-(7).

I. Boc-Pro-Glv-OEt. Boc-Pro 8,3 г (38,45 ммоль) растворяли в 50 мл CH₂Cl₂, охлаждали до +5°C, добавляли 38,45 ммоль (5,38 мл) ТЭА. Реакционную смесь охлаждали до -25-30°C. При этой температуре из пипетки прибавляли 38.45 ммоль (4,84 мл) изобутилового эфира хлормуравьиной кислоты. Температуру реакционной смеси удерживали в интервале -18-20°C 20 минут. Одновременно готовили раствор 5,9 г (42,3 ммоль) избыток 1,1 HCl-H-Gly-OEt в 75 мл хлороформа, содержащего 5,92 мл ТЭА. Раствор охлаждали до -25°C и, после образования смешенного ангидрида в первой колбе, ее содержимое приливали сразу же к раствору эфира. Реакционную смесь выдерживали при температуре -10°C 1 час и затем при температуре +4°C 12 часов при перемешивании на магнитной мешалке. Реакционную смесь упаривали, добавляли 250 мл этилацетата, раствор этилацетата промывали 3 раза по 25 мл 0,1 н. HCl, 3 раза по 25 мл H₂O, 1 раз насыщенным раствором NaCl. Органический слой высушивали над MgSO₄, фильтровали и упаривали. Остаток высушивали в вакууме над P₂O₅/KOH и парафином.

Выход - 10,2 г (30,3 ммоль), 78,83%.

Rf - 0,5 (3); 0,862 (4).

II. Boc-Pro-Gly-N₂H₃. Boc-Pro-Gly-OEt 10,2 г (30,3 ммоль) растворяли в 80 мл абсолютного метанола, добавляли 4-х кратный избыток гидразин-гидрата 5,88 мл (121,2 ммоль). Перемешивали 12 часов на магнитной мешалке при комнатной температуре. Реакционную смесь упаривали, два раза упаривали с эфиром, остаток заливали эфиром (5 мл) и оставляли в холодильнике на ночь (для лучшей кристаллизации добавляли затравку). Выпавшие кристаллы отфильтровывали, промывали на фильтре эфиром, сушили в эксикаторе.

Выход - 6,9 г (20,79 ммоль), 68,62%.

Т.пл. 98-100°C.

Rf - 0,284 (3); 0,474 (4); 0,189 (5).

III. Boc-Pro-Glv-Pro-OBzl.

К охлажденному до -20°C раствору Boc-Pro-Gly-N₂H₃ 4,7 г (14,6 ммоль) в 40 мл ДМФА добавляли 58,4 ммоль (4-х кратный избыток) раствора хлористого водорода в этилацетате и сразу же 1,73 мл (14,6 ммоль) трет-бутилнитрита, реакционную смесь перемешивали 30 минут при -5°C. Реакционную смесь охлаждали до -40°C и добавляли охлажденный до -10°C раствор 8,2 мл (58,4 ммоль) ТЭА в 4 мл ДМФА; когда температура реакционной смеси повышалась до -20°C добавляли 3,7 г (15,3 ммоль) избыток 1,05 HCl-H-Pro-OBzl в 20 мл ДМФА и 2,14 мл ТЭА. Выдерживали при +4°C 24 часа, перемешивая на магнитной мешалке. Реакционную смесь упаривали, остаток растворяли в 200 мл этилацетата и промывали 2 раза по 20 мл H₂O, 3 раза по 20 мл 10% раствором KHSO₄, 3 раза по 20 мл H₂O, 3 раза по 20 мл 5% раствором NaHCO₃, 3 раза по 20 мл H₂O. Этилацетатный слой высушивали над MgSO₄. Упаривали, остаток заливали небольшим количеством эфира (10 мл). Оставляли в холодильнике. Для лучшей кристаллизации продукта добавляли затравку. Выпавшие кристаллы отфильтровывали, промывали на фильтре небольшим количеством эфира. Сушили в эксикаторе.

Выход - 5,358 г (11,65 ммоль), 79,92%.

Rf - 0,326 (3); 0,947 (4); 0,390 (5).

Т.пл. 125-126°C.

[α]_D ²²=-101,2° (с=0,85; CH₃OH).

Элементный анализ: С 62,89 (62,73); N 9,21 (9,14); Н 7,52 (7,24).

IV. ТФА-H-Pro-Gly-Pro-OBzL 5,358 г (11,65 ммоль) Boc-Pro-Gly-Pro-OBzl растворяли в 29,13 мл хлористого метилена, добавляли 29,13 мл ТФУ, выдерживали 45 минут при комнатной температуре, два раза упаривали с абс. этанолом, два раза с бензолом, два раза с эфиром, растворяли в бензоле и заливали гексаном. Гексан сливали, а полученное масло сушили в эксикаторе над P₂O₅/KOH и парафином.

Выход - 4,63 г (9,7 ммоль), 98%.

Rf - 0,043 (3); 0,247 (4); 0,018 (5).

V. Boc-Arg(NOr)-Pro-Glv-Pro-OBzL 3,09 г (9,7 ммоль) Boc-Arg(NO₂) растворяли в 50 мл ТГФ и 10 мл ДМФА, добавляли 2,07 г (10,67 ммоль) ДЦГК, охлаждали до 0°C, перемешивали в течение 40 минут и добавляли раствор ТФА-H-Pro-Gly-Pro-OBzl в 50 мл ТГФ и 4,46 мл (9,7 ммоль) ТЭА. Перемешивали реакционную смесь в течение трех суток. Отфильтровывали осадок ДЦМ, упаривали раствор в вакууме, к остатку приливали раствор 200 мл гексана, при этом отделялся целевой продукт в виде масла, которое растворяли в 500 мл этилацетата и промывали 3 раза по 25 мл 0,1 н. HCl, 3 раза по 25 мл H₂O, 1 раз насыщенным раствором NaCl. Органический слой высушивали над MgSO₄, фильтровали и упаривали. Остаток высушивали в вакууме над P₂O₅/KOH и парафином.

Выход 4,76 г (7,9 ммоль), 85%.

Rf - 0,44 (1); 0,8 (6).

Т.пл. 108-110°C.

VI. TFA-Arg(NO₂)-Pro-Gly-Pro-OBzl. 4,76 г (7,9 ммоль) Вос-Arg(NO₂)-Pro-Gly-Pro-OBzl растворяли в 20 мл хлористого метилена, добавляли 20 мл ТФУ, выдерживали 45 минут при комнатной температуре, два раза упаривали с абс.этанолом, два раза с бензолом, два раза с эфиром, растворяли в бензоле и заливали гексаном. Гексан сливали, а полученное масло сушили в эксикаторе над P₂O₅/KOH и парафином.

Выход количественный.

Rf - 0,16 (1); 0,27 (6).

VII. Boc-Pro-Arg(NOi)-Pro-Glv-Pro-OBzl. Boc-Pro 1,7 г (7,9 ммоль) растворяли в 20 мл ТГФ, добавляли 1,07 г (7,9 ммоль) БТ, охлаждали до 0°C и добавляли 1,8 г ДЦГК в 50 мл ТГФ. Через 40 мин к реакционной смеси добавляли раствор TFA-Arg(NO₂)-Pro-Gly-Pro-OBzl (7,9 ммоль) в 50 мл ТГФ и 1,1 мл (7,9 ммоль) ТЭА. Перемешивали 2 часа при 0°C и 2 суток при комнатной температуре, затем отфильтровывали ДЦМ, упаривали в вакууме, растворяли в 500 мл ЭА и обрабатывали аналогично

Boc-Pro-Arg(NO₂)-Pro-Gly-Pro-OBzl.

Выход 4,07 г (67,8%).

Rf - 0,42 (1); 0,72 (6); 0,31 (7).

Т.пл. 147-148°C.

VIII. Boc-Pro-Arg-Pro-Gly-Pro. 4,07 г (6,5 ммоль) растворяли в 100 мл метанола, добавляли 1 мл 1 н. соляной кислоты и 0,85 г катализатора -10% окись палладия на нейтральной окиси алюминия, гидрировали в токе сухого водорода при комнатной температуре и давлении 1 атм в течение 6 часов. Затем катализатор отфильтровывали, промывали на фильтре метанолом. Объединенный фильтрат упаривали досуха. Остаток высаждали из абс. метанола эфиром.

Выход - 3,02 г 5,8 ммоль (89%).

Rf - 0,125 (1), 0,57 (2), 0,37 (6).

IX. Pro-Arg-Pro-Glv-Pro. 3,02 г (5,8 ммоль) Boc-Pro-Arg-Pro-Gly-Pro суспензировали в 10 мл 2 н. соляной кислоты в диоксане и выдерживали при комнатной температуре в течение 45 мин. Затем добавляли сухой эфир, выпавший осадок промывали декантацией сухим эфиром. Переосаждали из абс. метанола эфиром. Полученный осадок растворяли в 7,5 мл 30% этанола и наносили на колонку с Амберлистом А-21 (AcO^- - форма) для обмена хлористоводородной соли на ацетат. Элюировали пептид 200 мл 30% этанола, упаривали в вакууме досуха и высаждали из метанола абс. эфиром.

Выход - 2,27 г (75%).

Rf - 0,2 (2); 0,1 (6).

Т.пл. 180-185°C.

[α]_D ²⁰=- 105° (с=0,4; CH₃COOH).

Аминокислотный состав по отношению к аргинину: Pro 2,78 (3); Gly 1,1 (1).

Результаты ВЭЖХ: Колонка Supercosil ABZ+Plus размер 4,6×250 мм; скорость потока 1 мл/мин. Элюент A: NH₄H₂PO₄+H₃PO₄ (50 mM, pH 2.8); элюент В: МеОН

Градиент: 0-20 мин (0-40%В); время выхода 10,13 мин.

Пример 3. Синтез трипептида Pro-Gly-Pro.

Схема синтеза трипептида Pro-Gly-Pro осуществляли по схеме, приведенной на фиг. 3.

Синтез трипептида Pro-Gly-Pro был осуществлен с использованием современных защитных групп и методов создания пептидной связи в растворе. Для создания пептидной связи использовался метод смешанных ангидридов с применением PivCl. Для защиты аминогрупп применялась трет-бутилоксикарбонильная защита (Вое), для защиты карбоксильной группы - бензиловый эфир (OBzl). Использовалось ступенчатое наращивание пептидной цепи.

Для синтеза использовали производные L-аминокислот. Упаривание растворов проводили на вакуумном испарителе при 40°C. Температуры плавления, определенные на столике для плавления Boetiys, даны без исправления. Индивидуальность полученных соединений проверяли с помощью ТСХ на пластинках с силикагелем фирмы Silufol (Чехия). Вещества обнаруживали, опрыскивая пластинки раствором нингидрина и(или) о-толидином. Приведены хроматографические подвижности (Rf) в системах растворителей: (этилацетат:ацетон:50% уксусная кислота:вода (2:1:1); бензол:этанол (8:2); хлороформ:метанол:аммиак (6:4:1); хлороформ:метанол:уксусная кислота (42:7:1); ацетон:бензол:уксусная кислота (50:100:1); хлороформ:метанол (9:1); гексан:ацетон (3:2); бутанол:уксусная кислота:вода (4:1:1); бутанол:уксусная кислота:пиридин:вода (30:6:20:24); гексан:этилацетат (4:1); хлороформ:метанол:аммиак (8:1,75:0,25); (изо-пропанол:муравьиная кислота:вода) (20:5:1); (хлороформ:метанол:аммиак) (7:2,5:0,5); метанол. Удельное вращение определяли на поляриметре «A1-ЕПО»). Элементный анализ на анализаторе "Carlo-Erba" модель 1106.

I. Получение Boc-Pro-Glv-OH.

1. 10,75 г (50 ммоль) Вос-Рго растворяли в 150 мл ацетонитрила, охлаждали до -5°C, к раствору прибавляли 7,7 мл (50 ммоль) триэтиламина (ТЭА), охлаждали до -20°C, перемешивая на магнитной мешалке. К охлажденному раствору прибавляли 6,8 мл (55 ммоль) пивалоил хлорида (PivCl), перемешивали на магнитной мешалке 20 минут при -10°C, охлаждали до -30°C и прибавляли предварительно охлажденный раствор Gly. Одновременно приготавливали раствор Gly. 2. Gly 4,5 г (60 ммоль, избыток 1,2) растворяли в 35 мл воды и 60 мл ацетонитрила, прибавляли 8,4 мл (60 ммоль) триэтиламина, охлаждали до -10°C и через 20 минут прибавляли к раствору в первой колбе. Реакционную смесь выдерживали 1 час при -10°C и 2 часа при 18-20°C, перемешивая на магнитной мешалке. Реакционную смесь упаривали на роторном испарителе. К остатку добавляли ~50 мл воды. Водный раствор подкисляли 3-х кратным избытком NaHSO₄ (24,84 г) до pH 3, экстрагировали 5 раз по 100 мл этилацетатом. Объединенный раствор этилацетата промывали H₂O (50 мл), 10% раствором KHSO₄ (50 мл), H₂O (50 мл), насыщенным раствором NaCl (50 мл). Этилацетатный раствор сушили над MgSO₄. Высушенный этилацетат отфильтровывали и упаривали. К остатку добавляли сухой эфир. При добавлении эфира в колбе выпадает продукт, который отфильтровывали, промывая его на фильтре сухим эфиром. Полученное вещество высушивали под вакуумом в эксикаторе над KOH, P₂O₅ и парафином, несколько раз меняя осушители.

М.в. продукта 272,3

Выход: 5,97 г (21,74 ммоль); (43,5%)

Т.пл. 70°C

Rf - 0,863 (ацетон-бензол-уксусная кислота) (50:100:1);

0,746 (бензол-этанол) (8:2);

0,903 (хлороформ:метанол) (9:1);

0,847 (этилацетат:ацетон:50% уксусная кислота:вода) (2:1:1).

II. Получение Boc-Pro-Gly-Pro-OBzl.

1. 5,97 г (21,74 ммоль) Boc-Pro-Gly-OH растворяли в 100 мл ацетонитрила, охлаждали до -5°C, к раствору прибавляли избыток 1,1 (3,35 мл; 23,9 ммоль) триэтиламина (ТЭА), охлаждали до -20°C, перемешивая на магнитной мешалке. К охлажденному раствору прибавляли избыток 1,1(2,34 мл; 23,9 ммоль) пивалоил хлорида (PivCl), перемешивали на магнитной мешалке 20 минут при -10°C, охлаждали до -30°C и прибавляли предварительно охлажденный раствор HCl·Pro-OBzl.

Одновременно приготавливали раствор HCl·Pro-OBzl. 2. HCl·Pro-OBzl 6,3 г (26,1 ммоль, избыток 1,2) растворяли в 50 мл ацетонитрила, прибавляли 4,0 мл (28,71 ммоль; избыток 1,1) триэтиламина, охлаждали до -10°C и через 20 минут прибавляли к раствору в первой колбе. Реакционную смесь выдерживали 1 час при -10°C и 2 часа при 18-20°C, перемешивая на магнитной мешалке. Реакционную смесь упаривали. К упаренному остатку прибавляли 300 мл этилацетата. Этилацетатный раствор промывали H₂O (3 раза по 25 мл), 10% раствором KHSO₄ (3 раза по 25 мл), H₂O (3 раза по 25 мл), 5% раствором NaHCO₃ (3 раза по 25 мл), H₂O (3 раза по 25 мл), насыщенным раствором NaCl (1 раз 25 мл). Этилацетатный раствор сушили над MgSO₄. Высушенный этилацетат отфильтровывали и упаривали. К остатку добавляли ~ 100 мл сухого эфира. При добавлении эфира в колбе выпадает продукт, который отфильтровывали, промывая его на фильтре сухим эфиром. Полученное вещество высушивали под вакуумом в эксикаторе над KOH, P₂O₅ и парафином, несколько раз меняя осушители.

М.в. продукта 459,82

Выход: 8,12 г (17,66 ммоль); (81,23%)

Т.пл. 125-126°C

Rf - 0,326 (ацетон:бензол:уксусная кислота) (50:100:1)

0,390 (гексан:ацетон) (3:2)

0,947 (хлороформ:метанол) (9:1)

0,716 (метанол)

0,620 (бензол:этанол) (8:2)

III. Получение Boc-Pro-GIv-Pro-OH.

8 г (17,4 ммоль) Вос-Pro-Gly-Pro-OBzl растворяли в 100 мл метанола, прибавляли 0,5 мл CH₃COOH и палладиевую чернь, перемешивая на магнитной мешалке, пропускали водород в течение 2-х часов. Раствор отфильтровывали, упаривали, 3 раза упаривали с бензолом, 2 раза с этилацетатом. Высаждали из ацетона эфиром гексаном, раствор сливали, а выпавший осадок в колбе сушили в эксикаторе над P₂O₅/KOH и парафином.

М.в. продукта 369,39

Выход 6,3 г (17,05 ммоль) (98%)

Т.пл.99-100°C

Rf: 0,560 (хлороформ-метанол) (9:1)

0,812 (хлороформ-метанол-уксусная кислота) (42:7:1)

0,187 (ацетон:бензол:уксусная кислота) (50:100:1)

0,164 (гексан:ацетон) (3:2)

IV. Получение Pro-Gly-Pro.

К 6,0 г (16,24 ммоль) Boc-Pro-Gly-Pro-OH прибавляли 40,6 мл хлористого метилена и 40,6 мл ТФУ, выдерживали 45 минут при комнатной температуре, после снятия защитной группы раствор два раза упаривали с абс. метанолом, два раза с бензолом, два раза с эфиром. Высаждали из ацетона эфиром. Остаток сушили в вакууме над P₂O₅, KOH и парафином. Высушенный продукт переосаживали из абсолютного MeOH сухим диэтиловым эфиром.

М.в. продукта 381,39

Выход 5,6 г (14,72 ммоль) (90,62%)

Полученный осадок TFA Pro-Gly-Pro-OH растворяли в 10 мл 30% этанола, добавляли 25 мл ионообменной смолы Амберлист А-21 (CH₃COO^-) для перевода трифторацетной соли в ацетатную, перемешивали на магнитной мешалке 45 минут, затем промывали 150 мл 30% этанола, упаривали в вакууме досуха и высаждали из абсолютного метанола сухим диэтиловым эфиром. Полученный осадок отфильтровывали, сушили в эксикаторе под вакуумом над P₂O₅, KOH и парафином, несколько раз меняя осушители.

М.в. продукта 328,34

Выход 4,54 г (13,84 ммоль) (94%)

Т.пл. 143-145°C

[α]_D ²² - 31,5° (с 1, MeOH)

Rf: 0,59 (хлороформ:метанол:аммиак) (6:4:1)

0,52 (хлороформ:метанол:аммиак) (4:4,5:1,5)

0,524 (этанол:аммиак) (7:3)

Пример 4. Синтез гексапептида Thr-Lys-Pro-Arg-Pro-Phe.

Синтез гексапептида Thr-Lys-Pro-Arg-Pro-Phe осуществляли по схеме, приведенной на фиг. 4.

Синтез гексапептида Thr-Lys-Pro-Arg-Pro-Phe был осуществлен с использованием современных защитных групп и методов создания пептидной связи в растворе. Для создания пептидной связи использовался метод ТБА солей, метод активированных эфиров, карбодиимидный метод и метод смешанных ангидридов. Использовались как ступенчатое наращивание пептидной цепи, так и блочный метод.

Пример 5. Синтез пентапептида Thr-Lys-Pro-Arg-Pro.

Синтез пентапептида Thr-Lys-Pro-Arg-Pro осуществляли по схеме, приведенной на фиг. 5.

Синтез пентапептида Thr-Lys-Pro-Arg-Pro был осуществлен с использованием современных защитных групп и методов создания пептидной связи в растворе. Для создания пептидной связи использовался метод ТБА солей, метод активированных эфиров, карбодиимидный метод. Использовались как ступенчатое наращивание пептидной цепи, так и блочный метод.

Пример 6. Синтез дипептида Thr-Lys.

Синтез дипептида Thr-Lys осуществляли по схеме, приведенной на фиг. 6.

Синтез дипептида Thr-Lys был осуществлен с использованием современных защитных групп и методов создания пептидной связи в растворе. Для создания пептидной связи использовался метод ТБА солей.

Для синтеза пептидов, приведенных в примерах 7-9, использовали производные как защищенные, так и свободные L-аминокислоты. Растворители, используемые при синтезе пептидов, абсолютировали соответствующим образом. Проверку гомогенности полученных пептидов проводили с помощью высокоэффективной жидкостной хроматографии (ВЭЖХ) на жидкостном микроколоночном хроматографе «Миллихром А-02». Синтезированные пептиды были охарактеризованы при помощи масс-спектрометрии на масс-спектрометре фирмы Bruker (^®Bruker Daltonik GmbH).

Пример 7. Синтез тетрапептида Thr-Lys-Pro-Phe.

Схема синтеза тетрапептида Thr-Lys-Pro-Phe осуществляли по схеме, приведенной на фиг. 7.

Синтез тетрапептида Thr-Lys-Pro-Phe был осуществлен с использованием современных защитных групп и методов создания пептидной связи в растворе. Для создания пептидной связи использовались метод ТБА солей и метод активированных эфиров. Использовалось ступенчатое наращивание пептидной цепи.

Для синтеза использовали производные как защищенные, так и свободные L-аминокислоты. Упаривание растворов проводили на вакуумном испарителе при 40°C. Температуры плавления, определенные на столике для плавления Boetiys, даны без исправления. Индивидуальность полученных соединений проверяли с помощью ТСХ на пластинках с силикагелем фирмы Silufol (Чехия). Вещества обнаруживали, опрыскивая пластинки раствором нингидрина и(или) о-толидином. Приведены хроматографические подвижности (Rf) в системах растворителей: (бутанол уксусная кислота:вода) (4:1:1); (бензол-этанол) (8:2); (хлороформ:метанол) (9:1); (изо-пропанол:муравьиная кислота:вода) (20:5:1); (хлороформ:метанол:уксусная кислота) (42:7:1); (хлороформ:метанол:аммиак) (8:1,75:0,25); (ацетон:бензол:уксусная кислота) (50:100:1); (хлороформ:метанол:аммиак) (6:4:1); (хлороформ:метанол:аммиак) (4:4,5:1,5); (бутанол:уксусная кислота:пиридин: вода) (30:6:20:24).

I. Получение Z-Lys(Boc)-Pro-OH.

К 46,32 ммоль (5,34 г) Pro добавляли 13% раствор ТБА (98 мл), 2 раза упаривали с этанолом, 2 раза смесью этанол/бензол, 2 раза с бензолом. Добавляли 300 мл абс. этилацетата, реакционную массу охлаждали до 0°C и добавляли 23,16 ммоль (12,66 г) ранее синтезированного Z-Lys(Boc)-OPfp, перемешивали на магнитной мешалке 1 час. Реакционную массу упаривали, к упаренному остатку прибавляли 40 мл воды. Водный раствор промывали 3 раза по 80 мл эфиром. После промывки эфиром водный раствор подкисляли лимонной кислотой до pH 3. После подкисления водный раствор экстрагировали этилацетатом 3 раза по 40 мл. Общий этилацетат после экстракции промывали 3 раза по 20 мл водой, 3 раза по 20 мл 10% раствором KHSO₄, 3 раза по 20 мл водой. Этилацетатный раствор сушили над MgSO₄. Отфильтровывали, упаривали на роторном испарителе. Полученное вещество высаждали из этилацетата гексаном. Гексан сливали, а полученное вещество высушивали под вакуумом в эксикаторе над KOH, P₂O₅ и парафином, несколько раз меняя осушители.

Выход: 9,68 г (20,26 ммоль); (87,51%).

Т.пл. 76-77°C

Rf - 0,705 (бутанол:уксусная кислота:вода) (4:1:1);

0,560 (бензол:этанол) (8:2);

0,476 (хлороформ:метанол) (9:1);

0,813 (изо-пропанол:муравьиная кислота:вода) (20:5:1);

0,297 (ацетон:бензол:уксусная кислота) (50:100:1).

II. Получение H-Lvs(Boc)-Pro-OH.

К 9,68 г (20,26 ммоль) Z-Lys(Boc)-Pro-OH прибавляли 300 мл абс. Метанола, 2 мл уксусной кислоты и Pd чернь, гидрировали в токе сухого водорода при комнатной температуре и давлении 1 атм в течение 8 часов. Затем катализатор отфильтровывали, промывали на фильтре метанолом. Объединенный фильтрат упаривали досуха. Остаток высаждали из абс. метанола эфиром. Сушили в вакууме, несколько раз меняя осушители.

Выход: 6,38 г (18,58 ммоль); (91,87%)

Т.пл. 98-99°C

Rf - 0,110 (хлороформ:метанол:уксусная кислота) (42:7:1);

0,166 (бутанол:уксусная кислота:вода) (4:1:1);

0,235 (хлороформ:метанол:аммиак) (8:1,75:0,25);

0,494 (изо-пропанол:муравьиная кислота:вода) (20:5:1)(2:1:1).

III. Получение Boc-Thr-Lys(Boc)-Pro-OH.

К 18,58 ммоль (6,38 г) Lys(Boc)-Pro-OH добавляли 13% раствор ТБА (39,4 мл) 2 раза упаривали с этанолом, 2 раз смесью этанол/бензол, 2 раза с бензолом. Добавляли 250 мл абс. этилацетата, реакционную массу охлаждали до 0°C и добавляли 9,2 ммоль (3,74 г) ранее синтезированного Boc-Thr-OPfp, перемешивали на магнитной мешалке 1 час. Реакционную массу упаривали, к упаренному остатку прибавляли 40 мл воды. Водный раствор промывали 3 раза по 80 мл эфиром. После промывки эфиром водный раствор подкисляли лимонной кислотой 18,58 ммоль (3,95 г) до pH 3. После подкисления водный раствор экстрагировали этилацетатом 3 раза по 40 мл. Общий этилацетат после экстракции промывали 3 раза по 20 мл водой, 3 раза по 20 мл 10% раствором KHSO₄, 3 раза по 20 мл водой. Этилацетатный раствор сушили над MgSO₄. Отфильтровывали, упаривали на роторном испарителе. Полученное вещество высаждали из этилацетата гексаном. Гексан сливали, а полученное вещество высушивали под вакуумом в эксикаторе над KOH, P₂O₅ и парафином, несколько раз меняя осушители.

Выход: 3,32 г (6,1 ммоль); (66,26%)

Т.пл. 105-107°C

Rf - 0,297 (ацетон:бензол:уксусная кислота) (50:100:1);

0,234 (хлороформ:метанол) (9:1);

0,560 (бензол:этанол) (8:2).

IV. Получение Boc-Thr-Lys(Boc)-Pro-Phe-OH.

1. Получение Boc-Thr-Lys(Boc)-Pro-OSu.

К 1,66 г (3,05 ммоль) Boc-Thr-Lys(Boc)-Pro в 50 мл абс. этилацетата прибавляли 3,53 ммоль (0,38 г) гидроксисукцинимида, полученный раствор охлаждали до 0°C при перемешивании на магнитной мешалке и прибавляли 0,76 г (3,53 ммоль) ДЦГК (дициклогексилкарбодиимида), перемешивали на магнитной мешалке при t комн в течение 2 часов. По окончании реакции полученную реакционную массу отфильтровывали, осадок отбрасывали, а к полученному раствору прибавляли 200 мл асб. этилацетата. Общий этилацетат промывали 2 раз по 20 мл насыщ. раствором NaCl, 2 раза по 20 мл 10% раствором KHSO₄, 2 раз по 20 мл насыщ. раствором NaCl, 2 раза по 20 мл 5% раствором NaHCO₃, 2 раз по 20 мл насыщ. раствором NaCl. Этилацетатный раствор сушили над MgSO₄. Отфильтровывали, упаривали на роторном испарителе. Полученное вещество высаждали из этилацетата смесью эфира с гексаном. Выпавший осадок отфильтровывали и высушивали под вакуумом в эксикаторе над KOH, P₂O₅ и парафином, несколько раз меняя осушители.

Выход: 1,52 г (2,37 ммоль) 77,74%.

Rf - 0,560 (бензол:этанол) (8:2);

0,457 (хлороформ:метанол) (9:1).

2. После получения 1,52 г (2,37 ммоль) Boc-Thr-Lys(Boc)-Pro-OSu растворяли в 25 мл диметилформамида и прибавляли его к приготовленному раствору, содержащему 0,392 г (2,37 ммоль) L-Phe в 25 мл диметилформамида. Перемешивали на магнитной мешалке при t комн. Реакционную смесь упаривали на роторном испарителе, высаждали из бензола эфиром. Выпавший осадок отфильтровывали и высушивали под вакуумом в эксикаторе над KOH, P₂O₅ и парафином, несколько раз меняя осушители.

Выход: 1,03 г (1,64 ммоль) 69,0%.

Rf - 0,063 (изо-пропанол:муравьиная кислота:вода) (20:5:1) (2:1:1).

0,745 (хлороформ:метанол:аммиак) (8:1,75:0,25);

V. Получение H-Thr-Lys-Pro-Phe-OH.

1,03 г (1,64 ммоль) Boc-Thr-Lys(Boc)-Pro-Phe-OH прибавляли 8,2 мл хлористого метилена и 8,2 мл ТФУ, выдерживали 45 минут при комнатной температуре, после снятия защитных [групп раствор два раза упаривали с абс. метанолом, два раза с бензолом, два раза с эфиром. Высаждали из метанола эфиром. Остаток сушили в вакууме над P₂O₅, KOH и парафином. Полученный осадок растворяли в 5 мл 30% этанола и наносили на колонку с Амберлистом А-21 (AcO^- - форма) для обмена трифторацетатной соли на ацетат. Элюировали пептид 100 мл 30% этанола, упаривали в вакууме досуха и высаждали из абс. метанола абс. эфиром. Полученный осадок отфильтровывали, сушили в эксикаторе под вакуумом над P₂O₅, KOH и парафином, несколько раз меняя осушители.

Выход: 0,7 г (1,43 ммоль) (87%).

Т.пл. 129-131°C

Rf: - 0,201 (бутанол:уксусная кислота:пиридин:вода) (30:6:20:24);

0,156 (хлороформ:метанол:аммиак) (4:4,5:1,5).

Хроматографический и масс-спектрометрический анализ пептидных последовательностей, приведенных в примерах 1-7, дан в Таблице 2.

Таблица 2 № Пептид MW Хроматогр. хар-ки Масс-спектрометрические характеристики Tr,мин Чист.% *[M+H]⁺ **Фрагментация мол. пика 1 ThrLysProArgPro 597 8.01 97 598 369 (100), 272 (31), 580 (29) 2 ThrLysProArgProPhe 744 14.8 96 745 516 (100), 263 (59), 327 (38) 3 ProArgProGlyPro 522 9.14 89 523 25 (100), 425 (27), 407 (11) 4 ThrLysProArg 500 5.72 94 501 457 (100), 272 (55), 484 (47), 5 ArgProGlyPro 425 6.82 85 426 408 (100), 293 (54), 254 (24) 6 ProGlyPro 269 5.42 >98 270 173 (100), 155 (98), 116 (75) 7 ThrLysPro 344 4.15 93 345 230 (100), 129 (19), 212 (16) 8 ThrLys 247 1.77 95 248 230 (100), 129 (78), 84 (30)   ThrLysProPhe 500 5.72 94 501 457 (100), 272 (55),             484 (47) *Молекулярный пик, соответствующий иону [М+Н]+ **Наиболее интенсивные ионы, образующиеся при фрагментации молекулярного пика при энергии ионных соударений с атомами гелия 35 эВ.

В Таблице 2 приведены данные высокоэффективной жидкостной хроматографии (ВЭЖХ) на жидкостном микроколоночном хроматографе «МиллиХром А-02» и масс-спектрометрические характеристики синтезированных пептидов, полученные при помощи масс-спектрометрии ThermoElectron LCQ Advantage MAX.

Разработанные хроматографические условия позволяют легко получать хроматографически чистые продукты.

Хроматографические условия анализа пептидов.

Хроматограф: МиллиХром-А-02

Колонка: Prontosil 120-5C18aq, 2*75 mm

Элюент А: 0.2 М LIC104+5 mM HClO4

Элюент В: метанол.

В Таблице 3 представлена форма градиента для разделения синтезированных пептидов.

Таблица 3 Время %В 0 5 16,5 80

Скорость потока: 150 мкл/мин

Набор длин волн: 210, 220, 230, 240 нм

Масс-спектрометрические условия анализа

Прибор: ThermoElectron LCQ Advantage MAX

Источник ионов: электроспрей; прямой ввод в источник раствора пептида с концентрацией 10 мкг/мл в 0,1% уксусной кислоте, со скоростью 5 мкл/мин

Фрагментация молекулярного иона при 35 эВ методом ионных соударений (Не)

Температура источника 250°C. Потенциал ионизации +3,5 кВ

Пример 8. Определение положения фармокофора.

Для определения фармокофора были синтезированы фрагменты исходного пептида «Селанк» -

Thr-Lys; Thr-Lys-Pro; Pro-Gly-Pro; Arg-Pro-Gly-Pro; Pro-Arg-Pro-Gly-Pro и были проведены тесты по эффективности in vivo, на релевантной доклинической модели (тест Лордоза).

В работе исследована эффективность группы пептидов Thr- Lys; Thr-Lys-Pro; Pro-Gly-Pro; Arg-Pro-Gly-Pro; Pro-Arg-Pro-Gly-Pro в дозе 100 мкг/крысу в отношении полового поведения самок крыс. Половое поведение регистрировали у овариоэктомированных, гормонально стимулированных самок при непосредственном контакте с сексуально активным самцом и при невозможности такого контакта. Было обнаружено, что пептид Thr-Lys-Pro увеличивает выраженность процептивного поведения самок с 14±4 до 29±6 актов за время регистрации (p=0,028, критерий Вилкоксона). Эффект в отношении реакции лордоза у самок имел ту же направленность (p=0,09), доля лордозов под действием пептида Thr-Lys-Pro возрастает с 0,73±0,12 до 0,97±0,12. Результаты свидетельствуют об усилении половой мотивации на фоне действия пептида Thr-Lys-Pro. Эффект специфичен и проявляется в адекватной поведенческой ситуации. Результаты исследования эффективности пептидов Thr-Lys; Thr-Lys-Pro; Pro-Gly-Pro; Arg-Pro-Gly-Pro; Pro-Arg-Pro-Gly-Pro на модели Лордоза приведены в Таблице 4.

Таблица 4 Группа Прогестерон, мг/крысу Исследуемый препарат, мкг/крысу Количество актов процептивного поведения Доля лордозов ОК 0,5 0 14±4 0,73±0,12 Thr-Lys 0,5 100 13±4 0,70±0,02 Thr-Lys-Pro 0,5 100 29±6 0,97±0,12 Pro-Gly-Pro 0,5 100 13±5 0,74±0,09 Arg-Pro-Gly-Pro 0,5 100 15±4 0,69±0,14 Pro-Arg-Pro-Gly-Pro 0,5 100 14±6 0,73±0,14 ПК 1,0 0 22±11 0,98±0,09

Из Таблицы 4 следует, что фармакофором является трипептид Thr-Lys-Pro, более того меньшая последовательность, т.е. дипептид Thr-Lys не работает, как следует из Таблицы 4.

Пример 9. Проверка фармакофора.

Для проверки фармокофора были синтезированы пептиды на его основе, а именно трипептид Thr-Lys-Pro, тетрапептиды Thr-Lys-Pro-Arg, Thr-Lys-Pro-Phe, пентапептид Thr-Lys-Pro-Arg-Pro, гексапептид Thr-Lys-Pro-Arg-Pro-Phe, отвечающие общей формуле A-Thr-Lys-Pro-Б-В-Г-Х, были проведены тесты по эффективности in vivo, на релевантной доклинической модели (тест Лордоза).

В работе исследована эффективность группы пептидов Thr-Lys-Pro; Thr-Lys-Pro-Arg; Thr-Lys-Pro-Arg-Pro; Thr-Lys-Pro-Arg-Pro-Phe в дозе 100 мкг/крысу в отношении полового поведения самок крыс. Половое поведение регистрировали у овариоэктомированных, гормонально стимулированных самок при непосредственном контакте с сексуально активным самцом и при невозможности такого контакта. Было обнаружено, что пептиды из группы Thr-Lys-Pro; Thr-Lys-Pro-Arg-Pro; Thr-Lys-Pro-Arg-Pro-Phe увеличивают выраженность процептивного поведения самок с 14±4 до 26±4-36±6 актов за время регистрации (p=0,028, критерий Вилкоксона). В то же время Thr-Lys-Pro-Arg и Thr-Lys-Pro-Phe не влияют на выраженность процептивного поведения самок и не увеличивают долю лордозов, основные показатели тетрапептидов Thr-Lys-Pro-Arg и Thr-Lys-Pro-Phe остаются на уровне отрицательного контроля. Эффект в отношении реакции лордоза у самок имел ту же направленность с (p=0,09). В отсутствие непосредственного контакта партнеров действие пептидов не проявлялось. Результаты свидетельствуют об усилении половой мотивации на фоне действия пептидов Thr-Lys-Pro; Thr-Lys-Pro-Arg-Pro; Thr-Lys-Pro-Arg-Pro-Phe и об отсутствии усиления половой мотивации у тетрапептидов Thr-Lys-Pro-Arg и Thr-Lys-Pro-Phe. Эффект специфичен и проявляется в адекватной поведенческой ситуации. Результаты исследования эффективности пептидов Thr-Lys-Pro; Thr-Lys-Pro-Arg; Thr-Lys-Pro-Phe; Thr-Lys-Pro-Arg-Pro; Thr-Lys-Pro-Arg-Pro-Phe на модели Лордоза представлены в Таблице 5.

Таблица 5 Группа Прогестерон, мг/крысу Исследуемый препарат, мкг/крысу Количество актов процептивного поведения Доля лордозов ОК 0,5 0 14±4 0,73±0,12 Thr-Lys-Pro 0,5 100 28±4 0,96±0,12 Thr-Lys-Pro-Arg 0,5 100 14±4 0,72±0,02 Thr-Lys-Pro-Phe 0,5 100 13±5 0,73±0,09 Thr-Lys-Pro-Arg-Pro 0,5 100 36±6 0,99±0,09 Thr-Lys-Pro-Arg-Pro-Phe 0,5 100 26±4 0,94±0,14 ПК 1,0 0 22±11 0,98±0,09